Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
Beta-Lactamase DataBase - Structure and Function Home Enzymes Structures Mutants Kinetics BLAST
Beta-Lactamase DataBase

Sequence alignment for the L1 beta-lactamase family

L1-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.....
-----MRSTLLAFALAVALPAAHTSAAEVPLPQLRAYTVDASWLQPMAPLQIADHTWQIGTEDLTALLVQTPDGAVLLDGGMPQMASHLLDNMKARGVTPRDLRLILLSHAHADHAGPVAELKRRTGAKVAANAESAVLLARGGSDDLHFGDGITYPPANADRIVMDGEVITVGGIVFTAHFMAGHTPGSTAWTWTDTRNGKPVRIAYADSLSAPGYQLQGNPRYPHLIEDYRRSFATVRALPCDVLLTPHPGASNWDYAAGARAGAKALTCKAYADAAEQKFDGQLAKETAGAR
L1-2 -----..F...............A....A......................V...................AE.............G.......L...A.Q...........................H......T.........N.............S....I.....V.....A......P...............D...................K......R.....K............L...........N....SK.S.E....N.......K...A...R....T.  88.62 %
L1-3 -----..F.............V.A....A......................V...................AE.............G.......L...A.Q...........................H......T.........N.............S....I.....V.....A......P...............D...................K......R.....K............L...........N..V.SK.S.E....N.......K...A..........  88.62 %
L1-4 -----...............I..A.G..T................................Q.........A..............G..IS...V...A.Q..........................................................S.........M......A......P...............E.................................H.L..........................SK.S..................A..........  92.07 %
L1-5 MRSTLLAFA.SSL...AT.FTFDGA..DAS....Q.....P....T...............H.........A..L..I.........Y..T......TNTGP..MV......T........I......Q.VV...T................E..F..V........R..VKL...A......P...............D......................A...R.V...........G....L...........N....SN.SE.V.S.........K...A..........  76.61 %
L1-6 -----..LC.TPL...AT.V-FDVA..DA.P......................................R.TE.............G...........A.Q...........................Q.V....T....P....N......D......S....I....RV....MA......P...............D....................Y.A...R.V.......T...G....L.........R.N.....E...NV...........KA..A......T...  82.07 %
L1-7 -----..LC.TTL..TAT.A-FDVT..DA.....Q...................R................A..............G...........AAQ...........................S................N......S..F...S....I....EV.....A......P...............D.Q....................A...R.V...........G....L...........N.....E...N............K...A.......T..  84.14 %
L1-8 -----..LC.TT...TAT.A-FDVT..DA.....Q...................R................A..............G...........AAQ...........................S................N......S..F...S....I....EV.....A......P...............D.Q....................A...R.V...........G....L...........N.....E...N............K...A.......T..  84.48 %
L1-9 -----..F.............V.A....A.............R........V...................AE.............G.......L...A.Q................T..........H......T.........N.............S....I.....V.....A......P...............D...................K......R.....K............L...........N....SK.S.E....N.......K...A...R....T.  87.59 %
L1-10 -----..F...............A....A......................V...................AE.............G.......L...A.Q...........................H......T.........N........A....S....I.....V.....A......P...............D...................K......R.....K............L...........N....SK.S.E....N.......K...A...R....T.  88.28 %
L1-11 -----..LC.TPL...AT.V-FDVA..DA........................................R.TG.............G...........A.Q...........................Q.V....T....P..S.N......D......S....I....RV....MA......P...............D....................Y.A...R.V.......T...G....L.........R.N.....E...NV...........KA..A....G.T...  81.72 %
L1-12 -----..LC.TPL...AT.V-FDVA..DA..........................................TE.............G.........E.A.Q...........................Q.V....T....P....N......D......S....I....RV....MA......P...............D....................Y.A...R.V.......T...G....L.P.......R.N.....E...NV...........KA..A......T...  82.07 %
L1-13 -----..LC.TTL..TAT.A-FDVT..DA.....Q....................................A..............G...........AAQ...........................S................N......S..F...S....L....GV.....A......P...............D.Q....................A...R.V................L...........N.....E...N............K...A...R.A.T..  84.14 %
L1-14 -----..................A....A.................I....V...................AE.............G.......L...A.Q...........................H......T.........N.............S....I.....V.....A......P...............D...................K......R.....K............L...........N....SK.STE....N.......K...A..........  88.97 %
L1-15 -----..LC.TPL...AT.V-FDVA..DA........................................R.TE.............G...........A.Q...........................Q.V....T....P....N......D......S....I....RV....MA......P...............D....................Y.A...R.V.......T...G....L.........R.N.....E...NV...........KA..A......T...  82.41 %
