Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
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Beta-Lactamase DataBase

Sequence alignment for the FOX beta-lactamase family

FOX-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380..
MQQRRAFALLTLGSLLLAPCTYARGEAPLTAAVDGIIQPMLKEYRIPGMAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFELDDKVSQHAPWLKGSAFDGVTMAELATYSAGGLPLQFPDEVDSNDKMRTYYRHWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEQLMSQTLLPKLGLHHTYIQVPESAIANYAYGYSKEDKPVRVTPGVLAAEAYGIKTGSADLLKFTEANMGYQGDAALKTRIALTHTGFYSVGDMTQGLGWESYAYPLTEQALLAGNSPAVSFQANPVTRFAVPKAMGEQRLYNKTGSTGGFGAYVAFVPARGIAIVMLANRNYPIEARVKAAHAILSQLAE
FOX-2......L................S.......................................................................................H........................................Q....S..................................K.......................M.............I........................V.............SA..........................V.................................................................................... 96.86 %
FOX-3.......................S.......T................I.......................................................V................L......................K.......Q....S..........................................................M.............I........................A..........LV.SA............E..........D..V...V................................................................................ 95.03 %
FOX-4......L...M............S.......T..........A.............................................................................................................Q....S..........................................................M.............I.A......................V.............SA........H...E..........D..V...V................................................................................ 95.29 %
FOX-5.......................S..................A..............................................................................L...................................S..........................................................MV.....................................A...........V.SA..........................V...T.....A.......................................................................... 96.60 %
FOX-7........................................................................................................................................................................................................................................A....................................SA............................................................................................................... 99.21 %
FOX-8.......................S.......T................I.......................................................V................L......................K.......Q....S..........................................................M.............I........................A..........LV.SA............E..........D..V...V..........L..................................................................... 94.76 %
FOX-9.......................S......VT..........A....................................................................................................E.............S.............A.T......Y........S..........................M..........E..I.....M..................A...........V.SA.......................D..V...V...D............................................................................ 94.24 %
FOX-10.......................S..................A..............................................................................L...................................S..................S.......................................MV.....................................A...........V.SA..........................V...T.....A.......................................................................... 96.34 %
FOX-12.............................................................................................................................................................................................................................................................................SA.....................................---....................................................................... 98.69 %
FOX-13.......................G...................................................N.....................................G.......L..................................QS..........................................................MV.....................................V...........V.SA............E.............V...T..............................................................................N. 95.81 %
FOX-14.......................G...................................................N.....................................G.......L..................................QS..........................................................MV.....................................V...........V.SA............E.............V...T................................................................................ 96.07 %
FOX-15......L..........T.............T...A.....................................H.........................................................................L....Q....S..........................................................M.............I...................................TV.SA............E.............V.................................................................................... 95.81 %
FOX-16....C.......V..........S.......T........................................................................V...N............L...................................S.................................................................................................A...........V.SA..........................V...T................................................................................ 96.34 %
FOX-17.......................S.......T................I.......................................................V................L......................K.......Q....S..........................................................M.............I................S.......A..........LV.SA............E..........D..V...V................................................................................ 94.76 %
FOX-18...LC..................SE......T......................................I....N...........................V................T........I...........................S..........................................................MV.....................................V...........V.SA............E.............V..PV................K............................................................... 94.24 %
FOX-19......L..........T.............T...A...............................................................................................................L.....................L.........................G....................MV.....................................A...........V.SA.............................L...V.......LK...I....A........................................................... 95.03 %
FOX-20......L..........T.............T...A.....................................H.........................................................................L....Q....S...............L..........................................M.............I...................................TV.SA............E.............V.................................................................................... 95.55 %
FOX-21......L................S.G......................................................................................................................K...........LS.............A.T......Y...S...P...........................MV............I........................V...........V.SA............E.............V...T..........L.........................................................T........... 93.98 %
FOX-23.......................S..................A..............................................................................L...................................S..........................................................MV.....................................A...........V.SA..........................V...T.....A----...................................................................... 95.55 %
C-FOX phylogenetic tree

Last updated: April 06, 2026.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database was funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

Live statistics (since March 29th, 2025)