Beta-Lactamase DataBase
Beta-Lactamase DataBase - Structure and Function Home Enzymes Structures Mutants Kinetics BLAST
Beta-Lactamase DataBase

Synthetic Mutants (work in progress)

Ambler class
Protein name
Mutations
PubMed ID
DOI
PDB structures
Hydrolytic profile
ABlaCE182A 2096111210.1021/BI1015088view
ABlaCK87A 2096111210.1021/BI1015088view
ABlaCK87A 2484640910.1021/bi500339jview
ACTX-M-14R276A S237A S70G 2548979010.1021/bi501195g
ACTX-M-14E166A 2575314910.1039/C5CC00904Aview
ACTX-M-14S237A S70G 2548979010.1021/bi501195g
ACTX-M-14S70G 2548979010.1021/bi501195gview
ACTX-M-9Q25PCA 1930539710.1038/NCHEMBIO.155view
ACTX-M-9S70G 2045235910.1016/J.JMB.2010.04.062view
ACTX-M-9S70G 2193088210.1128/AAC.00245-11view
AKPC-2C-ter 292VNGQQ296 deleted 1862577210.1128/AAC.00163-08
AKPC-2G175S 1973193210.1021/BI9007963view
AKPC-2W105F 2066200610.1002/pro.454view
AKPC-2W105N 2066200610.1002/pro.454view
AKPC-2W105L 2066200610.1002/pro.454view
AKPC-2W105V 2066200610.1002/pro.454view
AKPC-2T237S 2042139610.1128/AAC.00197-10view
AKPC-2T237A 2042139610.1128/AAC.00197-10view
AKPC-2R220H 2268751110.1128/AAC.05769-11view
AKPC-2R220A 2268751110.1128/AAC.05769-11view
AKPC-2R220M 2268751110.1128/AAC.05769-11view
AKPC-2R220K 2268751110.1128/AAC.05769-11view
AKPC-2E276A 2268751110.1128/AAC.05769-11view
AKPC-2E276D 2268751110.1128/AAC.05769-11view
APC1-1A238S I239DEL 886964010.1093/PROTEIN/8.12.1275
APC1-1N170D E166Q 1043608310.1093/PROTEIN/12.7.573
APC1-1N170Q 898798010.1021/BI962242Aview
APC1-1N170M 898798010.1021/BI962242Aview
APC1-1D179N 189284910.1021/BI00103A017view
APC1-1E166D N170Q 1132785510.1021/BI002277H
APC1-1K73H 882315810.1021/BI961153Vview
APC1-1S70A 882315810.1021/BI961153Vview
APenPE166A 843396510.1093/PROTEIN/6.1.11
APenPE166C 2170532510.1074/JBC.M110.198895
APenPE166S 2502003110.1021/BI401609H
APenPW210F W229F W251F 2249605310.1002/PRO.2076
APSE-4R234K 1114803310.1021/BI001653Vview
ASFC-1E166A 2303030010.1021/JA304460Jview
ASFC-1S70A 2303030010.1021/JA304460Jview
ASHV-1R164H 2135729810.1128/AAC.01360-10view
ASHV-1R164S 2135729810.1128/AAC.01360-10view
ASHV-1D104E 2129415710.1002/PROT.22961view
ASHV-1D104K 1680934010.1074/JBC.M603878200view
ASHV-1E166A 14744126view
ASHV-1E166A 1605592310.1074/JBC.M505333200view
ASHV-1E166A 2445494410.1371/JOURNAL.PONE.0085892view
ASHV-1E166A M69V 1700229010.1021/BI060990M
ASHV-1K234R 2325255310.1021/JM301490Dview
ASHV-1K234R 2445494410.1371/JOURNAL.PONE.0085892view
ASHV-1M69V 2243827410.1002/CMDC.201200006view
ASHV-1S130G 1551856110.1021/BI0487903view
ASHV-1S130G 2243827410.1002/CMDC.201200006view
ASHV-1S130G 2569163910.1128/AAC.04405-14view
ASHV-1S70C 2297428110.1021/JA3073676view
ATEM-1R120G R241H I208M T265M T195S M182T A224V I56V 2254591310.1021/BI2018738
ATEM-1R243S 1205804610.1074/JBC.M204212200view
ATEM-1N100R 1503708510.1016/J.JMB.2003.12.068view
