Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
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Beta-Lactamase DataBase

Sequence alignment for the OXA-184-like beta-lactamase family

OXA-184
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250........
MKKILLLFSLFYSFALA-NDKLKDFFKDYNTSGVFITFDGKHYASNNFKRAKEPFSPASTFKIFNALIALDNGVVKDTKEIFYHYKGEKVFLPSWKQDASLSSAIKRSQVPAFKELARKIGLKTMQESLNKLSYGNTKISKIDTFWLDNSLQISAKNQADLLFKLSQNSLPFSKKSQEEVKKIILFKEDKIQKIYAKTGFNDGINLAWIVGFIESKNKILSFALNVDIKNIKNLKIREELLEKYIYSLN---------
OXA-185 .................-.......................................................................................................................................................................................................................I...............---------  99.60 %
OXA-446 .RNFIVFILF-LNI.IGEDKI.GN....C....T..V....N....D.Q...QA.....................R...................................................G.....................................................E....................N.........VKTE.........I...D...I..........LAIITN--------  81.60 %
OXA-447 .RNFIVFILF-LNI.IGEDKI.GN....C....T..V....N....D.....QA.....................R............................................................A......................................I.....E....................N.........VKTE.............D...I.......N..LANFFNNNRIKSFY  79.07 %
OXA-448 ....I.FLWI-LN..FGQDKI.E..........T..I....N....D.Q...QT..................................................................................A....................................N........LL....N.............N.........VKT..............D...I...............---------  86.75 %
OXA-449 ....I.FLWI-LN..FGQDKI.E..........I..I....N....D.Q...QT..................................................................................A.............................................LL....N.............N.........VKT..............H...I..........LAIITN--------  84.80 %
OXA-465 .................-............................D.........................................................................................A............................................................................................D...I...............---------  98.39 %
OXA-466 .................-...................................................................................R...................................................................................................................................................---------  99.60 %
OXA-613 .RNFIVFILF-LNI.IGEDKI.GN....C....T..V....N....D.Q...QT.....................R...................................................G.....................................................E....................N.........VKTE.............D...I.......N..LANFFQQ-------  81.27 %
OXA-614 .RNFIVFILF-LNI.IGEDKI.GN....C....T..V....N....D.Q...QT.....................R...................................................G.....................................................E....................N.........VKTE.............D...I.......N..LANFSNNNRIKSFY  79.07 %
OXA-615 .RNFIVFILF-LNI.IGEDKI.GN....C....T..V....N....D.Q...QA.....................R...................................................G.....................................................E....................N.........VKTE.............D...I.......N..LANFSNNNRIKSFY  79.07 %
OXA-616 .RNFIVFIMF-LNI.IGEDKI.GN.........T..V....N....D.....KA.....................R............................................................A......................................N.....E.............V......S.........VKT..............D...I..........LAIITN--------  82.40 %
OXA-617 .RNFIVFILF-LNI.IGEDKI.GN.........T..V....N....D.....KA.....................R............................................................A......................................I.....E......N.............N.........VKTE.............D...I.......N..LANFFNNNRIKSFY  79.07 %
OXA-618 .RNFIVFILF-LNI.IGEDKI.GN.........T.MV....N....D.....KA.....................R............................................................A.....................V................I.....E....................N.........VKTE.............D...I.......N..LANFFNNNRIKSFY  78.68 %
OXA-619 .RNFIVFILF-LNI.IGEDKI.GN....C....T..V....N....D.....QA.....................R............................................................A......................................I.....E....................N.........VKTE.............D...I.......N..LANFSNNNRIKSFY  79.07 %
OXA-620 .RNFIVFILF-LNI.IGEDKI.GN....C....T..V....N....D.....QA.....................R............................................................A............................................E....................N.........VKTE.............D...I.......N..LANFSNNNRIKSFY  79.46 %
OXA-621 .RDFIVFIWF-LNI.IGEDKI.GN.........T..V....N....D.Q...QA.....................R...................................V........................A......................................N.....E....................N.........VKTE.............D...I.......N..LANFSNNNRIKSFY  78.68 %
OXA-622 .RNFIVFILF-LNI.IGEDKI.GN.........T..V....N....D.....KA.....................R..............................C...........N........................................................N.....E....................N.........VKI..............D...I.......N..LANFFNNNRIKSFY  79.46 %
OXA-623 ....I.FLWI-LN..FGQDKI.E..........T..V....N....D.Q...QT....................I.............................................................A....................................N........LL....N.............N.........VKT..............D...I....K..........---------  85.94 %
