Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
Beta-Lactamase DataBase - Structure and Function Home Enzymes Structures Mutants Kinetics BLAST
Beta-Lactamase DataBase

Sequence alignment for the AQU beta-lactamase family

AQU-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.....
MKQTSPLSLLALSALLLS---PLTQAAPADPLVGVVDDVIRPLVKEHRIPGMAVAVFKEGQPHYFNYGVAELATGKKVSEQTLFEIGSVSKTLTATLGAYAVVKGSIGLDDKVSRHAPWLKGSAFDGITMVELATYSAGGLPLQFPDEVESLEQMQAYYRQWTPAYQPGSHRQYSNPSIGLFGYLAASSLQQPFAQLMEQTLLPGLGLHHTYINVPKQAMANYAYGYSKEDKPIRVTPGVLADEAYGIKTSSADLLAFMKANISGVDDKGLQQAIALTHQGRYSVGGMTQGLGWESYPYPVSEQTLLAGNSAQVIMKANPTTA--APKEMGSQRLFNKTGSTNGFGAYVAFVPAKGVGIVMLANRNYPIQERVKAAHAILSKLAP
AQU-2..................---.............................................................................................................A..................A..............................................F.............................................................V....N......................E........................V...........--....................................................S....... 97.89 %
AQU-3..................---...................................L.G..A....................................................................A............................................................................M..S.........................N..M..................V...VN.........................................................K.--............................................................ 96.84 %
AQU-4----..............---................E...................................................................G........................A.................................................................F.............................................................V....N...........S.....H.........................T...............--..............................................-------------- 92.89 %
AQU-5----..............---................E............................................................................................A...............................................................................................................................V....N.................H......................A.QV...RE.SF.G..VKGFK..VTF.EA..Y.............................S.....-------------- 88.74 %
AQU-6----....S.........---.............................................................................................................A.........................................................................................................N..M..................V...........................E...................QV...RE.SF.G..VKGFKV.VTF.EA..Y......S......................S.....-------------- 88.22 %
AQU-7---...............---.............................................................................................................A................K........................................................................................N..M..................V....N........................................A..................--.................S......................S.....-------------- 93.16 %
AQU-8........S.........---................E......................................................Y.....................................A...............................................................................................................................V....N......................E........................V...........--....................................................S....... 97.63 %
AQU-9..................---.............................................................................................................A...............................................................................................................................V....K......................E....................................--............................................................ 98.95 %
AQU-10...RKTILWG.VAT.MWTGLAHAEAIS..E..RS...AS.Q..L..Q.........L.D.KA.......................V.....P..........I..AMK....A........D........A............................................................................M..S.........................N..M..................V...VN.................H........................QV...RE.SF.G..VKGFK..VTF.EA..Y......S......................S................... 81.56 %
AQU-11...RKTILWG.VAT.MWTGLAHAEATS.....RS...AS.Q..L..Q.........L.D.KA....................................................................A...............................................................................................................................V....K......................E.................A.QV...RE.SF.G..VKGFK..VTF.EA..Y.............................S................... 85.19 %
AQU-12..................---.............................................................................................................A................K..............................................................................................................V....K......................E....................................--............................................................ 98.68 %
AQU-13..................---.............................................................................................................................................................................................................................................V....N.................H......................V..................--............................................................ 98.95 %
AQU-14..................---................E...................................................................G........................A.................................................................F.............................................................V....N.................H.........................T...............--...................................................N........ 97.63 %
AQU-15..................---...................................L.G..A....................................................................A.........................................................................................................N..M..................V................................................................--E........................................................... 97.89 %
AQU-16...RKTILWG.VAT.MWAGLAHAEATS.....RS...AS.Q..L..Q.........L.D.KA.......................V.....P.........................S...D........A............................................................................M..S.........................N..M..................V...VN.................H........................QV...RE.SF.G..VKGFK..VTF.EA..Y......S......................S................... 82.86 %
AQU-17..................---.............................................................................................................A.........................................................................................................N..M..................VQ...N.................H.........................................--..X......................................................... 97.89 %
AQU-18..................---...................................L.G..A....................................................................A...............................................................................................................................V....N.................H........................QV...RE.SF.G..VKGFK..VTF.EA..Y................X................................ 93.19 %
AQU-19...RKTILWG.VAT.MWTGLAHAEAIS..E..RS...AS.Q..L..Q.........L.D.KA.......................V.....P..........I..AMK....A.Q......D........A.......................................Y....................................M..S.........................N..M..................V...VN.................H........................QV...RE.SF.G..VKGFK..VTF.EA..Y......S.......................................... 81.30 %
AQU-20...RKTILWG.VAT.MWTGLAHAEATS.....RS...AS.Q..L..Q.........L.D.KA....................................................................A...............................................................................................................................V....K.................H........................QV...RE.SF.G..VKGFK..VTF.EA..Y......S......................S................... 85.19 %
AQU-21...RKTILWG.VAT.MWTGLAHAEATS.....RS...AS.Q..L..Q.........L.D.KA.......................V.....P..........I..AMK....A........D........A............................................................................M..S.........................N..M..................V...VN.................H........................................--A..............................R............................. 86.20 %
C-AQU phylogenetic tree

Last updated: April 06, 2026.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database was funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

Live statistics (since March 29th, 2025)