Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
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Beta-Lactamase DataBase

Sequence alignment for the BcII beta-lactamase family

BcII-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270........
-------MKKNTLLKVGLCVGLLGTIQFVSTISSVQASQKVEKTVIKNETGTISISQLNKNVWVHTELGSFNGEAVPSNGLVL--------NTSKGLVLVDSSWDDKLTKELIEMVEKKFQKRVTDVIITHAHADRIGGIKTLKERGIKAHSTALTAELAKKNGYEEPLGDLQTVTNLKFGNMKVETFYPGKGHTEDNIVVWLPQYNILVGGCLVKSTSAKDLGNVADAYVNEWSTSIENVLKRYRN----INAVVPGHGEVGDKGLLLHTLDLLK--
BcII-2 -------.-......L.V..S...ITP..........ERT..HK.........................Y...........I.--------......................D.A....KN...........................T...T...................AI.K..............................M.........A.......IT..................E.----..F......................--  88.72 %
BcII-3 -------.............S....T................QI.........................Y.............--------..............N..................................TA....................S...................T.......................Q..A.......AE..N..................M......----..L......K...............--  93.00 %
BcII-4 -------.-......L.V..S...ITP..........ER...HK.........................Y...........I.--------........................A....K.S..............................T...................AI.K..............................M.........A.......IT..................E.----..F......................--  89.88 %
BcII-5 -------.-......L.V..S...ITP..........ER...HK.........................C...........I.--------........................A....K.S..............................T...................AI.K..............................M.........A.......IT..................E.----..F......................--  89.88 %
BcII-6 MKERVEK.-......L.V..S...ITPI.........ERT..HK.........................Y...........I.--------........................A....K........................K......................I....AI.K.......I..................S.....A.......A........................T....----.............R.......E...--  86.36 %
BcII-7 -------........L.V..S..............K.E..L.QK.........................Y...V....S....--------T............................K.....................................................I..M....I..........................A.......AE..........................G.----M.L..........R..F........--  90.66 %
BcII-8 -------...KMM.......S...VS..A.AAFPA..AE...QKI...QE.A.......SH......MVY.............--------.....I..I..............KI....H.PI..A......V...........K..QV.......T..........IA..KDM..M....I................T......K..F........D.......V..F.DV.VG.VG..MS....----.KS......K....S..S......QAK  74.13 %
BcII-9 -------...KMM.......S...VS..A.ATFPA..VGNE.RN....QE.........SY......V.Y....T......I.--------........IE..............I....H.PI..A..................K.V.V.......T....Y.....IA..KEI..M........A............T......K..F.......AD............D...H.VGK.MS..K.----.KS..........SR..S.......SK  74.90 %
BcII-10 -------.............S...VS..A.A..P...VE.I.QK....AE.........SK......V.Y.......A.....--------......................................................K..Q............E..........K.I..M............................K..A.......AD................A..G..MN..K.----MKS......D.......I.......--  85.21 %
BcII-11 -------........I....S...AS..ATA..P...E.E..QK................H........Y...VT........--------..........................................E........................................I.SM.Y..........................K..A........E................G......N..G.----MIS......H...............--  87.94 %
BcII-12 -------........I....S...AS..ATA..P...E.E..QK.........................Y...V.........--------..........................................E.....M..................I...............I..M.Y.............................A........E................G......N..G.----MIS......H...............--  88.72 %
BcII-13 -------........I....S...AS..ATA..P...E.E..QK.........................Y...V.........--------..........................................E.....M..................I...............I..M.Y..........................K..A........E................G......N..G.----MIS......H...............--  88.33 %
BcII-14 -------......I......S...A............E....QK..........L..............Y........S....--------T.........................N................................................K.......I..M............................K..A.......AE.......................N..G.----..S..........R...........--  91.44 %
BcII-15 -------......I......S...A............E....QK..R.......L..............Y........S....--------T.....................K......K.....................................................I...............................K..A........E.......................N..K.----M.L.L........R...........--  91.05 %
BcII-16 -------......I......S...A............E....QK..........L..............Y........S....--------T.....................K......K.....................................................I...............................K..A........E.......................N..K.----M.L.L........R...........--  91.44 %
BcII-17 -------....S.....V..S...AT...........ERT..QK.........................Y.............--------..........................................................................D........I..M....I............D..........K..A.......AE................I......N..G.----M.L..........R...........--  89.88 %
BcII-18 -------....I........S...A.....V..P...ERT...K.........................Y...V.........--------T............................K.....................................................I..M....I..........................A.......AE.......................N..G.----M.L..........R...........--  90.66 %
BcII-19 -------.............S.........V..P...ERT...K.........................Y...V.........--------T............................K.....................................................I..M....I....................L.....A.......AE................I.........G.----M.L..........R...........--  91.05 %