OXA-624 .RNFIVFILF-LNI.IGEDKI.GN.........T..V....N....D.....KA.....................R..............................C...........N........................................................N..........................N.........VKI..............D...I.......N..LANFFNNNRIKSFY  79.84 %
OXA-625 .................-............................D.........................................................................................A................................................................................................................---------  99.19 %
OXA-626 .................-.......................................................I..............................................................A................................................................................................................---------  99.19 %
OXA-627 .................-.................................................................................G.....................................................................................................................................................---------  99.60 %
OXA-628 .................-...................................................................................................................C...................................................................................................................---------  99.60 %
OXA-629 .................-......................................................................................................................................................................................................T.F..............................---------  99.19 %
OXA-630 .................-...................................................................................R..............................................................................................................M....................................---------  99.19 %
OXA-631 .................-............................D..........................I...........................................................................................................................................................D...I...............---------  98.39 %
OXA-632 .................-.......................................................I...........................................................................................................................................................D...I...............---------  98.79 %
OXA-633 .................-...................................................................................R....................................................................................................N.........VKT..................................---------  97.98 %
OXA-634 ...YFYFLVF.......-.......................................................................................................................................................................................................................................---------  97.18 %
OXA-635 ....I.FLWI-LN..FGQDKI.E..........I..I....N....D.Q...QT......................................S...........................................A.............................................LL....N.............N.........VKT..............HV..I..........LAIITN--------  84.00 %
OXA-636 ....I.FLWI-LN..FGQDKI.E..........I..I....N....D.Q...QA..................................................................................A.............................................LL....N.............N.........VKT..............HV..I..........LAIITN--------  84.40 %
OXA-637 .RNFIVFILF-LNI.IGEDKI.GN....C....T..V....N....D.Q...QT.....................R...................................................G.....................................................E....................N.........VKTE.............D...I..........LAIITN--------  82.00 %
OXA-638 .RNFIVFILF-LNI.IGEDKI.GN....C....T..V....N....D.....QA.....................R............................................................A............................................E....................N.........VKTE.............D...I..........LAIITN--------  82.40 %
OXA-639 .RNFIVFILF-LNI.IGEDKI.GN....C.................D.....QA.....................R...................................................G.....................................................E....................N.........VKTE.............D...I..........LAIITN--------  83.60 %
OXA-640 .RNFIVFILF-LNI.IGEDKI.GN....C.................D.....QA..................D..R...................................................G.....................................................E....................N.........VKTE.............D...I..........LAIITN--------  83.20 %
OXA-658 .RNFIVFILF-LNI.IGEDKI.GN.........T..V....N....D.Q...QA.....................R............................................................A...........................F..........I.....E....................N.........VKTE.............D...I....NY------------------  79.52 %
OXA-783 ....T.FLLF-LNLVFGQDKI.NNW..E.....T.VFY...TW...D.S..M.T......................NI..........................................................A.............................................LL....N.............N.........VKT..............H...I..........LAIITN--------  80.80 %
OXA-785 .................-............................D.........................................................................................A..................................................................V.............................................---------  98.79 %
D-OXA-184-like phylogenetic tree

Last updated: November 20, 2024.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database was funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

Live statistics (since December 3rd, 2023)