Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
Beta-Lactamase DataBase - Structure and Function Home Enzymes Structures Mutants Kinetics BLAST
Beta-Lactamase DataBase

Sequence alignment for the CMY-2-like beta-lactamase family

CFE-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.....
MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANNRPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTQYWPELTGKQWQGISLLHLATYTAGGLPLQVPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTTRVLQPLKLAHTWITVPQSEQKDYALGYREGKPVHVSPGQL--DAEAYGVKSSVVDMTRWVQANMDASQVQEKTLQQGIKLAQSRYWRIGDMYQGLGWEMLNWPVKADSIING--SDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ
CFE-2 ...........V...L.....D..........................RF....................D....R......................................K......L..................................................P...............G......K..............................R.........--..........L......I..............R...EI..A...H............V....N.......--...............................TS....T...L......VGM........K...............  92.13 %
CMY-2 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......W...............--...........I..A..........H..........A........................L........--.............................................................V.............  95.28 %
CMY-2b .....L.S...V.......................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......W...............--...........I..A..........H..........A........................L........--.............................................................V.............  94.75 %
CMY-4 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......R...............--...........I..A..........H..........A........................L........--.............................................................V.............  95.28 %
CMY-5 .....L.............................................V...................H................................F.....K.............R...............I....R......H.........T................................R.................N......W...............--...........I..A..........H..........A........................L........--.............................................................V.............  95.01 %
CMY-6 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......................--...........I..A..........H..........A........................L........--.............................................................V.............  95.54 %
CMY-7 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................E...............R.................N......W...............--...........I..A..........H..........A........................L........--.............................................................V.............  95.01 %
CMY-12 .....L.............................................V...................H......................................K.............R...............I....R......H.........T.......S........................R.................N......R...............--...........I..A..........H..........A........................L........--........................................................N....V.............  94.75 %
CMY-13 .....L..............S..................................................H......................................K.............................I......................................................R.................N......W...............--.........N.T..A....V.....R..........A........................L........--.............................................................V.............  95.80 %
CMY-14 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......R...............--...........I..A..........H..........A........................L........--..............I..............................................V.............  95.01 %
CMY-15 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......R...............--...........I..A..........H..........A........................L........--........................................................N....V.............  95.01 %
CMY-16 .....L.............................................V...................H......................................K.............R...............I....R......H.........T.......S........................R.................N......R...............--...........I..A..........H..........A........................L........--.............................................................V.............  95.01 %
CMY-17 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......W...............--...........I..A..........H..........A........................L........--......F......................................................V.............  95.01 %
CMY-18 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......W...............--...........I..A..........H..........A........................L........NG.............................................................V.............  94.78 %
CMY-20 -....L.............................................V...................H......................................K.............................I...........H.........T................................R.................N......W...............--...........I..A..........H..........A........................L........--..N..........................................................V.............  95.28 %
CMY-21 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................E...............R.................N......W.............K.--...........I..A..........H..........A........................L........--.............................................................V.............  94.75 %
CMY-22 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......W...............--...........I..A..........H..........A........................L........--.............................................................V....Y........  95.01 %
CMY-23 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......W...............--..G........I..A..........H..........A........................L........--.............................................................V.............  95.01 %
CMY-24 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......W........Y......--...........I..A..........H..........A........................L........--.............................................................V.............  95.01 %
CMY-25 .....L.............................................V...................H......................................K.............R...............I...........H.........T................................R.................N......W...............--...........I..A..........H..........A........................L........--.............................................................V.............  95.54 %
CMY-26 .....L..............S..............................V.....T.............H......................................K...........D.................I.......T...H..........................................R........................W...............--.........N.T..A....V.....R..........A........................L........--.............................................................V.............  94.75 %
CMY-27 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......C...............--...........I..A..........H..........A........................L........--.............................................................V.............  95.28 %
CMY-28 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................E...............R.................N......W...............--...........I..A..........H..........A........................L........--..N..........................................................V.............  94.75 %
CMY-29 .....L.............................................V...................H......................................K.............R...............F....R......H.........T................E...............R.................N......W...............--...........I..A..........H..........A........................L........--.............................................................V.............  95.01 %
CMY-30 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......W.........G.....--...........I..A..........H..........A........................L........--.............................................................V.............  95.01 %
CMY-31 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......W.............R.--...........I..A..........H..........A........................L........--.............................................................V.............  95.01 %
CMY-32 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......W............E..--...........I..A..........H..........A........................L........--.............................................................V.............  95.01 %