L1-16 -----..LC.TPL...AT.V-FDVA..DA..........N...............................TE.............G...........A.Q...........................T.V....T.........N......D......S...TI....RV....MA......P.............S.D....................H.A...R.V...W...T...G....L.........R.N.....E...NV...........KA..A.....A....  81.72 %
L1-17 -----..FI............V.A....A.................I....V...................AE.............G.....V.L...A.Q...........................H......T.........N.............S....I.....V.....A......P...............D...................K......R.....K............L...........N....SK.STE....N.......K...A...R....T.  86.90 %
L1-18 -----...............S..A....A......................V...................AE.............G.......L...A.Q...........................H......T.........N.............S....I.....V.....A......P...............D...................K......R.....K............L...........N..V.SK.S.E....N.......K...A..........  88.97 %
L1-19 -----..F...............A....A......................V...................AE.............G.......L...A.Q...........................H......T.........N.............S....I.....V.....A......P...............D...................K......R.....K............L...........N....SK.S.E....N.......K...A...R......  88.97 %
L1-20 -----..................A....A......................V...................AE.............G.......L...A.Q...........................H......T.........N.............S....I.....V.....A......P...............D...................K......R.....K............L...........N....SK.S.E....N.......K...A..........  89.66 %
L1-21 -----..........V....D..A.G..T................................Q.........A..............G..IS....L..A.Q..........................................................S..........VE....E......P...........S...E......................A...R.VD..K...........................S.SK.S..................A..........  89.66 %
L1-22 -----..........VT...V..A.G..T...........T.....................N........AE.............G...........A.Q........................S..H.V.......................................VE....E......P...............E...................K......R.V...K.................................T.................A..........  90.69 %
L1-23 -----..F...............A....A......................V...................AE.............G.......L...A.Q...........................H......T.........N.............S....I.....V.....A......P...............D...................K......R.....K............L...........N....SK.S.E....N.......K...A..........  89.31 %
L1-24 -----..F.......P.......A....A......................V...................AE.............G.......L...A.Q...........................H......T.........N.............S....I.....V.....A......P...............D...................K......R.....K............L...........N....SK.S.E....N.......K...A..........  88.97 %
L1-25 -----..F.......P.......A....A......................V...................AE.............G.......L...A.Q...........................H......T.........N.............S....I.....V.....A......P...............D...................K......R.....K............L...........N....SK.S.E....N.......K...A.......R..  88.62 %
L1-26 -----..CS.......AV..V..A....A..................E.............WN........AE.............G.......L...A.Q..Q......................S.H.M..............N............TS....I.....V.....E......P...............D...................K......R.....K...T...G....L...........N....SK........S.......KT..A.....S.AH.  84.83 %
L1-27 -----..CS.......AV..V..A....A..................E..............N........AE.............G.......L...A.Q..Q........................H.V..............N............TS....I.....V.....E......P...............D...................K......R.....K.......G....L...........N....SK........S.......KT..A.....S.AH.  85.86 %
L1-28 -----..CS.......AV..V..A....A..................E.............WN........AE.............G.......L...A.Q..Q........................H.V..............N............TS....I.....V.....E......P...............D...................K......R.....K...T...G....L...........N....SK........S.......KT..A.....S.AH.  85.17 %
L1-29 -----..CS.......A.V.V..A....A...........T.....................N......E.AE.............G.......V...A.Q...........................H.V..............N............TS....I.....V.....A......P.............R.D...................A......R.....K...T...G....L...........N...RSK........S....V..KT..A...R.A.AH.  84.14 %
L1-30 -----..CS.......A.V.V..A....A...........T.....................N......E.AE.............G.......V...A.Q...........................H.V..............N............TS....I.....V............P...............D...................E......R.....K...T...G....L...........N....SK........S....V..KT..A.......AH.  85.86 %
