Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
Beta-Lactamase DataBase - Structure and Function Home Enzymes Structures Mutants Kinetics BLAST
Beta-Lactamase DataBase

Sequence alignment for the IMP beta-lactamase family

IMP-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240........
MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN--
IMP-2 .K..F.LCVCFL...TA.GAR.........E..................S.........TD..........T......N...........T..................Q......................K......S..................Q.........K........V..D.........L........I.M...V......S....I.......R.W..............Q...--  85.37 %
IMP-3 ........................................................................................................G............................................................................................................G................................--  99.19 %
IMP-4 ....................P.....................................D..................................................Q......................K...G........................L............................L..........I...............A.........................L..--  95.93 %
IMP-5 ....F...M......TA..........................................T.................................................Q......................K.....AS.....K......................NRV......V............V..........M.......................R....................--  93.09 %
IMP-6 .....................................................................................................................................................................................................................G................................--  99.59 %
IMP-7 .K......M.......ASG.A......................................TD................................................Q......................K.....AS.....K...I..................HRV......V............L..........V.......................R..............L.....--  91.06 %
IMP-8 .K..F.LCVCFL...TA.GAA.........E..................S.........TD..........T......N...........T..................Q......................K......S..................Q.........K........V..D.........L........I.M..........S....I.......R.W..............Q...--  85.77 %
IMP-9 ....F...M......TA.G.............................I..........TD..............N..N.......R......................Q......................KY.....S.....K...........A..........NRV......V............L..........M...S..........DI..S......W..T...F.....STTAH---  85.37 %
IMP-10 ................................................F.....................................................................................................................................................................................................--  99.59 %
IMP-11 .K..F.LC.......TA.GA..........E..................S.........TD.................N..............................Q.......V..............K......S..................Q........KN........V........D...V....H..EK.I....N.........DI.........W............SNTVH---  84.96 %
IMP-12 .K..F.LC....L..TASG.V.........E....L.......S.....T.........ND.........N.......A...G..FT....V.................Q................N............S.........I........Q.........N........V..D.....D...LK.......I.M..........SG...I.N.......W.......K.....LL...--  82.52 %
IMP-13 .K..F.LCVCF....TA.GAA.........E...F..............T.........TD..........T......N.......E...T..................Q................S.....KY...E.S..................Q..L......S...........H.........L........I.M..........S....K.....M.R.W...L...K....T.S...--  82.52 %
IMP-14 .K..F.LCV.F..N..V.E...........E............K..S..T........KND.......I.........N..............T...G...A.......Q.................N....KH..N..S.S.I..............Q.........K........V..D...Y.....L........I.M..........S...DI..V....R.W............S.Q..D--  81.30 %
IMP-15 .N......M.M....TA.G........................................T.................................................Q......................K.....GS....N.......................NRV......V............L........I.M..........S....T.N.......W.......K......L...--  89.84 %
IMP-16 .K..F.LC.......TA.G...........ED.................T.....F...TD........A........N.....................S........Q................N.....K......S...L.....I........Q.........K........V........D...V....H..EI.M.R..N.........D..........W.......K......Q...--  84.96 %
IMP-17 .K..F.LCVCF....TA.GAA.........E...F..............T.........TD..........T......N.......E...T..................Q................S.....KY.....S..................Q..L......SE..........H.........L........I.M..........S....K.....M.R.W...L...K....T.S...--  82.52 %
IMP-18 .K..F.LCV.FL.N..A.DD..........EK...........K.....T........KND.......I.........N..I.H..R......T...G...A.......Q..S..............N...........S.S.I..............Q.........K........V..D.........L........I.M..........S....I.N....QR.W.............LQ..S--  80.49 %
IMP-19 .K..F.LCVCFL...TA.GAA.........E..................S.........TD..........T......N...........T..................Q......................K......S..................Q.........K........V..D.........L........I.M...V......S....I.......R.W..............Q...--  85.37 %
IMP-20 .K..F.LCVCFL...TA.GAA.........E.................FS.........TD..........T......N...........T..................Q......................K......S..................Q.........K........V..D.........L........I.M...V......S....I.......R.W..............Q...--  84.96 %