CMY-33 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......W...............--...........I..A..........H..........A........................L........SD.----KV......................................................V.............  93.21 %
CMY-34 .....L.............................................V...................H......................................K.............................I...........H.........T................................R.................N......W...............--...........I..A..........H..........A........................L........--.............................................................V.............  95.80 %
CMY-35 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......W......A........--...........I..A....V.....R..........A........................L........--.............................................................V.............  94.75 %
CMY-36 .....L.............................................V...................H........................C.............K.............R...............I....R......H.........T................................R................EN......W...............--...........I..A..........H..........A........................L........--.............................................................V.............  94.75 %
CMY-37 .....L.............................................V...................H......................................K..S..........................I.......T...H..........................................R........................W...............--...........I..A..........R..........A........................L........--.........I...................................................I.............  95.54 %
CMY-38 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......R...............--N..........I..A..........H..........A........................L........--........................................................N....V.............  94.75 %
CMY-39 .....L........PL...................................V................T..H......................................K.............................I......................................................R.............K..........W......A........--...........I..A....V.....R..........A........................L........--.............................................................V.............  95.01 %
CMY-40 .....L.............................................V...................H......................................K.............................I.....................T................T...............R........................W...............--...........I..AH.........H..........E........................L........--...............................Y.............................V.............  95.54 %
CMY-41 .....................T................................EE...............H......................................K..........R..................I..E..................T................................R.....................N..W...............--...........I..A..........H..........E........................L........--...........................................................................  95.54 %
CMY-42 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......W.........S.....--...........I..A..........H..........A........................L........--.............................................................V.............  95.01 %
CMY-43 .....L.............................................V...................H......................................K.............R...............I....R......H.........T...............A................R.................N......W...............--...........I..A..........H..........A........................L........--.............................................................V.............  95.01 %
CMY-44 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......W...............--...........I..A..........H..........A........................L........SD.K------VA...................................................V.............  92.43 %
CMY-45 .....L.............................................V...................H......................................K.............R..............KI....R......H.........T.......S........................R.................N......R...............--...........I..A..........H..........A........................L........--.................................V...........................V.............  94.49 %
CMY-46 .....L.............................................V................T..H......................................K.............................I......................................................R................KN......W......A........--...........I..A....V.....R..........A........................L........--.............................................................V.............  95.28 %
CMY-47 ......................................................E................H......................................K..........R..................I..E.....E............T..................V.............R.....................N..W...............--...........I..A..........H..........E........................L........--...........................................................................  95.54 %
CMY-48 ......................................................E................H......................................K..........R..................I.....................T................................R.....................N..W...............--...........I..A..........H..........E........................L........--...........................................................................  96.33 %
CMY-49 .....L.................................................................H......................................K.............................I.....................T................................R.................N......W..........T....--.........N.T..A..I.V.....R..........A........................L........--..........HT..............................I..................V.............  94.49 %
CMY-50 .....L................................................E................H......................................K..........R..................I..E..................T....................Q...........R.....................N..W...............--...........I..A..........H..........E.......C................L........--.............................................................V.............  95.01 %
CMY-51 ......................................................E................H.................................N....K..........R..................I.....................T....................Q...........R.....................N..W...............--...........I..A..........H..........E........................L........--...........................................................................  95.80 %
CMY-53 .....L.............................................V...................H......................................K.............C...............I....R......H.........T................................R.................N......W...............--...........I..A..........H..........E........................L........--...........................................................................  95.54 %
CMY-54 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......W...............EL...........I..A..........H..........A........................L........--.............................................................V.............  94.78 %
CMY-55 .....L.............................................V...................H.......................E..............K.............R...............I....R......H.........T................................R.................N......W...............--...........I..A..........H..........A........................L........--.............................................................V.............  95.01 %
CMY-56 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......W...............--...........I..A..........H..........A........................L.T......--.............................................................V.............  95.01 %
CMY-57 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......W..............F--...........I..A..........H..........A........................L........--.............................................................V.............  95.01 %
CMY-58 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......W...............--.....C.....I..A..........H..........A........................L........--.............................................................V.............  95.01 %
CMY-59 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......W.........A.....--...........I..A..........H..........A........................L........--.............................................................V.............  95.01 %
