Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
Beta-Lactamase DataBase - Structure and Function Home Enzymes Structures Mutants Kinetics BLAST
Beta-Lactamase DataBase

Sequence alignment for the ACT beta-lactamase family

ACT-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.....
MMMTKSLCCALLLSTSCSVLATPMSEKQLAEVVERTVTPLMKAQAIPGMAVAVIYEGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVKDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAITTRVFKPLKLDHTWINVPKAEEAHYAWGYRDGKA---VHVSPGMLDAEAYGVKTNVQDMASWVMVNMKPDSLQDNSLRKGLTLAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVEGSDNKVALAPLPAREVNPPAPPVNASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILSAL-
ACT-2 ..................................................................................................................................................T..................................................................................---........................................................................................................................................................-  99.74 %
ACT-3 ..................................................................................................................................................T..................................................................................---I.......................................................................................................................................................-  99.48 %
ACT-4 -....................A.................................Q..........................................................................................A..........................T.......................................................---.........................................Q.IA...........................................................................................................-  97.90 %
ACT-5 -..K.........GI...A..A.V.........AN.........S..........Q.K...Y......I..S..................................D....R...Q..............................T...A......................................PF...M....L.............................---.R........Q...M........N...A..A.ENVA.A..KQ.IS........I.S..............E.N..I....S........VA.........K........................I....................P..D..Q  86.39 %
ACT-6 -....................A.................................Q..........................................................................................T..................................................................................---...................K...N.............S..KE.I.........................................................................................................D..Q  96.86 %
ACT-7 -..R.........GI...A....V.........AN.........SV.........Q.K...Y......I.....................................D....R...Q..............................T..........................................P....M....L.............................---.R........Q............N...A..A.ENVA.A..KQ.IA........I.S..............E.N.......S........VA.........K........................I.......T............H..E..Q  87.43 %
ACT-8 .......................................................Q..........................................................................................T......................................................................S...........---.......................N.............S.....I............................................................................................................-  98.43 %
ACT-9 -.K..................A.......SD........................Q.............T............................................................................T..T.......H...............................NF...M.K.................E..............---I.................I......LKA..N..A.S.ST.KQ.IA.........................E.................LVA.........K.......................E...........................-  90.81 %
ACT-10 -..K..V..............A..........................I......Q..................................................................K.......................T...................................................................T..............---...................K...............E.S.....F.........................................................................................................D..Q  96.07 %
ACT-12 -..K.............AA..A.L..T...K.............S..........Q................T...A...............................................V.....................T..........S.....A.........................RF...M.E..L...N.N...........Q...........---...................K......VA..A..GV..A..KQ.MV........T.S..............E..................VA.........K.......................E...........................Q  88.74 %
ACT-13 .....................A.................................Q..........................................................................................T..................................................................................---...................K...............EES..................................................................................................................-  98.16 %
ACT-14 -..K.........GI...A..A.V.........AN.........S..........Q.K...Y......I.....................................D....R...Q..............................T...A......................................G....M....L.............................---.R........Q............N...A..A.EKVA.A..KQ.IA........I.S..............E.N..I....S........VA.........K................L.......I....................H..D..Q  86.91 %
ACT-15 -..K.........GI...A....V.........AN.........SV.........Q.K...Y......I.....................................D....R...Q..............................T.................S........................P....M....L.............................---.R........Q............N...A..A.ENVA.A..KQ.IA........I.S..............E.N.......S........VV.........K........................I.......T............H..E..Q  87.17 %
ACT-16 -..K.........GL...A..A.V.........AN.........SV.........Q.KS..Y......I.....................................D....R...Q..............................T..........................................P....M....L.............................---.R........Q............N...A..A.EKVA.A..KQ.IA........I.S..............E.N.......S........VA.........K........................I....................H..E..Q  87.17 %
ACT-17 -..K.........GI...A....V.........AN.........SV.........Q.K...Y......I.....................................D....R...Q..............................T..........................................P....M....L.............................---.R........Q............N...A..A.ENVA.A..KQ.IA........I.S..............E.N.......S........VA.........K........................I.......T............H..E..Q  87.43 %
ACT-18 -..K.........GI...A..A.V.........AN.I.......S..........Q.K...Y......I.....................................D....R...Q..............................T...A......................................G....M....L.............................---.R........Q............N...A..A.EKVA.A..KQ.IA........I.S..............E.N..I....S........VA.........K........................I....................H..D..Q  86.91 %
ACT-19 -..K..F......AI.G.A..A.V.........AN.......T............Q.K...Y...E..I..K..................................D.....F..............................E..T..........H...............................R....M.K......R.N..........A............---..I....................N...A..A.ENIA.A..KQ.IA........I.S..............E..M.I.............VA.........K........................I....................H..D..Q  85.86 %
ACT-20 -..K.........GL...A..A.V.........AN.........SV.........Q.KS..Y............................................D....R...Q..............................T..........................................P....M....L.............................---.R........Q............N...A..A.EKVA.A..KQ.IA........I.S..............E.N.......S........VA.........K........................I....................H..E..Q  87.43 %
ACT-21 -..K.........GI...A..A.V.........AN.........S..........Q.K...Y.........S..................................D....R...Q..............................T...A......................................PF...M....L.............................---.R........Q...M........N...A..A.ENVA.A..KQ.IS........I.S..............E.N..I....S........VA.........K........................I....................P..D..Q  86.65 %
ACT-22 -..K.............AA..A....T...K..A..........S..........Q................T...A.............................S.................V.....................T..........S.....A.........................RF...M.E..L...N.N...........Q...........---...................K......VA..A..GV..A..KQ.MA........T.S..............E..................VA.........K.......................K...........................Q  88.48 %
ACT-23 -..K.........GI...A..A.V.........AN.........S..........Q.K...Y......I..S..................................D....R...Q..............................T...A......................................G....M....L.............................---.R........Q............N...A..V.EKVA.A..KQ.IS........I.S..............E.N..I....S........VA.........K........................I....................H..D..Q  86.91 %
ACT-24 -..K.........GI...A..A.V.........AN.I.......S..........Q.K...Y......I..S..................................D....R...Q..............................T...A......................................G....M....L.............................---.R........Q............N...A..A.ENVA.A..KQ.IS........I.S..............E.N..ID...S........VA.........K........................I....................H..D..Q  86.39 %
ACT-25 -..K.........GL...A..A.V.........AN.........SV.........Q.KS..Y......I.....................................D....R...Q..............................T..........................................P....M....L.............................---.R........Q............N...A..A.EKVA.A..KQ.IA........I.S..............E.N.......S........VA.........K........................I....................H..K..Q  87.17 %
ACT-27 -..K.........GI...A..A.V.........AN.........SV.........Q.K...Y......I.....................................D....R..................................T..........................................P....M....L.............................---.R........Q............N...A..A.ENVA.A..KQ.IA........I.S..............E.N.......S........VV.........K........................I.......T............H..E..Q  87.43 %
ACT-28 -.K..................A.......SD........................Q..........................................................................................T..........H........A.......................F...M.K.................E..............---I.................I......LKA..N..A.P.ST.KQ.IA.........................E..................VA.........K.......................E...........................Q  91.36 %
ACT-29 -..K.................A.........M.......................Q..........................................................................................T..................................................................................---...................K.................S.....I.........................................................................................................D..Q  97.12 %
ACT-30 -..K.........GL...A..A.V.........AN......I..SV.........Q.KS..Y......I.....................................D....R...Q..............................T..........................................P....M....L.....................R.......---.R........Q............N...A..A.EKVA.A..KQ.IA........I.S..............E.N.......S........VA.........K........................V....................H..D..Q  86.65 %
ACT-31 -..K.........GL...A..A.V.........AN.........SV.........Q.KS..Y......I.....................................D....R...Q..............................T..........................................P....M....L.............................---.R........Q............N...A..A.EKVA.A..KQ.IA........I.S..............E.N.......S........VA.........K........................I....................H..D..Q  87.17 %
ACT-32 -..K.........GI...A....V.........AN.........SV.........Q.K...Y......I.....................................D....R...Q..............................T..........................................P....M....L.............................---.R........Q............N...A..A.ENVA.A..KQ.IA........I.S..............E.N.......S........VV.........K........................I.......T............H..D..Q  87.43 %
ACT-33 -..K.........GI...A....V.........AN.........SV.........Q.K...Y......I.....................................D....R...Q..............................T..........................................P....M....L.............................---.R........Q............N...A..A.ENVA.A..KQ.IA........I.S..............E.N.......S........VA.........K........................I.......T............H..D..Q  87.43 %
ACT-34 .....................I.............................................................................V..............................................T..................................................................................---.............................................................................................K..V.......................................................-  98.69 %
ACT-35 -..K.........GI...A....V.........AN.........SV.........Q.K...Y......I.....................................D....R...Q..............................T..........................................P....M....L.............................---.R........Q............N...A..A.ENVA.A..KQ.IA........I.S..............E.N.......S........VV.........K........................I.......T............Y..E..Q  87.43 %
ACT-36 -..K.........GI...A..A.V.........AN.I.......S..........Q.K...Y......I..S..................................D....R...Q..............................T...A...............................T......G....M....L.............................---.R........Q............N...A..A.ENVA.A..KQ.IS........I.S..............E.N..I....S........VA.........K........................I....................H..D..Q  86.39 %
ACT-37 -..K..F......AI.GAA..A.V.........AN....................Q.K...Y...E..I..K..................................D...I................................E..T..........H...............................R....M.K......R.N..........A............---.......................N...A..A.ENVA.A..KQ.IA........I.S..............E....I.............VA.....V...K........................I....................H..D..Q  86.13 %
ACT-38 -....................A.................................Q................N.................................................L.......................T.................................................M................................---...................K...N.............S..KE.I.........................................................................................................D..Q  96.07 %
ACT-39 -..K.........GI...A..A.V.........AN.........S..........Q.K...Y......I..S..................................D....R...Q..............................T...A......................................G....M....L.............................---.R....I...Q............N...A..A.EKVA.A..KQ.IS........I.S..............E.N..I....S........VA.........K........................I....................H..D..Q  86.65 %
ACT-40 -..K.........GI...A....V.........AN.........SV.........Q.K...Y......I......................A..............D....R...Q..............................T..........................................P....M....L.............................---.R........Q............N...A..A.ENVA.A..KQ.IA........I.S..............E.N.......S........VA.........K........................I.......T............H..E..Q  87.17 %
ACT-41 -..K.........GL...A..A.V.........AN.........SV.........Q.K...Y......I.....................................D....R...Q..............................T..........................................P....M....L.............................---.R........Q............N...A..A.EKVA.A..KQ.IA........I.S..............E.N.......S........VA.........K........................I....................H..E..Q  87.43 %
ACT-42 -..K.........GI...A....V.........AN.........SV.........Q.K...Y......I......................A..............D....R...Q..............................T..........................................P....M....L........R....................---.R........Q............N...A..A.ENVA.A..KQ.IA........I.S..............E.N.......S........VA.........K........................I.......T............H..E..Q  86.91 %
ACT-43 -..K.........GI...A....V.........AN.........SV.........Q.K...Y......I.....................................D....R...Q..............................T...................................V......P....M....L.............................---.R........Q............N...A..A.ENVA.A..KQ.IA........I.S..............E.N.......S........VV.........K........................I.......T............H..E..Q  87.17 %
ACT-44 -..K.........GI...A....V.........AN.........SV.........Q.K...Y......I.....................................D....R...Q..............................T..........................................P....M....L.............................---.R........Q............N...A..A.ENVA.A..KQ.IA........I.S..............E.N.......S........VA.........K........................I.......TN...........H..E..Q  87.17 %
ACT-45 -..K.........GL...A..A.V.........AN.........SV.........Q.K...Y......I.....................................D....R...Q..............................T..........................................P....M....L.............................---.R....T...Q............N...A..A.EKVA.A..KQ.IA........I.S..............E.N.......S........VA.........K........................I....................H..K..Q  87.17 %
ACT-46 -..K.........GL...A..A.V.........AN......I..SV.........Q.KS..Y......I.....................................D....R...Q..............................T..........................................P....M....L.............................---.R........Q............N...A..A.EKVA.A..KQ.IA........I.S..............E.N.......S........VA.........K........................I....................H..E..Q  86.91 %
ACT-47 -..K.........GI...A..A.V.........AN.........S..........Q.K...Y......I..S..................................D....R...Q..............................T...A......................................G....M....L.............................---.R........Q............N...A..A.EKVA.A..KQ.IS........I.S..............E.N..I....S........VA.........K........................I....................H..D..Q  86.91 %
ACT-48 -....T...............A.L...............................Q..............K...........................V................A..............................T.S..................................................L.............................---................................ET...T...Q.I................................D.............S.........K................A......S........................D..Q  93.98 %
ACT-49 -..K.F...............A........D....N........G..........Q............I....S.........................................D..............................T..........................S...............N....M......................T...........---...........................A..A..A...T..KQ.I................................G................S..V...K................................................D..Q  92.41 %
ACT-50 -..K...S......VA..AF.A........K....A.....N.............Q.......................................................R................................D.T...........................................F.E.M.K......R.........................---..............I....K......VA..A..A...S..KQ.IA...............................G...................V...K..........................................T.....D..Q  90.31 %
ACT-51 -.K........M.........A.......SD........................Q..........................................................................................T..........H................................F...M.K.................E..............---T.........................KA..N..A.P.ST.KQ.IA.........................E..................VA.........K.......................E...........................Q  91.88 %
ACT-52 -.K..................A.......SD........................Q..........................................................................................T..........H........A.......................F...M.K.................E..............---.....................IS...KA..N.AA.P.ST.KQ.IA.........................E..................VA.........K.......................E...........................Q  91.36 %
ACT-53 -....T............A..G.L..........Q...................................K...........................V................A............................D.T.....................................Q..............L.............................---................................EA...T..GQ.I................................D.......................K.......................N........................D..Q  93.72 %
ACT-54 -..K.............AA..A....T...K.............S..........Q................T...A...............................................V.....................T..........S.....A.........................RF...M.E..L...N.N........S..Q...........---...................K.......A..A..GV..A..KQ.MV........T.S..............E..................VA.........K.......................E...........................Q  89.01 %
ACT-55 -..K.........GI...A..A.V.........AN.........SV.........Q.K...Y......I.....................................D....R...Q.............................IT...............................................M....L.............................---.R........Q............N...A..A.ENVA.AT.KQ.IA........I.S..............E.N...G...S........VA.........K........................I....................H..E..Q  86.91 %
ACT-56 -..K.........GI...A....V.........AN.........SV.........Q.K...Y......I.....................................D....R...Q..............................T..........................................P....M....L.............................---.R........Q............N...A..A.ENVA.A..KQ.IA........I.S..............E.N.......S........VV.........K........................I.......T............H..E..Q  87.43 %
ACT-57 -....................A.........M.......................Q..........................................................................................T......................................................R...........................---...................K...N...........E.S...............................................................................................................D..Q  96.86 %
ACT-58 -...............S....A.................................Q.................A........................................................................T...................................................................T..............---...................................P.T...Q.IA...............................K...........T.........................................................H..D..Q  95.55 %
ACT-59 -..K.T....V..GI...A..A.V..Q......AK.........S..........Q.K...Y......I.............................L.......D...I...................................T.D........H...............................R....M.E......A.H.......................---..........Q............N...A..A.ENVA.A..KQ.IA........I.S..............E.....D...S.....A...V.I.......K........................I....................H..D..Q  85.86 %
ACT-60 -..K...F.....GI...A..A.V.........AN.........SV.........Q.K...Y......I.....................................D....R...Q.............................IT...................................T...........M....L.............................---.R........Q............N...A..A.ENVA.AT.KQ.IA........I.S..............E.N...G...S........VA.........K........................I....................H..E..Q  86.39 %
ACT-61 -..K.........GL...A..A.V.........AN.I.......SV.........Q.K...Y......I.....................................D....R...Q..............................T..........................................P....M....L.............................---.R........Q............N...A..A.EKVA.A..KQ.IA........I.S..............E.N.......S........VA.........K........................I....................H..K..Q  87.17 %
ACT-62 -..K...S......A......A.................................Q................................................T....................................A....T.T............K...........T....................M..................................---..............................M......SP.KH.IA...........................Q...G.....................T.K................................................D..Q  93.19 %
ACT-63 -....T...............A.L...............................Q..............K...........................V................A..............................T.S...............S..................................L.............................---.................................AI..T...Q.I................................D.............S.........K................A......S........................D..Q  93.72 %
ACT-64 -.K..................A.......SD........................Q.H........................................................................................T..........D................................F...M.K.............D...ED............T---..........................KA..N.AA.P.ST.KQ.IA.........................E..................VA.........K.......................E...........................Q  91.10 %
ACT-65 -..K.........GI...A....V.........AN.........SV.........Q.K...Y......I....S................................D....R...Q..............................T..........................................P....M....L.............................---.R........Q............N...A..A.ENVA.A..KQ.IA........I.S..............E.N.......S........VA.........K........................I.......T............H..E..Q  87.17 %
ACT-66 -..K.........GI...A..A.V.........AN.I.......S..........Q.K...Y......I..S..................................D....R...Q..............................T...A..H...................................G....M....L.............................---.R........Q............N...A..A.EKVA.A..KQ.IA........I.S..............E.N..I....S........VA.........K........................F....................H..D..Q  86.39 %
ACT-67 -..K.........GI...A..A.V.........AN.........S..........Q.K...Y......I..S..................................D....R...Q..............................T...A......................................G..R.M....L.............................---.R........Q............N...A..A.EKVA.A..KQ.IA........I.S..............E.N..I....S........VA.........K........................I....................H..D..Q  86.65 %
ACT-68 ..................................................................................................................................................T..................................................................................---....................................................G............................................L......................................................-  99.21 %
ACT-69 -..K.........GL...A..A.V.........AN.........SV.........Q.KS..Y......I.....................................D....R...Q..............................T..........................................P....M....L.............................---.R........Q............N...A..A.EKVA.A..KQ.IA........I.S..............E.N.......S........VA.........K........................V....................H..E..Q  87.17 %
ACT-70 -..K.........GI...A....V.........AN.........SV.........Q.K...Y......I.....................................D....R...Q..............................T...................................V......P....M....L.............................---.R........Q............N...A..A.ENVA.A..KQ.IA........I.S..............E.N.......S........VA.........K........................I.......T............H..E..Q  87.17 %
ACT-72 -..K.........GL...A..A.V.........AN.........SV.........Q.K...Y......I.....................................DG...R...Q..............................T..........................................P....M....L.............................---.R........Q............N...A..A.EKVA.A..KQ.IA........I.S..............E.N.......S........VA.........K........................I....................H..E..Q  87.17 %
ACT-73 -..K.........GI...A....V.........AN.........SV.........Q.K...Y......I.....................................D....R...Q..............................T..........................................P....M....L.............................---.R........Q............N...A..A.ENVA.A..KQ.IA........I.S..............E.N................VA.........K........................I.......T............H..E..Q  87.70 %
ACT-74 -..K.........GI...A....V.........AN.........SV.........Q.K...Y......I.....................................D....R...Q..............................T..........................................P....M....L.............................---.R........Q............N...A..A.EKVA.A..KQ.IA........I.S..............E.N.......S........VA.........K........................I.......T............H..E..Q  87.43 %
ACT-75 -..K.........GL...A..A.V.........AN......I..SV.........Q.KS..Y......I.....................................D....R...Q..............................T..........................................P....M....L.....................R.......---.R........Q............N...A..A.EKVA.A..KQ.IA........I.S..............E.N.......S........VA.........K........................V....................H..E..Q  86.65 %
ACT-76 -..K.F...............A........D....N........G..........Q............I..............................................D..............................T..........................S....................M....L.................T...........---...........................A..A..A...T..KQ.I................................G....M...........S..V...K................................................D..Q  92.41 %
ACT-77 -..K.F...............A........D....N........G..........Q............I..............................................D..............................T..........................S....................M......................T...........---...........................A..A..A...T..KQ.I................................G................S..V...K................................................D..Q  92.93 %
ACT-78 -..K.F...............A........D....N........G..........Q............I.............................................................................T..........................S....................M.A....................T...........---...........................A..A..A...S..KQ.I................................G................S..V...K................................................D..Q  92.93 %
ACT-79 -..K.T....V..GI...A..A.V..Q......AK.........S..........Q.K...Y......I.............................L.......D..................................L....T.DT.......H...............................R....M.E......A.H.......................---..........Q............N...A..A.QNVA.A..KQ.IA........I.S..............E.....D...S.....A...V.I.......K........................I....................H..D..Q  85.60 %
ACT-80 -..K.F...............A........D....N........G..........Q............T..............................................D..............................T..........................S....................M......................T...........---...........................A..A..A...T..KQ.I................................G................S..V...K................................................D..Q  92.93 %
ACT-81 -..K.F...............A........D....N........G..........Q............I....S...R.....................................D..............................T..........................S......T........N....M......................T...........---...........................A..A..A...T..KQ.I................................G................S..V...K..........................................T.....D..Q  91.62 %
ACT-82 -..K.F...............A........D....N........G..........Q............I....S.........................................D..............................T..............K...........S....................M......................T...........---...........................A..A..A...T..KQ.I................................G................S..V...K................................................D..Q  92.41 %
ACT-83 -..K.........GL...A..A.V.........AN.........SV.........Q.KS..Y......I.....................................D....R..................................T.D........H...............................R....M.E......A.H.......................---.R........Q............N...A..A.EKVA.A..KQ.IA........I.S..............E.N.......S........VA.........K........................I....................H..E..Q  86.39 %
ACT-84 -..K.........GL...A..A.V.........AN.........SV.........Q.K...Y......I.....................................D....R..................................T.D........H...............................R....M.E......A.H.......................---.R........Q............N...A..A.EKVA.A..KQ.IA........I.S..............E.N.......S........VA.........K........................I....................H..E..Q  86.65 %
ACT-85 -..K.........GI...A....V.........AN.........SV.........Q.K...Y......I.....................................D....R...Q..............................T..........................................P....M....L.............................---.R........Q............N......A.EKVA.A..KQ.IA........I.S..............E.N.......S...--...VA.........K........................I.......T............H..E..Q  87.17 %
ACT-86 -..K.........GI...A....V.........AN.........SV.........Q.K...Y......I.....................................D....R...Q..............................T..........................................P....M....L.............................---.R........Q............N...A..A.ENVA.A..KQ.IA........I.S..............E.N.......S...--...VA.........K........................I.......T............H..E..Q  86.91 %
ACT-87 -.K..................A.......SD........................Q.....................................................................S....................T..........Y........A.......................F...M.K.................E..............---I........T........I......LKA..N..A.S.ST.KQ.IA.........................E..................VA.........K.......................E...........................Q  90.84 %
ACT-88 -..K.............AA..A.L..T...K.............S..........Q................T...A...............................................V.....................T......H...S.....A...M.....................RF...M.E..L...N.N...........Q...........---...................K.......A..A..GV..T..KQ.MVF.......T.S..............E..................VA.........K.......................E...........................Q  88.22 %
ACT-89 -..R.........GI...A....V.........AN.I.......SV.........Q.K...Y......I.....................................D.A..R...Q..............................T..........................................P....M....L.............................---.R........Q............N...A..A.ENVA.A..KQ.IA........I.S..............E.N.......S........VA.........K........................I.......T............H..E..Q  86.91 %
ACT-90 -..K.........GI...A..A.V.........AN.........S..........Q.K...Y......T..S..................................D....R...Q..............................T...A......................................G....M....L.............................---.R........Q............N...A..A.ENVA.A..KQ.IA........I.S..............E.N..I....S........VA.........E......M.................I....................H..D..Q  86.65 %
ACT-91 -......S......VAS.AF.A.................................Q.................A........................................................................T...................................................................T..............---...................................P.T...Q.IA...............................K...........T............................................................D..Q  94.50 %
ACT-92 -....................A.................................Q..........................................................................................T..................................................................................---.......................N..I..........S.....I................................................................D........................................D..Q  97.12 %
ACT-93 -....................A......................V..........Q..........................................................................................T..............................................T...................................---.....................................S...............................................................................................................D..Q  97.64 %
ACT-94 -..K.........GV...A....V.........AN.........SV.........Q.K...Y......I.....................................D....R...Q..............................T.................S........................P....M....L.............................---.R........Q............N...A..A.ENVA.A..KQ.IA........I.S..............E.N.......S........VV.........K........................I.......T............H..E..Q  87.17 %
ACT-95 -.K..................A.......SD........................Q..........................................................................................T..........H................................F...M.K.................E..............---I.................I......LKA..N..A.S.ST.KQ.IA.........................E..................VA.....V...K.......................E...........................Q  91.36 %
ACT-96 -.K........M.........A.......SD........................Q..........................................................................................T..........H...............................NF...M.K.................E..............---I.................I......LKA..N..A.S.ST.KQ.IA.........................E..................VA.........K.......................E....................F......Q  90.84 %
ACT-97 -.K........M.........A.......SN........................Q..........................................................................................T..........H................................F...M.K.................E..............---T.........................KA..N..A.P.ST.KQ.IA.........................E..................VA.........K.......................E...........................Q  91.88 %
ACT-98 -.K..................A.......SD........................Q..........................................................................................T..........H................................F...M.K.................ED.............---..........................KA..N.AA.P.ST.KQ.IA.........................E..................VA.........K.......................K...........................Q  91.88 %
ACT-99 -.K.....S............A.......SD........................Q......................................................A...................................T..........H................................F...M.K.................E...Y..........---..........................KA..N.AA.P.ST.KQ.IA.........................ES.................VA.........K.......................E...........................Q  91.10 %