IMP-21 .K..F.LC.......TA.GA..........E.................AS.........TD.................N..............................Q.......V..............K......S..................Q........KN........V........D...V....H..EK.I....N.........DI.........W............SNTVH---  84.55 %
IMP-22 .K..F.LCV......TA.G...........E..................S.....I...TD................................................Q...........D...QN.....K......S..................Q.........K........V........D...VV...H..EI.M.R..N.........DI.........W.......K......E...--  85.37 %
IMP-23 .K..F.LCVCFL...TA.GAA.........E.................FS.........TD..........T......N...........T..................Q......................K......S..................Q.........K........V..D.........L........I.M..........S....I.......R.W..............Q...--  85.37 %
IMP-24 .K..F.LCVCFL...TA.GAA.........E..................S.........TD..........T......N...........T..................Q......................K......S..................Q.........K........V..D.........L........I.M..........S....I.......R.W..........R...Q...--  85.37 %
IMP-25 ..........................................................................................................................................................................................S..........................G................................--  99.19 %
IMP-26 ....................P...........................F.........D..................................................Q......................K...G........................L............................L..........I...............A.........................L..--  95.53 %
IMP-27 .K..F.LCV.V....TV.G.T..N.RV...E........Y...K.....T.......IG.D.................N...........TV.................Q......................K...D..S...A.D............Q.........KE.......V..H.........L....E...I.ME.........SG...T...TH..R.W.......K....TLQ...--  79.67 %
IMP-28 ....F...M......TA...........R..............................T......................G..........................Q......................K...G..S............................NRV......V............L..........M.......................R...H................--  92.28 %
IMP-29 ....F..L.......TA..........................................T.................................................Q................G.....K......S.....K......................NRV......V........D...V....H..EI.M.R..N.........DI.N.......W.......K......Q...--  88.62 %
IMP-30 ........................................K.............................................................................................................................................................................................................--  99.59 %
IMP-31 .K.IF.L.V......TA.G.....I.......D........KIT....IT.........TD..I..............R...G.................A........Q.......K........N.NA..E......S.....H............Q.........K...........D...Y.....L.......ET.M....N.....S....I.G.....R.W.......K...NHHS.K---  79.67 %
IMP-32 .K..F.LCV.F..N..V.E...........E............K..S..T........KND.......I.........N..............T...G...A.......Q.................N....KH..Y..S.S.I..............Q.........K........V..D...Y.....L........I.M..........S...DI..V....R.W............S.Q..D--  81.30 %
IMP-33 .K..F.LCVCF....TA.GS..........E...F..............T.........TD..........T......N...........T..................Q................S.....KY...E.S..................Q..L......S........V..H.........L........I.M..........S....K.......R.W...L...K....T.S...--  83.33 %
IMP-34 ........................................................................................................G.............................................................................................................................................--  99.59 %
IMP-35 .K.IF.L.V......TA.G.....I.......D.........D.....IT.........TD..I..............R...G.................A........Q.......K........N.NA..E......S.....H............Q.........K...........D...Y.....L.......ET.M....N.....S....I.G.....R.W.......K......Q.N.--  82.11 %
IMP-37 .K..F.LCVCF....TA.GAA.........E...F..............T.........TD..........T......N.......E...T..................Q................S.....KY...E.S..................Q..L......S...........H.........L........I.M..........S....K.....M.R.W...L...K....T.SQ.TAS  81.05 %
IMP-38 ....................P.....................................D..................................................Q......................K...G........................L............................L..........I...........G...A.........................L..--  95.53 %
IMP-39 .K..F.LCVCFL...TA.GAA.........E..................S.........TD..........T......N...........T..................Q......................KH.....S..................Q.........N........V..H.........L........I.M..........S....T.G.....R.W...L...K......P...--  84.15 %
IMP-40 ................................................F...................S.................................................................................................................................................................................--  99.19 %
IMP-41 .K..F.LC.......TA.GA..........E.................FS.........TD.................N..............................Q.......V..............K......S..................Q........KN........V........D...V....H..EK.I....N.........DI.........W............SNTVH---  84.55 %
IMP-42 ............................................R.........................................................................................................................................................................................................--  99.59 %
IMP-43 .K......M.......ASG.A...........................F..........TD................................................Q......................K.....AS.....K...I..................HRV......V............L..........V.......................R..............L.....--  90.65 %
IMP-44 .K..F.LC.......TA.GA..........E.................FS.........TD.......S.........N..............................Q.......V..............K......S..................Q........KN........V........D...V....H..EK.I....N.........DI.........W............SNTVH---  84.15 %
IMP-45 ....F...M......TA.G.............................I..........TD..............N..N.......R......................Q......................KY.....S.....K...........A..........NRV......V............L..........M...S.......G..DI..S......W..T...F.....STTAH---  84.96 %
IMP-46 .K..F.LCV..L.N....ED.......D..E............K..N..T........KND.......I.V.......N.L............T...D..SA.......Q.......R.....R..G..P......D..S.S.I..............Q.........K........V..D...Y.....L........I.M...A......S....I..T....R.W.............-------  78.46 %
IMP-48 .K..F.LCV.F..N..V.E...........E............K..S..T........KND.......T.........N..............T...G...A.......Q.................N....KH..N..S.S.I..............Q.........K........V..D...Y.....L........I.M..........S...DI..V....R.W............S.Q..D--  81.30 %
IMP-49 .K..F.LCV.FL.N..A.DD..........EK...........K....FT........KND.......I.........N..I.H..R......T...G...A.......Q..S..............N...........S.S.I..............Q.........K........V..D.........L........I.M..........S....I.N....QR.W.............LQ..S--  80.08 %
IMP-50 .K..F.LC....L..TASG.V.........E....L.......S.....T.........ND.........T.......A......FT....V.................Q................N............S.........I........Q.........N........V..D.....D...LK.......I.M..........S....I.N.......W.......K...Q.LL...--  82.93 %
IMP-51 .K......M.......ASG.A......................................TD................................................Q......................K.....AS.....K...I..................HRV......V............L..........V...........G...........R..............L.....--  90.65 %
IMP-52 ...............................................................I.............G........................................................................................................................................................................--  99.19 %
IMP-53 ....F...M......TA.G.............................I..........TD..............N..N.......R......................Q......................KY.....S.....K........S..A..........NRV......V............L..........M...S.......G..DI..S......W..T...F.....STTAH---  84.55 %
IMP-54 .K..F.LCV.F..N..V.E...........E............K..S..T........KND.......V.........N..............T...G...A.......Q.................N....KH..N..S.S.I..............Q.........K........V..D...Y.....L........I.M..........S...DI..V....R.W............S.Q..D--  81.30 %
IMP-55 ...........I..................E.........K..................................................................................................................................F............K.............................................................--  97.97 %
IMP-56 .K..F.LCV.FL.N..A.DD..........EK...........K.....T........KND.......I.........N..I.H..R......T...G...A.......Q..S..............N...........S.S.I..............Q.........K........V..D.........L........I.M..........SG...I.N....QR.W.............LQ..S--  80.08 %
IMP-58 .K..F.LCV......TA.G...........E.................FS.....I...TD................................................Q...........D...QN.....K......S..................Q.........K........V........D...VV...H..EI.M.R..N.........DI.........W.......K......E...--  84.96 %
IMP-59 ....................P.....................................D..................................................Q......................K...G........................L......................Y.....L..........I...............A.........................L..--  95.53 %
IMP-60 .......................................................................................................................................................................K..............................................................................--  99.59 %
IMP-61 ...........................................................................................................I..........................................................................................................................................--  99.59 %
IMP-62 .N......M.M....TA.G........................................T.................................................Q......................K.....GS....N.......................NRV......V............L........I.M..........SG...T.N.......W.......K......L...--  89.43 %
IMP-63 .K..F.LC....L..TASG.V.........E....L.......S.....T.........ND.........N.......A...G..FT....V.................Q................N............S.........I........Q.........N........V..D.....D...LK.......I.M..........S....I.N.......W.......K.....LL...--  82.93 %
IMP-64 .K..F.LCV.V....TV...T..N.RV...E........Y...K.....T.......IG.D.................N...........TV.................Q......................K...D..S...A.D............Q.........KE.......V..H.........L....E...I.ME.........SG...T...TH..R.W.......K....TLQ...--  80.08 %
IMP-65 .K..F.LCV.F..N..V.E...........E............K..S..T........KND.......I.........N..............T...G..AA.......Q.................N....KH..N..S.S.I..............Q.........K........V..D...Y.....L........I.M..........S...DI..V....R.W............S.Q..D--  80.89 %
IMP-66 ...............................................F......................................................................................................................................................................................................--  99.59 %
IMP-67 .K..F.LCV.V....TV.G.T..N.RV...E........Y...K.....T.......IG.D.................N...........TV.................Q......................K...D..S...A.D............Q.........KE.......V..H.........L....E...I.ME.........SG...T..STH..R.W.......K....TLQ...--  79.27 %
IMP-68 .K..F.LC.......TA.GA..........E..................S.........TD.................N..............................Q.......V..............K......S..................Q........KN........V........D...V....H..EK.I....N......G..DI.........W............SNTVH---  84.55 %
IMP-69 .K..F.LCVCFL...TA.GAT.........E..................S.........TD..........T......N...........T..................Q......................K......S..................Q.........K........V..D.........L........I.M..........S....I.......R.W..............Q...--  85.77 %
IMP-70 ...................................................................................................................................................................................................................................I..................--  99.59 %
IMP-71 .K..F.LCV.FL.N..A.DD..........EK...........K....FA........KND.......I.........N..I.H..R......T...G...A.......Q..S..............N...........S.S.I..............Q.........K........V..D.........L........I.M..........S....I.N....QR.W.............LQ..S--  80.08 %
IMP-73 .K......M.......ASG.A...........................A..........TD................................................Q......................K.....AS.....K...I..................HRV......V............L..........V.......................R..............L.....--  90.65 %
IMP-74 .K..F.LC.......TA.G...........ED................FT.....F...TD........A........N.....................S........Q................N.....K......S...L.....I........Q.........K........V........D...V....H..EI.M.R..N.........D..........W.......K......Q...--  84.55 %
IMP-75 .K..F.LCV.FL.N..A.DD..........EK...........K....FA........KND.......I.........N..I.H..R......T...G...A.......Q..S..............N...........S.S.I..............Q.........K........V..D.........L........I.M...............I.N....QR.W.............LQ..S--  80.49 %
IMP-76 ................................................A.....................................................................................................................................................................................................--  99.59 %
IMP-77 ................................................F......................................................................................................................................................S..............................................--  99.19 %
IMP-78 ................................................F....................................................................................................................................................................G................................--  99.19 %
IMP-79 ......................................................................................................................................................................................................R...............................................--  99.59 %
IMP-80 ................................................F....................................................................................................................................................................A................................--  99.19 %
IMP-81 ....F..CM......TA.G........................................TD..............................V.................Q......................K......S.......V.I..................NRV......V............L..........M..........................V.................--  91.46 %
IMP-82 ....F...M......TA.G........................................TD..............N..N..............................Q......................K......S.....K...........A..........NRV......V............L..........M...S..........DI..S......W..T...F..R..STTAH---  86.18 %
IMP-83 .K..F.LCV.FL.N..A.DD..........EK...........K.....T........KND.......V.........N..I.H..R......T...G...A.......Q..S..............N...........S.S.I..............Q.........K........V..D.........L........I.M..........S....I.N....QR.W.............LQ..S--  80.49 %