L1-31 -----..CS......TA...V..A....A...........T.............Q.......N........AE.............G.......V...A.Q...........................H.V..............N............TS....I.....V.....A......P...............D...................K......R.....K...T...G....L......S....N....SK........S.......KT..A.....S.AH.  85.17 %
L1-32 -----..CS.......A.V.V..A....A...........T.....................N........AE.............G.......V...A.Q...........................H.V..............N............TS....I.....V.....A......P...............D...................K......S.....K...T...G....L...........N....SK....T...S.......KT..A.....S.AH.  85.52 %
L1-33 -----..CS.......A.V.V..A....A...........T.....................N........AE.............G.......V...A.Q...........................H.V..............N............TS....I.....V.....A......P...S...........D...................K......R.....K...T...G....L...........N....SK....T...S.......KT..A.....S.AH.  85.17 %
L1-34 -----..CS......TA.V.V..A...DA...........T.....................N........AE.............G.......V...A.Q...........................H.V..............N............TS....I.....V.....A......P...............D.................K.A......R.....K...T...G...EL...........N....SK........S.......KT..A...R...AH.  84.48 %
L1-35 -----..LC.TT--..LTTL.LDVT...A......................V...................AE.............G.......L...A.Q...........................H......T.M.......N.............S....I.....V.....A......P...............D...................K......R.....K............L...........N....SK.S......N.......K...V.......T..  84.83 %
L1-36 -----..LC.TT--..LTTL.LDVT...A......................V...................AE.............G.......L...A.Q...........................H......T.M.......N.............S....I.....V.....A......P...............D.................E.K......R.....K............L...........N....SK.S......N.......K...V.......T..  84.48 %
L1-37 -----..F...............A....A..........................................AE................IS...V...A.Q...........................H................N....A........S....I....AV.....T......P...............D...................K......R.....K...I...G....L...........N....SK.S.N....S.......K...A........D.  87.93 %
L1-38 -----..F...............A....A..........................................AE................IS...V...A.Q...........................H................N....A........S....I....AV.....T......P...............D...................K......R.....K...T...G....L...........N....SK.S.N....S.......K...A........D.  87.93 %
L1-39 -----................V.A....A......................V...................AE.............G.......L...A.Q................L..........H......T.........N.............S....I.....V.....A......P...............D...................K......R.....K............L...........N....SK.S.E....N.......K...A..........  88.97 %
L1-40 -----.......L........V.A....A......................V...................AE.............G.......L...A.Q................L..........H......T.........NE............S....I.....V.....A......P...............D...................K......R.....K............L...........N....SK.S.E....N.......K...A..........  88.28 %
L1-41 -----...........A...F.QAH...A................................QE........AE.............G...........A.Q.............................V.....P......................S....I.....FSI...D......P...............D...................KD.....R.....K.T.....G....L...........S....SK.S.N............K..EA..........  86.90 %
L1-42 -----..F...............A....A......................V...................AE.............G.......L...A.Q.....................M.....H......T.........N.............S....I.....V.....A......P...............D...................K......R.....K............L...........N....SK.S.E....N.......K...A...R....T.  88.28 %
L1-43 -----..CS..T....A...F.QAH...A................................QE........AE.............G...........A.Q.............................V............................S....I.....VSI...D......P...............D...................KD.....R.....K.T.....G....L...........S....SK.S.N............K..EA.....S.AH.  85.17 %
L1-44 -----..F...............A....A......................V...................AE.............G.......L...A.Q...........................H......T.........N.............S....I.....V.....A......P...............D...................K......R.....K............L...........N..V.SK.S.E....N.......K...A...R....T.  88.28 %
L1-45 -----..F...............A....A.................I....V...................AE.............G.......L...A.Q...........................H..V...T.........N.............S....I.....V.....A......P...............D...................K......R.....K............L...........N....SK.S.E....N.......K...A...R....T.  87.93 %
L1-46 -----..F...............A....A.................I....V...................AE.............G.......L...A.Q...........................H......T.........N.............S....I.....V.....A......P...............D...................K......R.....K............L...........N....RK.S.E....N.......K...A...R....T.  88.28 %
