Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
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Beta-Lactamase DataBase

Sequence alignment for the CphA beta-lactamase family

CphA-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.....
MMKGWMKCGLAGAVVLMASFWGGSVRAAGMSLT-QVSGPVYVVEDNYYVQENSMVYFGAKGVTVVGATWTPDTARELHKLIKRVSRKPVLEVINTNYHTDRAGGNAYWKSIGAKVVSTRQTRDLMKSDWAEIVAFTRKGLPEYPDLPLVLPNVVHDGDFTLQEGKVRAFYAGPAHTPDGIFVYFPDEQVLYGNCILKEKLGNLSFADVKAYPQTLERLKAMKLPIKTVIGGHDSPLHGPELIDHYEALIKAAPQS
CphA-2 .................................-....................................................Q....................................................................E.........L....................Q.........................R...............V..........................  97.64 %
CphA-3 .....I.Y.....L..V........H..AI...-...............K...................................N....................................................................................L...............Q...........T...................R.......I.V.................E....S.H.  92.91 %
CphA-4 ........T....................I..K-...............K...V...............................S...............V..............A.........................................................................................N.......I...............................E.....AAV  94.49 %
CphA-5 .....I..........V........H..AI...-...............K.............I....................NN.............GQ..........................................................N..........................Q.......................................I.V................Q......TH.  92.91 %
CphA-6 ...S....T....................I..K-...............K...................................S........................................................................................................................N.......I...............................E.....AH.  95.67 %
CphA-7 .............................I..K-...............K.............A.....................S..............................A..........................................K..D...........................................N..E....I.....................................AH.  94.88 %
CphA-8 .....I..T.......................M-...............K...................................S.........................................................................K..........................Q..F................N..E....I...............................E.....TH.  94.49 %
CphA-9 ...S.........................I..K-...............K....I..............................S...............RA.............A.........................................................................................N.......I........................S...........S.H.  94.49 %
CphA-10 .....I...........................-...................................................S........N...........................E..........................................L..............................................................V.......................TH.  96.85 %
CphA-11 .....I...........................Q.................................................................................I.......................................E.........L....L....S..........Q.........................................V.......................S..  96.08 %
CphA-12 .................................-...................................................S..............................A........................D.............E......G..L........................................N..E..................V..........................  96.46 %
CphA-13 .................................-....................................................Q..............................................................................L....................QL........................................V..........................  98.03 %
CphA-14 .....I..T.......................M-...............K...................................S.........................................................................K..........................Q...................N..E....I...............................E........  95.67 %
CphA-15 .............................I..K-...............K.............A.....................S..............................A..........................................K..D...........................................N..E....I...............................E........  95.28 %
CphA-16 .....I..T....................IE.K-...............K...................................S..............................A.........................................................................................N.......I...............................E....V...  95.28 %
CphA-17 .....I..T....................I..K-...............K...................................S..............................A....W...............................................F....................................N.......I.............V......................S.H.  94.49 %
B2-CphA phylogenetic tree

Last updated: November 20, 2024.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database was funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

Live statistics (since December 3rd, 2023)