ATEM-1N132A 1187086810.1002/PROT.10058.ABSview
ATEM-1N170G 1981204110.1074/JBC.M109.053819view
ATEM-1N276D V84I A184V 1042323410.1021/BI990758Z
ATEM-1E104A Y105A V84I 1561840010.1073/PNAS.0407280102
ATEM-1E104K R164S M182T 1207933610.1016/S0022-2836(02)00400-X
ATEM-1E147G V80I R273L I208M L201P P62S M182T A224V I246V 1870642410.1016/J.JMB.2008.07.082
ATEM-1E166N 143603410.1038/359700A0view
ATEM-1E166Y L201P P167G W165Y 2571306210.1074/JBC.M114.633438
ATEM-1E166Y M182T P167G W165Y 2571306210.1074/JBC.M114.633438
ATEM-1E166Y P167G S70G W165Y 2571306210.1074/JBC.M114.633438
ATEM-1E219R Q247R V64I A248K T249K E84K M250T A164V 2142522910.1002/CBIC.201000568
ATEM-1G238A 1207933610.1016/S0022-2836(02)00400-Xview
ATEM-1L200A N51A R119G A41G E103K T262M G237S M181T 2354234110.1016/J.JMB.2013.03.033
ATEM-1L201A N52A R120G A42G T265M M182T 2354234110.1016/J.JMB.2013.03.033
ATEM-1L201P 1882229810.1016/J.JMB.2008.09.009view
ATEM-1M182T 1207933610.1016/S0022-2836(02)00400-Xview
ATEM-1M182T 1199657410.1021/JA0259640view
ATEM-1M182T 1285918810.1021/BI034242Yview
ATEM-1M182T 1503708510.1016/J.JMB.2003.12.068view
ATEM-1M69I M182T 1205804610.1074/JBC.M204212200
ATEM-1M69V 1205804610.1074/JBC.M204212200view
ATEM-1S130G 1598199910.1021/BI0502700view
ATEM-1S235A 1529979710.1107/S0907444994014496view
ATEM-1S70G 1604107210.1107/S0907444905014356view
ATEM-1Y105N V84I E104Y 1707084310.1016/J.JMB.2006.09.076
ATEM-1V84I A184V 1157308810.1038/NSB1001-848
AToho-1R274N R276N 2116841110.1016/J.FEBSLET.2010.12.017
AToho-1R274N R276N 1934278510.1107/S1744309109008240
AToho-1R274N R276N 2325559410.1074/JBC.M112.436238
AToho-1R274N R276N 10.1107/S1600576714010772
AToho-1E166A 992578610.1006/JMBI.1998.2432
AToho-1E166A 1222110210.1074/JBC.M207884200
AToho-1E166A R274N R276N 2003625910.1016/J.JMB.2009.12.036
AToho-1G238C A26M 1559582910.1021/BI048488U
B1BcIIR121C 1577991010.1021/BI047709T
B1BcIIR91H C168S 1791524910.1016/J.JMB.2007.08.031
B1BcIID120S 1742602810.1074/JBC.M700742200
B1BcIIC168D 2272914810.1038/NCHEMBIO.1005
B1BcIIC168D R91H 1791524910.1016/J.JMB.2007.08.031
B1BcIIC168S 1093350810.1110/ps.9.7.1402
B1BcIIV112A L250S G262S N70S 1909809610.1073/PNAS.0807989106
B1CfiAA171T 954543210.1016/S1074-5521(98)90632-9view
B1CfiAD208N A171T 957856410.1021/BI9730339
B1CfiAC181S 1021020310.1110/ps.8.1.249view
B1IMP-1D81A 1578841510.1074/JBC.M414314200view
B1IMP-1D81E 1578841510.1074/JBC.M414314200view
B1IMP-1C221G 2290817110.1128/AAC.01276-12
B1IMP-1C221E 2290817110.1128/AAC.01276-12
B1IMP-1C221X 19351604
B1IMP-1N223X 2189690310.1128/AAC.00340-11
B1IMP-1N233A 1171492410.1110/ps.40884
B1IMP-1XXX 1553343510.1016/j.jmb.2004.09.074
B1IMP-1D90N 1095257210.1128/AAC.44.9.2304-2309.2000
B1IMP-1H28A 1095257210.1128/AAC.44.9.2304-2309.2000
B1IMP-1H86A 1095257210.1128/AAC.44.9.2304-2309.2000
B1IMP-1H88A 1095257210.1128/AAC.44.9.2304-2309.2000