L1-47 -----..F...............A....A.................I....V...................AE.............G.......L...A.Q...........................H......T.........N.............S....I.....V.....A......P...............D...................K......R.....K............L...........N....SK.S.E....N.......K...A...R....T.  88.28 %
L1-48 -----...S...LT..AV..V..AR..DA.................................N........SE.............G.....L.....AAQ...........................R.V.....................D..FA..ST.........V.....A......P...............E...................R..A...R.....T.......G....L.........H......SK.............D..A...A...N..VR..  84.83 %
L1-49 -----...S...LT..A......AA...T.................................N........SE.............G.....L.....AAQ...........................R.V.....................D......ST...I.....V.....A......P..............HE...................R..V...R.....T.......G....L.........H......SK.............E..K...A......VR..  86.21 %
L1-50 -----...S.......AT...HQVH.GQA........S.................................TE.............G.......L...A.Q...W.....................A.HLV....T.........N.............S....I.....V.....A......P...............D...................K......R.........S...G....L.........H.N....SK.S.N............K...A.....A.TT.  84.14 %
L1-51 -----...S...LT..A...V..AA...A................................DN........SE.............G.....L.....AAQ...........................R.V.....................D......ST.........V.....A......P...............E...................R..V...R.....T.......G....L.........H......SK.............D..A..NA.......H.H  85.86 %
L1-52 -----...S...LT..A...V.YAA...T.................................S........SE.............G.....L.....AAQ...........................R.V.....................D......ST.........V.....A......P...............D...................R..A...R.....M.......G....L.........H......SK...N.........D..A..NA.......R..  85.86 %
L1-53 -----..PHM..L...A...IT.A....A.....Q....................................A.................IS...V...A.Q............................I...............N......D.......V...I.....V.....T......P...............D.................K..E.A...R.V...........G....L.................K....................A.....V....  87.93 %
L1-54 -----..PHM..LM..AV..IT.A....A................................Q.........A.................IS...V...A.Q............................I...............N......D.......V...I.....V.....T......P...............D.................K..E.A...R.V.......T...G....L.................K....................A.....I....  86.90 %
L1-55 -----.NLR..TL..VAV..MT.A....A..........................................A............................Q............................................N......D......SV...I.....V.....T......P...........S...D.................K..E.A...R.V.......T...G....L......D..........K....................A..V..V....  87.24 %
L1-56 -----..FSP.....VT...I..A.G..T................................Q.........A..............G..IS.......A.Q.....................................................................VE....E......P...............E...L..................A...R.V...K...................................................A.......R..  90.34 %
L1-57 -----..FSP.....VT...I..A.G..T................................Q.........A..............G..IS.......A.Q..........................................................S..........VE....E......P...........S...E......................A...R.VD..K...........................S.SK.S..................A..........  88.62 %
L1-58 -----..FSP.....VT...I..A.G..T................................Q.........A..............G..IS.......A.Q...............................S..........................S..........VE....E......P...........S...E......................A...R.VD..K...........................S.SK.S............V.....A.......R..  87.59 %
L1-59 -----..QHM..LT.SAV..I..AT...A.................................N........AK.........................A.Q........................S..H.V............................S..........VE....E......P...............E...L................................................................................A.....A....  90.00 %
L1-60 -----..FS...VT..AV..V..A....A.................................N........AE..I..........G...........A.Q........................S..H.VT....................D......SV...I.....VE....E......P...............E......................A...R.V...K..........................S........................A.......R..  87.59 %
L1-61 -----..FS...VT..AV..V..A....A.................................N........AE.............G..IS.......A.Q...................................................A......S..........VE....E......P...........S...E......................A...R.VD..K...........................S.SK.S..................A.......R..  87.59 %
