Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
Beta-Lactamase DataBase - Structure and Function Home Enzymes Structures Mutants Kinetics BLAST
Beta-Lactamase DataBase

Sequence alignment for the VIM beta-lactamase family

VIM-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260......
MLKVISSLLVYMTASVMAVASPLAHSGEPSGEYPTVNEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEAEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSANVLYGGCAVHELSSTSAGNVADADLAEWPTSVERIQKHYPEAEVVIPGHGLPGGLDLLQHTANVVKAHKNRSVAE
VIM-2 .F.LL.K....L...I..I.....F.VDS.......S...........................................................................................................V..............................................S.......IY...R.................I....Q.....QF..............K..T......T....V.  90.60 %
VIM-3 .F.LL.K....L...I..I.....F.VDS.......S......................K....................................................................................V..S...........................................S.......IY...R.................I....Q.....QF..............K..T......T....V.  89.85 %
VIM-4 ............................................................................................................................................................................................................R.............................................................  99.62 %
VIM-5 ...............................................................................................................................K........................................................................LA..R...................................................T.........  98.12 %
VIM-6 .F.LL.K....L...I..I.....F.VDS.......S......................R....................................................................................V..S...........................................S.......IY...R.................I....Q.....QF..............K..T......T....V.  89.85 %
VIM-7 .FQ-.R.F..GIS.F....LGSA.Y.AQ.G......DD.........K.G..........KLGDT..S........A...............V................SI.......................T..L..Q....A...V.A...KA......V.......V........G........AVR..F.......A.RE........N.....ATIK...QR.................E.....T....T..V.P...  77.07 %
VIM-8 .F.LL.K....L...I..I.....F.VDS.......S.....................................................................................................A.....V..............................................S.......IY...R.................I....Q.....QF..............K..T......T....V.  90.23 %
VIM-9 .F.LL.K....L...I..I.....F.VDS.......S.....................................................................................................I.....V..............................................S.......IY...R.................I....Q.....QF..............K..T......T....V.  90.23 %
VIM-10 .F.LL.K....L...I..I.....F.VDS.......S...........................................................................................................V..............................................S.......IY...R.................I....Q.....QY..............K..T......T....V.  90.60 %
VIM-11 .F.LL.K....L...I..I.....F.VDS.......S...........................................................................................................V..S...........................................S.......IY...R.................I....Q.....QF..............K..T......T....V.  90.23 %
VIM-12 ..............................................................................................................................................................................................................................I....Q.....QF..............K..T......T....V.  96.99 %
VIM-13 .........F.....L............SR......S............D.........HT...V.......................T...V................S..............A........................V..................................................L...R...............G......Q...............................T......  92.86 %
VIM-14 ..............................S.............................................................................................................................................................................R.............................................................  99.25 %
VIM-15 .F.LL.K....L...I..I.....F.VDS.......S...........................................................................................................V..............................................S..F....IY...R.................I....Q.....QF..............K..T......T....V.  90.23 %
VIM-16 .F.LL.K....L...I..I.....F.VDS.......S.................L.........................................................................................V..............................................S.......IY...R.................I....Q.....QF..............K..T......T....V.  90.23 %
VIM-17 .F.LL.K....L...M..I.....F.VDS.......S...........................................................................................................V..............................................S.......IY...R.................I....Q.....QF..............K..T......T....V.  90.60 %
VIM-18 .F.LL.K....L...I..I.....F.VDS.......S......................R...................................................................................----............................................S.......IY...R.................I....Q.....QF..............K..T......T....V.  89.10 %
VIM-19 ...............................................................................................................................................................................................K............R.............................................................  99.25 %
VIM-20 .F.LL.K....L...I..I.....F.VDS.......S...........................................................................................................V..............................................S.......IY...R.................I....QR....QF..............K..T......T....V.  90.23 %
VIM-23 .F.LL.K....L...I..I.....F.VDS.......S...........................................................................................................V..............................................S.......IY.....................I....Q.....QF..............K..T......T....V.  90.98 %
VIM-24 .F.LL.K....L...I..I.....F.VDS.......S...........................................................................................................V..............................................S.......IY...L.................I....Q.....QF..............K..T......T....V.  90.60 %
VIM-25 ...............................................................................................................................K........................................................................LA..R............................QF..............K..T......T....V.  96.24 %
VIM-26 ........................................................................................................................................................................................................L.................................................................  99.62 %
VIM-27 .........................................................S................................................................................................................................................................................................................  99.62 %
VIM-28 ........................................................................................................................................................................................................L...R.............................................................  99.25 %
VIM-29 ...............................................................................................................................................................................................K....................................R.....................................  99.25 %
VIM-30 .F.LL.K....L...I..I.....F.VDS...................................................................................................................V..............................................S.......IY...R.................I....Q.....QF..............K..T......T....V.  90.98 %
