Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
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Beta-Lactamase DataBase

Sequence alignment for the NDM beta-lactamase family

NDM-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.....
MELPNIMHPVAKLSTALAAALMLSGCMPGEIRPTIGQQMETGDQ-----RFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR
NDM-2 ...........................A................-----..................................................................................................................................................................................................................................  99.63 %
NDM-3 ............................................-----..................................................N...............................................................................................................................................................................  99.63 %
NDM-4 ............................................-----.............................................................................................................L....................................................................................................................  99.63 %
NDM-5 ............................................-----...........................................L.................................................................L....................................................................................................................  99.26 %
NDM-6 ............................................-----............................................................................................................................................................................................V.....................................  99.63 %
NDM-7 ............................................-----.....................................................................................N.......................L....................................................................................................................  99.26 %
NDM-8 ............................................-----.....................................................................................G.......................L....................................................................................................................  99.26 %
NDM-9 ............................................-----...........................................................................................................K......................................................................................................................  99.63 %
NDM-10 ...............................S...D........-----........................S....T.............................................................................................................................R......................................................................  98.15 %
NDM-11 ............................................-----.............................................................................................................V....................................................................................................................  99.63 %
NDM-12 ............................................-----.............................................................................................................L...................................................................D................................................  99.26 %
NDM-13 ............................................-----..................................................N..........................................................L....................................................................................................................  99.26 %
NDM-14 ............................................-----.....................................................................................G............................................................................................................................................  99.63 %
NDM-15 ............................................-----.............................................................................................................L..............................................................................V.....................................  99.26 %
NDM-16 ............................................-----...........................................................................................................................................................................................................................H......  99.63 %
NDM-16b ............................................-----...........................................L.................................................................L..............................................................................V.....................................  98.89 %
NDM-17 ............................................-----...........................................L.................................................................L...............K....................................................................................................  98.89 %
NDM-18 ............................................RFGDQ..................................................................................................................................................................................................................................  98.18 %
NDM-19 ............................................-----.....................................................................................N.......................L..............................................................................V.....................................  98.89 %
NDM-20 ............................................-----...........................................L.................................................................L...................................................................................................................H  98.89 %
NDM-21 ............................................-----........................S..................L.................................................................L....................................................................................................................  98.89 %
NDM-22 ............................................-----...........................................................................................................................................................................................................L......................  99.63 %
NDM-23 ............................................-----........................................................L.........................................................................................................................................................................  99.63 %
NDM-24 ............................................-----...........................................L......................................................................................................................................................................................  99.63 %
NDM-25 ............................................-----..........S.......................................................................................................................................................................................................................  99.63 %
NDM-26 ............................................-----...........................................L.................................................................L...................................................................S................................................  98.89 %
NDM-27 ............................................-----..................................................N.........................................................................................................................................V.....................................  99.26 %
NDM-28 ............................................-----.............................................................................................................................................................................................................................V....  99.63 %
NDM-29 ............................................-----.....................................................................................N............................................................................................................................................  99.63 %
NDM-30 ............................................-----..................................................................................................................................................................................Y...............................................  99.63 %
NDM-31 ............................................-----..............................................................................................................................T...................................................................................................  99.63 %
NDM-33 ............................................-----...........................T...............L.................................................................L....................................................................................................................  98.89 %
NDM-34 ............................................-----....M....I.................................L......................................................................................................................................................................................  98.89 %
NDM-35 ............................................-----.......................................D...L.................................................................L....................................................................................................................  98.89 %
NDM-36 ............................................-----...........................................L.................................................................L..............................................................................V...........................Y.........  98.52 %
NDM-37 ............................................-----...........................................L.................................................................L..........................................................................................................Y.........  98.89 %
NDM-38 ..........................V.................-----..................................................................................................................................................................................................................................  99.63 %
NDM-39 ...L........................................-----...........................................L.................................................................L....................................................................................................................  98.89 %
NDM-40 ...R........................................-----..................................................................................................................................................................................................................................  99.63 %
NDM-41 ............V...............................-----...........................................L.................................................................L....................................................................................................................  98.89 %
NDM-42 ...........................L................-----..................................................................................................................................................................................................................................  99.63 %
NDM-43 ............................................-----.................................................................................................................................................................................................................N............N...  99.26 %
NDM-44 ............................................-----..............................................................................................................................................................................................................................N...  99.63 %
NDM-45 ............................................-----...........................................L.........................................A.......................L....................................................................................................................  98.89 %
NDM-46 .................V..........................-----...........................................L.................................................................L....................................................................................................................  98.89 %
NDM-47 ............................................-----..........................................................................................................L.......................................................................................................................  99.63 %
NDM-48 ...........................H................-----...........................................L.................................................................L....................................................................................................................  98.89 %
NDM-49 ............................................-----...........................................L.................................................................L........................R...........................................................................................  98.89 %
NDM-50 .....................I......................-----.....................................................................................N.......................L....................................................................................................................  98.89 %
NDM-51 ............................................-----...........................................L.................................................................L.................................................................................................D..................  98.89 %
NDM-52 ............................................-----.....................................................................................A............................................................................................................................................  99.63 %
NDM-53 ...............................H............-----...........................................L.................................................................L....................................................................................................................  98.89 %
NDM-54 ...............................L............-----..................................................................................................................................................................................................................................  99.63 %
NDM-55 ............................................-----...........................................L..........T......................................................L....................................................................................................................  98.89 %
NDM-56 ............................................-----............T.............................RL.................................................................L.......................................................................................Q...........E.............T..  97.41 %
NDM-57 .G..........................................-----...........................................L.................................................................L....................................................................................................................  98.89 %
NDM-58 ............................................-----............................................................................................................................................S.....................................................................................  99.63 %
NDM-60 ............................................-----...........................................L.................................................................L...............................................N....................................................................  98.89 %
NDM-61 ............................................-----.....................................................................................G......................................................................................................V.....................................  99.26 %
NDM-64 ...................V........................-----..................................................................................................................................................................................................................................  99.63 %
NDM-65 ............................................-----.................................................................................................................................................................................S................................................  99.63 %
NDM-66 ............................................-----..................................L........L.................................................................L....................................................................................................................  98.89 %
NDM-67 ............................................-----...........................V...............L.................................................................L....................................................................................................................  98.89 %
NDM-68 ............................................-----...........................................L....................L............................................L....................................................................................................................  98.89 %
B1-NDM phylogenetic tree

Last updated: November 20, 2024.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database was funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

Live statistics (since December 3rd, 2023)