BcII-20 -------.............S.........V..P...ERT...K.........................Y...V.........--------T............................K.....................................................I..M....I..........................A.......AE................I.........G.----M.L..........R...........--  91.44 %
BcII-21 -------..........V..S...LT.........K.E..L.QK.........................Y.............--------T................................................R........................D........I..M......I.....................K..A.......AE..........................G.----M.V.L....................--  90.66 %
BcII-22 MKERVEK..........V..S...LT.........K.E..L.QK......E..................Y.............--------T.........................................................................D........I..M............................K..A.......AE..........................G.----M.V.L....................--  88.64 %
BcII-23 -------........L.V..S....T.........K.E..L.QK..........L..............Y........S....--------T............................K.....................................................I...............................K..A.......AE.......................N..G.----M.S......DI..............--  90.27 %
BcII-24 -------........L.V..S....T.........K.E..L.QK..........L..............Y........S....--------T............................K.....................................................I..M..E.........................K..A.......AE................I......N..G.----M.S......D...............--  89.49 %
BcII-25 -------........L.V..S....T.......F.K.E..L.QK..........L..............Y........S....--------T...............................................M.........................D........I..M............................K..A.......AE.......................N..G.----..S..........R...........--  89.88 %
BcII-26 -------........L.V..S....T.........K.E..L.QK..........L..............Y........S....--------T..................................................................................I...............................K..A.......AE.......................N..G.----..S..........RE..........--  91.05 %
BcII-27 -------........L.V..S....T.........K.E.ML..K.........................Y....T........--------...........................................................................D.......I..................................A.......AG................I.......L.G.----M.L..........R...........--  91.44 %
BcII-28 -------.-......L.V..S...ITP..........ERT..HK.....P...................Y.S...........--------.............................K..................M.................................S................................Q..A.......A.S.........................G.----..L..........R...........--  90.27 %
BcII-29 -------........L.V..S....T.........K.E.ML..K.........................Y....T........--------...........................................................................D.......I..................................A.......AG................I.........G.----M.L..........R...........--  91.83 %
BcII-30 -------........L.V..S....T.........K.E..L.QK..........L..............Y........S....--------T............................K.....................................................I..M....I.......................K..A.......ADS.G................G...N..G.----MKL..........R...........--  88.33 %
BcII-31 -------....I.....V..S..............K.E..L.QK.........................Y...V.........--------...................................................................................I..M....I..........................A.......AE................I......N..G.----T.S......DI..........N...--  90.66 %
BcII-32 -------....I.....V..S..............K.E..L.QK.........................Y...V.........--------..........................................T........................................I..M....I..........................A.......AE................I......N..G.----T.S......DI..........N...--  90.27 %
BcII-33 -------....I.....V..S..............K.E..L.QK.........................Y...V.........--------.......................................................D...........................I.......I..........................A.......AE................I.........G.----T.L..........R...........--  91.83 %
BcII-34 -------....I.....V..S..............K.E..L.QK.........................Y...V.........--------..................................................M................................I.......I..........................A.......AE................I......N..G.----M.L..........R...........--  91.44 %
BcII-35 -------....I.....V..S..............K.E..L.QK.........................Y...V.........--------..................................................M................................I.......I..................G.......A.......AE................I......N..G.----M.L..........R...........--  91.05 %
BcII-36 -------..........V..S..............K.E..L.QK.........................Y...V.........--------.............................K................................V....................I..M....I..........................A.......AE................I.V.......G.----T.L..........R...........--  91.05 %
BcII-37 -------....I.....V..S..............K.E..L.QK.........................Y...V.........--------.............................K................................V....................I..M....I..........................A.......AE................I......N..G.----T.S..........R...........--  90.66 %
BcII-38 -------....I.....V..S..............K.E..L.QK.........................Y...V.........--------T............................K................................V....................I..M....I..........................A.......AE.......................N..G.----M.L..........R...........--  90.66 %
BcII-39 MKERVEK....I.....V..S..............K.E..L.QK.........................Y...V.........--------T............................K................................V....................I..M....I..........................A.......AE................I......N..G.----M.L..........R...........--  87.88 %
