Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
Beta-Lactamase DataBase - Structure and Function Home Enzymes Structures Mutants Kinetics BLAST
Beta-Lactamase DataBase

Sequence alignment for the OXA-270-like beta-lactamase family

OXA-270
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270...
MTKKALFFAISTIFLSACSFNTVQHHQIHAISTHKNSEEIKSLFDQAQTTGVLVIKRGNTEEIYGNDLKRASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPDWEKDMTLGDAMKASAIPVYQELARRIGLDLMSKEVKRIGFGNADIGSKVDNFWLIGPLKITPQQEAQFAYELAHKTLPFSKNVQEQVQSMVFVEEKNGRKIYAKSGWGWDVEPQVGWLTGWVVQPQGEIVAFSLNLEMKKGTPSSIRKEIAYKGLEQLGIL
OXA-271 .......L................Q.....L.........Q.................KK......................................................................................I..VD...............V.....................................................................Q................I...................  95.60 %
OXA-272 ..........G.M...........Q...QS...N....K..........E........Q...........S.........................P......Y..........................................................D...V..........VR...K..N..................I..................D.....F...........I...........I...................  91.58 %
OXA-273 ..........G.M..........EQ...QS...N....K.................H.R...V....................V............P.....................................................................V..........V....K..N..................I..................D.E...F...........I........E..I........T..........  90.84 %
OXA-421 ....T.....G.M..........EQ...QS...N....K.Q............I....Q...V.................................P.....................................................D.........I.....V...................................L.I........................F..............A........I...................  91.94 %
OXA-500 ..........G.M..........EQ...QS...N....K...................Q...V.................................P.................................................................D...V...........................M.......L.I....................................I...........I...................  93.41 %
OXA-501 ..........G.M..........EQ...QS...N....K.................H.Q...V.................................P.................................................................D...V.....................................I................................................I...................  94.14 %
OXA-502 ..........G.M...........Q...QS...N....K..........E........Q...........S.........................P.................................................................D...V...................................L.I................................................I...................  94.14 %
OXA-503 ..........G.M...........Q...QS...N....K.........NE........Q...........S.........................P.................................................................D...V...................................L.I..................................K.............I...................  93.41 %
OXA-506 ..........G.M...........Q...QS...N....K..........E........Q...........S.........................P.................................................................D...V...................................L.I..................................K.............I...................  93.77 %
OXA-533 ..........G.M...........Q...QS...N....K..........E........QI..V.................................P.................................................................D...V...................................L.I..................D.....F...........I...........I...................  92.67 %
OXA-563 ..........G.M..........EQ...QS...N....K...................Q...V.................................P..........H..........................................................V...............K..N..................I..................D.....F.......................I...................  93.04 %
OXA-564 ..........G.M...........Q...QS...N....K..........E........Q...........S.........................P.................................................................D...V...................................L.I.....Q..........................................I...................  93.77 %
OXA-642 ..........G.M...........Q...QS...N....K..........E........QI..........S.........................P.....................................................S........T..D...V...........................M.......L.I..................D.....F.......................I........T..........  91.58 %
OXA-678 ........................Q.....................................................................................F.......................................................V..........................................................................................................  98.90 %
OXA-777 ..........G.M..........EQ...QS...N...KK..........E......H.Q...V....................V............P..................................R..................................V..........V....K...................L.I........................F.......................I...................  91.58 %
OXA-778 ..........G.M..........EQ...QS...N....K..........E........QI..V.................................P...........................................N.........................V...............K...........M.......L.I....................................I...........I...................  92.31 %
OXA-801 ...........A............Q.................................Q........................................M....................E.............................................V..........T..........................................L.MD.............................I...................  95.97 %
OXA-802 ...R....................Q....T............................Q........................................M....................E.............................................V..........V.........................L...................D.................................................  96.34 %
OXA-803 ..........G.M...........Q...QS...N....K..........E........QI..V.................................P.................................................................D...V...................................L.I................N...................I...........I...................  93.04 %
OXA-804 ..........G.M...........Q...QS...N....K..........E........Q...........S.........................P.................................................................D...V..........VR...K..N..................I..................D.E...F...........I...........I...................  91.58 %
OXA-820 ..........G.M..........EQ...QS...N....K..........E........QI..V.................................P.............................T...................I...S...........D...V...................................L.I..................................K.............I...................  91.94 %
OXA-821 ............M...........Q...QS...N....K..........E........Q...........S.........................P.................................................................D...V..............................E....L.I................................................I...................  94.14 %
OXA-826 ..........G.M..........EQ..TQS...N....K..........E........QI..V.................................P............................Y....................................D...V...........................M.......L.I....................................I...........I...................  91.94 %
OXA-832 ..........G.M.......D..EQ...QS...N....K.Q..........I.I....Q...V.................................P...............................................................I.....V..................................LL.I........................F..............A........I...................  91.58 %
OXA-840 ..........GMM..........EQ...QS...N....K...................Q...V.................................P.......V.........................................................D...V...........................M.......L.I....................................I...........I...................  92.67 %