VIM-31 .F.LL.K....L...I..I.....F.VDS.......S...........................................................................................................V..............................................S.......I....R.................I....QR....QF..............K..T......T....V.  90.60 %
VIM-32 .................................................................................................................................................A........................................................................................................................  99.62 %
VIM-33 ..................................................................................................................................................................................................F.......................................................................  99.62 %
VIM-34 ..............................................................................................................I...........................................................................................................................................................  99.62 %
VIM-35 ...................................................................................................................................................................................................................T......................................................  99.62 %
VIM-36 .F.LL.K....L...I..I.....F.VDS.......S......................R....................................................................................V..............................................S.......IY...R.................I....Q.....QF..............K..T......T....V.  90.23 %
VIM-37 .........................................................S..................................................................................................................................................R.............................................................  99.25 %
VIM-38 ...........L...................................................................................................................K........................................................................LA..R...................................................T.......V.  97.37 %
VIM-39 ..................................A.....................................................................................................................................................................L.................................................................  99.25 %
VIM-40 ..............................................................................................................................................V.............................................................R.............................................................  99.25 %
VIM-41 .F.LL.K....L...I..I.....F.VDS.......S...........................................................................................................V..............................................S.......IY...R.......N.........I....Q.....QF..............K..T......T....V.  90.23 %
VIM-42 ..............................................................................................................................................................................................................................I...........................................  99.62 %
VIM-43 .......................V....................................................................................................................................................................................R.............................................................  99.25 %
VIM-44 .F.LL.K....L...I..I.....F.VDS.......S...........................................................................................................V..............................................S.......IY...R.................I....Q.....QF..............K..T...N..T....V.  90.23 %
VIM-45 .F.LL.K....L...I..I.....F.VDS.....I.S...........................................................................................................V..............................................S.......IY...R.................I....Q.....QF..............K..T......T....V.  90.23 %
VIM-46 .F.FL.K....L...I..I.....F.VDS......AS...........................................................................................................V..............................................S.......IY...R.................I....Q.....QF..............K..T......T....V.  90.23 %
VIM-47 .F..V....F.....L............SR......S............D.........HT...V.......................T...V................S..............A........................V..................................................L...R...............G......Q...............................T......  92.11 %
VIM-48 .F.FL.K....L...I..I.....F.VDS.......S...........................................................................................................V..............................................S.......IY...R.................I....Q.....QF..............K..T......T....V.  90.60 %
VIM-49 .........................................................S.....................................................................K........................................................................LA..R...................................................T.........  97.74 %
VIM-50 .F.LL.K....L...I..I.....F.VDS.......S...........................................................................................................V..S...........................................S.......IY...L.................I....Q.....QF..............K..T......T....V.  90.23 %
VIM-51 .F.LL.K....L...I..I.....F.VDS.......S...........................................................................................................V..............................................S.......IY...R..V..............I....Q.....QF..............K..T......T....V.  90.23 %
VIM-52 ........................................................................................................................................................................................................R.................................................................  99.62 %
VIM-53 ...........L...I..I.....F.VDS.......S...........................................................................................................V..............................................S.......IY...R.................I....Q.....QF..............K..T......T......  92.48 %
VIM-54 ...................................................................................................................................................S........................................................R.............................................................  99.25 %
VIM-55 ...............................................................................................................................................................................................K............R.......................R.....................................  98.87 %
VIM-56 .FTLL.K....L...I..I.....F.VDS.......S...........................................................................................................V..............................................S.......IY...R....G............I....Q.....QF..............K..T......T....V.  89.85 %
VIM-57 ...........................................................................................................................................................................I..............................................................................................  99.62 %
VIM-58 .F.FL.K....L...I..I.....F.VDS.......S...........................................................................................................V..............................................S.......IY...R....G............I....Q.....QF..............K..T......T....V.  90.23 %
VIM-59 ....................................................................................................................................................................................................................................R.....................................  99.62 %