L1-62 -----..FS...VT..AV..V..A....A.................................N........AK.G.......................A.Q...................................................D......SV...I.....V.....A......P...............E....................S.......................................S.SK.S..................A.......R..  89.66 %
L1-63 -----..CS......TA.V.V..A...DA...........T.............Q.......N........AE.............G.......V...A.Q...........................H.V..............N.....E......TS....I.....V.....A......P...............D...................K......R.....K............L...........N....SK.S.N.........G..K...A...N.S.AH.  84.48 %
L1-64 -----..FS.......A......A....A.................................N........AE.............G...........A.Q........................S..H.V.......................................VK....E......P...........S...E......................A...R.....K...........................S.SK.S..................A.......R..  90.00 %
L1-65 -----..LR.SSL...AT.ITFDGA..DAS....Q.....P....T........N......H.........A..L..I.........Y..T....S.TNTGP..MV......T........I......Q.VV...T................E..F..V........R..VKL...A......P...............D......................A...R.V...........G....L...........N....SK.SE.V.S.........K...A.......T..  77.59 %
L1-66 -----.HPC.SSL...AT.L.LDAT..DA.....Q..........................Q.........DQ.............D.V.A..T....A.............................H......................ND..F..VT..........VSI...A......P...............D.L....................A...R..D...............L.........H.N....RN...Q..S......E..KR..A.......AR.  81.72 %
L1-67 -----..LC.TPL...AT.V-FDVA..DA..................E..............N........TE.............G...........A.Q............G..............T.V....T.........N......D......S....I....RV....M.......P.............S.D....................H.A...R.V.......T...G....L.........R.N.....E...NV....G......KA..A......T...  81.72 %
L1-68 -----..LC.TPL...AT.V-FDVA..DA..................E..............N........TE.............G...........A.Q...........................T......T.........N......D......S....I....RV....M.......P.............S.D....................H.A...R.V.......T...G....L.........R.N.....E...NV...........KT..A.....P....  82.76 %
L1-69 -----..LC.TPL...AT.V-FDVA..DA..........................................TE.............G...........A.Q...........................T.V....T.........N......D......S....I....RV....MA......P.............S.D....................H.A...R.V.......T...G....L.........R.N.....E...NV...........KA..A.....A....  82.76 %
L1-70 -----..LC.TPL...AT.V-FDVA..DA..........................................TE.............G...........A.QN..........................T.V....T.........N......D......S....I....RV.I..MA......P.............S.D.................H..H.A...R.V.......T...G....L.........R.N.....E...NV...........KT..A.....A....  81.72 %
L1-71 -----..LC.TPL...AT.V-FDVA..DA........................................R.TE.............G...........A.Q........................S..Q.V....T....P....NV.....D......S....I....RV....MA......P...............D....................Y.A...R.V.......T...G....L.........R.N.....E...NV...........KA..A....G.T...  81.38 %
L1-72 -----..LC.TPL...AT.V-FDVA..DA.P......................................R.TE.............G...........A.Q...........................Q.V....T....P....N......D......S....I....RV....MA......P........C......E....................Y.A...R.V.......T...G....L.........R.N.....E...NV...........KA..A......T...  81.72 %
L1-73 -----..LC.TPL...AT.V-FDVA..DA..........................................TE.............D...........A.Q...........................Q.V....T.........N......D......S....I....RV....MA......P...............D....................H.A...R.V.......T...G....L.........R.N.....E...NV....G......KA..A..........  83.10 %
L1-74 -----..LC.TPL...AT.V-FDVA..DA..........................................TE.............G...........A.Q...........................Q.V....T.........N......D......S....I....RV....MA......P...............D....................Y.A...R.V.......T...G....L.........R.N.....E...NV...........KA..A......T...  83.10 %
L1-75 -----..LC.TTL...AT.A-FDVT..DE...........S..............................A..............G...........AAQ.............................V..............N......S..F..VST...I.....VN....A......P...............D...L..................A...R.VH..........G....L...........N....SK.S......N.......K...A.....A..V.  82.76 %
L1-76 -----..LC.TTL...AT.A-FDVT..DE...........S..............................A..............G.......L.D.A.Q...........................H......T.........N......S..F..VSP...I.....VN....A......P...............D......................A...R.VQ.......M..G....L...........N....SN.SENV.S.........K...A.......T..  81.38 %