OXA-841 ........................Q....P..........................H........................................................................................................................................................................................................................  98.90 %
OXA-842 .......L................Q........D........................................................................................................................S...........V..............................................................F.......................I...................  97.44 %
OXA-843 .............................T............................................................................................................................T...........V..........................................................................................................  98.90 %
OXA-941 ..........G.M..........EQ...QS...N....K..............I....Q...V.................................P.................................................................D...V...........................M.......LVI....................................I..........SI...........A.......  91.94 %
OXA-942 ..........G.M..........EQ...QS...N....K..........E........QI..V...N.............................PI....................................................................V...............K.....................I..................D.....F.......................I...................  92.31 %
OXA-943 ..........G.M..........EQ...QS...N....K..............I....Q...V.................................P.................................................................D...V...................................L.I................................................I...................  93.77 %
OXA-978 ..........G.M...........Q...QS...N....K..........E........Q........I..S.........................P..........................................F....................A.D...V...................................L.I....................................I...........I...................  92.67 %
OXA-986 ..........G.M...........Q...QS...N....K..........E........Q...........S.........................P.......................................................S.............V...................................L.I........................F.......................I...................  93.77 %
OXA-988 ..........G.M...........Q...QS...N....K.....E....E........Q...........S.........................P......Y..........................................................D...V..........VR...K..N................L.I..................D.....F...I.......I...........I...................  90.48 %
OXA-992 ..........A.M.......D..EQ...QS...N....K.Q............I....Q...V.................................P......................D........................................I.....V...................................L.I........................F..............A........I...................  91.94 %
OXA-1000 ..........G............EQ...QS...N....K..T.......E.......EQ...V....................V............P.................................................................D...V..........V....K...................L.I.....Q............D.....F...........I...........I...................  90.84 %
OXA-1002 ..........G.M...........Q...QS...N....K.................C.Q...V.................................P.......V.............................................................V...............K...................L.I....................................I...........I...................  93.41 %
OXA-1045 ..........G.M..........EQ...QS...N....K..........E........Q...V................................MP.............................T......................V................V...................................L.I..................D.....F.......................I...................  92.31 %
OXA-1113 ..........G............EQ...QS...N...KK..........E........QI..V.................................P.................................................................D...V...................................L.I..................................K.............I...................  93.04 %
OXA-1114 ..........G............EQ...QS...N....K..T.......E.......EQ...V....................V............P.....................................................................V..........V....K...................L.I.....Q............D.....F...........I...........IS..................  90.84 %
OXA-1115 ..........G.M..........EQ...QS...N....K...................Q...V....................V............P.....................................................................V..........V....K...................L.I........................F.......................I..T................  92.67 %
OXA-1138 ..........G.M..........EQ...QS...N....K...................Q...V.................................P.................................................................D...V...........................M.......L.I....................................I...........I.T.................  93.04 %
OXA-1150 ..........G.M...........Q...QS...N....K..........E........Q...........S.........................P.................................................................D...V...........................L.........I..................D.....F...I...................I...................  93.04 %
OXA-1164 ..........G.M..........EQ...QS...N...KK..........E........QI..V.................................P................................................................HD...V...................................L.I..................D.....F......S....I...........I...................  91.21 %
OXA-1165 ..........G.M...........Q...QS...N....K..........E........Q...................................T.P.................................................................D...V...................................L.I..................................K.............I...................  93.77 %
OXA-1166 ..........G.M..........EQ...QS...N....K..........E........QI..V...A.............................P.................................................................D...V...........................M.......L.I....................................I...........I...................  92.31 %
OXA-1222 ..........G.M...........Q...QS...N....K.....E....E........Q...........S.........................P......Y..........................................................D...V..........VR...K..N......N.........L.I..................D.....F...I.......I...........I...................  90.11 %
OXA-1234 ........................Q.................................................................................................................................T...........V..........................................................................................................  98.90 %
OXA-1235 ..........G............EQ...QS...N....K..T......IE.......EQ...V.......V.........................P.................................................................D...V..........V....K..N..................I....................................I...........I........T..........  91.21 %
OXA-1236 .N.YFTCYVVASL...G.TVQHNLINETPSQIVQGHNQV.HQY..EKN.S.....QTDKKINL...A.S..N...................NQ.TDIN.I...K.E..S.TA........E...L..V...............Q...........E..QQ......V....V..I..VE.VSQ...TQ....EK..AN.KN.LLL..S..Y..FG.T..AM.INS.........E..D.K....A..M..RSEM.A...N.LLM.S.K..N.I  57.14 %
OXA-1237 ..........G.M..........EQ..TQS...N....K..........E........Q...V.................................P...........................................N.........S...............V..........V....K...................L.I........................F...I.......I...........I...................  91.21 %
D-OXA-270-like phylogenetic tree

Last updated: November 20, 2024.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database was funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

Live statistics (since December 3rd, 2023)