CMY-60 .....L.............................................V...................H.................I....................K.............R...............I....R......H.........T................................R.................N......W...............--...........I..A..........H..........A........................L........--.............................................................V.............  95.01 %
CMY-61 -.MNRYAA...........................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......W...............--...........I..A..........H..........A........................L........--.............................................................V.............  93.70 %
CMY-62 .....L.............................................V...................H......................................K.............R...............I....R......H.........T...............S................R.................N......W...............--...........I..A..........H..........A........................L........--.............................................................V.............  95.01 %
CMY-63 .....L.............................................V................T..H......................................K.............................I......................................................R.................N......W......A........--...........I..A....V.....R..........A........................L........--..............................................K..............V.............  95.28 %
CMY-64 .....L.........L.................................I.V................T..H......................................K.............................I......................................................R.................N......W......A........--...........I..A....V.....R..........A........................L........--.............................................................V.............  95.01 %
CMY-65 ......................................................E................H......................................K..........R..................I........E............T..................V.............R.....................N..W...............--...........I..A..........H..........E........................L........--...........................................................................  95.80 %
CMY-66 ......................................................E................H......................................K..........R..................I...I.................T..................V.............R.....................N..W...............--...........I..A..........L..........E........................L........--...........................................................................  95.80 %
CMY-67 ......................................................E................H......................................K..........R..................I..E..................T....................Q...........R.....................N..W...............--...........I..A..........H..........E........................L........--.................................................................V.........  95.54 %
CMY-68 ...............................................I......E................H......................................K..........R..................I..E.....E............T..................V.............R.....................N..W...............--...........I..A..........H..........E........................L........--.............................................................V.............  95.01 %
CMY-69 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......W...............--...........I..A..........H..........A........................L........--.......P.....................................................V.............  95.01 %
CMY-70 ..................................................................................................................................................................................................SK...H....................W...............--...........I........................E...............................S.--.............................................................V.............  97.90 %
CMY-71 .....L........P...............T....................V................T..H......................................K.............................I......................................................R.................N......W......A........--...........I..A....V.....R..........A........................L........--..............................................K..............V.............  94.75 %
CMY-72 ......................................................E................H......................................K..........R..................I........E............T.....................S..........R.....................N..W..L............--...........I..A..........H..........E........................L........--...........................................................................  95.54 %
CMY-73 .....L.............................................VL..................H......................................K.L...........................I.....................T................................R.................N......W..........T....--.........N.T..A..I.V.....R..........A........................L........--...........T.................................................V.............  94.23 %
CMY-74 ..............................................................................................................H....................................................................................K...H....................W...............--...........I........................E........V......................S.--.............................................................V.............  97.64 %
CMY-75 ......................................................E................H......................................K..........R..................I........E............T..................V.............R.....................N..W...............--...........I..A..........H..........E........................L........--.............................................................V.............  95.54 %
CMY-76 ......................................................EE...............H......................................K..........R..................I.....................T....................Q...........R.....................N..W...............--...........I..A..........H..........E........................L........--.............................................................V.............  95.54 %
CMY-77 .....L........PL...................................V................T..H......................................K.............................I......................................................R.................N......W......A........--...........I..A....V.....R..........A........................L........--.............................................................V.............  95.01 %
CMY-78 ......................................................E................H......................................K..........R..................I.G......E............T.....................S..........R.....................N..W..L............--...........I..A..........H..........E........................L........--...........................................................................  95.28 %
CMY-79 ......................................................E................H......................................K..........R..................I...I.................T................................R.....................N..W...............--...........I..A..........H..D.......E........................L........--..................V..........................................V.............  95.28 %
CMY-80 .....L...................P.........................V.....S..........T..H......................................K.............................I......................................................R.............K..........W...............--...........I..A....V.....R..........A........................L........--.............................................................V.............  95.28 %
CMY-81 ......................................................E.............V..H......................................K..........R..................I..Y.....E............T..................V.............R.....................N..W...............--...........I..A..........H..........E........................L........--...........................................................................  95.28 %
CMY-82 ..............................................................................................................H....................................................................................K...R....................W...............--...........I........................E...............................S.--.............................................................V.............  97.90 %
