Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
Beta-Lactamase DataBase - Structure and Function Home Enzymes Structures Mutants Kinetics BLAST
Beta-Lactamase DataBase

Sequence alignment for the LHK beta-lactamase family

LHK-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380..........
MKKRITPFSRFASKGLFACSTGMLLVTVAHAANTA--AAGMDAMIQTVMQAHQIPGMAIAIIQSGKTTYHNYGVASRETGQPVRETTLFEIGSLSKPFTALIAQRAETEGRIDLSAPASRYVTALRGSAFDRITLRQLGTYSAGGLPLQFPDNVTTPADVLAYYRHWQPVHPAGTTRLYSNPSIGLMGLAASLATGESFAGLLGTTVLQPLGMNSTYLQMPPEARSRYAMGYTAAGKPVRVNPGPLDEETYGVKSTTADMAGFLLAHMDPARSKGALRSALQQTRVPVYCAGQTRQGLGWESYQDWKNLDVLLAGNSNQMVFEPQPVKACPAGTMNEPDVWVNKTGSTAGFGAYAVFLPARQTGIVILANRNYPIADRIRLAHGILTALH
LHK-2 ....................A..............AAP..V...V..................P...S.................................V....................A....................................M....Q...........................Q..........................V.....................S..........I.....................D........-.A.........................................................................................T..............  94.87 %
LHK-3 ....................A............M.AAP......V..................P.....................................V........................................................................S.................Q..........................V..............................................................................................................L...........................................................  96.92 %
LHK-4 ................S...A..............AAP..V...V..................P.....................................V........................................................................S.................Q..........................V..............................................................................................................L...........................................................  96.67 %
LHK-5 ................S...A..............AAP......V..................P.....................................V.....................................................................................................................V........................................V.................................................M..............L............N...................................................  96.67 %
LHK-6 ................S...A..............AAP......V..................P.........I...........................V..........................................E...............................................Q..........................V.....................S........................................................................................L...S...........................A...........................  95.90 %
LHK-7 ....................A..............AAP......V..................P.....................................V....................A.........................................Q...........................Q...............H..........V.................A...S...................................Q..........................................................D...................................F.................  95.64 %
C-LHK phylogenetic tree

Last updated: November 20, 2024.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database was funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

Live statistics (since December 3rd, 2023)