Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
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Beta-Lactamase DataBase

Sequence alignment for the CMH beta-lactamase family

CMH-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.
MMTKSLSCALLLSVACSAFAAPMSEKQLADVVERTVTPLMKAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSVSKTFTGVLGGDAIARKEISLADPVTKYWPELTGKQWQGIRLLDLATYTAGGLPLQVPDDVTDNASLLRFYQSWQPKWAPGTTRLYANTSIGLFGSLAVKPSGMCFEQAMAERVFKPLKLNHTWINVPHAEEPHYAWGYREGKAVHVSPGMLDAEAYGVKSNVKDMASWVMANMAPETLPQSTLQQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVDGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANKSYPNPVRVETAYRILDALQ
CMH-2 ...............................................................................................................................................A............................................R..E..T.....................S....................................................................................................................................................................  98.69 %
CMH-3 ..K.........................................................................................................................................................................................R............................N...............................................................................................................................................................ET..  98.69 %
CMH-4 ..K.........................................................................................................................................................................................R................................................................................................................................................................................................  99.48 %
CMH-5 ..K..........................N....N.............................................................T..............................................A.....................................T......R..E..T...............I...................................................IQ.PS.K................................................A.................................................L..........T..  95.28 %
CMH-6 ..K.....................K.................................................................................................S.........................V.......................................R............................................................................................................................................................................................ET..  98.16 %
CMH-7 ..K.....................K.................................................................................................S.........................V.......................................R..........................................................................S.................................................................................................................ET..  97.90 %
CMH-8 ..K.........................................................................................................................................................................................R.....V..........................................................L.............................................V.............................................................................ET..  98.16 %
CMH-9 ..K............................................................................................................................................N............................................R...........................S...............................................P..................................V.............................................................................ET..  97.90 %
CMH-10 ..K.........................................................................................................................................................................................R...........................................................................P................................................V...............G...................................................  98.69 %
CMH-11 ..K.........................................................................................................................................................................................R.....V.........T................................................L...........................................................................................................................ET..  98.16 %
CMH-12 ..K.........................................................................................................................................................................................R............................................................................P..K.............S................V.................................................................T...........ET..  97.64 %
CMH-13 ..K.....................................................................................................................................................S...................................R............................................................................................................................................................................................ET..  98.69 %
CMH-14 ..K.........................................................................................................................................................................................R...........................................................................P....................................................................................................................  99.21 %
CMH-15 ..K.........................................................................................................................................................................................R............................................................................................................................................................................................ET..  98.95 %
CMH-16 ..K.........................................................................................................................................................................................R...........................................................................P................................................................................................................ET..  98.69 %
CMH-17 ..K..........................N....N............................................................................................................A............................................R..E..T...............I.......................L.........................D.IQ.PA.K.............................E..................A.................................................L..........T..  95.01 %
CMH-18 ..K..........................................................................................................................................................................................................................................................................................................................................................................................  99.74 %
CMH-19 ..K...............................................................................................................D.........................................................................R...........................................................................P...................................................................................................................H  98.69 %
CMH-20 ..K............................................................................................................................................A........................................L...R...........................S................................................................................................................................................................ET..  98.16 %
CMH-22 ..K...............................................................................................................D..................V......................................................R...........................................................................P....................................................................................................................  98.69 %
CMH-23 ..K..........................N....N............................................................................................................A............................................R..E..T...............I.......................L...........................IQ.PS.K................................................A.................................................L..........T..  95.54 %
CMH-24 ..K.........................................................................................................................................................................................R.....V..........................................................L...........................................................................................................................ET..  98.43 %
CMH-25 ..K........F...S............................................................................................................................................................................R............................................................................P..K..............................V.............................................................................ET..  97.64 %
CMH-26 ..K...........................................................................................................................I.............................................................R...........................................................................P...............................Q...................L................................................................  98.43 %
CMH-27 ..K.................................................................................................................K.......................................................................R...........................................................................P...................................................................................................S................  98.69 %
CMH-28 ..K...............................................................................................................................................................V.........................R.......................................I....................................................................................................................................................ET..  98.43 %
CMH-29 ..K................................I................................................................................................................V...........E...........................R..............................................................................................................V.................................................................................  98.43 %
CMH-30 ..K.........................................................................................................................................................................................R........................................................................A......K..............................V................................................................................H  98.43 %
CMH-31 ..K.........................................................................................................................................................................................R............................................................................P..K............................................................................................................ET..  98.43 %
CMH-32 ..K..........................NA...N............................................................................................................A............................................H..E..T...............I.......................L.........................D.IQ.PS.K.............................E..................A.................................................L..........T..  94.75 %
CMH-33 ..K..................................................................V................................................N.....................................................................R...................................................................................T............................................................................................................  98.69 %
CMH-34 ..K..........................N....N............................................................................................................A............................................R..E..T...............I...................................................IQ.PA.K................................................A.................................................L..........T..  95.80 %
CMH-T1 ..K............................................................................................................................................N............................................R...........................S...............................................P..................................V.............V--.............................................................ET..  97.11 %
C-CMH phylogenetic tree

Last updated: January 22, 2025.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database was funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

Live statistics (since March 29th, 2025)