Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
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Beta-Lactamase DataBase

Sequence alignment for the FOX beta-lactamase family

FOX-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380..
MQQRRAFALLTLGSLLLAPCTYARGEAPLTAAVDGIIQPMLKEYRIPGMAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFELDDKVSQHAPWLKGSAFDGVTMAELATYSAGGLPLQFPDEVDSNDKMRTYYRHWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEQLMSQTLLPKLGLHHTYIQVPESAIANYAYGYSKEDKPVRVTPGVLAAEAYGIKTGSADLLKFTEANMGYQGDAALKTRIALTHTGFYSVGDMTQGLGWESYAYPLTEQALLAGNSPAVSFQANPVTRFAVPKAMGEQRLYNKTGSTGGFGAYVAFVPARGIAIVMLANRNYPIEARVKAAHAILSQLAE
FOX-2 ......L................S.......................................................................................H........................................Q....S..................................K.......................M.............I........................V.............SA..........................V....................................................................................  96.86 %
FOX-3 .......................S.......T................I.......................................................V................L......................K.......Q....S..........................................................M.............I........................A..........LV.SA............E..........D..V...V................................................................................  95.03 %
FOX-4 ......L...M............S.......T..........A.............................................................................................................Q....S..........................................................M.............I.A......................V.............SA........H...E..........D..V...V................................................................................  95.29 %
FOX-5 .......................S..................A..............................................................................L...................................S..........................................................MV.....................................A...........V.SA..........................V...T.....A..........................................................................  96.60 %
FOX-7 ........................................................................................................................................................................................................................................A....................................SA...............................................................................................................  99.21 %
FOX-8 .......................S.......T................I.......................................................V................L......................K.......Q....S..........................................................M.............I........................A..........LV.SA............E..........D..V...V..........L.....................................................................  94.76 %
FOX-9 .......................S......VT..........A....................................................................................................E.............S.............A.T......Y........S..........................M..........E..I.....M..................A...........V.SA.......................D..V...V...D............................................................................  94.24 %
FOX-10 .......................S..................A..............................................................................L...................................S..................S.......................................MV.....................................A...........V.SA..........................V...T.....A..........................................................................  96.34 %
FOX-12 .............................................................................................................................................................................................................................................................................SA.....................................---.......................................................................  98.69 %
FOX-13 .......................G...................................................N.....................................G.......L..................................QS..........................................................MV.....................................V...........V.SA............E.............V...T..............................................................................N.  95.81 %
FOX-14 .......................G...................................................N.....................................G.......L..................................QS..........................................................MV.....................................V...........V.SA............E.............V...T................................................................................  96.07 %
FOX-15 ......L..........T.............T...A.....................................H.........................................................................L....Q....S..........................................................M.............I...................................TV.SA............E.............V....................................................................................  95.81 %
FOX-16 ....C.......V..........S.......T........................................................................V...N............L...................................S.................................................................................................A...........V.SA..........................V...T................................................................................  96.34 %
FOX-17 .......................S.......T................I.......................................................V................L......................K.......Q....S..........................................................M.............I................S.......A..........LV.SA............E..........D..V...V................................................................................  94.76 %
FOX-18 ...LC..................SE......T......................................I....N...........................V................T........I...........................S..........................................................MV.....................................V...........V.SA............E.............V..PV................K...............................................................  94.24 %
FOX-19 ......L..........T.............T...A...............................................................................................................L.....................L.........................G....................MV.....................................A...........V.SA.............................L...V.......LK...I....A...........................................................  95.03 %
FOX-20 ......L..........T.............T...A.....................................H.........................................................................L....Q....S...............L..........................................M.............I...................................TV.SA............E.............V....................................................................................  95.55 %
FOX-21 ......L................S.G......................................................................................................................K...........LS.............A.T......Y...S...P...........................MV............I........................V...........V.SA............E.............V...T..........L.........................................................T...........  93.98 %
C-FOX phylogenetic tree

Last updated: November 20, 2024.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database was funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

Live statistics (since December 3rd, 2023)