Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
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Beta-Lactamase DataBase

Sequence alignment for the ASA3 beta-lactamase family

ASA3-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380...
MEKATTRSLLVLSTLLLSPLSHAKEAEPLTALVDGAIQPLLKEHRVPGMAVAVLKEGKANYFNYGVADRESGARVSEQTLFEIGSVSKTLTATLGAYAAVKGGFQLEDKASQHAPWLKGSAFDGITMAELATYSAGGLPLQFPDEVDSTDKMRAYYRQWTPAYPAGTHRQYSNPSIGLFGHLAANSLGQPFEQLMSQTLLPKLGLHHTYIQVPESAMANYAYGYSKEDKPVRVNPGVLAAEAYGIKTGSADLLKFVEANMGYQGDAVVKSAIALTHTGFYYVGEMTQGLGWESYAYPVTEQTLLAGNSSAVIYNANPVKSVATSQEMGGARLYNKTGSTGGFGAYVAFVPAKGIGIVMLANRNYPNEARVKAAHAILSQLAE-
ASA3-2 ...........................................................H..................................................................................................................................................................................................................................................................................................................................-  99.74 %
ASA3-3 .A.........................................................H..................................................................................................................................................................................................................................................................................................................................-  99.48 %
ASA3-4 ...........................................................H....................................................................................................................................................................................................................................................................................C.............................................-  99.48 %
ASA3-5 ...........................A...V...........................H............................................................................................................................................................................................................................S.........................................K...........................................................-  98.69 %
ASA3-6 ...............................V...........................Y............................................................................................................................................................................................................................S.........................................K...........................................................-  98.95 %
ASA3-7 ...............................V...........................H................................................................VS..................G.......H................................................................................S................................A.T..........HS..G.................V......P..SFQ....TRF.VPKA..EQ.......................................I.......EA..AE  91.91 %
ASA3-8 ....P........A...............A.V.....R.....................H............T............................V.......V..........................................H..............Y..............................................................I...................................E.T..........HS..D........................P..SLK....TRF.VPKA..EQ.....................R.............I...............L-  91.36 %
ASA3-9 .KQN.AV...A......P.............V...........................Y............................................................................................H................................................................................S................................A.T..........HS..G........................P..SFQ....TRF.VPKA..EQ.......................................I............-  92.15 %
ASA3-10 .KQN.AV...A..A........GEG.D...TV..........Q..I.........D...H.......N....S...........................................................................S...H...............................S.................................................................................A.T..........HS..D........................P..SFQ....TRF.VPKA..EQ...................................I...............L-  89.01 %
ASA3-11 .KQN.AV...A..A........GEG.D...TV..........Q..I.........D...H........................................................................................S...H...............................S................R................................................................A.T..........HS...........................P..SFQ.....RF.VPKA..EQ...................................................L-  90.05 %
ASA3-12 ...............................V...........................H.......A....................................................................................H................................................................................S..M.............................A.T..........HS..G.................V......PV.SFQ....TRF.VPKA..EQ.......................................I.......EA..AE  91.91 %
ASA3-13 .KQN.AV...A......P.............V...........................H............................................................................................H................................................................................S................................A.T..........HS..G........................P..SFQ....THF.VPKA..EQ.......................................I............-  92.15 %
ASA3-14 .KQN.AV...A..A........GEG.D...TV.......................D...H......................................IA......D..V..Q...................................S........H........S.................S................R............................I......................R.....I.....EA.............S..D...................................P..A...T.L..........N........................................EL-  89.79 %
ASA3-15 .KQN.AV...A....................V...........................H.........................................................................................................................................................................................................D..................S.....................................................................................................-  97.38 %
ASA3-16 ...........................................................H..................................................................................S.........................................................................................................................................S...........................P..SFQ....TRF.VPKA..EQ.......................................I............-  95.55 %
ASA3-17 .......................N...A...V...........................H......T.....V............................................................N...............N....................................................................................................................A.T..........HS..G........................P..SFQ....TRF.VPKA..EQ...............................................EA..AE  92.17 %
ASA3-18 .KQN.AV...A..A........GEG.D...TV..........Q..I.........D...H.......N....S.........................IA......D.....Q...................................I........H.A......S.................S................G...........DA...............I......................R.....I.....EA.............S......................................P..G...T.L..........N.............................I...........L-  88.48 %
ASA3-19 .KQN.AV.M.A................A...V...........................H......................................................................................................F.....................................................................................................................S.....................................................................................................-  96.86 %
ASA3-20 ...........................................................H...........................................................................................................................................................................W..................................E.......................................................................I...........................................-  98.95 %
ASA3-21 ...........................A...V.................T.........H........................................................................................................................................................................................................E...................S..........................................T..........................................................-  98.17 %
ASA3-22 .......................N...A...V...........................H........................................................................................................................................................................................................E...................S..........................................T..........................................................-  98.17 %
ASA3-23 ...............................V..........................VY............................................................................................................................................................................................................................S.........................................K...........................................................-  98.69 %
ASA3-24 ...............................V...........................Y............................................................................................................................................................................................................................S.....................................................................................................-  99.21 %
ASA3-25 ....P........A...............A.V.....R.....................H........Q...T....................................V..........T...............................H.............................................................................I.....................................T..........HS..D........................P..SFQ....TRF.VPKA..EQ.....................R.............I...............L-  91.62 %
ASA3-26 .....................Y.N.......V...........................H................................MI.............................S........................................................................................L........F............................................A.............S...........................P..SFQ....TRF.VPKA..EQ.........S...........R.................I.......EA..AE  91.91 %
ASA3-27 ......Q..............Y.N...........V.......................H..............................................................................................................................................................................................................A.T..........HS..G........................P..SFQ.....RF.VPKA..EQ.....................R..........S..I........V..EA..AE  92.17 %
ASA3-28 .KQN.AV...A....................V...........................H.................................I.....................................................................L......................................................................................................A.T..........HS..G..................................MRF.VPKA..EQ.......................................I.......EA..AE  92.43 %
ASA3-29 ...............................V...........................Y............................................................................................H................................................................................S................................A.T..........HS..G........................P..SFQ....TRF.VPKA..EQ.......................................I............-  93.98 %
ASA3-30 .KQN.AV...A................A...V...........................H.....................................V........................................................................................................................................................................A.T..........HS..G........................P..SFQ....TRF.VPKA..EQ.......................................I............-  92.41 %
C-ASA3 phylogenetic tree

Last updated: November 20, 2024.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database was funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

Live statistics (since December 3rd, 2023)