Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
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Beta-Lactamase DataBase

Sequence alignment for the MOX beta-lactamase family

MOX-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380...
MQQRQSILWGAVATLMWAGLAHAGEASPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGASVSEQTLFEIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSVFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAQLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLAFVKANIGGVDDKALQQAISLTHKGHYSVGGMTQGLGWESYAYPVTEQTLLAGNSAKVILEANPTA-APRESGSQVLFNKTGSSNGFGAYVAFVPARGIGIVMLANRNYPIPARVKAAHAILAQLAG
MOX-2 ...........L.............T..............R.............................D..RAVG..............P...............................A...........................L...Q......T.A........................M.................L............................S...................R......S..H..................................S....................-........M.......TS...........K.........................T...R  92.93 %
MOX-3 .........................T............................................D..RAVG..............P...............................A...........................L...Q......T.A..........................................L............................S...................R......S...............................R.....S....................-........M.......TS...........K.........................T...R  93.72 %
MOX-4 ...........L............DT.A............R.............................D..RAVG..............P...............................A...........................L...Q......T.A........................M.................L............................S...................R......S.....................................S..........E.........-......NLM.......TS...........K.........................T...R  91.88 %
MOX-5 ...........L............DKAAT...........R.............................D..RAVG..........................Q.GFE......LF.......A..N........................L...Q......T.A..R......A........Y.....M....DR.....M.....LY...L...E.P.GH.....W.....F..T.A...E.P...........R......S...NA.M....D...Q.Q.A..E........R.P...S.........PAM.YN...A.P..AAA.HP...K....T............K...V.........NEGTL..G....T...R  78.85 %
MOX-6 ..........VLP...........DRAAT...........R.............................D..RAVG..........................Q.SFE......LF..........N........................L...Q......T.A.........A........Y.....M....DR.....I.....LY...L...E...GH..............T...................R......S...NA.M....D...Q.Q.A..E........R.....S..........AM.YN...A.P..AAR.HP........T............K...........S..EGTL..G....T...R  81.46 %
MOX-7 ...........L........V...DKAAT...........R.............................D..RAVG..........................Q.SFE......LF..........N........................L...Q......T.A.........A........Y.....M....DR.....M.....LY...LT..E...GH..............T...................R..........NA.M....D...Q.Q.A..E........R.....S.........PAM.YN.I.AVP..AAA.HP........T............K...........S..E..I.......T...R  81.72 %
MOX-8 ...........L............DKAAT...........R.............................D..RAVG..............P...............................A...........................L...Q......T.A........................M.................L............................S...................R......S.....................................S.........PAM.YN...A.P..AAA.HP........TS...........K.........................T...R  89.30 %
MOX-9 ...QVRMTLLMAS..L.....Q.TADTQA.....L.....R.V.................................R.............................LK....V.Q.G......A..G...A...............D....ID.........T.A.RA...................Q..G...E...S........LE...LK..AE...N.................V................K..G..MT.TG.E.M....A.....V....A................E.......G..........P.SN.T...........TG...........K..............Q...ET.....SK..E  80.42 %
MOX-10 ......F..................T............................................D..RAVG..............P...............................A...........................L...Q......T.A..........................................L............................S...................R......S.....................................S..I.................-........M.......TS...........K.........................T...R  93.46 %
MOX-11 ......F..................T............................................D..RAVG..............P...............................A...........................L...Q......T.A..........................................L............................S...................R......S...............................R.....S....................-........M.......TS...........K.........................T...R  93.46 %
MOX-12 ...........L............DKAAT...........R.............................D..RAVG..........................Q.GFE......LF.......A..N........................L...Q......T.A.........A........Y.....M....DR.....I.....LY...L...E...GH..............T...................R......S...NA.M....D...Q.Q.A..E........R.....S.........PAM.YNT..A.P..AAA.HP........T............K...V.........NE..I.......TK..R  81.46 %
MOX-13 ...........L............DKAAT...........R........L....................D..RAVG..........................Q.SFE......LF.S.....A..N........................L...Q......T.A.........A........Y.....M....DR.....I.....LY...L...E...GH..............T...................R......S...NA.M....D...Q.Q.A..E........R.....S.........PAM.YN...A.P..AAT.HP........T............K.............NE..I.......T...R  81.72 %
MOX-14 ............................................................................G..............................................A.......................................................................P............................................................R....................P.Q..........................................-................T...........................E..I............  97.64 %
MOX-15 ...........L............DKAAT...........R.............................D..RAVG..........................Q.GFE......LF.......A..N........................L...Q......T.A.........A........Y.....M....DR.....I.....LY...LT..E...GH..............T...................R......S...NA.M....D...Q.Q.A..E........R.....S.........PAM.YN...A.P..AAT.HP........T............K.............NE..I.......TK..R  81.72 %
MOX-16 .........................................................................................................................................................................................................................................................................................................................E...V....-............................................................  99.48 %
MOX-17 ...........L............DKAAT...........R.............................D..RAVG..............P...............................A...........................L...Q......T.A........................M.................L............................S...................R......S.....................................S.........PAMM-----A.P..AAA.HP........TS...........K.........................T...R  88.25 %
MOX-18 .........................T..I...........R.............................D..RAVG..............P...............................A...........................L...Q......T.A..........................................L............................S...................R......S.....................................S....................-........M.......TS...........K.........................T...R  93.46 %
MOX-19 ...........L............DKAAT...........R.............................D..RAVG..........................Q.GFE......LF.......A..N........................L...Q......T.A.........A........Y.....M....DR.....I.....LY...L...E...GH..............T...................R......S...NA.M....D...Q.Q.A..E........R.....S.........PAM.YN...AVP..AAA.HP........T............K.............NE..I.......TK..R  81.72 %
MOX-20 .........................T..............R.............................D..RAVG..............P...............................A...........................L...Q......T.A..........................................L............................S...................R......S.....................................S....................-........M.......TS...........K.........................T...R  93.72 %
MOX-21 ...........L............DKAAT...........R.............................D..RAVG..........................Q.GFE......LF.......A...........................L...Q......T.A........................M.................L............................S...................R......S.....................................S....................-........M.......TS...........K....A....................T...R  90.58 %
MOX-22 ...........L.............T..............R.............................D..RAVG..............P...............................A...........................L...Q......T.A........................M.................L............................S...................R......S.....................................S....................-........M.......TS...........K.........................T...R  93.19 %
MOX-23 .........................T............................................D..RAVG..............P......................LF.......A...........................L...Q......T.A........................M.................L............................S...................R......S...............................R.....S....................-........M.......TS...........K.........................T...R  92.93 %
MOX-24 ...........L............DKAAT...........R.............................D..RAVG..........................Q.SFE......QF.......A..N........................L...Q......T.A.........A........Y.....M....DR.....I.....LY...L...E...GH..............T...................R......S...NA.M....D...Q.Q.A..E........R.....S.........PAM.YN...A.P..AAT.HP........T............K...V.........NE..I.......T...R  81.98 %
MOX-25 ...........L............DKAAT...........R.............................D..RAVG..........................Q.GFE......LF.......A..N........................L...Q......T.A.........A........Y.....M....DR.....I.....LY...L...E...GH..............T...................R......S...NA.M....D...Q.Q.A..E........R.....S.........PAM.YN...A.P..AAT.HP........T............K...V.........NE..I.......T...R  81.98 %
C-MOX phylogenetic tree

Last updated: November 20, 2024.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database was funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

Live statistics (since December 3rd, 2023)