CMY-83 ..............................................................................................................H........................................................................N...........K...R....................W...............--...........I........................E...............................S.--.............................................................V.............  97.64 %
CMY-84 ......................................................E................H......................................K...A......R..................I...I.................T................................R.....................N..W...............--...........I..A..........H..........E........................L........--...........................................................................  95.80 %
CMY-85 ......................................................E................H......................................K..........R..................I.....................T.....................S..........R.....................N..W..L....L.......--...........I..A..........H.......L..E........................L........--.............................................................V.............  95.01 %
CMY-86 .....L........P....................................V................T..H......................................K.............................I......................................................R........................W...............--...........I..A....V.....R..........A........................L........--.............................................................V...V..H......  95.28 %
CMY-87 .....L................................................E................H.................................N....K..........R..................I.....................T....................Q...........R.....................N..W...............--...........I..A..........H..........E........................L........--...........................................................................  95.54 %
CMY-89 .....L..........P.....................................E...............KH......................................K..........R..................I........E............T..................V.............R.....................N..W...............--...........I..A..........H..........E........................L........--..................V..........................................V.............  94.49 %
CMY-90 .....L................................................E................H......................................K..........R..................I.G......E............T.....................S..........R.....................N..W..L............--...........I..A..........H..........E........................L........--...........................................................................  95.01 %
CMY-93 ........................................................................................................F.....H....................................................................................K...R....................W...............--...........I........................E........V......................S.--.............................................................V.............  97.38 %
CMY-94 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......W...............--...........I..A..........H..........A........................L........--......S......................................................V.............  95.01 %
CMY-95 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......W.........A.....--...........I..A..........H..........A........................L........--......S......................................................V.............  94.75 %
CMY-96 .....L.........L.........P.........................V................T..H......................................K.............................I......................................................R.................N......W......A........--...........I..A....V.....R..........A........................L........--............................................................LV.............  94.75 %
CMY-97 ......................................................E................H......................................K..........R..................I.....E...............T..................V.............R.....................N..W...............--...........I..A..........H..........E........................L........--...........................................................................  95.80 %
CMY-98 .AAQ.L................................................................D....R................................................................................................................G......K........................W...............--..........L......I..............R...EI..A...H.................N.......--......................................................................-----  94.23 %
CMY-99 .....L.............................................V...................H......................................K.............R...............I....R......H.........T.......S........................R.................N......R...............--...........I..A..........H..........A........................L........--...................T.........................................V.............  94.75 %
CMY-100 ........................................................................................................................................................H..........S...............................K...H....................W...............--...........I........................E...............................S.--.............................................................V.............  97.64 %
CMY-101 ..............................................................................................................H....................................................................................K...H....................W...............--...........I........................E...............................S.--.............................................................V.............  97.90 %
CMY-102 .....L...........................C.................V...................H......................................K.............................I...........H.........T................................R.................N......W...............--...........I..A..........H..........A........................L........--.............................................................V.............  95.54 %
CMY-103 .....................T................................EE...............H......................................K..........R..................I..E..................T................................R.....................N..W...............--...........I..A..........H..G.......E........................L........--...........................................................................  95.28 %
CMY-104 .....L...........................H.......K.........V...................H......................................K.............................I.....................T.ST.............................R........................W...............--...........I..A.....................E........................L........--................................................................D..........  95.54 %
CMY-105 ......................................................E................H......................................K..........R..................I..E.....E............T..................V.............R.....................N..W...............--...........I..A..........H..........E........................L........--.............................................................V.............  95.28 %
CMY-106 .....L.............................................V...................H......................................K.............................I.....................T................................R.................N......W..........T....--.........N.T..A..I.V.....R..........A........................L........--..................T..........................................V.............  94.75 %
CMY-107 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N....C.W...............--...........I..A..........H..........A........................L........--.............................................................V.............  95.01 %
CMY-108 .....L.............................................V...................H......................................K.............................I......................................................R........................W...............--...........I..A....V.....R..........A........................L........--.............................................................V......H......  96.06 %
CMY-109 ......................................................K................H....H.................................K..........R..................I...I.................T................................R.....................N..W...............--...........I..AH.........H..........E........................L........--...........................................................................  95.54 %
