Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
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Beta-Lactamase DataBase

Sequence alignment for the OCH beta-lactamase family

OCH-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380..........
MRKSTTLLIGFLTTAAIIPNSGALAASKVNDGDLRRIVDETVRPLMAEQKIPGMAVAITIDGKSHFFGYGVASKESGQKVTEDTIFEIGSVSKTFTAMLGGYGLATGAFSLSDPATKWAPELAGSSFDKITMRDLGTYTPGGLPLQFPDAVTDDSSMLAYFKKWKPDYPAGTQRRYSNPSIGLFGYLAARSMDKPFDVLMEQKLLPAFGLKNTFINVPASQMKNYAYGYSKANKPIRVSGGALDAQAYGIKTTALDLARFVELNIDSSSLEPDFQKAVAATHTGYYHVGANNQGLGWEFYNYPTALKTLLEGNSSDMALKSHKIEKFDTPRQPSADVLINKTGSTNGFGAYAAFIPAKKTGIVLLANRNYPIDERVKAAYRILQALDNKQ
OCH-2 ..T.............V...N...............................................................................................................L.............................N.......................................................E....................................................L......................................A..........................WL....................................I..............  97.18 %
OCH-3 ....................N.......A................................................................................T.............D........L..................S..................................................................E...................................................................R.D.........................................S......WL....................I..............................  96.67 %
OCH-4 ....................N....T..A.........................................................................................................................................................................................................................................................................................A................................................I..............................  98.72 %
OCH-5 ....................N.......A.......................................................................................................L...............................R........H............................................E......................T..............................................D.....................A................................................I...V..........................  97.18 %
OCH-6 ....................N.......A.............................................................................................................................................................................................E...........................................................................................A..........................WL...................................................  98.46 %
OCH-7 ......................................................................................................................................................................................................................................................................................................................A..........................WL...................................................  99.23 %
OCH-8 ....................N....T..A.......................................................................................................L.....................................................................................E...........................................................................................A................................................I..............................  98.21 %
OCH-9 ....................N.......A.................................N...................H.................................................L.............................N.......................................................E...........................................................................................A..........................WL...................................................  97.44 %
OCH-10 ....................N.......A.......................................................................................................L.............................N.......................................................E...........................................................................................A..........................WL...................................................  97.95 %
OCH-11 .....IF.....A...N---...---FAADHS...............................G................D.N..............T..................................L................S........S...................................................T...V...E.R..........TD.....................P..I........N..........M......................S.........T............V....Q.L...........................................................  90.26 %
OCH-12 .....IF.....A...N---...---FAADHSE..............................G................D.N..............T..C...............................L................S........S...................................................T...V...E.R..........TD.....................P..I........N..........M......................S.........T............V....Q.L...........................................................  89.74 %
OCH-13 ....................N.......A....................R........................................................................................................................................................................E...........................................................................................A..........................WL...................................................  98.21 %
OCH-14 .....IF.....A...N---...---FAADHSE..............................G................D.N..............T..................................L................S........S...................................................TY..V...E.R..........TD.....................P..I........N..........M......................S.........T............V....Q.L...........................................................  89.74 %
OCH-15 .....IF.....A...N---...---FAADHSE..............................G................D.N..............T..................................L................S........S...................................................T...V...E.R..........TD.....................P..I........N..........M......................S.........T............V....Q.L...........................................................  90.00 %
OCH-16 ........L.L.A....V...R...---AG.S......................G...................D.....D.N.L.....I......T..A...............R.....KD....RV..L...........................................................GQ....................VH..E.R........T..D..T...A.T...E........P..L...A......P.A...............R...........I.A..VS.....T.......R....V....H.HA..PNM.V..................T.............N...I.........I.G..  84.10 %
C-OCH phylogenetic tree

Last updated: November 20, 2024.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database was funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

Live statistics (since December 3rd, 2023)