BcII-40 -------........L.V..S....T.........K.E..L.QK.........................Y...V....S....--------T..N.........................K.....................................................I..M....I..........................A.......AE.......................N..G.----M.L..........R...........--  89.88 %
BcII-41 -------........L.V..S..............K.E..L.QK.........................Y...V.........--------...................................................................................I..M....I..........................A.......AE................I.........G.----M.L..........R...........--  91.83 %
BcII-42 -------........L.V..S..............K.E..L.QK.........................Y...V.........--------.............................K.....................................................I..M....I..........................A.......AE.......................N..G.----M.L..........R...........--  91.44 %
BcII-43 -------.............S....T................QI.......................................--------.................................................................................................................................-----......................----..V.........N............--  95.72 %
BcII-44 -------.-......L.V..S...ITP..........ERT..HK.....A...................Y.S...........--------.............................K.....A............M.................................S................................Q..A.......A.S.........................G.----..L.....E....R...........--  89.49 %
BcII-45 ---------M.S.....V..S...AT.........K.E..L.QK.........................Y...V.........--------T............................K..................T...T........................I.....I..................................A.......AE..........................G.ININ..S..........R...........--  88.12 %
BcII-46 -------..MHS.....V..S...AT...........ERT..QK..........L..............Y...V.........--------T............................K...............................................I.....I..................................A.......AE..........................G.IN--..S..........R...........--  89.58 %
BcII-47 -------..MHS.....V..S...AT...........ERT..QK..........L..............Y...V.........--------T............................K.....................................................I.K................................A.......AE..........................G.IN--..L.........NR...........--  89.19 %
BcII-48 MKEGGEK..MHS.....V..S...AT...........ERT..QK..........L..............Y...V.........--------T............................K.....................................................I.K................................A.......AE.......................I..G.IN--..L.........NR...........--  86.47 %
BcII-49 -------.-......L.V..S...ITP..........ERT..HK.........................Y.S...........--------.............................K..................M.................................S................................Q..A.......A.......IT..................G.----..L..........R...........--  90.27 %
BcII-50 -------.-......L.V..S...ITP..........ERT..HK.........................Y.S...........--------.............................K..................M.................................S................................Q..A.......A.......IT..................G.----..L..S.......R...........--  89.88 %
BcII-51 -------.-......L.V..S...ITPI.........ERT..HK.........................Y...........I.--------........................A....K........................K................................N....................I.........A.......A........T..................G.----..L..........R...........--  89.88 %
BcII-52 -------.-......L.V..S.....P..........ERT..HK.........................Y.S...........--------I............................K..................M.......................R.........S................................Q..A.......A.S.........................G.----..L..........R...........--  90.66 %
BcII-53 -------.-......L.V..S...ITP..........ERT..HK.....A...................Y.S...........--------I............................K..................M.................................S................................Q..A.......A.S.......................Q.G.----..L..........R...........--  89.49 %
BcII-54 MKERVEKI-......L.V..S...ITP..........ERT..HK.........................Y.S...........--------.............................K..................M.................................S................................Q..A.......A.S.........................G.----..L..........R...........--  87.88 %
BcII-55 -------.-......L.V..S...ITP..........ERT..HK.....A...................Y.S...........--------.............................K..................M.................................S................................Q..A.......A.S......V..................G.----..L..........R...........--  89.88 %
BcII-56 -------.-......L.V..S...ITP..........ERT..HK.........................Y.S...........--------.............................K..................M.................................S................................Q..A.......A.S.........................G.----..L..........R...........--  90.66 %
BcII-57 -------.-......L.V..S...ITP..........ERT..HK.....A...................Y.S...........--------.............................K..................M.................................S................................Q..A.......A.S.........................G.----..L..........R...........--  90.27 %
BcII-58 -------.-......L.V..S....T...........ERT..QK...................I.....Y.............--------T............................K.S..............................T......................K.............E...............Q..A.......A.S.........................G.----..L..........R...........--  90.27 %
BcII-59 -------.-......L.V..S....T...........ERT..QK...................I.....Y.............--------T............................K.S.....................................................K.............E...............Q..A.......A.S.........................G.----..L..........R...........--  90.66 %
