Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
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Beta-Lactamase DataBase

Sequence alignment for the MOX-1-like beta-lactamase family

CMY-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380...
MQQRQSILWGAVATLMWAGLAHAGEASPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGAGVSEQTLFEIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAPLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLRFVKANIGGVDDKALQQAISLTHQGHYSVGGMTQGLGWESYAYPVTEQTLLAGNSAKVILEANPTA-APRESGSQVLFNKTGSTNGFGAYVAFVPARGIGIVMLANRNYPNEARIKAAHAILAQLAG
CMY-8 ............................................................................S..............................................V.......................................................................Q............................................................A......................K..........................................-...........................................IP..V............  97.91 %
CMY-8b ............................................................................S......................................................................................................................Q............................................................A......................K..........................................-...........................................IP..V............  98.17 %
CMY-9 ............................................................................S.......D......................................V.......................................................................Q............................................................A......................K..........................................-...........................................IP..V............  97.64 %
CMY-10 ..................................................................................................................................................................................................................................................................................................................................-...........................................I................  99.74 %
CMY-11 ..........................................................................................................................................................................................................................................................................................................................S.......-...........................................I................  99.48 %
CMY-19 ............................................................................S.......D......................................V.......................................................................Q............................................................A......................K..................................S.......-...........................................IP..V............  97.38 %
MOX-1 ............................................................................S..............................................V.......................................................................Q............................................................A......................K..........................................-................S..........................IP..V............  97.64 %
MOX-2 ...........L.............T..............R.............................D..RAV...............P...........................................................L...Q......T.A........................M.....Q...........L............................S..........................S..H............K.....................S....................-........M........S...........K.............IP..V.......T...R  92.67 %
MOX-3 .........................T............................................D..RAV...............P...........................................................L...Q......T.A..............................Q...........L............................S..........................S...............K...............R.....S....................-........M........S...........K.............IP..V.......T...R  93.46 %
MOX-4 ...........L............DT.A............R.............................D..RAV...............P...........................................................L...Q......T.A........................M.....Q...........L............................S..........................S...............K.....................S..........E.........-......NLM........S...........K.............IP..V.......T...R  91.62 %
MOX-8 ...........L............DKAAT...........R.............................D..RAV...............P...........................................................L...Q......T.A........................M.....Q...........L............................S..........................S...............K.....................S.........PAM.YN...A.P..AAA.HP.........S...........K.............IP..V.......T...R  89.03 %
MOX-10 ......F..................T............................................D..RAV...............P...........................................................L...Q......T.A..............................Q...........L............................S..........................S...............K.....................S..I.................-........M........S...........K.............IP..V.......T...R  93.19 %
MOX-11 ......F..................T............................................D..RAV...............P...........................................................L...Q......T.A..............................Q...........L............................S..........................S...............K...............R.....S....................-........M........S...........K.............IP..V.......T...R  93.19 %
MOX-14 .....................................................................................................................................................................................................................................................................................P............................................-...........................................I................  99.48 %
MOX-16 ............................................................................S..............................................V.......................................................................Q............................................................A......................K.................................E...V....-................S..........................IP..V............  97.12 %
MOX-17 ...........L............DKAAT...........R.............................D..RAV...............P...........................................................L...Q......T.A........................M.....Q...........L............................S..........................S...............K.....................S.........PAMM-----A.P..AAA.HP.........S...........K.............IP..V.......T...R  87.99 %
MOX-18 .........................T..I...........R.............................D..RAV...............P...........................................................L...Q......T.A..............................Q...........L............................S..........................S...............K.....................S....................-........M........S...........K.............IP..V.......T...R  93.19 %
MOX-19 ...........L............DKAAT...........R.............................D..RAV...........................Q.GFE......LF..........N........................L...Q......T.A.........A........Y.....M....DR.....I.....LY...L...E...GH..............T..........................S...NA.M....D.....Q.A..E........R.....S.........PAM.YN...AVP..AAA.HP.....................K.........................TK..R  83.81 %
MOX-20 .........................T..............R.............................D..RAV...............P...........................................................L...Q......T.A..............................Q...........L............................S..........................S...............K.....................S....................-........M........S...........K.............IP..V.......T...R  93.46 %
MOX-21 ...........L............DKAAT...........R.............................D..RAV...........................Q.GFE......LF...................................L...Q......T.A........................M.....Q...........L............................S..........................S...............K.....................S....................-........M........S...........K....A........IP..V.......T...R  90.31 %
MOX-22 ...........L.............T..............R.............................D..RAV...............P...........................................................L...Q......T.A........................M.....Q...........L............................S..........................S...............K.....................S....................-........M........S...........K.............IP..V.......T...R  92.93 %
MOX-23 .........................T............................................D..RAV...............P......................LF...................................L...Q......T.A........................M.....Q...........L............................S..........................S...............K...............R.....S....................-........M........S...........K.............IP..V.......T...R  92.67 %
MOX-24 ...........L............DKAAT...........R.............................D..RAV...........................Q.SFE......QF..........N........................L...Q......T.A.........A........Y.....M....DR.....I.....LY...L...E...GH..............T..........................S...NA.M....D.....Q.A..E........R.....S.........PAM.YN...A.P..AAT.HP.....................K...V.....................T...R  84.07 %
MOX-25 ...........L............DKAAT...........R.............................D..RAV...........................Q.GFE......LF..........N........................L...Q......T.A.........A........Y.....M....DR.....I.....LY...L...E...GH..............T..........................S...NA.M....D.....Q.A..E........R.....S.........PAM.YN...A.P..AAT.HP.....................K...V.....................T...R  84.07 %
C-MOX-1-like phylogenetic tree

Last updated: November 20, 2024.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database was funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

Live statistics (since December 3rd, 2023)