B1IMP-1H149A 1095257210.1128/AAC.44.9.2304-2309.2000
B1IMP-1H210A 1095257210.1128/AAC.44.9.2304-2309.2000
B1IMP-1C168A 1095257210.1128/AAC.44.9.2304-2309.2000
B1IMP-1N167A 1128715110.1111/j.1574-6968.2001.tb10587.x
B1IMP-1N167D 1128715110.1111/j.1574-6968.2001.tb10587.x
B1IMP-1K161R 1128715110.1111/j.1574-6968.2001.tb10587.x
B1IMP-1K161A 1128715110.1111/j.1574-6968.2001.tb10587.x
B1IMP-1K161E 1128715110.1111/j.1574-6968.2001.tb10587.x
B1NDM-1D124N 2526857510.1021/JA508388Eview
B1NDM-1D120N 2458484610.1039/c3cp55069a
B1VIM-7D120A 2491315810.1128/AAC.02735-13view
B1VIM-7H224Y 2491315810.1128/AAC.02735-13view
B1VIM-7F218Y 2491315810.1128/AAC.02735-13view
B2CphAN220G 1558882610.1016/J.JMB.2004.10.070
B2CphAN220G 1965191310.1128/AAC.00288-09
B2CphAN220G 2052788810.1021/JM100213C
B3AIM-1Q157A 2266496810.1128/AAC.00448-12view
B3AIM-1Q157N 2266496810.1128/AAC.00448-12view
B3FEZ-1Y228A 1250747010.1016/S0022-2836(02)01271-8view
B3GOB-18M221X 2225282410.1128/AAC.05418-11
B3L1D120N 1771594610.1021/BI700707U
B3L1D120C 1771594610.1021/BI700707U
CAmpCR397A 2167661610.1016/J.BMCL.2011.05.065
CAmpCR397A 2443386210.1016/J.BMCL.2013.12.101
CAmpCN152A 1143476810.1021/BI010641M
CAmpCN152H 1214478510.1016/S0022-2836(02)00599-5
CAmpCN289A 1466196010.1021/BI035054A
CAmpCN289A 1650677710.1021/JA056806M
CAmpCE219K 1991303410.1016/J.JMB.2009.11.005
CAmpCK67R 1924137610.1002/PRO.60
CAmpCK67Q 1214478510.1016/S0022-2836(02)00599-5
CAmpCS64D 1214478510.1016/S0022-2836(02)00599-5
CAmpCS64G 1200543910.1016/S0969-2126(02)00725-6
CAmpCS64G 1214478510.1016/S0022-2836(02)00599-5
CAmpCT70I 1991303410.1016/J.JMB.2009.11.005
CAmpCY147E Q117L 10.1021/JA001676X
CAmpCY150E Q120L 1290402710.1021/JA034861U
CAmpCY221G 1991303410.1016/J.JMB.2009.11.005
CAmpCV298E 1991303410.1016/J.JMB.2009.11.005
CHaBLAN288Q N321Q 2576060410.1107/S1399004714027734
CP99N152G A88P I16V A299V 2294891910.1107/S0907444912024080
DBlaR1K369A K370A K372A 2177544010.1074/JBC.M111.252189
DBlaR1K39A K40A K42A 2177544010.1074/JBC.M111.252189
DBlaR1K39A K40A K42A N109V 2226285810.1074/JBC.M111.333179
DOXA-1K70D 2416518010.1128/AAC.01483-13view
DOXA-10K70C 2110860510.1042/BJ20101122view
DOXA-10W154A 1986047110.1021/BI901548Cview
DOXA-10W154G 1986047110.1021/BI901548Cview
DOXA-10W154H 1986047110.1021/BI901548Cview
DOXA-10V117T 2110860510.1042/BJ20101122view
DOXA-160V130D 2571019210.1021/BI501547Kview
DOXA-225K82D 2571019210.1021/BI501547Kview
DOXA-24K84D 2121575810.1016/J.JMB.2010.12.042view
DOXA-24V130D 2121575810.1016/J.JMB.2010.12.042view

Statistics (number of mutants): Overall (167); class A (91); subclass B1 (35); subclass B2 (3); subclass B3 (6); class C (19); class D (13).

Last updated: January 08, 2024.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database is funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

Live statistics (since December 3rd, 2023)