Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
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Beta-Lactamase DataBase

Sequence alignment for the BlaB beta-lactamase family

BlaB-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.........
MLKKIKISLILALGLTSLQAFGQENPDVKIEKLKDNLYVYTTYNTFNGTKYAANAVYLVTDKGVVVIDCPWGEDKFKSFTDEIYKKHGKKVIMNIATHSHDDRAGGLEYFGKIGAKTYSTKMTDSILAKENKPRAQYTFDNNKSFKVGKSEFQVYYPGKGHTADNVVVWFPKEKVLVGGCIIKSADSKDLGYIGEAYVNDWTQSVHNIQQKFSGAQYVVAGHDDWKDQRSIQHTLDLINEYQQKQKASN
BlaB-2 ..............................D.........................................................................................................................................................................................................R................  99.20 %
BlaB-3 .M..M.WA.V......G.N.....T.E.................................S.......S....E...N.......R........................KSL................D...................D..............H.......D...........G......FL................K..PNV.............TA........S..........  87.55 %
BlaB-4 ............................................................................................I.......................................................................................................................................T.........S..........  98.80 %
BlaB-5 ...RL.GL.V....F.G..V...Q...I..................K..........M..........S...........................................L......................K............NT......................D........V..G...................I.......PDV.............T.........SD.........  89.16 %
BlaB-6 .M.RL.GL.V....F.G..V...Q...I..................K..........M..........S...........................................L......................K............NT......................D........V..G......F............I.......PDV.............T.........S..........  88.76 %
BlaB-7 .M.GL.GL.V....F.G..V...Q...I..................K..........M.....I....S...........................................L......................K.............T......................D........V..G......F............I.......PDV.............T.........S..........  88.76 %
BlaB-8 .M.GL.GL.V....F.G..V...Q...I..................K..........M..........S...........................................L......................K.............T......................D........V..G......F............I.......PDV.............T.........S..........  89.16 %
BlaB-9 .M.GL.GL.V....F.G..V...Q...I..................K..........M..........S...........................................L......................K............NT......................D........V..G......F............I.......PDV.............T.........S..........  88.76 %
BlaB-10 .M.GL.GL.V....F.G..V...Q...I..................K..........M..........S...........................................L......................K.............T......................D........V..G......F............I.......PYV.............T.........S..........  89.16 %
BlaB-11 ........................................................................................................................................................................................................................................R................  99.60 %
BlaB-12 .M..M.WA.V......G.N.....T.E.................................S.......S....E...N.......R........................KSL.V..............D...................D......................D...........G......FL................K..PNV.............TA........S..........  87.55 %
BlaB-13 .M..M.WA.V......G.N.....T.E.................................S.......S....E...N.......R........................KSL.V..............D...................D......................D...........G...N..FL................K..PNV.............TA........S..........  87.15 %
BlaB-14 .M.N.MRA...VF.FM.FFM.............R......................................................................................................................................................................................................R................  94.38 %
BlaB-15 ...R..GL.V....F.G..V...Q...I..................K..........M..........S...........................................L......................K.............T......................D........V..G...................I.......PDV.............T.........SD.........  89.96 %
BlaB-16 .M.RL.GL.V....F.G..V........................SYK.V........I...............E.................................G..K........................E.......................................................F.............Y...........I.............K......S..........  90.76 %
BlaB-17 .................................R......................................................................................................................................................................................................R................  99.20 %
BlaB-18 .M.N.MRA...VF.FM.FFM..........D.........................................................................................................................................................................................................R................  94.38 %
BlaB-19 .M..M.WA.V......G.N.....T.E.................................S.......S....E...N.......R........................KSL................D...................D......................D...........G......FL................K..PNV.............TA........S..........  87.95 %
BlaB-20 .M.N.MRA...VF.FM.FFM.............R...............R......................................................................................................................................................................................R................  93.98 %
BlaB-21 ..................K......................................................................................................................................................................................................................................  99.60 %
BlaB-22 .M.RL.GL.V....F.G..V...Q...I..................K..........M......M...S...........................................L......................K.............T......................D........V..G...................I.......PDV.............T.........SD.........  88.76 %
BlaB-23 .M..M.WA.V......G.N.....T.E.................................S.......S....E...N.......R........................KSL................D...................D...I..................D...........G......FL................K..PNV.............TA........S..........  87.55 %
BlaB-24 .M.RL.GL.V....F.G..V...Q...I..................K..........M..........S...........................................L......................K.............T......................D........V..G...................I.......PDV.............T.........S..........  89.56 %
BlaB-25 .M.RL.GL.V....F.G..V...Q...I..................K..........M..........S...........................................L......................K.............T......................D........V..G...................I.......PDV.............T.........SD.........  89.16 %
BlaB-26 .M.RL.GL.V....F.G..V..........................K..........M..........S...........................................L......................K.............T......................D........V..G......F............I.......PDV.............T.........S..........  89.96 %
BlaB-27 .M.GL.GL.V....F.G..V...Q...I..................K..........M..........S...........................................L......................K.............T......................D........V..G......F............I.......PD..............T.........S..........  89.56 %
BlaB-28 .M.RL.GV.V....F.G..V...Q...I......E...........K..........M..........S.....................................F.....L....................................T......................D........V..G......F............I.......PDV.............T.........S..........  88.76 %
BlaB-29 .M.N.MRA...VF.FM.FFM..........D.................................................................................................................................................A.......................................................R................  93.98 %
BlaB-30 .M.N.MRA...VF.FM.FFM....................................................................................................................................................................................................................R................  94.78 %
BlaB-31 ......................................................................................................................................................................L.................................................................R................  99.20 %
BlaB-32 .................................R..............................................................................................................................................L.......................................................R................  98.80 %
BlaB-33 ............................................................................................I............................................................................................................................................................  99.60 %
BlaB-34 .M.GL.GL.V....F.G..V...Q...I..................K..........M..........S.............................A.............L......................K.............T......................D........V..G...................I.......PDV.............T.........SD.........  88.76 %
BlaB-35 .M..M.WA.V......G.N.....T.E.................................S.......S....E...N.......R........................KSL................D...................D...............L......D...........G......FL................K..PNV.............TA........S..........  87.55 %
BlaB-36 .M.GL.GL.V....F.G..V...Q...I..................K..........V..........S...........................................L....................................T......................D........V..G...................I.......PDV.............T.........SD.........  89.56 %
BlaB-37 --MR..YV.......M...I...Q...I..................K..........M..........S...........................................L......................K............NT......................D........V..G......F............I.......PDV.............T.........S..........  89.16 %
BlaB-38 ......LT....F.F.............................SYK.V........M...............E.................................G..K........................E.......................................................F.........................I....................S..........  93.57 %
BlaB-39 .M.GL.GL.V....F.G..V...Q...I..................K..........M..........S......................................G....L......................K.............T......................D........V..G......F.......N....I.......PDV.............T.........S..........  88.35 %
B1-BlaB phylogenetic tree

Last updated: November 20, 2024.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database was funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

Live statistics (since December 3rd, 2023)