Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
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Beta-Lactamase DataBase

Sequence alignment for the BJP beta-lactamase family

BJP-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......
MRRLTAALCALTLLS-TGAQAQTIKDFLAVAMKKWTAPFEPFQLIDNIYYVGTDGIAVYVIKTSQGLILMDTAMPQSTGMIKDNIAKLGFKVADIKLILNTHAHLDHTGGFAEIKKETGAQLVAGERDKPLLEGGYYPGDEKNEDLAFPAVKVDRAVKEGDRVTLGDTTLTAHATPGHSPGCTSWEMTVKDGKEDREVLFFCSGTVALNRLVGQPTYAGIVDDYRATFAKAKAMKIDVLLGPHPEVYGMQAKRAE-MKDGAPNPFIKPGELVTYATSLSEDFDKQLAKQTAALEKK-
BJP-2 ..T.A......A.IT-S......L...M.TV..............G.............I..............Q...........R.........Y...S.................A...I..................N.T..S.QP.....T.....K........................LK....DQE.N...Y............H...P.......S.Y..V....V..................Q-.........V....N...V.G.EQ.............Q.AN  83.73 %
BJP-3 ..TIA........IA-.......L...M.TV..............G.............I...P..........Q.....................E..................Q......I....................T..G..P.....T.....K.....V.....T..................NQE.T................R...T.......S....V.G..V...........D......Q-.........V....NAS.VAG.EQ.....I.......Q.AN  83.73 %
BJP-4 ..TIA......A.IA-.......L...M..V.............V..............I..............Q................EG...Y..................R......I..................S.A....TPA....T.....K.....V.....T..............A...NQQ.N................R...P.......S....V....V...........D.......-.........V....NAS.VAG.EQ.............Q.AN  83.39 %
BJP-5 ..TIA........IA-.D.....L...M..V.............................V.............Q...............REG...I.........................I..................N.A....TP.....T.....K.....V.....T..................NQQ.N................R...P.......S.L.RV....V...........D......Q-.........V....NA..VAG.EQ.............Q.SN  83.73 %
BJP-6 ..TIA......A.IA-.......L...M..V...........................................Q................EG...I.........................I..................N.A....TP.....T.....K.....V.....T..............A...SQT.N................R...P.......S..T.V....V...........D......Q-.....A...V....NA..VAG.EQ.............Q.SN  84.07 %
BJP-7 ..TIA........IA-.......L...M..V...........................................Q............V...EG...I.........................I..................N.T....TP.....T.....K...........T............I.....SQA.N................R...P.......S..T.V....V...........D......Q-.........V....NA..VAG.EQ.............Q.AN  84.75 %
BJP-8 ..TIA........IA-.......L...M..V...............................S...........Q................EG...I.........................I..................N.A....TP.....T.....K.....V.....T..................SQA.N................R...P.......S..T.V....V...........D......Q-.........A....NA..VAG.EQ.............Q.AN  84.75 %
BJP-9 ..TIA........IA-.......L...M..V...................A........I..............Q................EG...I.........................I..................N.A....TP.....T.....K.....V.....T............I.....SQA.N................R...P.......S..T.V....V...........A......Q-.R.......V....NA..VAG.EQ.............Q.AN  83.73 %
BJP-10 ..TIA........IA-.......L...V..V............................I..............Q................EG...I.........................I..................N.A....TP.....T.....K.....V.....T............I.....SQA.N................R...P.......S..T.V....V...........A......Q-.........V....NA..VAG.EQ.............Q.AN  84.41 %
BJP-11 ..TIA........IA-.......L...M..V............................I..............Q................EG...I.........................I..................N.A....TP.....T.....K.....V.....T............I.....SQA.N................R...P.......S..T.V....V...........A......Q-.........V....NA..LAG.EQ.............Q.AN  84.41 %
BJP-12 ..TIA......A.IA-.......L...M.TV..........YE................I..............Q..........TR....E....I...S..............Q.....MI..................S.A....TP.....T.....K.....V........................NQQ.N................R...P.......S....V....V...........D......Q-.........V....NA..VAA.EQ.............Q.AN  82.71 %
BJP-13 ..TIA......A.IA-.......L...M.TV..........Y...........................I....Q..........T..........I...S..............Q.....MI..................S.A....TP...........K..............................T.K.D................R...P.......S....V....V...........D.......-.........V....NA..VAG.EQ.............Q.DN  85.08 %
BJP-14 .KK.A......A.FA-PA....S....V..V........D..H................I....................................Y...S..............Q.S.......................R.A..S..P.....T.....K..............................GQ.......................P................................D...QQI.SET....V.....A...SG..K..............AAK  85.81 %
BJP-15 ..K......T...FA-PV.....L.....TV.Q.........................................S.......G...R.........Y..............................................Q..T.TP...........K..............................GQ..K....................P..M.............................E..GQQI.NET....V.....A....G...E..R.........QGAK  86.15 %
BJP-16 .KT.AG.I...A.FA-GS.....V.....QV.V..........................I....D.......GV.........H........S...I...S...F...........D.....I..L.......S.T.....T.T.IG..P.....T.T...K....A.........................N.N..................N..H........S.Y..........................A-.........V.....AA..AT.EQ.......R.....QSGK  81.02 %
BJP-17 .KT.AG.I...A.FA-GN.....V.....QV.V..........................L....D.......GV....S...EH.......E....I...S...F...........D.....I..L.......S.T.......T.IG..P.....T.T...K....G.........................S.N..................N..H........S.Y..........................A-.........V.Q...AA..AT.EQ.............QSGK  80.68 %
BJP-18 .KT.AG.I...A.FA-GN.....V.....QV.V..........................L....D.......GV........EH.......E....I...S...F...........D.....I..L.......S.T.......T.IG..P.....T.T...K....G.........................S.N..................N..H........S.Y..........................A-.........V.....AA..AT.EQ.............QSGK  81.36 %
BJP-19 .KT........A.MV-S......L.....AVT....T........G.............I.............L.................LG...Y.......F..........Q.........K..T..............A.............G...K........I..E...............H..DQ..T................T..H.............V.G..V...........D......L-...STQ...V.S..NA..VAG.EQ............MQ.AN  82.03 %
