Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
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Beta-Lactamase DataBase

Sequence alignment for class B2 beta-lactamases

CphA-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.....
MMKGWMKCGLAGAVVLMASFWGGSVRAAGMSLT-QVSGPVYVVEDNYYVQENSMVYFGAKGVTVVGATWTPDTARELHKLIKRVSRKPVLEVINTNYHTDRAGGNAYWKSIGAKVVSTRQTRDLMKSDWAEIVAFTRKGLPEYPDLPLVLPNVVHDGDFTLQEGKVRAFYAGPAHTPDGIFVYFPDEQVLYGNCILKEKLGNLSFADVKAYPQTLERLKA----MKLPIKTVIGGHDSPLHGPELIDHYEALIKAAPQS------
CphA-2 .................................-....................................................Q....................................................................E.........L....................Q.........................R.......----........V..........................------  97.64 %
CphA-3 .....I.Y.....L..V........H..AI...-...............K...................................N....................................................................................L...............Q...........T...................R.----......I.V.................E....S.H.------  92.91 %
CphA-4 ........T....................I..K-...............K...V...............................S...............V..............A.........................................................................................N.......I.....----..........................E.....AAV------  94.49 %
CphA-5 .....I..........V........H..AI...-...............K.............I....................NN.............GQ..........................................................N..........................Q.................................----......I.V................Q......TH.------  92.91 %
CphA-6 ...S....T....................I..K-...............K...................................S........................................................................................................................N.......I.....----..........................E.....AH.------  95.67 %
CphA-7 .............................I..K-...............K.............A.....................S..............................A..........................................K..D...........................................N..E....I.....----................................AH.------  94.88 %
CphA-8 .....I..T.......................M-...............K...................................S.........................................................................K..........................Q..F................N..E....I.....----..........................E.....TH.------  94.49 %
CphA-9 ...S.........................I..K-...............K....I..............................S...............RA.............A.........................................................................................N.......I.....----...................S...........S.H.------  94.49 %
CphA-10 .....I...........................-...................................................S........N...........................E..........................................L......................................................----........V.......................TH.------  96.85 %
CphA-11 .....I...........................Q.................................................................................I.......................................E.........L....L....S..........Q.................................----........V.......................S..------  96.08 %
CphA-12 .................................-...................................................S..............................A........................D.............E......G..L........................................N..E..........----........V..........................------  96.46 %
CphA-13 .................................-....................................................Q..............................................................................L....................QL................................----........V..........................------  98.03 %
CphA-14 .....I..T.......................M-...............K...................................S.........................................................................K..........................Q...................N..E....I.....----..........................E........------  95.67 %
CphA-15 .............................I..K-...............K.............A.....................S..............................A..........................................K..D...........................................N..E....I.....----..........................E........------  95.28 %
CphA-16 .....I..T....................IE.K-...............K...................................S..............................A.........................................................................................N.......I.....----..........................E....V...------  95.28 %
CphA-17 .....I..T....................I..K-...............K...................................S..............................A....W...............................................F....................................N.......I.....----........V......................S.H.------  94.49 %
CVI-1 ---MRTVF.F...LLGL.A---AACA.Q.GLALKHLK.G......G..AK...V..V..EH................ARQ.RA.TY..IA..V.P...P..............RI......A.E.RRG.D.V.....R.F.D..A..VS..DRE.P...E..D.RIK..HL.A...R....IH..Q.R.........QE.....Y..LNE..K......L----SE.DFD...A..LDA..........QR.L.RQASDAAAERS  56.70 %
PFM-1 -----..VINILSA.S.FCITCQALANDINLTLTHFK..L.I...KE.........I..QDI.II......A..EK.EQE.RKI.SL.IK...................KL..SI...QM.Y..E.TN.RG..D...Q.MEH..V.EQS..DQ.YP...A..N.H...L.L.AS..E........E.R..............MT..NRSE..K..KK.QGLIRSGE.SVEAI.A..N..IQSV......LN.LEHGE.-------  50.97 %
PFM-2 -----..LINILSAISL.CITSQVFANQSDLTLIHFK..L.I...KE.........I.EQHI..I......A..EK.EQE.RKI.PL.IK..................RKL..SI...QM.Y..E..Q.RS..D...Q.MEH..V.EQS..DQ.YP...A..N.H...L.L.AS..E........E.R..............MT..NRSE..K..KK.QGLISSGE..VEAI.A..N..IQSV......LN.LEHGE.-------  50.97 %
PFM-3 -----..LINILSAISL.CITSQVFANQSDLTLTHFK..L.....KE.........V..QHI..I......A..EK.EQE.RKI.PL.IK...................KL..SI...QM.Y..E..Q.RS..D...Q.MEH..V.EQS..DQ.YP...A..N.H...L.L.AS..E........E.R..............MT..NRSE..K..KK.QGLISSGE..VEAI.A..N..IQSV......LN.LEHGE.-------  52.12 %
PFM-4 -----..LINILS.ISL.CITSQVFANKSDLTLTHFK..L.I...KE.........V.EQHI..I......A..EK.EQE.RKI.PL.IK...................KL..SI...QM.Y..E..Q.RS..D...Q.MEH..I.EQS..DQ.YP.N.D..N.H...L.L.AS..E........E.R..............MT..NRSE..K..KK.QGLIRSGE..VEAI.A..N..IQNV......LT.LEHGE.-------  51.35 %
SFH-1 ---MILNIKYLFTA.TFLLIACE.MASEKNLTLTHFK..L.I...KE.........I.TD.I.II......E..ET.Y.E.RK..PL.IN...................TL...I.A.QM.Y..Q..Q.GS..N...Q.NNK..N.EKS..DT.FP...N..N.SI..M.L.E...K........A.R..........N...M...NRTE..K...K..GLIEQGE.KVDSI.A...T.I.DVG.....LT.LEK..K-------  52.51 %
YEM-1 .L.TIL--------QFFVL.TVTQGAY.SKIALVKL.DNL.....D..YR......I.KDYI..I.........K..DAQ..KI.K..IA...............L.......ELI..KM.YN..EKH.QD.LET....YDGF..I.....TKTF.NN.E..N.EIK.I.T.ES...........K.KT......I.......AS.NI.E..K..QK..N----LN.D....V......I..S....S.KK..E..NK-------  54.90 %

Last updated: November 20, 2024.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database was funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

Live statistics (since December 3rd, 2023)