BcII-60 -------.-......L.V..S....T...........ERT..QK.........................Y.............--------T............................K............S.......................................RI..................................A.......AE..N.......................G.----.........D...R...........--  91.05 %
BcII-61 -------.-......L.V..S....T...........ERT..QK.........................Y.............--------T............................K................................................A....I.K................................A.......AE..........................G.----.............R...........--  91.83 %
BcII-62 -------.-......L.V..S....T...........ERT..QK.........................Y.............--------T............................K.....................................................I.K................................A.......A.................K.........G.----.............R...........--  92.22 %
BcII-63 -------.-......L.V..S....T...........ERT..QK.........................Y.............--------T............................K.....................................................I.K................................A.....E.A.................K.........G.----.........................--  92.22 %
BcII-64 ------MK-..I...L.V..S....T........I..ERT..QKI......................V.Y.............--------TA................................................M................................I..................................A.......AE.......................T....----.............R...........--  89.92 %
BcII-65 ------ME-..I...L.V..S....T...........ERT..QKI........................Y.............--------T............................K....................M................................I..................................A.......AE..N.........................----.IS..........R...........--  89.92 %
BcII-66 -------..N.....L.V..S....T...........E..L..K.....S..........H........Y.............--------T............................K.........................................S..........SI..................................A.......A...........................G.----..S......G..ERD..........--  90.66 %
BcII-67 -------..........V..S....T.........K.E..L.QK.....A...................Y.............--------T...............................................M.............V........G...........I..................................A.......A.S..............PI.........G.----..S......G...RD..........--  90.27 %
BcII-68 -------........L.V..S....T.........K.E..L.QK.....A...................Y.............--------T...............................................M.............V........S...........I..................................A.......A.S..............PI...........----..S......G...RD..........--  90.27 %
BcII-69 -------........L.V..S....T.........K.E..L.QK.....A...................Y.............--------T...............................................M.............V........S...........I..................................A.......A.S..............PI.........G.----..S......G...RD..........--  89.88 %
BcII-70 -------........L.V..S....T.........K.E..L.QK.....A...................Y.............--------T...............................................M.............V........S...........I..................................A.......A.S...............I.........G.----..S......G...RD..........--  90.27 %
BcII-71 --------M.T....L.V..S......L...V...K.EHTL.QK.....A...................Y.S...........--------T............................K...........................R.........................I..................................A.......A........................T....----.............R...........--  89.88 %
BcII-72 --------M......L.V..S......L...V...K.E..L.QK.V.......................Y.............--------.....V.......................K......................I..............................I.K.............................K..A.......V........................T....----.............R...........--  90.66 %
BcII-73 --------M......L.V..S......L...V...K.E..L.QK.V.......................Y.............--------T....V.......................K......................I..............................I.K.............................K..A.......V........................T....----.............R...........--  90.27 %
BcII-74 -------.-......L.V..S...ITPI.........ERT..HK.........................Y...........I.--------........................A....K........................K......................I....AI.K.......I......................M.........A........T..................G.----..L..........R...........--  88.72 %
BcII-75 -------....I...L.V..S....T................QK.M...A...................Y.............--------T...............................................M.................A..........................I.....................Q..A.......AG............................----.IS..........R...........--  91.83 %
BcII-76 -------.-......L.V..S...ITPI.........ERT..HK.........................Y...........I.--------........................A....K........................K......................I....AI.K.......I................................A........T..................G.----..L..........R...........--  89.11 %
BcII-77 -------....I...L.V..S....T................QK.M...A...................Y.............--------T...............................................M.................A...E......................I.....................Q..A.......AE............................----.TS..........R...........--  91.44 %
BcII-78 -------....I...L.V..S....T................QK.M...A...................Y.............--------T..R.........................K..................M.................................S................................Q..A.......A.S.........................G.----..L..........R...........--  91.44 %
BcII-79 -------....I...L.V..S....T................QK.M...A...................Y...........I.--------T..R.........................K....................................A.....................................G.............A.......AD..........................G.----..L..........R...........--  91.44 %
BcII-80 -------....I...L.V..S....T................QK.M...A...................Y.............--------T............................K.C..................................A.....................................G.............A.......AD............................----..L..........R...........--  92.22 %
