Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
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Beta-Lactamase DataBase

Sequence alignment for the GOB beta-lactamase family

GOB-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290....
MRNFATLFFMFICLG----LNAQVVKEPENMPKEWNQAYEPFRIAGNLYYVGTYDLASYLIVTDKGNILINTGTAESLPIIKANIQKLGFNYKDIKILLLTQAHYDHTGALQDFKTETAAKFYADKADVDVLRTGGKSDYEMGKYGVTFKPVTPDKTLKDQDKIKLGNITLTLLHHPGHTKGSCSFIFETKDEKRKYRVLIANMPSVIVDKKFSEVTAYPNIQSDYAYTFGVMKKLDFDIWVASHASQFDLHEKRKEGDPYNPQLFMDKQSYFQNLNDLEKSYLDKIKKDSQDK
GOB-3 ...........V...----..................T...........................................................................L....G.........A.......N...........................T...TI....................................I............L..........KA..N....L......................................................  94.83 %
GOB-4 ...............----..................T...........................................................................L..............A.......N...........................T...TI............................................................KA..N....L......................................................  96.21 %
GOB-5 ....VI.........----..................T...........................................................................L............E.A.......................................TI............................................................KA..N....L............................................N.........  95.52 %
GOB-6 ...........V...----..................T...........................................................................L..............A.......N.............................................................................................KA..N....L............................................N.........  96.55 %
GOB-7 ....V....LLV..S----..................T.......................................F....G...................................G.........A............L......................T...T........................N...KI.......I.............G.........KA..N.................T......S.........EN..KR.ER..NN.FE...E..K..  87.93 %
GOB-8 ....VI.........----..................T...........................................................................L....G.......E.A...................................T...TI............................................................KA..N.................................................N.R.......  94.83 %
GOB-9 ....VI.........----..................T...........................................................................L....G.......E.A...................................T...TI.S..........................................................KA..N.................................................N.........  94.83 %
GOB-10 ....VI.........----..................T...........................................................................L....G.......E.A...................................T...TI............................................................KA..N...........................................................  95.52 %
GOB-11 .........LSA..SLS--..................T........................................T...G.............V..............E......G.........A...K........L.........I...R........T...T.....................................I.........A..............A.......L......................................................  92.12 %
GOB-12 ...........V...----..................T...........................................................................L..............A......................I...R........T...T.....................................I........................A.......L......................................................  96.21 %
GOB-13 .........LSV..NLN--..................T............................................G...................................G....T....A...K........L.........I...R........T...T...................D.................I........................A.......L..............................N...S..N................  91.78 %
GOB-14 .........LSV..DLN--..................T............................................G...................................G....T....A...K........L.........I...R........T...T...................D.................I........................A.......L..............................N...S..N................  91.78 %
GOB-15 .........LSV..NLN--..................T......................................P.....G...................................G....T....A...K........L.........I...R........T...T...................D.................I........................A.......L..............................N...S..N................  91.44 %
GOB-16 .....I...LL.TF----SWK.........TNE..SRS...................................L.G...M..E..K.........................K.LQ...G......S..A...K.............A...AIK..IL...........T........................N.N.K............R....IKD.....A......KA.......L............T.H.........V....AN..AF..S..TD..E...N...K.  80.07 %
GOB-17 .....I...LL.TF----SWK.........TNE..SRS...................................L.G...M..E..K.........................K.LQ...G......S..A...K.............A....IK..IL...........T........................N.N.K............R....IKD.....A......KA.......L............T.H.........V....AN..AF..S..TD..E...N...K.  80.41 %
GOB-18 ...............----.S........................................................F.............................................V................................................................................................................................................................N.........  98.62 %
GOB-19 .........LSV..SLN--..................T............................................G............................E......G.........A...K..................I...R........T...T.....................................I........................A.......L......................................................  93.49 %
GOB-20 ....VI.........----..................T...........................................................................L....G.......E.A...................................T...TI............................................................KA..N.................................................N.........  95.17 %
GOB-21 ...........V...----..................T...........................................................................L..............A.......N...............................TI............................................................KA..N....L......................................................  96.21 %
GOB-22 ...LVI...LL.TF----SWK.........TNE..SRS...................................L.G...M..E..K.........................K.LQ...G......S..A...K.............A....IK..IL...........T........................N.N.K............R....IKD.....A......KA.......L............T.H.........V....AN..AF..S..TD..E...N...K.  79.73 %
GOB-23 .....I...LSV..S----..................T............................................G............................E......G.........A...K..................I...RA.......T.A.T.....................................I........................A.......L......................................................  93.10 %
GOB-24 ...............----............................................G.............................G.............................V................................................................................................................................................................N.........  98.62 %
GOB-25 .........LSV..SLNLN..................T..................T.........................G............................E......G.........A............L.........I...R........T...T.....................................I........................A.......L......................................................  92.52 %
GOB-26 .........LSV..SLN--...............................................................G............................E......G.........A............L.........I...R........T...T...................D.................I........................A.......L..............................N...S..N................  92.47 %
GOB-27 .....I...LL.TF----SWK.........TNE..SRS...................................L.G...M..E..K.........................K.LQ...G......S..A...K.............A....IK..IL...........T........................N.N.K............R....IKD.....A......KA.......L............T.H....L....V....AN..AF..S..TD..E...N...K.  80.07 %
GOB-28 ...............----..........................................................................G..................................A..........................N........T.......................................................................................................................N.........  98.28 %
GOB-29 ....V....LLV..S----..................T.......................................F....G...................................G.........A............L......................T...T........................N...KI.......I.............G.........KA..N....V............T......S.........KN..KR.ER..NN.FE...E..K..  87.59 %
GOB-30 ...............----..........................................................F.............................................V................................................................................................................................................................N.........  98.97 %