VIM-60 .F.LL.K....L...I..I.....F.VDS.......S...........................................................................................................V..............................................S.......IY...L.................I....QR....QF..............K..T......T....V.  90.23 %
VIM-61 .FQ-.R.F..GIS.F....LGSA.Y.AQ.G......DD.........K.G..........KLGDT..S........A...............V................SI.......................T..L..Q....A...V.A...KA......V.......V........G........AVR..F.......A.RE...Y....N.....ATIK...QR.................E.....T....T..V.P...  76.69 %
VIM-62 .F.LL.K....L...I..I....VF.VDS.......S...........................................................................................................V..............................................S.......IY...R.................I....Q.....QF..............K..T......T....V.  90.23 %
VIM-63 .F.LL.K....L...I..I.....F.VDS.......S...........................................................................................................V..............................................S.......IY...R.................I..L.Q.....QF..............K..T......T....V.  90.23 %
VIM-64 ............................................................................................................................................................................................................L.............................................................  99.62 %
VIM-65 .F.LL.K....L...I..I.....F.VDS......AS...........................................................................................................V..............................................S.......IY...R..V..............I....Q.....QF..............K..T......T....V.  89.85 %
VIM-66 .F.LL.K....L...I..I.....F.VDS.......S....................................................................................................L......V..............................................S.......IY...L.................I....QR....QF..............K..T......T....V.  89.85 %
VIM-67 .F.LL.K....L...I..I.....F.VDS......AS...........................................................................................................V..............................................S.......IY...R.................I....Q.....QF..............K..T......T....V.  90.23 %
VIM-68 ............................................................................................V.............................................................................................................................................................................  99.62 %
VIM-69 .FQ-FR.F..GIS.F....LGSA.Y.AQ.G......DD.........K.G..........KLGDT..S........A................................SI..........................L..Q....A...V.....KA......V.......V........G........AVR..F.......A.RE........N.....ATIK...QR.................E.....TD...T..V.P...  77.44 %
VIM-70 ............................................................................................................................................................................................................G.............................................................  99.62 %
VIM-71 .S....R..............S.S...A..................F....S..........N.T.........................................I...............D..............L....................A........................I......S...F.........R.................L....ER...............T...............I.....  91.73 %
VIM-72 .F.LL.K....L...I..I.....F.VDS.......S...........................................................................................................V..............................................S.......IY...R....T............I....Q.....QF..............K..T......T....V.  90.23 %
VIM-73 .F.LL.K....L...I..I.....F.VDS.......S...........................................................................................................V.....S........................................S.......IY...R.................I....Q.....QF..............K..T......T....V.  90.23 %
VIM-74 .F.LL.K....L...I..I.....F.VDS.......S...........................................................................................................V..............................................G.......IY...R.................I....Q.....QF..............K..T......T....V.  90.60 %
VIM-75 ...........................................................R..............................................................................................................................................................................................................  99.62 %
VIM-76 .F.LL.K....L...I..I.....F.VDS.......S...........................................................................................................L..............................................S.......IY...L.................I....QR....QF..............K..T......T....V.  90.23 %
VIM-77 .F.LL.K....L...I..I.....F.VDS.......S...........................................................................................................V..D...........................................S.......IY...R.................I....Q.....QF..............K..T......T....V.  90.23 %
VIM-78 ...........................................................R................................................................................................................................................R.............................................................  99.25 %
VIM-79 ..................................................................................................................................................................................................F.........R.............................................................  99.25 %
VIM-80 .F.LL.K....L...I..I.....F.VDS.......S...........................................................................................................V.....-........................................S.......IY...R.................I....Q.....QF..............K..T......T....V.  90.23 %
VIM-81 .F.LL.K....L...I..I.....F.VDS...H...S...........................................................................................................V..............................................S.......IY...R.................I....Q.....QF..............K..T......T....V.  90.23 %
VIM-82 .F.LL.K....L...I..I.....F.VDS.......S......................R....................................................................................V..............................................S.......IY...R....T............I....Q.....QF..............K..T......T....V.  89.85 %
VIM-83 .................................................................................................................................................K........................................................................................................................  99.62 %
VIM-84 .F.LL.K....L...I..I.....F.VDS.......S......................R....................................................................................V..............................................S.......IY...L.................I....Q.....QF..............K..T......T....V.  90.23 %
VIM-85 .F.LL.K....L...I..I.....F.VDS.......S......................R........................................................N...........................V..............................................S.......IY...L.................I....Q.....QF..............K..T......T....V.  89.85 %
VIM-86 ...............................................................................................................................................................................................K..........................................................................  99.62 %
VIM-87 .F.LL.K....L.T.I..I.....F.VDS.......S...........................................................................................................V..............................................S.......IY...R.................I....Q.....QF..............K..T......T....V.  90.23 %
B1-VIM phylogenetic tree

Last updated: November 20, 2024.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database was funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

Live statistics (since December 3rd, 2023)