BcII-81 -------....I...L.V..S....T................QK.M...A...................Y.............--------T............................K....................................A.....................................G.............A.......AE............................----..L..........R...........--  92.61 %
BcII-82 -------....I...L.V..S....T................QK.M...A...................Y.............--------T............................K....................................A.....................................G.............A.......AD............................----..L..........R...........--  92.61 %
BcII-83 --------M......L.V..S...VT.....V...K.E..L.HKA..............N.......................--------.......................................................................S.....F............................................................................G.----..S..........R...........--  92.22 %
BcII-84 -------........L.V..S....T....AT...K.E..L.QK.........................Y...........I.--------.................................R.....................................T..........AI.........I.....................Q..A.......AD............................----.TS..........R...........--  90.27 %
BcII-85 -------.R......L.V..S....T.........K.EH.L.HK............H......I.....Y.............--------T............................K...............................................I..................................S.....A.......A........................T....----.............R.......E...--  91.05 %
BcII-86 -------.-......L.V..S...ITP..........ERT..HN.............F...........Y.S...........--------I............................K..................M.................................S................................Q..A.......A.S.......................Q.G.----..L..........R...........--  89.49 %
BcII-87 ----MEK........L.V..S...IT..I......K.E..L.QK.........................Y.............--------T............................K...................T.....................S...........I.S.....T.......................Q..A.......AE................V..G......K.----M.S......D...............--  87.69 %
BcII-88 -------..........V..S....T....AV...K.E..L.QKI...............H........Y.............--------I............................K................................V............K..........................................A.......A...........................GT----..S..........R...........--  91.05 %
BcII-89 -------...S......V..S.V.LT..G........E..L.QK.....A...................Y.............--------T....V.......................K................................T....................I...............................K..A.......A....................G..R...G.----.............R...........--  90.27 %
BcII-90 -------...S......V..S...LT..G........E.NL.QK.V...S..........H........Y.............--------T............................K................................T....................I..................................A.......A...........................GT----.........................--  91.05 %
BcII-91 --------M........V..S....M......F..K.E..L.QK.........................Y.............--------T............................K.........................................S..........SI...S..............................A.......AE................A.........G.----..S......................--  90.66 %
BcII-92 -------..........V..S...IT..M........E..L.QK.........................Y.............--------I............................K.....................................................I..................................A.......A...........................G.----.............R...........--  93.39 %
BcII-93 -------........L.V..S...IT.....V.....E..L.QK.....A...................Y.............--------T............................K.........................................S...........I..................................A.......AE................A.........G.----..S......................--  91.44 %
BcII-94 --------M......L.V..S...IT.........K.E..L.QK.........................Y.............--------T............................K........................................RY...........I.K.........M......................A.......AE..N.......................G.----.............R...........--  89.88 %
BcII-95 -------........L.V..S....T.........K.E..L.QK.........................Y.............--------T............................KQ....F...........................M...................I..................................A.......AE..........................G.----..............E..........--  91.83 %
BcII-96 -------........L.V..S....T.....V...K.E..L.QK.........................Y.............--------T............................K............S........................................I.K...E............................A.......AE..N.......................G.----.............R...........--  91.05 %
BcII-97 MKERVEK........L.V..S....T.....V...K.E..L.QK.........................Y.............--------T............................K.....................................................I.K...E............................A.......AE..N.......................G.----.........................--  89.39 %
BcII-98 -------...D....L.V..S....T.....F...K.E..L.QK.........................Y.............--------T............................K.....................................................I.K...E............................A.......AE..N.......................G.----.............R...........--  91.05 %
BcII-99 -------...D....L.V..S....T.....V...K.E..L.QK.........................Y.............--------T............................KQ....................................................I.K...E............................A.......AE..N.......................G.----.............R...........--  90.66 %
BcII-100 -------........L.V..S....T.....V...K.E..L.QK.........................Y.............--------T.......I....................KQ....................................................I.K...E............................A.......AE..N.......................G.----.............R...........--  90.66 %
