Beta-Lactamase DataBase
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Beta-Lactamase DataBase

Synthetic Mutants (work in progress)

Ambler class
Protein name
Mutations
PubMed ID
DOI
PDB structures
Hydrolytic profile
ATEM-1R120G R241H I208M T265M T195S M182T A224V I56V 2254591310.1021/BI2018738
ATEM-1R243S 1205804610.1074/JBC.M204212200view
ATEM-1N100R 1503708510.1016/J.JMB.2003.12.068view
ATEM-1N132A 1187086810.1002/PROT.10058.ABSview
ATEM-1N170G 1981204110.1074/JBC.M109.053819view
ATEM-1N276D V84I A184V 1042323410.1021/BI990758Z
ATEM-1E104A Y105A V84I 1561840010.1073/PNAS.0407280102
ATEM-1E104K R164S M182T 1207933610.1016/S0022-2836(02)00400-X
ATEM-1E147G V80I R273L I208M L201P P62S M182T A224V I246V 1870642410.1016/J.JMB.2008.07.082
ATEM-1E166N 143603410.1038/359700A0view
ATEM-1E166Y L201P P167G W165Y 2571306210.1074/JBC.M114.633438
ATEM-1E166Y M182T P167G W165Y 2571306210.1074/JBC.M114.633438
ATEM-1E166Y P167G S70G W165Y 2571306210.1074/JBC.M114.633438
ATEM-1E219R Q247R V64I A248K T249K E84K M250T A164V 2142522910.1002/CBIC.201000568
ATEM-1G238A 1207933610.1016/S0022-2836(02)00400-Xview
ATEM-1L200A N51A R119G A41G E103K T262M G237S M181T 2354234110.1016/J.JMB.2013.03.033
ATEM-1L201A N52A R120G A42G T265M M182T 2354234110.1016/J.JMB.2013.03.033
ATEM-1L201P 1882229810.1016/J.JMB.2008.09.009view
ATEM-1M182T 1207933610.1016/S0022-2836(02)00400-Xview
ATEM-1M182T 1199657410.1021/JA0259640view
ATEM-1M182T 1285918810.1021/BI034242Yview
ATEM-1M182T 1503708510.1016/J.JMB.2003.12.068view
ATEM-1M69I M182T 1205804610.1074/JBC.M204212200
ATEM-1M69V 1205804610.1074/JBC.M204212200view
ATEM-1S130G 1598199910.1021/BI0502700view
ATEM-1S235A 1529979710.1107/S0907444994014496view
ATEM-1S70G 1604107210.1107/S0907444905014356view
ATEM-1Y105N V84I E104Y 1707084310.1016/J.JMB.2006.09.076
ATEM-1V84I A184V 1157308810.1038/NSB1001-848

Statistics (number of mutants): Overall (167); class A (91); subclass B1 (35); subclass B2 (3); subclass B3 (6); class C (19); class D (13).

Last updated: November 16, 2022.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database is funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu