Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
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Beta-Lactamase DataBase

Sequence alignment for the ACC beta-lactamase family

ACC-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380..........
MRKKMQNTLKLLSVITCLAATVQGALAANIDESKIKDTVDDLIQPLMQKNNIPGMSVAVTVNGKNYIYNYGLAAKQPQQPVTENTLFEVGSLSKTFAATLASYAQVSGKLSLDQSVSHYVPELRGSSFDHVSVLNVGTHTSGLQLFMPEDIKNTTQLMAYLKAWKPADAAGTHRVYSNIGTGLLGMIAAKSLGVSYEDAIEKTLLPQLGMHHSYLKVPADQMENYAWGYNKKDEPVHVNMEILGNEAYGIKTTSSDLLRYVQANMGQLKLDANAKMQQALTATHTGYFKSGEITQDLMWEQLPYPVSLPNLLTGNDMAMTKSVATPIVPPLPPQENVWINKTGSTNGFGAYIAFVPAKKMGIVMLANKNYSIDQRVTVAYKILSSLEGNK
ACC-1a .....................A................................................................................................................................................................................................................................................................................................................................................................................  99.74 %
ACC-1b .....................A...........................................................................................................................................................................M....................................................................................................................................................................................................  99.49 %
ACC-1c .....................A.................................................................................................................................................................................................................................................................................G..............................................................................................  99.49 %
ACC-1d .....................A.........................................................S......................................................................................................................................................................................................................................................................................................................  99.49 %
ACC-2 .....................A...M..............G...................IR.R..................................I......A......E.............................................T..........................................Q.I..L...NQT..........................................................G...I.H.............................................................................................................V..  94.87 %
ACC-4 .............................................................................................................................................................................................................................................G........................................................................................................................................................  99.74 %
ACC-7 .....................A...M..............S...................IR.R..................K......................A......E.............................................T..........................................Q.I..L...NQT.............................................H............G...I.H................................................................................................................  94.87 %
ACC-8 ----................................................................................................................................................................................................K.................................................................................................................................................................................................  98.72 %
ACC-P1 ..........M........L.A...M.SEM.QA.......S...................L............S........D..............................K.I..............I....A....T..A.....EV...D.............P....................Q.M.MT...........K...T.T..N.....A..........N..I.....V........R.NA...I.............G.STL.K...D..I......K.................D...................................................................-------------  84.36 %
ACC-P2 ----.................A...................................................................................L............................................................................................................................................................................................................................................................................................  98.46 %
ACC-P3 ..........M........V.A...M.SEM.QA.......S...................L...D........S........D..............................K.I..............I....A....T..A.....EV...D.............P....................Q.M.MT...........K...T.T..N.....A..........N..I.....V........R.NA...I.............G.STL.K...D..I......K.................D...................................................................-------------  84.10 %
C-ACC phylogenetic tree

Last updated: November 20, 2024.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database was funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

Live statistics (since December 3rd, 2023)