CMY-110 .................K....................................E................H......................................K..........R..................I.....................T................................R.....................N..W...............--...........I..A..........H..........E.......G................L........--...........................................................................  95.80 %
CMY-111 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......W...............--.V.........I..A..........H..........A........................L........--.............................................................V.............  95.01 %
CMY-112 .....L................................................EE...............H......................................K..........R..................I..E..................T................................R.....................N..W...............--...........I..A..........H..........E........................L........--...........................................................................  95.54 %
CMY-113 .....L................................................E................H......................................K..........R..................I........E............T..................V.............R.....................N..W...............--...........I..A..........L..........E........................L........--...........................................................................  95.54 %
CMY-114 .....L................................................E................H......................................K..........R..................I..Y.....E............T..................V.............R.....................N..W...............--...........I..A..........H..........E........................L........--...........................................................................  95.28 %
CMY-115 .....L................................................K................H....H.................................K..........R..................I...I.................T................................R.....................N..W...............--...........I..AH.........H..........E........................L........--...........................................................................  95.28 %
CMY-116 .....L................................................E................H......................................K..........R..................I...I.................T................................R.....................N..W...............--...........I..A..........H..........E........................L........--..................V..........................................V.............  95.28 %
CMY-117 .....L................................................E................H......................................K..........R..................I...I.................T................................R.....................N..W...............--...........I..A..........HA.........E........................L........--..................V........................................................  95.28 %
CMY-118 .....L................................................E................H......................................K..........R..................I.....................T................................R.....................N..W...............--...........I..A..........H..........E........................L........--...........................................................................  96.06 %
CMY-119 .....L..............S..............................V...................H......................................K.............................I.....................T................................R........................W...............--...........I..A..I.V.....R....M.....A........................L........--............A................................................V.............  95.01 %
CMY-121 -....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......S...............--...........I..A..........H..........A........................L........--.............................................................V.............  95.01 %
CMY-122 .....L.............................................V...................HS.....................................K.............................I.....................T................................K..............I..N......W....W.....T....--...........T..A....V.....R..........A........................L........--.............................................................V.............  94.75 %
CMY-124 .....L.............................................V...................H......................................K.............................I.....................T................................R.................N......W..........T....--.........N.T..A..I.V.....R..........A........................L........--..........HT.................................................V.............  94.49 %
CMY-125 .....L.............................................V...................H............................S.........K.............................I...........H.........T................................R.................N......W...............--...........I..A..........H..........A........................L......S.--.............................................................V.............  95.28 %
CMY-127 .....L........PL.................................I.V................T..H......................................K.R...........................I..........................................N...........R.................N......W......A........--...........I..A....V.....R..........A........................L........--.............................................................V.............  94.23 %
CMY-128 ..........................................R...........E................H......................................K..........R..................I.......TE............T..................V.............R.....................N..W...............--...........I..A..........L..........E........................L........--...........................................................................  95.28 %
CMY-129 .....L........P....................................V................T..H......................................K.............................I......................................................R.................N......W......A........--...........I..A....V....NR..........A........................L........--.............................................................V.............  95.01 %
CMY-130 .....L....................................L........V...................H......................................K.............R...............I....R......H.........T................................R.................N......W...............--...........I..A..........H..........A........................L........--.............................................................V.............  95.01 %
CMY-131 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................E...............R.................N......W............R..--G..........I..A..........H..........A........................L........--.............................................................V.............  94.49 %
CMY-132 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......W...............--...........I..A..........H..........A........................L........--..............................................K..............V.............  95.01 %
CMY-133 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......W...............--...........I..A..........H..........A........................L........--N............................................................V.............  95.01 %
CMY-134 .....L.............................................V...................H......................................K.............R...............I....R......H.........T.....F..........................R.................N......W...............--...........I..A..........H..........A........................L........--.............................................................V.............  95.01 %
CMY-135 ......................................................E................HL.....................................K..........R..................I...I.................T................................R.....................N..W...............--...........I..A..........H..........E........................L........--...........................................................................  95.80 %
CMY-136 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......W...............--....H......I..A..........H..........A........................L........--.............................................................V.............  95.01 %