BcII-101 --------M......L.V..S....T....A....K.E..L.QN.........................Y.............--------T............................K.....................................................I................R..............K..A...I...AE.......................Q....----..S..L.......R......V....--  89.49 %
BcII-102 --------M......L.V..S....T....A....K.E..L.QN.........................Y.............--------T............................K.....................................................I...............................K..A...I...AE.......................Q....----..S..........R......V....--  90.27 %
BcII-103 --------M......L.V..S....T....A....K.E..L.QK...................I.....Y.............--------T............................K.....................................................I...........A......................A........E..........................G.----.............R...........--  91.44 %
BcII-104 -------........L.V..S....T....V....K.E..L.QN.........................Y.............--------T............................K.....................................................I..................................A.......AE..N.......................G.----...........R.R...........--  91.83 %
BcII-105 --------M......L.V..S....T....A....K.E..L.QN.........................Y.............--------T............................K.....................................................I..................................A.......AE..........................G.----.............R...........--  91.83 %
BcII-106 -------............................................................................--------.......I.A.............................................................S....................................................................................----..S..........R...........--  98.05 %
BcII-107 -------............................................................................--------.......................................................................S.....F..............................................................................----..S..........R...........--  98.44 %
BcII-108 -------............................................................................--------.......................................................................S....................................................................................----..S..........R...........--  98.83 %
BcII-109 -------............................................................................--------.......................................................................S....................................................................................----................F........--  99.22 %
BcII-110 -------............................................................................--------.......................................................................S....................................................................................----.....L..........F........--  98.83 %
BcII-111 -------............................................................................--------.................................................TA.........................................................................................................----............N............--  98.83 %
BcII-112 -------............................................................................--------..A.......................................V.................................................................................................................----............N............--  98.83 %
BcII-113 MKERVDD............................................................................--------..A.........................................................................................................................................................----............N............--  96.59 %
BcII-114 MKERVDN............................................................................--------............................................................................................................................................................----............N............--  96.97 %
BcII-115 -------............................................................................--------.......................................................................S....................................................................................----..V.........N............--  98.83 %
BcII-116 -------............................................................................--------............................................................................................................................................................----..V.........N............--  99.22 %
BcII-117 -------.............S....T................QK.........................Y.............--------...............................C....V.......................G..........S...........I.S.....T.......................Q..A.......AE..N..................M......----..L..........R......W....--  91.83 %
BcII-118 MKERVDN.............S....T................QK.....K..........K........Y.............--------.......................................................................S...........I.S.....T....LH.................K..A.......AE..........................G.----..S..........R...........--  89.77 %
BcII-119 -------.............S....T................Q..........................Y.............--------..A.................................V.................................NS...........I.S.....T.......................Q..A.......AE..........................G.----..S......................--  93.39 %
BcII-201 -------.-......L.V..S...ITP..........ERT..HK.....A...................Y.S...........--------.............................K....................................A.....................................G.............A.......AD............................----..L..........R...........--  91.05 %