IMP-84 .K..F.LCVCF....TA.GAA.........E...F.............FT.........TD..........T......N.......E...T..................Q................S.....KY...E.S..................Q..L......S...........H.........L........I.M..........S....K.....M.R.W...L...K....T.S...--  82.11 %
IMP-85 ....F...M......TA..........................................T.................................................Q......................K.....AS.....K......................NRV......V............V..........M.......................R..................G.--  92.68 %
IMP-86 .K..F.LCV.F..N..V.E...........E...........AK.....T........KND.......V.........N..............T...G...A.......Q.................N....KH..N..S.S.I..............Q.........K........V..D...Y.....L........I.M..........S...DI..V....R.W............S.Q..D--  81.30 %
IMP-87 .K..F.LCV.F..N..V.E...........E...........AK.....T........KND.......I.........N..............T...G...A.......Q.................N....KH..N..S.S.I..............Q.........K........V..D...Y.....L........I.M..........S...DI..V....R.W............S.Q..D--  81.30 %
IMP-88 ................................................F.............................................................................H.......................................................................................................................--  99.19 %
IMP-89 .............N......P...........................F.........D..................................................Q......................K...G........................L............................L..........I...............A.........................L..--  95.12 %
IMP-90 .K..F.LC....L..TASG.V.........E....L.......S.....T.........ND.......S.T.......A......FT....V.................Q................N............S.........I........Q.........N........V..D.....D...LK.......I.M..........S....I.N.......W.......K...Q.LL...--  82.52 %
IMP-91 .K..F.LCV.F..N..V.E...........E...........AK..S..T........KND.......I.........N..............T...G...A.......Q.................N....KH..N..S.S.I..............Q.........K........V..D...Y.....L........I.M..........S...DI..V....R.W............S.Q..D--  80.89 %
IMP-92 .K.IF.L.V......TA.G.....I.......D........KIT....IT.........TD..I..............R...G.................A........Q.......K........N.NA..V......S.....H............Q.........K...........D...Y.....L.......ET.M....N.....S....I.G.....R.W.......K...NHHS.K---  79.67 %
IMP-93 .K..F.LC.......TA.G...........ED................FA.....F...TD........A........N.....................S........Q................N.....K......S...L.....I........Q.........K........V........D...V....H..EI.M.R..N.........D..........W.......K......Q...--  84.55 %
IMP-94 ....FI..M......TA...........R..............................T......................G..........................Q......................K...G..S............................NRV......V............L..........M.......................R...H................--  91.87 %
IMP-95 .K..F.LCVCF....TA.GAA.........E...F....Y...K.....T.......IG.D.................N...........TV.................Q......................K...D..S...A.D............Q.........KE.......V..H.........L....E...I.ME.........SG...T...TH..R.W.......K....TLQ...--  79.67 %
IMP-96 .K..F.LCVCFL...TA.GAA.........E..................S.........TD..........T......N...........T..................Q......................K......S..................Q.........K........V..D.........L........I.M..........SG...I.......R.W..............Q...--  85.37 %
IMP-97 ....................................................................................................................................K.................................................................................................................--  99.59 %
IMP-98 ....................................................................................................................................................................................................................S.................................--  99.59 %
IMP-99 .K..F.LCV.FL.N..A.DD..........EK...........K.....T........KND.......S.........N..I.H..R......T...G...A.......Q..S..............N...........S.S.I..............Q.........K........V..D.........L........I.M..........S....I.N....QR.W.............LQ..S--  80.49 %
IMP-100 .K..F.LC.......TA.G...........E....I............FN........DTD.................N..............................Q................N.....K......S.........I........Q.........N........V..D.....D...L........I.M..........S....I.N.......W.......K......L...--  86.18 %
IMP-101 ....F...M......TA..........................................T.................................................Q......................K.....AS.....K......................NRV......V............L..........M.......................R....................--  93.09 %
IMP-102 ....FI..M......TA...........R..............................TD.....................G..........................Q......................K...G..S............................NRV......V............L..........M.......................R...H................--  91.46 %
B1-IMP phylogenetic tree

Last updated: November 20, 2024.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database was funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

Live statistics (since December 3rd, 2023)