Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
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Beta-Lactamase DataBase

Sequence alignment for the OXA-134-like beta-lactamase family

OXA-134
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270..........
MKILIFLPLLSCLGLTACSLPVSSLPSQSI---ST-QAIASLFDQAQSSGVLVIQRDQQVQVYGNDLNRANTEYVPASTFKMLNALIGLQHGKATTNEIFKWDGKKRSFTAWEKDMTLGQAMQASAVPVYQELARRIGLELMQQEVQRIQFGNQQIGQQVDNFWLVGPLKVTPKQEVQFVSALAREQLAFDPQVQQQVKAMLFLQERKAYRLYVKSGWGMDVEPQVGWLTGWVETPQAEIVAFSLNMQMQNGIDPAIRLEILQQALAELGLYPKAEG---
OXA-235 ..T..L.......S.........NSS..ITSTQ.I-.T..K...............GPHL.......S..H...I......I...........................A.......................................R........HI..........I..E...E.A....Q.................L....QD....A..................I....D............SNM......K.........A.......---  84.78 %
OXA-236 ..T..L.......S.........NSS..ITSTQ.I-.T..K...............GPHL.......S..H...I......I...........................A.......................................R........HI..........I..V...E.A....Q.................L....QD....A..................I....D............SNM......K.........A.......---  84.78 %
OXA-237 ..T..L.......S.........NSS..ITSTQ.I-.T..K...............GPHL.......S..H...I......I...........................A.......................................R........HI..........I..E...E.A....Q.................L....QG....A..................I....D............SNM......K.........A.......---  84.78 %
OXA-276 .....LW....Y.S.....F...NS...ITSTQ.I-....K...............GPHL.......S..H..........IF..........................A...............................................H...................E.A....Q.......R......T..L....Q.....A..................I....D............SNM......K.................---  86.23 %
OXA-277 .....LW......S.....FA..NS...ITSTQ.I-..T.K...............GPHL.......S..H...........F..........................A...............................................H............I......E.A....Q.......R......T..L....Q.....A..................I....D...V........SNM......K................A---  85.14 %
OXA-278 .....LW....Y.S.....F...NS...ITSTQ.I-....K...............GPHL.......S..H..........IF..........................A................................E...R.......H...............I......E......Q.................L...QQ.....A....................................SNM......K.................---  86.59 %
OXA-282 .....L...................L...TSTQ..-....Q.......A.......G..I.......S..D......................................A.........E.............................................................................................................................................................---  94.93 %
OXA-283 .....L...................L...TSTQ..-....Q.......A.......G..I.......S..D......................................A.........E.................................................................................................................................R..M........................---  94.20 %
OXA-284 ..T.......N..S....T.....S..HITSTQ..-....Q...............G..I.......S..D......................................S.........E..................................................I......E...................................................................................................---  92.75 %
OXA-285 .....L............TS....F...ITSTQ..-....Q...............G.K........S..G......................................A.........E...............H..................................I......E........................L....Q.....A........Q..................S..........M........................---  90.94 %
OXA-335 .....L.......................T---..-..............................................P..................................................................................................................................................................................................---  98.90 %
OXA-360 .....L.......S.....FA..NS...ITSTQ.I-...VK...............GPHL.....E.S..H................................R.....A................................................HI.................K.A....Q.......RF.....T..L....Q.....A..................I....D............SNM......K.................---  85.51 %
OXA-361 .....L...F..............S...ITSIQ..-....Q.......A.......G..I.......S.........................................S.....................................C...................................................V..L...QQ.....A...................K...............R..M........................---  91.67 %
OXA-362 .....L............TS....F..HITSTQ..-....Q...............G.K........S..G......................................A.........E..........................R.......................I......E........................L..........A......................................M........................---  91.67 %
OXA-363 ..T.......N..S....T.....S..HITSTQ..-....Q...............G..I.......S..D......................................S............................................................I......E........................L..........A......................................M........................---  92.03 %
OXA-496 .............S..........S...ITSTQ..-.T..Q...........G...G..I.......S.........................................S.......................................................................V....................................................................................G.......VGQQSK  92.11 %
OXA-537 ..T..L.......S.........NSS..ITSTQ.I-.T..K...............GPHL.......S..H...I..................................A.....L..AE.............................R........HI..........I..E...E.A....Q.................L....Q.....A..................I....D............SNM......K.................---  84.78 %
OXA-646 .....L............TS....F...ITSTQ..-....Q...............G.K........S..G......................................A.........E...............H..................................I......E........................L....Q.....A....................................TNMN............G.......VGQQSK  88.17 %
OXA-647 .....L.....................P.T---..-..............................................................................................................................................................................................................................................D..---  98.53 %
OXA-648 .....L..................S....TLTQ..-....................G..L.I.....S.............IV............A.............A.........E.............................R...............I....IS.....E.......GE.P.............L....Q.....A......A.............I..G............TNMN............G.........QQSK  86.38 %
OXA-915 .....L...F..............S...ITSTQ..QE...Q.......A.......G..I.......G..D.......................................T........E..........................R..............................................................................................T...................................---  92.78 %
OXA-991 ..T..L.......S.........NSS..ITSTQ.I-.T..K...............GPHL.......S..H...I..................................A.......................................R........HI.................K.A....Q.................L....Q.....A..................I....D............SNM......K.................---  86.59 %
OXA-1005 .....L.L.V..............S....TSTQ..-....Q.......A..........I.......S..D......................................S................................E...R.......H...............I......E......Q.................L...QQ.....A......................................M........................---  90.94 %
OXA-1110 .............S..........S...ITSTQ..-.T..Q...........G...G..I.......S.........................................S.......................................................................V...............................................................................................---  94.57 %
OXA-1111 .....L............TS....F...ITSTQ..-....Q...............G.K........S..G..............................................................................................................................................................................................................---  94.93 %
OXA-1112 .....L...F..............S...ITSIQ..-....Q.......A.......V..I.....N.S..G......................................A.........E.............................................................................................................................................................---  93.84 %
OXA-1116 .....LW....Y.S.....F...NS...ITSTQ.I-....K...............GPHL.......S..H..........IF..........................A................................E...R.......H...............I......E.A....Q.......RF.....T..L....Q.....A..................I....D............SNM......K.................---  84.78 %
D-OXA-134-like phylogenetic tree

Last updated: November 20, 2024.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database was funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

Live statistics (since December 3rd, 2023)