Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
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Beta-Lactamase DataBase

Sequence alignment for the AQU beta-lactamase family

AQU-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.....
MKQTSPLSLLALSALLLS---PLTQAAPADPLVGVVDDVIRPLVKEHRIPGMAVAVFKEGQPHYFNYGVAELATGKKVSEQTLFEIGSVSKTLTATLGAYAVVKGSIGLDDKVSRHAPWLKGSAFDGITMVELATYSAGGLPLQFPDEVESLEQMQAYYRQWTPAYQPGSHRQYSNPSIGLFGYLAASSLQQPFAQLMEQTLLPGLGLHHTYINVPKQAMANYAYGYSKEDKPIRVTPGVLADEAYGIKTSSADLLAFMKANISGVDDKGLQQAIALTHQGRYSVGGMTQGLGWESYPYPVSEQTLLAGNSAQVIMKANPTTA--APKEMGSQRLFNKTGSTNGFGAYVAFVPAKGVGIVMLANRNYPIQERVKAAHAILSKLAP
AQU-2 ..................---.............................................................................................................A..................A..............................................F.............................................................V....N......................E........................V...........--....................................................S.......  97.89 %
AQU-3 ..................---...................................L.G..A....................................................................A............................................................................M..S.........................N..M..................V...VN.........................................................K.--............................................................  96.84 %
AQU-4 ----..............---................E...................................................................G........................A.................................................................F.............................................................V....N...........S.....H.........................T...............--..............................................--------------  92.89 %
AQU-5 ----..............---................E............................................................................................A...............................................................................................................................V....N.................H......................A.QV...RE.SF.G..VKGFK..VTF.EA..Y.............................S.....--------------  88.74 %
AQU-6 ----....S.........---.............................................................................................................A.........................................................................................................N..M..................V...........................E...................QV...RE.SF.G..VKGFKV.VTF.EA..Y......S......................S.....--------------  88.22 %
AQU-7 ---...............---.............................................................................................................A................K........................................................................................N..M..................V....N........................................A..................--.................S......................S.....--------------  93.16 %
AQU-8 ........S.........---................E......................................................Y.....................................A...............................................................................................................................V....N......................E........................V...........--....................................................S.......  97.63 %
AQU-9 ..................---.............................................................................................................A...............................................................................................................................V....K......................E....................................--............................................................  98.95 %
AQU-10 ...RKTILWG.VAT.MWTGLAHAEAIS..E..RS...AS.Q..L..Q.........L.D.KA.......................V.....P..........I..AMK....A........D........A............................................................................M..S.........................N..M..................V...VN.................H........................QV...RE.SF.G..VKGFK..VTF.EA..Y......S......................S...................  81.56 %
AQU-11 ...RKTILWG.VAT.MWTGLAHAEATS.....RS...AS.Q..L..Q.........L.D.KA....................................................................A...............................................................................................................................V....K......................E.................A.QV...RE.SF.G..VKGFK..VTF.EA..Y.............................S...................  85.19 %
AQU-12 ..................---.............................................................................................................A................K..............................................................................................................V....K......................E....................................--............................................................  98.68 %
AQU-13 ..................---.............................................................................................................................................................................................................................................V....N.................H......................V..................--............................................................  98.95 %
AQU-14 ..................---................E...................................................................G........................A.................................................................F.............................................................V....N.................H.........................T...............--...................................................N........  97.63 %
AQU-15 ..................---...................................L.G..A....................................................................A.........................................................................................................N..M..................V................................................................--E...........................................................  97.89 %
AQU-16 ...RKTILWG.VAT.MWAGLAHAEATS.....RS...AS.Q..L..Q.........L.D.KA.......................V.....P.........................S...D........A............................................................................M..S.........................N..M..................V...VN.................H........................QV...RE.SF.G..VKGFK..VTF.EA..Y......S......................S...................  82.86 %
AQU-17 ..................---.............................................................................................................A.........................................................................................................N..M..................VQ...N.................H.........................................--..X.........................................................  97.89 %
AQU-18 ..................---...................................L.G..A....................................................................A...............................................................................................................................V....N.................H........................QV...RE.SF.G..VKGFK..VTF.EA..Y................X................................  93.19 %
AQU-19 ...RKTILWG.VAT.MWTGLAHAEAIS..E..RS...AS.Q..L..Q.........L.D.KA.......................V.....P..........I..AMK....A.Q......D........A.......................................Y....................................M..S.........................N..M..................V...VN.................H........................QV...RE.SF.G..VKGFK..VTF.EA..Y......S..........................................  81.30 %
AQU-20 ...RKTILWG.VAT.MWTGLAHAEATS.....RS...AS.Q..L..Q.........L.D.KA....................................................................A...............................................................................................................................V....K.................H........................QV...RE.SF.G..VKGFK..VTF.EA..Y......S......................S...................  85.19 %
AQU-21 ...RKTILWG.VAT.MWTGLAHAEATS.....RS...AS.Q..L..Q.........L.D.KA.......................V.....P..........I..AMK....A........D........A............................................................................M..S.........................N..M..................V...VN.................H........................................--A..............................R.............................  86.20 %
C-AQU phylogenetic tree

Last updated: November 20, 2024.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database was funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

Live statistics (since December 3rd, 2023)