BJP-20 .KT.A......A.MV-S......L.....AVT....T........G.............I.............L..................G...Y.......F..........Q.S...MI..K..V..............A.............G...K........I..E...............H.SDQ..T................T..H.............V.G..V...........D......L-....TQ...V.S..NA..VAG.EQ............MQ.AN  81.02 %
BJP-21 ..K........AMFA-PA.....L.....AVT....T........G...........................L.E.............L..S.V.I.......F......................................A........L........E...........S...............R..NQ....................A..P................................T....-.........V.....A...IG...................-  88.44 %
BJP-22 ..K........A.FA-PA...........AVT....T........G...........................L...............L..S.V.I.......F.................M....................A.................K...........S...............N..SQ........................................................T....-.........V.....A....G...................-  90.48 %
BJP-23 .KK........AFFA-.......V...I.AVT....T....................................L...........T...L......I.......F........V........I................................T.....K....E.........................GQ..Q...................H..........Y..V.......................A-.........V.....A........................-  89.46 %
BJP-24 .KK........AF.A-.......V...I.AVT....T........G.............I.............L.E.............L..S...I.......F............................................T...........K..............................NQ..K...................H..........Y..V........................-.........V.....AA...T...................-  89.46 %
BJP-25 .KK........AF.A-.......V......VT....T........G....I........I.............L.E.............L..S...I.......F.................I..D...................................KI.............................NQ......................H..........Y..V........................-.........V.....AA.S.T...................-  89.12 %
BJP-26 ..KF.......M.FG-.A...........AVT....T......................I.............L......................Y...S...F........................................................K..............................SQ......................H..........Y..V........................-.........V.....A........................-  92.18 %
BJP-27 ...............-................................................................................I.........................I.......................T..........N...K.......................KL.I.....N......................P.....................................-..E..A...V....I.....G.........T.........-  94.56 %
BJP-28 ..K........V.FV-PA..........................................V...................................I.........................I.......................T..............K..............................R.S......................P.....................................-..E......V....I.....G...................-  93.88 %
BJP-29 ...............-.............................................................................................................................................................P.................................................................................-........................................-  99.66 %
BJP-30 ...............-...............................................................................................................................................................................................................................................-....................G...................-  99.66 %
BJP-31 ...FA.....VA.FA-.......L.....AVT....T........G.............I.............L.........S............Y.......F............S....I......................................K..............................GQ.......................P.........Y......................D...Q-.........V.....T...AG.EQ.............QTAK  87.80 %
BJP-32 .KK.A.T....AF.A-............TAV.Q......D.....G...................................EEH.....L......I................................................................K..............................GQ.............................................................-.........V..D..A..............T.........-  91.50 %
BJP-33 .KK.A.T....AF.A-............TAV.Q......D....VG...................................EEH.....L......I..........................................................T.....K..............................GQ.............................................................-.........V.....A........................-  91.50 %
BJP-34 .KK.A......AF.A-.............AV.Q......D.....G...................................E.......L......I..............................................D..T........T.....K..............................GR.......................T.....................................-.........V.....A........................-  92.18 %
BJP-35 .KK.A.V....AF.A-.............AV.Q......D.....G...................................E.......L......I.................................................T........T.....K..............................GQ....................S........................................-.........V.....A........................-  92.18 %
BJP-36 .KK.A.T....AF.A-.............AV.Q......D.....G...................................E.......L......I................................A.........................T.....K..............................GQ.............................................................-...............A........................-  92.86 %
BJP-37 .KK.A.T....AF.A-.............AV.Q......D.....R...................................E......SL......I................................A.........................T.....K..............................GQ.............................................................-...............A........................-  92.52 %
BJP-38 .KK.A.T....AF.A-.............AV.Q......D.....R...................................E.......L......I................................A.........................T.....K..............................GQ.............................................................-...............A........................-  92.86 %
