Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
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Beta-Lactamase DataBase

Sequence alignment for the CMH beta-lactamase family

CMH-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.
MMTKSLSCALLLSVACSAFAAPMSEKQLADVVERTVTPLMKAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSVSKTFTGVLGGDAIARKEISLADPVTKYWPELTGKQWQGIRLLDLATYTAGGLPLQVPDDVTDNASLLRFYQSWQPKWAPGTTRLYANTSIGLFGSLAVKPSGMCFEQAMAERVFKPLKLNHTWINVPHAEEPHYAWGYREGKAVHVSPGMLDAEAYGVKSNVKDMASWVMANMAPETLPQSTLQQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVDGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANKSYPNPVRVETAYRILDALQ
CMH-2...............................................................................................................................................A............................................R..E..T.....................S.................................................................................................................................................................... 98.69 %
CMH-3..K.........................................................................................................................................................................................R............................N...............................................................................................................................................................ET.. 98.69 %
CMH-4..K.........................................................................................................................................................................................R................................................................................................................................................................................................ 99.48 %
CMH-5..K..........................N....N.............................................................T..............................................A.....................................T......R..E..T...............I...................................................IQ.PS.K................................................A.................................................L..........T.. 95.28 %
CMH-6..K.....................K.................................................................................................S.........................V.......................................R............................................................................................................................................................................................ET.. 98.16 %
CMH-7..K.....................K.................................................................................................S.........................V.......................................R..........................................................................S.................................................................................................................ET.. 97.90 %
CMH-8..K.........................................................................................................................................................................................R.....V..........................................................L.............................................V.............................................................................ET.. 98.16 %
CMH-9..K............................................................................................................................................N............................................R...........................S...............................................P..................................V.............................................................................ET.. 97.90 %
CMH-10..K.........................................................................................................................................................................................R...........................................................................P................................................V...............G................................................... 98.69 %
CMH-11..K.........................................................................................................................................................................................R.....V.........T................................................L...........................................................................................................................ET.. 98.16 %
CMH-12..K.........................................................................................................................................................................................R............................................................................P..K.............S................V.................................................................T...........ET.. 97.64 %
CMH-13..K.....................................................................................................................................................S...................................R............................................................................................................................................................................................ET.. 98.69 %
CMH-14..K.........................................................................................................................................................................................R...........................................................................P.................................................................................................................... 99.21 %
CMH-15..K.........................................................................................................................................................................................R............................................................................................................................................................................................ET.. 98.95 %
CMH-16..K.........................................................................................................................................................................................R...........................................................................P................................................................................................................ET.. 98.69 %
CMH-17..K..........................N....N............................................................................................................A............................................R..E..T...............I.......................L.........................D.IQ.PA.K.............................E..................A.................................................L..........T.. 95.01 %
CMH-18..K.......................................................................................................................................................................................................................................................................................................................................................................................... 99.74 %
CMH-19..K...............................................................................................................D.........................................................................R...........................................................................P...................................................................................................................H 98.69 %
CMH-20..K............................................................................................................................................A........................................L...R...........................S................................................................................................................................................................ET.. 98.16 %
CMH-22..K...............................................................................................................D..................V......................................................R...........................................................................P.................................................................................................................... 98.69 %
CMH-23..K..........................N....N............................................................................................................A............................................R..E..T...............I.......................L...........................IQ.PS.K................................................A.................................................L..........T.. 95.54 %
CMH-24..K.........................................................................................................................................................................................R.....V..........................................................L...........................................................................................................................ET.. 98.43 %
CMH-25..K........F...S............................................................................................................................................................................R............................................................................P..K..............................V.............................................................................ET.. 97.64 %
CMH-26..K...........................................................................................................................I.............................................................R...........................................................................P...............................Q...................L................................................................ 98.43 %
CMH-27..K.................................................................................................................K.......................................................................R...........................................................................P...................................................................................................S................ 98.69 %
CMH-28..K...............................................................................................................................................................V.........................R.......................................I....................................................................................................................................................ET.. 98.43 %
CMH-29..K................................I................................................................................................................V...........E...........................R..............................................................................................................V................................................................................. 98.43 %
CMH-30..K.........................................................................................................................................................................................R........................................................................A......K..............................V................................................................................H 98.43 %
CMH-31..K.........................................................................................................................................................................................R............................................................................P..K............................................................................................................ET.. 98.43 %
CMH-32..K..........................NA...N............................................................................................................A............................................H..E..T...............I.......................L.........................D.IQ.PS.K.............................E..................A.................................................L..........T.. 94.75 %
CMH-33..K..................................................................V................................................N.....................................................................R...................................................................................T............................................................................................................ 98.69 %
CMH-34..K..........................N....N............................................................................................................A............................................R..E..T...............I...................................................IQ.PA.K................................................A.................................................L..........T.. 95.80 %
CMH-T1..K............................................................................................................................................N............................................R...........................S...............................................P..................................V.............V--.............................................................ET.. 97.11 %
C-CMH phylogenetic tree

Last updated: April 06, 2026.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database was funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

Live statistics (since March 29th, 2025)