BcII-121 -------.............S....T.................K.........................Y.............--------...............................C.................TA.......V............S...........I.S.....T...A...................Q..A.......AE..........................G.----..S......................--  92.61 %
BcII-122 -------.............S....T................QK.........................Y.............--------...............................C.................TA....................S...........I.S.....T.......................Q..A.......AE..........................G.----..S......................--  93.00 %
BcII-123 -------.............S....T................QI.........................Y.............--------..............N..................................TA...................NS..........II.S.....T........E..............Q..A.......AE..........................G.----.........................--  92.22 %
BcII-124 -------.............S....T................QI.........................Y.............--------..............N..................................TA....................S..........II.S.....T........E..............Q..A.......AE..........................G.----..S......................--  92.22 %
BcII-125 -------...................................QI.........................Y.............--------..............N..................................TA...............Q...NS...........I.S.....T.......................Q..A.......AE..........................G.----..S......K...............--  92.61 %
BcII-126 -------...................................QI.........................Y.............--------..............N..................................TA...................NS...........I.S.....T.......................Q..A.......AE..........................G.----..S......................--  93.39 %
BcII-127 -------.............S....T................QI.........................Y.............--------..............N..................................TA...................NS...........I.S.....T.......................Q..A.......AE...................G......G.----..S......................--  92.22 %
BcII-128 -------.............S....T........A.......QI.........................Y.............--------..............N..................................TA...................NS...........I.S.....T......L................Q..A.......AE..........................G.----..S......................--  91.83 %
BcII-129 MKERVDN.............S....T........A.......QI.........................Y.............--------..............N..................................TA...................NS...........I.S.....T.......................Q..A.......AE..........................G.----..S......................--  89.77 %
BcII-130 -------...........................................R................................--------..A....................................................................S...........I.S.....T.......................K..A.......AE..........H..........M......----.SS..........R...........--  94.16 %
BcII-131 -------............................................................................--------.......................................................................S...........I.S.....T...................V...K..A.......AE..N.......H..........M......----..L..........R...........--  94.55 %
BcII-132 -------............................................................................--------.......................................................................S...........I.S.....T...................V...K..A.......AE..N..................M......----..L..........R...........--  94.94 %
BcII-133 -------..............................................................Y.............--------..A..............................................TA...K.V.............NS..........II.S.....T...........R...........Q..A.......AE..........................G.----..S......K...............--  92.22 %
BcII-134 -------..............................................................Y.............--------..A...........N.................R.....................................NS..........II.S.....T.......................Q..A.......AE..........................G.----..S......................--  93.77 %
BcII-135 MKERVDN..............................................................Y.............--------..A...........N.................I.....................................NS..........II.S.....T.......................Q..A.......AE..........................G.----..S......................--  91.29 %
BcII-136 -------..............................................................Y.............--------..T...........N......M..........I.....................................NS..........II.S.....T.......................Q..A.......AE..........................G.----..S......................--  93.39 %
BcII-137 -------..............................................................Y.............--------..T...........N......M..........I.....................................NS..........II.S.....T.......................QT.A.......AE..........................G.----..S......................--  93.00 %
BcII-138 -------..............................................................Y.............--------..A....................................................................S...................T.......................K..A.......AE..N..................M....G.----..S......................--  95.33 %
BcII-139 -------............................................................................--------.......................................................................S...................T.......................K..A.......AE..N..................M....G.----..S......................--  96.11 %
BcII-140 MKERVDD..............................................................Y.............--------..A.............................I.E...................................NS...................T.......................Q..A.......AE..........................G.----..S......................--  92.42 %