CMY-137 ..............................................................................................................H...................................................................................SK...H....................W...............--...........I........................E...............................S.--.............................................................V.............  97.64 %
CMY-138 .....LY............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......R...............--...........I..A..........H..........A........................L........--.............................................................V.............  95.01 %
CMY-139 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R........T........N......W.........S.....--...........I..A..........H..........A........................L........S--....................L.......................................V.............  93.98 %
CMY-140 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......W...............--...........I..A..........H..........A........................L........--..N..........................................................V.............  95.01 %
CMY-141 .....L.............................................V...................H......................................K.............R...............L....R......H.........T................................R.................N......W.........S.....--...........I..A..........H..........A........................L........--.............................................................V.............  95.01 %
CMY-142 .....L.............................................V...................H......................................K.............R...............I....R......H.........T............S...................R.................N......W...............--...........I..A..........H..........A........................L........--.............................................................V.............  95.01 %
CMY-143 .....L.............................................V...................H......................................K.............R...............I....R......H.........T...............D................R.................N......W...............--...........I..A..........H..........A........................L........--.............................................................V.............  95.01 %
CMY-144 .....L.......V.....................................V...................H...............................N......K.............................I....................................................I.R........................W...............--.........N.T..A....V.....R..........A........................L........--..........................................I..................V.............  95.01 %
CMY-145 .....L.............................................V...................H.................T....................K.............R...............I....R......H.........T................................R.................N......W.........S.....--...........I..A..........H..........A........................L........--.............................................................V.............  94.75 %
CMY-146 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......W.........S.....--...........I..A..........H..........A........................L........--..N..........................................................V.............  94.75 %
CMY-147 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......W.........S.....--..A........I..A..........H..........A........................L........--.............................................................V.............  94.75 %
CMY-148 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R........T........N......W.........S.....--...........I..A..........H..........A........................L........S--............................................................V.............  94.24 %
CMY-149 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N...Y..R...............--...........I..A..........H..........A........................L........--.............................................................V.............  95.01 %
CMY-150 ......................................................E................H......................................K..........R..................I........E............T..................V..H..........R.....................N..W...............--...........I..A..........L..........E........................L........--...........................................................................  95.54 %
CMY-151 ......................................................E................H......................................K..........R...M..............I........E............T.....................S..........R.....................N..W..L............--...........I..A..........H..........E........................L........--...........................................................................  95.28 %
CMY-152 ......................................................EE...............H......................................K..........R..................I..E..................T................................R.....................N..W...............--...........I..A..........H..........E........................L........--...........................................................................  95.80 %
CMY-153 .....L..............................P..............V...................H......................................K.............R...............I....R......H.........T................................R.................N......W...............--...........I..A..........H..........A........................L........--.............................................................V.............  95.01 %
CMY-154 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................E...............R.................N......W.........S.....--...........I..A..........H..........A........................L........--.............................................................V.............  94.75 %
CMY-155 .....L.........L.........P.........................V................T..H......................................K.............................I......................................................R.................N......W......A........--...........I..A....V.....H..........A........................L........--............................................................LV.............  94.75 %
CMY-156 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......W.........S.....--...........I..A..........H..........A........................L........--......F......................................................V.............  94.75 %
CMY-157 .....L.............................................V.....................I..N.................................R...........N.................I..E....T..........................................G..IR........T........N..R...W...D...........--..........IM..A....V.....H..........G..........E.................T....--....I.....................................I.....................D..........  92.65 %
CMY-158 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......M...............--...........I..A..........H..........A........................L........--.............................................................V.............  95.28 %
CMY-159 .....L................................................................D....R......................................................................................V........................IG......K........................W...............--..........L.....................R...EI..A...H.................N.......--...........V...............................................................  95.80 %
CMY-160 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......W.........S.....--..G........I..A..........H..........A........................L........--.............................................................V.............  94.75 %
CMY-161 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......W...............--...........I..A..........H..........A........................L........--.............................................................V.F...........  95.01 %
CMY-162 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......W..............I--...........I..A..........H..........A........................L........--.............................................................V.............  95.01 %
CMY-163 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R........T........N......W.........S..R..--...........I..A..........H..........A........................L........S--............................................................V.............  93.98 %
CMY-164 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......W...............--...........I..A..........H..........A........................L........SD.KVA-LA......................................................V.............  93.21 %