L1-77 -----..LC.TTL...AT.A-FDVT..DE...........S..............................A..............G.......L...A.Q....V......................H......T.........N......S..F..VST...I.....VN....A......P...............D......................A...R.VQ.......M..G....L...........N....SN.SE.V.S.........K...A.......T..  81.72 %
L1-78 -----..LC.TTL..TAT.A-FDVT..DA.....Q...................R................A..............G...........AAQ...........................S................N......S..F...S....I....EV.....A......P...............D.Q.A..................A...R.V...........G....L...........N.....E...N............K...A.......T..  83.79 %
L1-79 -----..LC.TTL..TAT.A-FDVT..DA.....Q...................R................A..............G...........AAQ...........................S................N......S..F...S....I....EV.....A......P...............D.Q.A......R...........A...R.V...........G....L...........N.....E...N............K...A.......T..  83.45 %
L1-80 -----..LC.TTL..TAT.A-FDVT..DA.....Q....................................A..............G...........AAQ...........................R.V..............N......S..F...S....I....GV.....A......P...............D.Q....................A...R.V................L...........N.....E...N............K...A.......T..  84.48 %
L1-81 -----..LC.TTL..TAT.A-FDVT..DA.....Q....................................A..............G...........AAQ...........................S................N......S..F...S....L....GV.....A......P...............D.Q....................A...R.V................L...........N.....E...N............K...A...R...T..  84.48 %
L1-82 -----..LC.TTL..TAT.A-FDVT..DA.....Q....................................A..............G...........AAQ...........................S...S............N......S..F...ST...I....GV.....A......P...............D.Q....................A...R.V...........G....L...........N.....E...N............K...A.......T..  83.79 %
L1-83 -----..LC.TTL..TAT.A-FDVT..DA.....Q....................................A..............G...........AAQ...........................S................N......S..F...S....I....GV.....A......P...............D.Q....................A...R.V...........G....L...........N.....E...N............K...A.......T..  84.48 %
L1-84 -----..LC.TTL..TAT.A-FDVT..DA.....Q....................................A..............G...........AAQ...........................S................N......S..F...S....I....GV.....A......P...............D.Q....................A...R.V.......T...G....L...........N.....E...N............K...A.......T..  84.14 %
L1-85 -----..LC.TTL..TAT.A-FDVT..DA.....Q....................................A..............G..IS...V...A.Q...V.......................S................N......S..F...ST...I.....V.....A......P...............D.Q....................A...R.V................L...........N.....E...N............K...A.......T..  83.79 %
L1-86 -----..LC.TTL..TAT.A-FDVT..DA.....Q....................................A..............G.......V...AAQ...........................S................N......S..F...ST...I.....V.....A......P...............D.Q....................A...R.V................L...........N.....E...N............K...A.......T..  84.48 %
L1-87 -----..FA.......AP..V..A....A...........T.........K...........N........AE.............G...........A.Q...........................H.V..........H...N.............S....I.....V.....A......P...............D....H..............K............K...T...G....L...........N....SK........S.......KT..A..........  86.90 %
L1-88 -----..LC.TTL..TAT.A-FDVT..DA.....Q....................................A..............G...........AAQ...........................S................N......S..F...S....I....AV.....A......P...............D.Q....................A...R.V................L...........N.....E...N............K...A.......T..  84.83 %
L1-89 -----..LC.TPL...AT.V-FDVA..DA..........................................TE.............G..........GA.Q...........................T.V....T.........N......D......S....I....RV.I..MA......P.............S.D.................H..H.A...R.V.......T...G....L.........R.N.....E...NV...........KT..A..........  82.07 %
L1-90 -----..RC.TTL..TAT.A-FDVT..DT.....Q.....P..............................A.................IS...V.D.A.Q...........................M.V..............N......S..F...ST...I.....V.....A......P...............D......................AG....V...........G....L...........N....SK.SD...N.........K...A...R...A..  82.07 %
L1-91 -----..RC.TTL..TAT.A-FDVT..DS.....Q.....P..............................A.................IS...V.D.A.Q...........................M.V..............N......S..F...ST...I.....V.....A......P...............D......................A.....V...........G....L...........N....SK.SD...N.........K...A.......A..  82.76 %
L1-92 -----..RC.TTL..TAT.A-FDAT..DT.....Q.....P..............................A.................IS...V.D.A.Q....................V......M.V..............N......S..F...ST...I.....V.....A......P...............D......................A.....V...........G....L...........N....SK.SD...N.........K...A.......A..  82.41 %
