Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
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Beta-Lactamase DataBase

Sequence alignment for the OXA-10-like beta-lactamase family

OXA-7
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280..
MKTFAAYVITACLSSTALASSITENTFWNKEFSAEAVNGVFVLCKSSSKLACATNNLARASKEYLPASTFKIPNAIIGLETGVIKNEHQIFKWD---------GKPRAMKQWERDLSLRGAIQVSAVPVFQQIAREVGEVRMQKYLKKFSYGNQNISG----GIDKFWLEGQLRISAVNQVEFLESLFLNKLSASKENQLIVKEALVTE-APEYLVHSKT--GFSGVGTESNPGVAWWVGWVEKGAEVYFFAFNMDIDNENKLPLRKSIPTKIMASEGIIGG
OXA-10 .........I.........G......S......................-S....D.................................V....---------.............T.........................................----.........................Y.....................A..........--......................ET..............S.............E.......  94.76 %
OXA-11 .........I.........G......S......................-S....D.................................V....---------.............T...................................S.....----........D................Y.....................A..........--......................ET..............S.............E.......  94.01 %
OXA-13 ..........................S......................-S......................S...............V....---------......................................................----G...............................................A..........--.......................T....................................  96.64 %
OXA-14 .........I.........G......S......................-S....D.................................V....---------.............T.........................................----........D................Y.....................A..........--......................ET..............S.............E.......  94.38 %
OXA-16 ---------I.........G......S......................-S....D.................................V....---------.............T................T........................----........D................Y.....................A..........--......................ET..............S.............E.......  90.64 %
OXA-17 .........I.........G......S......................-S....D.................S...............V....---------.............T.........................................----.........................Y.....................A..........--......................ET..............S.............E.......  94.38 %
OXA-19 ..........................S......................-S......................................V....---------......................................................----G........D......................................A..........--.......................T....................................  96.64 %
OXA-28 ..........................S......................-S......................................V....---------......................................................----G.....G.........................................A..........--.......................T....................................  96.64 %
OXA-35 ..........................S......................-S......................................V....---------......................................................----G...............................................A..........--.......................T....................................  97.01 %
OXA-56 .................................................-S...........................................---------......................................................----G...............................................A..........--............................................................  98.13 %
OXA-74 .........I.........G......S......................-S....D..........V......S...............V....---------.............T.........................................----.........................Y.....................A..........--......................ET..............S.............E.......  94.01 %
OXA-101 .................................................-S......................................V....---------......................................................----G...............................................A..........--.......................T....................................  97.39 %
OXA-142 .........I.........G......S......................-S....D.................S...............V....---------.............T.........................................----........D................Y.....................A..........--......................ET..............S.............E.......  94.01 %
OXA-145 ..........................S......................-S......................................V....---------.......................................................----......-........................................A..........--.......................T....................................  97.38 %
OXA-147 ..........................S......................-S......................................V....---------......................................................----G.....L.........................................A..........--.......................T....................................  96.64 %
OXA-183 ..........................S......................-S......................................V....---------......................................................----G.T......D......................................A..........--.......................T....................................  96.27 %
OXA-233 .........I.........G......S......................-S....D.................S...............V....---------.............T.........F...............................----.........................Y.....................A..........--......................ET..............S.............E.......  94.01 %
OXA-240 .........I.........G......S......................-S....D.................................V....---------......N......T.........................................----.........................Y.....................A..........--......................ET..............S.............E.......  94.38 %
OXA-246 .........I.........G......S......................-S....D.................................V....---------.............T..............................N..........----.........................Y.....................A..........--......................ET..............S.............E.......  94.38 %
OXA-251 .........I.........G......S......................-S....D.................................V....---------.............T....................D.........N..........----.........................Y............T........A..........--......................ET..............S.............E.......  93.63 %
OXA-256 .........I.........G......S......................-S....D.................D...............V....---------.............T.........................................----.........................Y.....................A..........--......................ET..............S.............E.......  94.38 %
OXA-368 .........I.........G......S......................-S....D..........V......S...............V....---------.............T.........................................----D........................Y.....................A..........--......................ET..............S.............E.......  93.63 %
OXA-454 .........I.........G......S......................-S....D............................E....V....---------.............T.........................................----.......K.................Y.....................A..........--......................ET..............S.............E.......  94.01 %
OXA-520 .........I.........G......S......................-S....D.................................V....---------.............T.........................................----.....G...................Y.....................A..........--......................ET..............S.............E.......  94.38 %
OXA-655 .........I.........G.....MS......................-S....D.................................V....---------.............T.........L...............................----.........................Y.....................A..........--......................ET..............S.............E.......  94.01 %
OXA-656 .........I.........G.....MS......................-S....D.................................V....---------.............T.........................................----.........................Y.....................A..........--......................ET..............S.............E.......  94.38 %
OXA-663 .........I.....K...G......S......................-S....D.................................V....---------.............T.........................................----.........................Y.....................A..........--......................ET..............S.............E.......  94.38 %
OXA-676 ..........................S......................-S......................................V....---------......................................................----G........D................................K.....A..........--.......................T....................................  96.27 %
OXA-677 .........I.........G......S......................-S....D.................................V....---------.............T.........F...............................----.........................Y.....................A..........--......................ET..............S.............E.......  94.38 %