CMY-165 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......W...............--...........I..A..........H..........A........................L........--....E........................................................V.............  95.01 %
CMY-166 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......W...............--...........I..A..........H..........A........................L........--........................................................N..I.V.............  94.75 %
CMY-167 .....L.............................................V...................H......................................K.............R..............KI....R......H.........T.......S........................R.................N......R...............--...........I..A..........H..........A........................L........--.............................................................V.............  94.75 %
CMY-168 ......................................................E................H......................................K..........R..................I..E..................T................................R.....................N..................--...........I..A..........H..........E........................L........--...........................................................................  96.33 %
CMY-169 .................K....................................E................H......................................K..........R..................I.....................T................................R.....................N..W...............--...........I..A..........H..........E........................L........--.........-----.............................................................  94.75 %
CMY-170 ......................................................E................H......................................K..........R..................I.....................T................................R.....................N..W............E..--...........I..A..........H..........E........................L........--...........................................................................  96.06 %
CMY-171 .....L........................................S....V...................H......................................K.............R...............I....R......H.........T................................R.................N......W...............--...........I..A..........H..........A........................L........--.............................................................V.............  95.01 %
CMY-172 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......W...............--...........I..A..........H..........A........................L........SD.-----.....................................................I.V.............  93.21 %
CMY-174 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......W...............--...........I..A..........H..........A........................L........--.............................................................V.....R.......  95.01 %
CMY-175 .....L.............................................V...................H......................................K.............................I...........H.........T................................R....Q............N......W...............--...........I..A..........H..........A........................L........--.............................................................V.............  95.54 %
CMY-176 .....L.............................................V...................HS.....................................K.............................I......................................................R.................N......W......A........--...........I..A....V.....R..........A........................L........--..........................................I..................V.............  95.28 %
CMY-177 .....L.............................................V...................H......................................K.............R...............I....R......H.........T................................R.................N......W.............R.--...........I..A..........H..........A........................L........--.....................................R.......................V.............  94.75 %
CMY-178 .....L.............................................V...................H.................T....................K.............R...............I....R......H.........T................................R.................N......W...............--...........I..A..........H..........A........................L........SD.-----.....................................................I.V.............  92.95 %
CMY-179 .....................S....H..............................................................................................R...M..............I....................................................L.R........................W...............--...........................K........E...............................S.--..............................................K............................  96.85 %
CMY-180 ......................................................EE...............H......................................K..........R..................I.....................T................................R.....................N..W...............--...........I..A..........H..........E........................L........--...........................................................................  96.06 %
CMY-181 ......................................................E................H......................................K..........R..................I...I.................T................................R.....................N..W...............--...........I..A..........H..........E........................L........--...........................................................................  96.06 %
CMY-182 ........................................................................................................F.........................................N.........S......................................K...H....................W...............--...........I........................E...............................S.--.............................................................V.............  97.38 %
CMY-183 .....L........P....................................V................T..H......................................K.............................I......................................................R.................N......W......A........--...........I..A....V.....R..........A........................L........--.............................................................V.............  95.28 %
CMY-184 .....L.............................................V...................H......................................K.............R...............I....R......H.........T.......S........................R.................N......R...............--...........I..A..........H.......E..A........................L........--.............................................................V.............  94.75 %
CMY-185 .....L.............................................V...................H......................................K.............R........E.....KI....R......H.........T................................R.................N......W.........S.....--...........I..A..........H..........A........................L........SD--.........................................................Y.V.............  93.21 %
CMY-186 .....L.............................................V...................H......................................K.............R...............I....R......H.........T.......S.......V................R.................N......R...............--...........I..A..........H..........A........................L........--.............................................................V.............  94.75 %
CMY-189 ......................................................E................H......................................K..........R..................I...I.................T................................R.....................N..W...............--...........I..A..........H..........E........................L........--..................V..........................................V.............  95.54 %
LAT-1 .....L.S...........................................V...................H........................C.............K........K....R...............I....R......H.........T................................R.................N......W.............R.--...........I..A..........H..........A........................L........S--............................................................V.............  93.72 %
C-CMY-2-like phylogenetic tree

Last updated: November 20, 2024.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database was funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

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