ACT-100 -.K........M.........A.......SD........................Q..........................................................................................T..........H................................F...M.K.................E..............---T.........K...............KA..N..A.P.ST.KQ.IA.........................E..................VA.........K.......................E...........................Q  91.62 %
ACT-101 -.K..................A.......SD........................Q..........................................................................................T..........H................................F...M.K.................E..............---I.................I......LKA..N..A.P.ST.KQ.IA.........................E..................VA.........K...I...................E...........................Q  91.36 %
ACT-102 -.K..................A.......SD........................Q.H........................................................................................T..........H........A.......................F...M.K.................E..............---I.................I.......KA..N..A.PNST.KQ.IA.........................E.Q................VA.........K.......................E...........................Q  90.84 %
ACT-103 -.K....F.............A.......SD........................Q..........................................................................................T..........H................................F...M.K.................E..............---I.................I......LKA..N..A.P.ST.KQ.IA.........................E..................VA.....V...K.......................E...........................Q  91.10 %
ACT-104 -.K..................A.......SD........................Q.H........................................................................................T..........D................................F...M.K.................ED.............---..........................KA..N.AA.P.ST.KQ.IA.........................E..................VA.........K.......................K...........................Q  91.62 %
ACT-105 ...................................................................................................V..............................................T..................................................................................---........................................................................................................................................................-  99.48 %
ACT-106 -..K.........GL...A..A.V.........AN.........SV.........Q.K...Y......I.....................................D....R..................................T.D........H...............................R....M.E......A.H.......................---.R........Q............N...A..A.EKVA.AP.KQ.IA........I.S..............E.N.......S........VA.........K.......................RI.......T............H..E..Q  85.86 %
ACT-107 -.IK.........GM.Y.GFTAQL.......A...........H...........Q....C................................................A..................................D.T.T........T................................F...M.E........N........S.AQ.......E..P---.......................A...A..A.ENVAEA..KQ.IA.............................L.D....N...........S......K.......................E........................D..Q  86.65 %
ACT-108 -..K.........GL...A..A.V.........AN.........SV.........Q.K...Y......I.....................................D....R..................................T.D........H...............................R....M.E......A.H.......................---.R........Q............N...A..A.EKVA.A..KQ.IA........I.S..............EVN.......S........VA.........K........................V....................H..E..Q  86.39 %
ACT-109 -..K.............AA..A....T...K.............S..........Q................T...A...............................................V.....................T..........S.....A.........................RF...M.E..L...N.N...........Q...........---...................K......VA..A..GV..A..KQ.MV........T.S..............E..................VA.........K.......................E...I..........E............Q  88.48 %
ACT-110 -.K..................A.......SD........................Q..........................................................................................T..........H................................F...M.K.................E..............---.....................I....KA..N.AA.P.ST.KQ.IA.........................E..................VA.........K.......................E....................F......Q  91.62 %
ACT-112 -..K.............AA..A.L..T...K.............S..........Q................T...A..........................M....................V.....................T..........Y.....A.........................RF...M.E..L...N.N...........Q...........---...................K......VA..A..GV..A..KQ.MV........T.S..............E..................VA.........K.......................E...........................Q  88.48 %
ACT-113 -..K.........GI...A....V.........AN.........SV.........Q.K...Y......I.....................................D....R...Q..............................T...................................V......P....M....L.............................---.R........Q............N...A..A.ENVA.A..KQ.IA........I.S..........K...E.N.......S........VA.........K........................I.......T............H..E..Q  86.91 %
ACT-114 -..K.........GI...A..A.V.........AN.I.......S..........Q.K...Y......I..S.S................................D....R...Q..............................T...A......................................G....M....L.............................---.R........Q............N...A..A.EKVA.A..KQ.IS........I.S..............E.N..I....S........VA.........K........................I....................H..D..Q  86.39 %
ACT-115 -..K.........GL...A..A.V.........AN.........SV.........Q.K...Y......I.....................................D....R...Q..............................T..........................................P....M....L.............................---.R........Q............N...A..A.EKVA.A..KQ.IA........I.S..............E.N.......S........VA.........K........................I....................H..K..Q  87.43 %
ACT-116 -....................A.................................Q..........................................................................................T..................................................................................---.....................................S.....I.........................................................................................................D..Q  97.91 %
