Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
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Beta-Lactamase DataBase

Sequence alignment for the PFL beta-lactamase family

PFL-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380....
MYTSIFPTVRKTTIFALLLGAGNCMAATDIRQVVDSNVEPLMQQQDIAGLSVAVIQNGKAQYFNYGVANKESKQPVTENTLFEIGSVSKTFTATLAGYALANGKLKLSDPASQYLPALRGDKFDHISLLNLGTYTAGGLPLQFPEESDNTGKMISYYQHWKPDFAPGTQRLYSNPSIGLFGHLAAQSLGQPFDRLMEQTLLPKLGLKHTFITVPKAQMNLYAQGYDKAGKPVRVGPGALDAEAYGIKTSTSDLIQYVEVNMHPAKLEKPLQQAIAATHTGYYTVDAMTQGLGWEMYPYPITLDALTEGNSAQMAFQPHKVSWLTPPQAPYADTLVNKTGATGGFGAYVAYVPSKGLGVVILANKNYPNAERVKVAHAILSAMDK
PFL-2 ....................................T...............................................................................................................T........................................K...............................................................................................G...........................................H......................................................  98.70 %
PFL-3 ....L.....N.A................M......T.Q..............IV.............S....................................................T......................D....A..............................................A..............S...S...........S.........................................................G....................Q.............N........H...........S...........R..............................  94.27 %
PFL-4 ....L.....N.A................M......T.Q..............IV.............S....................................................T......................D....A..............................................A..............S...S.....................................................................G..................................N........H......................................................  95.31 %
PFL-5 ....................................T.Q..............IV...............D.Q.......................................................................................................................N............................................................................................G......................................Q....H......................................................  97.40 %
PFL-6 -MHERSS.TARVS.L..............L......TI..................D.............DG.................................................T......................D....AS.......R......................................H.......................................................................................G....................A......................H...........................................A..........  92.45 %
PFL-P1 --------------------------..........T.................................D....I......................................................................................A.............................EK.....V...........S..ET..S...............S...................H..............................G..............KV...V....T...ME....N.......APL........S.................................A.........Q  86.20 %
C-PFL phylogenetic tree

Last updated: November 20, 2024.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database was funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

Live statistics (since December 3rd, 2023)