Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
Beta-Lactamase DataBase - Structure and Function Home Enzymes Structures Mutants Kinetics BLAST
Beta-Lactamase DataBase

Sequence alignment for the BPU beta-lactamase family

BPU-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260...
MKKKYIKRLFSCIMLMAFCISQPSSTEARSIAWSVD-EFFKNREGTFVIQEVKEKSPWVYNKKRAKERFAPQSTFKVANALIGLQTGAVRDEYDIKYWDGVKREIDNWNRDHTLGSGMRDSVVWYYQAMARDIGEERMNHWVKAIHYGNKDISGGIDQFWLSSTLRISPIEQVRFLKQLYEETLPFDLKNMRTVKRMMVQEEEKHATLYGKTGSGSDIGWYVGFIKHEHKTYILATNIKGTGIEAKDITYRILKKYHLMEASV
BPU-2 .......W...G.....L............S.....-.......................................I.............................S..........................................................................................................LE.G...........N....F....E........................  95.42 %
BPU-3 .......W..TGM....L.........GA.P.....-..L.D................................................................S............N..................S..............................................................................................F........................I....  94.27 %
BPU-4 .......W..TGM....L.........GA.P.....-..L.D................................................................R...............................SQ.........E...................V..................NA........I......G..........G...........N....F....E.......E...L.......I....  90.08 %
BPU-5 .......W...S.....L........V...P.....-...............E.....................................................S.............................................................................................................G...........N....F....E.......E...........I....  95.04 %
BPU-6 .......W...G.....L............S.....-.......................................I..........T..................S....................................D........................................................................G...........N....F....E........................  95.42 %
BPU-7 .......W...G.V...L....S.......P.....-.....................................................................S...............................TR.........E.......................................T..........................G...........N....F....E...................I....  93.89 %
BPU-8 .......W...G.V...L....S.......P.....-.....................................................................S............................K.....................................................T..........................G.D.........N....F....E...................I...A  93.89 %
BPU-9 .......W.ITGM....L.........GA.P.....-..M.D.....................................S.............H...........................................................................................................................................F........................I....  94.27 %
BPU-10 .Q..KM.W.IAGV..AVL.M.K.A.S.GT.PK....-..M.E.......................NK.........I............K...................KA.......................K...G..I.......Q...................V...H........S.....SV........I.................G....A......N....FT...E.......E...........V....  82.82 %
BPU-11 ....HM.W.V.S.....L..G....S.GT.P.....-..L.D.......................NQ..........................................K............................S..........E.............S.........H........S.....SV........I.................G...........N....F....E...L...E......E....I....  87.79 %
BPU-12 .Q..KM.W.IAAV..A.L.M.E.A.S.GT.PK....-..M.D....................R..NK.........I............K...................K............................S..I.......Q...................V...H........S.....SV........I......T..........G....A......N....F....E...L...E...........V....  83.21 %
BPU-13 .Q..KM.W.IAAV..A.L.M.E.A.S.GT.PK....-..M.D.......................NK.........I............K...................K............................S..I.......Q....R..............V...H........S.....SV........I......T..........G....A......N....FT...E...L...E...........V....  82.82 %
BPU-14 ....HM.W..CT........G....S.GT.P.....-..M.D...................Q...NK..........................................K............................S..........E.............S.K...V...H........S.....SV........I.................G....A......N....F....E...LK..E................  87.02 %
BPU-15 .Q..KM.W.IAGV..A.L.M.K.A.S.GT.PK....-..M.E.......................NK.........I............K...................K............................G..I.......Q.......................H........S.....SV........I.................G....A......N....F....E...L...E...........V.G..  83.97 %
BPU-16 ....H..W...GF....L..G....S.GT.P.....-..M.D.......................NK..................................N.......K.......................................E.............S.....V...H...R....S.....SV..K.....I.................G....A......N....F....E...L...E...........I....  87.02 %
BPU-17 ....HM.W...GF....L..G....S.GT.P.....-..MID.......................NK..........................................K............................S..........E...................V...H.....N..S.....SV........I.K...............G...........N....F....E...L...E...........I....  87.02 %
BPU-18 .Q..KM.W.IAGA..V.L.M.K.A.S.GT.PK....-..M.D.......................NK.........I............K...................K............................A..I.......Q...................V...H........S.....SV........I......T..........G....A......N....F....E...L...E...........V....  83.59 %
BPU-19 .Q..KM.W.IAGA..A.L.M.K.A.S.GT.PK....-..M.D.......................NK.........I............K...................K............................G..I.......Q...................V...H........S.....SV........I......T..........G....A......N....F....E...L...E...........V....  83.59 %
BPU-20 ....HM.W.V.S.....L..G....S.GT.P.....-..L.D.......................NK..........................................K............................S......Q...E.............S.....V...H........S.....SV........I.................G..........KN....F....E...L...E...........I....  87.02 %
BPU-21 .Q..KM.W.IAGV..A.L.M.K.A.S.GT.PK....-..M.E.D.....................NK.........I............K...................K............................S..I.......Q...................V...Q........S.....SV........I......T..........G....A......N....FT...E...L...E...........I....  82.82 %
BPU-22 .Q..KM.W.IAAV..A.L.M.E.A.S.GT.PK...H-..M.D....................R..NK.........I............K...................K............................S..I.......Q...................V...H........S.....SV........I......T..........G....A......N....FT...E...L...E...........V....  82.44 %
BPU-23 ....HM.W.V.S....VL..G....S.GT.P.....-..L.D.......................NKC.........................................K............................S......Q...E.............S.........H........S.....SV........I.................G...........N....F....E...L...E...........I....  87.02 %