L1-93 -----..RC.TTL..TAT.A-FDAT..DT.....Q.....P..............................A.................IS...V.D.A.Q...........................M.V..............N......S..F...ST...I.....V.....A......P...............D......................A.....V...........G....L...........N....SK.SD...N.........K...A.......A..  82.76 %
L1-94 -----..RC.TTL..TAT.A-FDVT..DT.....Q.....P..............................A.................IS...V.D.A.Q...........................M.V..............N......S..F...ST...I.....V.....A......P...............D......................V...R.V...........G....L...........N....SK.SE.V.S.........K...A.......T..  82.07 %
L1-95 -----..................A....A.................I....V...................AE.............G.......L...A.Q...........................H......T.........N.............S....I.....V.....A......P...............D...................K......R.....K............L...........N....SK...E....N.......K..............  90.00 %
L1-96 -----...........T...V..A.G..T...........T.....................N........AE.............G...........A.Q........................S..H.V.......................................VE....E......P...............E...................K......R.V...K...................................................A..........  91.38 %
L1-97 -----..................A....A......................V...................AE.............G.......L...A.Q.....................M.....H......T.........N.............S....I.....V.....A......P...............D...................K......R.....K............L...........N....SK.S.E....N.......K...A..........  89.31 %
L1-98 -----..F.......VA.VQIT.VA...A.................................N........SE.............D...A...T...A.Q...W.....................A.HLV..............N.............S...L.....TVSL...T......P...............D...L...............R..A...R.V...........G....L.........R......SK.AVN.MS.N....E..K...A..........  82.07 %
L1-99 -----................V.A....A......................V...................AE.............G.......L...A.Q...........................H......T.........N.............S....I.....V.....A......P...............D...................K......R.....K............L...........N....SK.S.E....N.......K...A..........  89.31 %
L1-100 -----..F.............V.A....A......................V...................AE.............G.......L...A.Q...........................H......T.........N.............S....I.....V.....A......P...............D...................K......R.....K............L...........N....SK.S.E....N.......K...A..........  88.97 %
L1-101 -----..........P.......A....A......................V...................AE.............G.......L...A.Q...........................H......T.........N.............S....I.....V.....A......P...............D...................K......R.....K............L...........N....SK.S.E....N.......K...A..........  89.31 %
L1-102 -----..........VT...I..A.G..T................................Q.........A..............G..IS.......A.................................S..........................S..........VE....E......P...........S...E......................A...R.VD..K...........................S.SK.S..................A..........  89.66 %
L1-103 -----..................A....A.................I....V...................AE.............G.......L...A.Q...........................H..V...T.........N.............S....I.....V.....A......P...............D...................K......R.....K............L...........N....SK.S.E....N.......K...A..........  88.97 %
L1-104 -----...........T...V..A.G..T...........T.....................N........AE.............G...........A.Q........................S..H.V.......................................VE....E......P...............E...................K......R.V...K...................................................A..G.......  91.03 %
L1-105 -----..........VT...I..A.G..T................................Q.........A..............G..IS.......A.Q..........................................................S..........VE....E......P...........S...E......................A...R.VD..K...........................S.SK.S..................A..........  89.66 %
L1-106 -----..................S....A......................V...................AE.............G.......L...A.Q...........................H.V....T.........N.............SV...I.....V.....A......P...............V...................K......R.....K............L...........N....SK.S.E....N.......K...A..G.......  88.62 %
L1-107 -----..................A....A.................I....V...................AE.............G.......L...A.Q...........................H......T.........N.............S....I.....V.....A......P...............D...................K......R.....K............L...........N....RK.S.E....N......RK...A..G.......  88.62 %