ACT-117 -..K.............AA..A....T...K.............S..........Q................T...A...............................................V.....................T..........S.....A.........................RF...M.E..L...N.N........S..Q...........---...................K......VA..A..GI..A..KQ.MV........T.S..............E..................VA.........K.......................E...........................Q  88.74 %
ACT-118 -.IK.........GV...SI.AS.T.....D...KSI.......S.....I....Q..........................................V...........I...................................T.S...Q....T...............................GF...M........G.........................---..........................VA..A..NV..A..KQ.I........................................................K................................................D..Q  89.79 %
ACT-119 -..K.........GI...A..A.V.D....Q..AD.I.......S..........Q.K...Y...............D....................V....................T..............T...........T.D......C.R...............................R....M.E......A.H.......E...KN..........---.......................G...A..A.EKVA.A..KQ.IA........I.S..............E.........G.....A...V..I......K........................I................D.G.......K  85.34 %
ACT-120 -..K...............F.A...D....D.....I..................QD........I........................................T..A.......S........L...................T....M............R........S.............D...A..M.Q......A.H...........E..........P---......A.........S..........T..A.ENIA.A..KQ.IA........I.S....................D..G..........V.........K........................I.............V......H..D..Q  86.91 %
ACT-121 -..K...............F.A...D....D.....I..................QD........I........................................T..A.......S........L...................T..........................S.............D...A..M.Q......A.H...........E..........P---......A.........S..........T..A.ENVA.A..KQ.IA........I.S....................D..G..........V.........K........................I.............V......H..D..Q  87.43 %
ACT-122 -..K.........GI...A....V.......M.AN.........SV.........Q.K...Y......I.....................................D....R...Q..............................T..........................................P....M....L.............................---.R........Q............N...A..A.EKVA.A..KQ.IA........I.S..............E.N.......S........VV.........K........................I.......T............H..E..Q  87.17 %
ACT-123 -..K.........GI...A....V.........AN.........SV.........Q.K...Y......I.....................................D....R...Q..............................T.....................H....................P....M....L.............................---.R........Q............N...A..A.ENVA.A..KQ.IA........I.S..............E.N.......S........VA.........K........................I.......T............H..E..Q  87.17 %
ACT-124 -..K......V..GI...A..A.V.Q.......TN.I.......SV.........Q.K...Y......I................................S....D....R...Q...........................N..T..........................................P....M....L.............................---.R........Q............N......A.EKVA.A..KQ.IA........I.S..............E.........S.....A...V.I.......K........................I....................H..E..Q  86.39 %
ACT-C190 -..K.........GI...A....V.........AN.........SV.........Q.K...Y......I.....................................D....R...Q..............................T..........................................P....M....L.............................VRA.R........Q............N...A..A.ENVA.A..KQ.IA........I.S..............E.N.......S........VA.........K........................I.......T............H..E..Q  86.75 %
ACT-C191 -..K.........GI...A....V.........AN.........SV.........Q.K...Y......I.....................................D....R...Q..............................T..........................................P....M....L.............................---.R........Q............N...A..A.ENVA.A..KQ.IA........I.S..............E.N.......------...VV.........K........................I.......T............H..E..Q  86.13 %
ACT-C192 -..R.........GI...A....V.........AN.........SV.........Q.K...Y......I.....................................D....R...Q..............................T..........................................P....M....L.............................---.R........Q............N...A..A.ENVA.A..KQ.IA........I.S..............E.N.......S........VV.........K........................I.......T............H..E..Q  87.43 %
ACT-C194 -..I.........GL...A..A.V.........AN.........SV.........Q.KS..Y......I.....................................D....R...Q..............................T..........................................P....M....L.............................---.R........Q............N...A..A.EKVA.A..KQ.IA........I.S..............E.N.......S........VA.........K........................I....................H..E..Q  87.17 %
ACT-C195 -.K..................A.......SD........................Q..........................................................................................T..........H................................F...M.K.................E..............---I.................IT.....LKA..N..A.P.ST.KQ.IA.........................E..................VA.........K...I...................E...........................Q  91.10 %
ACT-C196 -..I.........GL...A..A.V.........AN.........SV.........Q.K...Y......I.....................................D....R...Q..............................T..........................................P....M....L.............................---.R....T...Q............N...A..A.EKVA.A..KQ.IA........I.S..............E.N.......S........VA.........K........................I....................H..E..Q  87.17 %
ACT-C197 -..K.........GI...A..A.V.........AN.........S..........Q.K...Y......I.....................................D....R...Q..............................T...A......................................G....M....L.............................---.R........Q............N...A..A.EKVA.A..KQ.IS........I.S..............E.N..I....S........VA.........E........................I....................H..D..Q  87.17 %
ACT-C198 -.KK.LVF.....GV...A..SSL...E..K..K..........S..........Q................T............V....................N....R..............L.................N.T.P.A..N...T...............S...............GF...M....L..........Q...S..Q...........---.........G......S.AE..........A.ERV.AT..KQ.IA..........S...............G..IID.....I...A.............K.............................................Q..N..Q  84.03 %
C-ACT phylogenetic tree

Last updated: July 23, 2024.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database was funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

Live statistics (since December 3rd, 2023)