BPU-24 .Q..KM.W.IAGV..A.L.M.K.A.S.GT.PK....-..M.D................L......NK.........IV...........K...................K............................G..I.......Q...................V...H........S.....SV........I.................G....A......N....FT...E...L...E...........I....  82.82 %
BPU-25 ....HM.W..CT........G....S.GT.P.....-..M.D.......................N...........................................K.......................................E.............S.KL..V...H........S.....SV........I.................G....A......N....F....E...LK..E................  87.79 %
BPU-26 ....HM.W...GF..V.L..G....S.GT.P.....-..M.D.......................N...........................................K............................S..........E.............S.....V...H........S.....SV........I.................G....A......N....F....E...L...E...........I....  87.40 %
BPU-27 ....HM.W...GF....L..G....S.GTTP.....-..M.D.......................NK..........................................K...................G........SY.........E.............S.....V...H........S.....SV........I.................G....A......N....F....E...L...E...........I....  86.26 %
BPU-28 ....HM.W...GF....L..G....S.GT.P.....-..M.D.......................NK..........................................K.......................................E.T...........S.....V...H........S.....SV........I.................G....A......N....F....E...L...E.....M.....I....  87.02 %
BPU-29 .Q..KM.W.IAGV..A.L.M.K.A.S.GT.PK....-..M.E.......................NK.........I............K...................K............................G..I.......Q...................V...H........S.....SV........I.................G....A....Y.N....FT...E...L...E...........I...-  82.82 %
BPU-30 ....HM.W.V.F.L...L..G....S.GT.P.....-..L.D.......................NK..........P...............................K..........................C.S..........E.............S.....V...H........S.....SV........I.K...............G..........KN....F....E...L...E...........I....  85.88 %
BPU-31 .Q..KM.W.IAGV..A.L.M.K.A.S.GT.PK....-..M.E.......................NK.........I............K...................K............................G..I.......Q...................V...H........S.....SV........I......T..........G....A......N....F....E...L...E...........I....  83.59 %
BPU-32 ....HM.W.VFF.L...L..G....S.GT.P.....D..L.D.......................NQ..........................................K............................S..........E.............S.....V...H........S.....SV........I.K...............G...........N....F....E...L...E...........I....  86.31 %
BPU-33 .Q..KM.W.IAGV..A.L.M.K.A.S.GT.PK....-..M.E.......................NK.........I............K...................K............................G..I.......Q...................V...H........S.....SV........I.................G....A......N....F....E...L...E...........V....  83.97 %
BPU-34 ....HM.W...GF..V.L..G....S.GT.P.....-..L.D.......................N.......................................E...K............................S..........E.............S.....V...H........S.....SV........I.................G....A......N....F....E...L...E...........I....  87.02 %
BPU-35 ....HM.W.V.S....TL..GH...S.GT.P.....-..L.D.......................NK..........................................K..........................H.S..........E.............S....S....H........S.....SA........I....EN...........G.......L..KN....F....E.......E...........I....  85.50 %
BPU-36 .Q..KM.W.IAGA..A.L.M.K.A.S.GT.PK....-..M.D.......................NK.........I............K...................K............................A..I.......Q...................V...H........S.....SV........I......T..........G....A......N....FT...E...L...E...........V....  83.21 %
BPU-37 ....HM.W...GF....L..G....S.GTTP.....-..M.D.......................NK..........................................K.......................................E...................V...H...R....S.....SV........I.................G...........N....F....E...L...E...........I....  87.79 %
BPU-38 .Q..KM.W.IAGV..A.L.M.K.A.S.GT.PK....-..M.E.......................NK.........I............K...................K............................G..I.......Q.......................H........S.L...SV........I.......M.........G....A..V...N....FT...E...L...E...........I....  82.82 %
BPU-39 .Q..KM.W.IAGV..A.L.M.E.E.S.GT.PK....-..M.D....................R..NK.........I............K...................K............................S..I.......Q...................V...H........S.....SV........I......T..........G....A......N....FT...E...L...E...........V....  82.82 %
BPU-40 ....HM.W.V.S.....L.......S.GT.P.....-..L.D.......................NQ....................V.....................K............................S..........E.............S.........H........S.....SV........I.K...............G..........KN....F....E...L...E...........I....  87.40 %
BPU-41 ....HM.W.V.S.....L..G....S.GT.P.....-..L.D.......................NQ....................V.....................K............................S.....S....E.............S.........H.I.H....S.....SV........I.................G...........N....F....E...L...E...........I....  86.64 %
BPU-42 .Q..KM.W.IAGV..A.L.M.K.A.S.GT.PK....-..M.E.......................NK.........I............K...................K............................S..I.......Q...................V...H........S.L...SV........I.................G....A....Y.N....FT...E...L...E...........V....  82.82 %
BPU-43 ....H..W..CT........G....S.GT.P.....-..M.D.......................NK..........................................K............................S..........E.............S.K...V...H........S.....SV........I.................G....A......N....F....E...L...E................  88.17 %
BPU-44 .Q..KM.W.IAGA..A.L.M.K.A.S.GT.PK....-..L.D.......................NK.........I............K...................K............................S..I.......Q...................V...H......K.S.....SV........I......T..........G....A......N....FT...E...L...E...........V....  82.82 %
BPU-45 .Q..KM.W.IAGV..A.L.M.K.A.S.GT.PK....-..M.E.............L.........NK.........I............K...................K............................G..I.......Q...................V...H........S.....SV........I.....R...........G....A......N....F....E...L...E...........V....  83.21 %
BPU-46 ....HM.W...GF....L..G....S.GT.P.....-..M.D................A......NK..........................................K............................S..........E.............S.....V...H........S.....SV........I.................G....A......N....F....E...L...E...........I....  87.02 %
D-BPU phylogenetic tree

Last updated: December 22, 2025.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database was funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

Live statistics (since March 29th, 2025)