L1-108 -----..........VT..RI..A.G..T................................Q.........A..............G..IS.......A.Q..........................................................S..........VE....E.....IP...........S...E......................A...R.VD..K...........................S.SK.S.............R....A..G.......  88.28 %
L1-109 -----..................A....A......................V...................AE.............G.......L...A.Q...........................H......T.........N.............S....I.....V.....A......P...................................K......R.....K............L...........N....SK.S.E....N.......E...A..........  90.00 %
L1-110 -----..................A....A......................V...................AE.............G.......L...A.Q...........................H......T.........N.............S....I.....V.....A......P...................................K......R.....K............L...........N....SK.S.E....N.......K...A..G.......  89.66 %
L1-111 -----..................A....A......................V...................AE.............G.......L...A.Q...........................H......T.........N.............S....I.....V.....A......P...............D...................K......R.....K............L...........N....SK.S.E....N.......K...A......G...  89.31 %
L1-112 -----..FS..............A....A......................V...................AE.............G.......L...A.Q...........................H......T.........N.............S....I.....V.....A......P...............D...................K......R.....K............L...........N....SE.S......N......RK...A..G.......  88.62 %
L1-113 -----..........P....P..A....A......................V...................AE.............G.......L...A.Q...........................H......T.........N.............S....I.....V.....A......P...............D...................K......R.....K............L...........N....SK.S.E....N.......K...A..G.......  88.62 %
L1-P1 -------------------------...A......................V...................AE.............G.......L...A.Q...........................H......T.........N.............S....I.....V.....A......P...............D...................K......R...G.K............L...........N....SK.S.E....N.......K...A..........  82.76 %
L1-P3 -------------------------...A......................V...................AE.............G.......L...A.Q...........................H......T.........N.............S....I.....V.....A......P...............D...................K......R.....K............L...........N....SK.S.E....N...........A..........  83.45 %
L1-P4 -------------------------...T..........................................A..............D...A.......A.QN..........................R.VT...........................S....I.....VS....D......P...............E.R...............R.KD.....R.........T...G....L...........N....SK.S......N.......K...A..........  82.07 %
L1-P6 -------------------------...A..........................................AE................IS...V...A.Q...........................H................N....A........S....I....AV.....T......P...............D...................K......R.....K...I...G....L...........N....SK.S.N....S.......K...A..........  82.07 %
L1-P7 -------------------------...A......................V...................AE.............G.......L...A.Q...........................H......T.........N.............S....I.....V.....A......P...............D...................K......R.....K............L...........N....SK.S.E....N.....R.K...A..........  82.76 %
L1-P8 -------------------------...A......................V...................AE.............G.......L...A.Q...........................H......T.........N.............S....I.....V.....A......P...................................K......R.....K............L...........N....SK.S.E....N.......K...A..........  83.45 %
L1-P9 ---------.......A......AA...T.................................N........SE.............G.....L.....AAQ...........................R.V.....................D......ST...I.....V.....A......P..............HE...................R..V...R.....T.......G....L.........H......SK.............E-----------------  81.38 %
L1-P10 -------------------------...T.................................S........SE.............G.....L.....AAQ...........................R.V.....................D......ST.........V.....A......P...............D...................R..V...R.....T.......G....L.........H......SK...N.........E..K...A..G.......  82.07 %
L1-P11 -------------------------...A.................I....V...................AE.............G.......L...A.Q...........................H......T.........N.............S....I.....V.....A......P...............D...................K......R.....K............L...........N....SK.S.E....N.......K...A..........  82.76 %
B3-L1 phylogenetic tree

Last updated: November 20, 2024.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database was funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

Live statistics (since December 3rd, 2023)