GOB-31 ....V....LLV..S----..................T.......................................F....G...................................G.........A............L......................T...T.......................KN...K........I.............C.........KA..N....V............T......S.........EN..KR.ER..NN.FE...E..K..  87.59 %
GOB-32 .........LSV..SLN--....I..........................................................D............................E......G.........A............L.........I...R........T...T.....................................I........................A.......L......................................................  93.49 %
GOB-33 .KRIT..L.LLV.F.----W..........T....S.N...................................L.G..ST..E..A.........................M......D......A..A.......Q.........A....II..R...NL.......T...M.............V.D.N.G.............I...N......E............NA..........................E....K......N...S..N............L...  83.79 %
GOB-34 .KRIT..L.LLV.F.----W..........T....S.N...................................LTG..ST..E..A.........................M......G......A..A.......Q.........A....II..R...NL.......T...M.............V.N.R.G.................N...................KA..........................A............................Q......  85.52 %
GOB-35 .KRIT..L.LLV.F.----W...T......T....S.N...................................L.G..ST..E..A.........................M......G......A..A.......Q.........A....II..R...NL.......T...M.............V.D.N.G.............I...N...................NA..........................E...........N......N..Q..R..........  84.14 %
GOB-36 .KRIT..L.LLV.F.----W...T......T....S.N...................................L.G..ST..E..A..E......................M......G......A..A.......Q.........A....II..R...NL.......T...M.............V.D.N.G.............I.I.N...................NA.........................RE...........N...S..N................  83.45 %
GOB-37 .KRIT..L.LLV.F.----W...T......T....S.N...................................L.G..ST..E..A.........................M......G......A..A.......Q.........A....II..R...NL.......T...M.............V.D.N.G.............I...N...................NA........................G.E...........N...S..N................  84.14 %
GOB-38 ....VI.........----..................T...........................................................................L....G.......E.A...................................T...TI............................................................KA..N....L......................................................  95.17 %
GOB-39 ...........V...----..................T...........................................................................L..............A.......N................L..............TI............................................................KA..N....L......................................................  95.86 %
GOB-40 ...............----..........................................................FS.............................................................................................................................................................................................................N.........  98.97 %
GOB-41 ...............----.............................................................................................................A..........................N........T.......................................................................................................................N.........  98.62 %
GOB-42 ...........V...----..................T...........................................................................L..............A.......N...............................TI....................................I.....................A.KA..N....L....................................................G.  95.17 %
GOB-43 ...............----.............................................................................................................A...K.......................................................................................................................................................N.........  98.97 %
GOB-44 .....I...LL.TF----SWK.........TNE..SRS...................................L.G...M..E..K.........................K.LQ...G..L...S..A...K.............A....IK..IL...........T........................N.N.K............R....IKD.....A......KA.......L............T.H.........V....AN..AF..S..TD..E...N...K.  80.07 %
GOB-45 ...............----.........................................................................................................................................................................................................................................................................N.........  99.66 %
GOB-46 .....I...LL.TF----SWK.........TNE..SRS...................................L.G...M..E..K.........................K.LQ...G..L...R..A...K.............A....IK..IL...........T........................N.N.K............R....IKD.....A......KA.......L............T.H.........V....AN..AF..S..TD..E...N...K.  80.07 %
GOB-47 .....I...LL.TF----SWK.........TNE..SRS.Q.................................L.G...M..E..K.........................K.LQ...G......S..A...K.............A....IK..IL...........T........................N.N.K............R....IKD.....A......KA.......L............T.H.........V....AN..AF..S..TD..E...N...K.  80.07 %
GOB-48 ...........V...----..................T...........................................................................L....G.........A.......N...........................T...TI............................................................KA..N....L......................................................  95.52 %
GOB-49 ....V....LLV..S----..................T.......................................F....G............................R......G.........A............L......................T...T........................N...KI.......I.............G.........KA..N....V............T......S.........KN..KR.ER..NN.FE...E..K..  87.24 %
GOB-50 ....VI.........----..................T...........................................................................L....G.........A...................................T...TI............................................................KA..N....L......................................................  95.52 %
GOB-51 .KRIT..L.LLV.F.----W..........T....S.N...................................L.G..ST..E..A.........................M......G......A..A.......Q.........A....II..R...NL.......T...M.............V.D.N.G.............I...N...................NA..........................E...................................  85.86 %
GOB-52 ...........V...----..................T...........................................................................L..............A.......N....I..........................TI............................................................KA..N....L......................................................  95.86 %
GOB-53 ...............----.............................................................................................................A.......E...............................T.............................................................................................................................  98.97 %
GOB-T1 ....VI.........----..................T...........................................................................L..............A.......N...........................T...TI............................................................KA..N....L......................................................  95.52 %
GOB-T2 .KRIT..L.LLV.F.----W...T......T....S.N...................................L.G..ST..E..A.........................M......G......A..A.......Q.........A....II..R...NL.......T...M.............V.D.N.G.............I...N...................NA..........................E...........N......N................  84.83 %
GOB-T3 .........LSV..SLN--..................T............................................G............................E......G.........A............L.........I...R........T...T.....................................I........................A.......L......................................................  93.49 %
GOB-T4 ....VI.........----..................T...........................................................................L....G.......E.A...................................T...TI....................................I.......................KA..N....L......................................................  94.83 %
GOB-T5 ...............----..................T...........................................................................L....G.........A...................................T...TI............................................................KA..N....L......................................................  96.21 %
GOB-P1 -------------------------.......N.................L..................................................................................................................................................................................................................................-----------------  86.21 %
B3-GOB phylogenetic tree

Last updated: January 08, 2024.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database is funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

Live statistics (since December 3rd, 2023)