Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
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Beta-Lactamase DataBase

Sequence alignment for the DHA beta-lactamase family

DHA-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.........
MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE
DHA-2 ..................................................................V...................................M.....E.......................T............N..E..H...................................................................................................................................................................................................................................  98.15 %
DHA-3 ...................................................................................................................................................................................................................D............................................I..........................................................................................................................  99.47 %
DHA-4 ..................................................................V........................................................................................................................................................................................................................................................................................................................  99.74 %
DHA-5 .......................................................R..........V....................................................................................H...................................................................................................................................................................................................................................  99.21 %
DHA-6 ....................................................................................................................................................................................................................................................T......................................................................................................................................  99.74 %
DHA-7 ...................................................................................................................................................................................................................................................................................................................................................S.......................................  99.74 %
DHA-9 .T..V...................................................................................................................................................................................................................H..................................................................................................................................................................  99.21 %
DHA-10 ..................................................................V...................................T.....E.................................E........H...................................................................................................................................................................................................................................  98.68 %
DHA-12 ..................................................................VE..................................S........R...TQ..................................H........W.................................T...S.......................................................................................................V............................................................................  97.10 %
DHA-13 ..................................................................V.............................................................................................W..........................................................................................................................................................................................................................  99.47 %
DHA-14 .......................................................................................................................................................H...................................................................................................................................................................................................................................  99.74 %
DHA-15 ....................................................................................................................................................................Y......................................................................................................................................................................................................................  99.74 %
DHA-16 .........V........................................................V..................................TS.....V......TQ........................E....SE...H........WQ..K.................T.........................................NQ....TG.P....................I..S.........................................................................................................................  94.20 %
DHA-17 ............................V..............................................................................................................................................................................................................................................................................................................................................................  99.74 %
DHA-18 ..................................................................V..................................T..........................................................W....................................................V..R..................................................................................................................................................................  98.68 %
DHA-19 ..................................................................V.............................................................................................W.......................................................................E..................................................................................................................................................  99.21 %
DHA-20 ..................................................................V...................................T.....E..............................................................................................................................................................................................................................................................................  99.21 %
DHA-21 ..................................................................V...................................T.....E..........................................H...................................................................................................................................................................................................................................  98.94 %
DHA-22 .................................A........................................................................L................................................................................................................................................................................................................................................................................  99.47 %
DHA-23 ....................................................................................................................................................................................................................................................S......................................................................................................................................  99.74 %
DHA-24 ................................................................................................................................................................................................................................................................................................................................................A..........................................  99.74 %
DHA-25 ....................................................................................................................................................................................................................................................D......................................................................................................................................  99.74 %
DHA-26 ........................................................................................................................................................................................................................H..................................................................................................................................................................  99.74 %
DHA-27 ................................................................................................................................................................W..........................................................................................................................................................................................................................  99.74 %
DHA-28 .T................................................................V...................................T..........................................N..............WQ...................................................................................................T...................V.................................................................................................  97.89 %
DHA-29 ..........................................................................................................................................L............................................................................................L...................................................................................................................................................  99.47 %
DHA-30 .T.......V..........L.............................................V..................................TS.....V......TQ........................E....SE...H........WQ..K.................T.........................................NQ....TG.P....................I..S.........................................................................................................................  93.67 %
DHA-31 .T..V.............................................................V..................................T..........................................................W....................................................V..R.............................................................................S....................................................................................  97.89 %
DHA-33 .............................................................................................................................................................................................................................................K.............................................................................................................................................  99.74 %
C-DHA phylogenetic tree

Last updated: November 20, 2024.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database was funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

Live statistics (since December 3rd, 2023)