BJP-39 .KK.A.T....VF.A-.............AV.Q......D.....G...................................E.......L......I..........................................................T.....K..............................GQ.............................................................-.........V.....A........................-  92.86 %
BJP-40 .KK.A.T....AF.A-.............AV.Q......D.....G...................................E.......L......I..........................................................T.....K..............................GQ.............................................................-.........V.....A....G...E...........M...-  91.84 %
BJP-41 .KK.A.T....AF.A-.............AV.Q......D.....G...................................E.......L......I.....................................................A....T.....K..............................GQ.............................................................-.........V.....A....G...................-  92.18 %
BJP-42 ..K.A.T....A...-.............I...............G...........................................L......I.........................I.......................T..P.....T.....K........I.....................SQ......................H..........Y..V.......................QQI..AS....V....NA..VAT...................-  89.83 %
BJP-43 ..K........AF.A-.......L.....TV.Q....T.......G.......E....................................Q.S...IV..S....................I...........................P.....V.....K..............................NQN......................P.........Y..V....V..................Q-.........V.Q...A....G...................-  89.12 %
BJP-44 ..K........AF.T-.............TV.Q............G.V.........................................L......I.........................I....................A..S........T...D.K..............................NQ..D....................P.........Y..V........................-.........V.....T....G...................-  91.16 %
BJP-45 ..K........AF.T-.............TV.Q............G..................................................I.........................I....................A..S........T.....K..............................NQ..D.........S..........P.........Y..V....V...................-.........V.....T....G...................-  91.50 %
BJP-46 ..K..T.....A.FTT.A...........AV.Q.........H..G...........................................L......I...S.............................................T........T.....K..........................A...SQ..Q...................HP.........Y..V.P.....................Q-.........V..D..A..I.T..D................-  88.47 %
BJP-47 ....A......A.F.T-............I...............G..................................................I.........................M................................T.....K..............................SQ..Q...................HP.........Y..V.P.....................Q-.........V..D..A..I.....................-  91.86 %
BJP-48 ....A......A...T-............I...............G..................................................I...S.....................I................................T.....K..............................R........................P.........YD.V........................-.........V..............E...............-  93.90 %
BJP-49 .TK.A......A.FA-.............T..Q............G.......G......................................S..RI.........................I................................T.....K.....V...................S....DQN......................P....................................Q-.........VA....T..V.G...E...............-  90.14 %
BJP-50 ..........IV..T-.............A..Q............G.......G......................................SN......S..........................................Q...........T.....K.....V..S................S....DQN......................P.........Y...........................-....V....V.....A..IAG..D.............D..-  90.14 %
BJP-51 ..........IV..T-.............A..Q............G.......G......................................S.......S..........................................Q...........T.....K.....V...................S....DQN......................P.........Y...........................-....V....V.....A..IAG..D.............D..-  90.82 %
BJP-52 .KT..........FA-.......V.....LVT....T........G.............I.............L..................G...Y.......F..........Q...........................S.IG..P.....T.....K.......V......................NQ..D................N..HP.......S........................Q....-.........V.....AI..AG.EQ.............Q.SN  86.10 %
BJP-53 ..T...V....A.FA-.......V.....QVT....T........G..................E........L....S............LG...Y.......F..........Q...........................A..G..P...........K............................E.GQ..D................N...P..A....S..G.....................Q...Q-....T....V.....AA..AG.EQ.............Q.SN  84.75 %
BJP-54 ..K........A.FA-PV.....V...I.AVT....T........G.............I.............L......................Y.......F........................A...............................K...........E..................SQ........................................................D...QQI..SSS...V.....T....G................QPAK  87.84 %
BJP-55 ..K........A.FA-PV.....V...I.AVT....T........G.............I.............L......................Y.......F........................A...............................K...........E..................SQ...............................S........................D...QQI..SS....V.....T....G............M...QPAK  87.50 %
BJP-56 .KK.A.....VA.FA-.S.....V...I.AVT....T........G.............I.............L.E...............I....Y...S...F........................................................K........M.....................NQ..D....................P.......S.Y...R..................D...Q-.........V.....A...AG.EQE............QTAK  85.08 %
BJP-57 ...FA.....VA.FA-.......L.....AVT....T........G.............I.............L.........S............Y.......F............S....I......................................K..............................SQ...............................T.Y......................D...Q-.........V.....T...AG.EQ.............QTAK  87.80 %
B3-BJP phylogenetic tree

Last updated: November 20, 2024.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database was funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

Live statistics (since December 3rd, 2023)