OXA-736 ..........................S......................-S......................................V....---------.................................................S....----G........D......................................A..........--.......................T....................................  96.27 %
OXA-794 .........I.........G......S......................-S....D.................................V....---------.............T.........................................----.....C...................Y.....................A..........--......................ET..............S.............E.......  94.38 %
OXA-795 .........I.........G......S......................-S....D.................................V....---------.............T.........................................----....--...................Y.....................A..........--......................ET..............S.............E.......  94.01 %
OXA-823 .........I.........G......S......................-S....D.................................V....---------.............T.........................................----........S................Y.....................A..........--......................ET..............S.............E.......  94.38 %
OXA-824 .........I.........G......S......................-S....D.................................V....---------.............T...................................K.....----.........................Y.....................A..........--......................ET..............S.............E.......  94.38 %
OXA-827 .........I.........G......S......................-S....D.................................V....---------.............T.........................................----.........................Y.....................A..........--.......................T....................................  95.88 %
OXA-836 .........I.........G......S......................-S....D.................S...............V....---------.............T.........................................----.........................Y.....................A..........GT......................ET..............S.............E.......  93.68 %
OXA-928 .........I.........G......S......................-S....D.................................V....---------.............T.........................................----.........................Y.....................A..........--.-----.A..............ET..............S.............E.......  92.51 %
OXA-935 .........I.........G......S......................-S....D.................................V....---------.............T.........................................----....S...D................Y.....................A..........--......................ET..............S.............E.......  94.01 %
OXA-1015 ..........................S......................-S......................D...............V....---------......................................................----G...............................................A..........--.......................T....................................  96.64 %
OXA-1046 .........I.........G......S......................-S....D.................................V....---------.............T....................................P....----.....G...................Y.....................A..........--......................ET..............S.............E.......  94.01 %
OXA-1053 .................................................-S......................................V....---------............................K.........................----G...............................................A..........--.......................T....................................  97.01 %
OXA-1086 .........I.........G......S......................-S....D.........................S.......V....---------.............T....................................P....----.....G...................Y.....................A..........--......................ET..............S.............E.......  93.63 %
OXA-1087 .................................................-S......................................V....---------......................................................----G........D......................................A..........--.......................T....................................  97.01 %
OXA-1088 .........I.........G......S......................-S....D.................................V....---------.............T.........................................----.T......D................Y.....................A..........--......................ET..............S.............E.......  94.01 %
OXA-1120 ..........................S......................-S......................................V....---------.......................L..............................----G...............................................A..........--.......................T....................................  96.64 %
OXA-1141 .........I.........G......S......................-S....D.................................V....---------.............T.........................................----..G.....D................Y.....................A..........--......................ET..............S.............E.......  94.01 %
OXA-1147 ...................G......S......................-S....D.................S...............V....---------.............T.........................................----.........................Y.....................A..........GTV.....................ET..............S.............E.......  93.68 %
OXA-1148 .........I.........G......S......................-S....D.................T...............V....---------.............T.........................................----.........................Y.....................A..........--......................ET..............S.............E.......  94.38 %
OXA-1168 ..........................S......................-S......................................V....---------.......................................................GISG...............................................A..........--.......................T....................................  96.31 %
OXA-1169 ..........................S......................-S......................T...............V....---------......................................................----G...............................................A..........--.......................T....................................  96.64 %
OXA-1170 ..........................S......................-S......................................V....---------......................................................----G.....R.........................................A..........--.......................T....................................  96.64 %
OXA-1171 ..........................S......................-S......................................V....---------.................................................K....----G...............................................A..........--.......................T....................................  96.64 %
OXA-1175 .................................................-S......................................V....GKPRVFKWD......................................................----G...............................................A..........--.......................T....................................  94.22 %
OXA-1184 ..........................S......................-S......................................V....---------......................................................----G.....S.........................................A..........--.......................T....................................  96.64 %
OXA-1202 .................................................-S......................................V....---------......................................................----G.......................................A.......A..........--.......................T....................................  97.01 %
OXA-1203 .................................................-S...............V......................V....---------......................................................----G...............................................A..........--.......................T....................................  97.01 %
OXA-1231 ..........................S......................-S......................................V....---------......................................................----G.....C.........................................A..........--.......................T....................................  96.64 %
OXA-1232 ..........................S......................-S......................................V....---------......................................................----G...I....D......................................A..........--.......................T....................................  96.27 %
OXA-1233 ..........................S......................-S......................................V....---------......................................................----G.......................A.......................A..........--.......................T....................................  96.64 %
D-OXA-10-like phylogenetic tree

Last updated: November 20, 2024.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database was funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

Live statistics (since December 3rd, 2023)