BcII-141 -------.............C..............................A.................Y.............--------..A...........................................................V........S...................T.......................Q..A.......AE..........................G.----..S.........G............--  94.55 %
BcII-142 -------..............................................................Y.............--------..A....................................................................S...................T.......................Q..A.......AE..........................G.----..S......................--  96.11 %
BcII-143 -------............................................A.................Y.............--------..A....................................................................S...................T.......................Q..A.......AE..........................G.----..S.........G............--  95.33 %
BcII-144 -------............................................A.................Y.............--------..A................................................................P...S...................T.......................Q..A.......AE..........................G.----..S.........G............--  94.94 %
BcII-145 --------M........V..S....T.........K.E..L.QK.....N....L..............Y...V.........TTSNGLVLT.......................I....K....................M................................I..................................A.......AG................I......N..G.----M.L..........R...........--  86.42 %
BcII-146 -------..........V..S....T....AV...K.E..L.QKI...............H........Y.............--------S............................K................................S.............................................I.........A.......A........................T....----.............R...........--  91.83 %
BcII-147 -------..........V..S...AT.L.......K.E..L.QK.V...S..........H........Y.............--------T............................K................................T....................I............................S.....A.......A...........................GT----.........................--  91.05 %
BcII-148 -------........L.V..S....T.....V...K.E..L.QK.........................Y.............--------T.......I....................KQ....................................................I.K...E............................A.......AE..N.......H...............G.----.............R...........--  90.27 %
BcII-149 -------...D....L.V..S....T.....V...K.E..L.QK.........................Y.............--------T............................KQ....................................................I.K...E............................A.......AE..N.......................G.----..V......Q...R...........--  89.88 %
BcII-150 -------...D....L.V..S....T.....V...K.E..L.QK.........................Y.............--------T............................KQ....................................................I.K...E............................A.......AE..N.......................G.----..V..........R...........--  90.27 %
BcII-151 -------.-......L.V..S....T...........ERT..QK.........................Y.............--------T............................K.....................................................I.K................................A.......A..........S......I.........G.----..........A..R...........--  91.44 %
BcII-152 -------.-......L.V..SV...T...........L....QK.........................Y.............--------T............................K....................M................................I..................................A.......AE..N.......................G.----..........G..R...........--  91.83 %
BcII-153 -------........L.V..S....T.........K.E..L.QK......................GV.Y.............--------T.........................N..K....................................A.....R...............................G.............A.......AD............................----..L..........R...........--  91.05 %
BcII-154 -------....I...L.V..S....T...........ERT..QK.M...A...................Y...........I.--------T..R.........................K....................................A.....................................G.............A.......AD..N.......................G.----..L..........R...........--  89.88 %
BcII-155 -------....I.....V..S..............K.E..L.QK.........................Y...V.........--------...............................C...................................................I..M....I..........................A.......AE................I......N..G.----T.S......DI..........N...--  90.27 %
BcII-156 -------..........V..S.........K....K.E..L.QK.........................Y...V.........--------.............................K................................V....................I..M....I..........................A.......AE................I.........G.----T.S......D...............--  91.05 %
BcII-157 -------......I......S...VT..S........ER...NKI........................Y.............--------................................................M.........................DQ.......I..M............................K..A.......AE.......................N..G.----..S..........R...........--  90.66 %
BcII-158 -------......I......S...VT..S........ER...NKI........................Y........S....--------T............................K.....................................................I...............................K..A.......AE.......................N..G.----..S......................--  91.44 %
BcII-159 -------..MHS.....V..S...AT...........ERT..QK.....I....L..............Y...V.........--------T............................K.....................................................I.K................................A.......AE..........................G.IN--..L.........NR...........--  88.80 %
BcII-160 MKERVDN.............S....T...............AQI.......................................--------.......................................................................S.....F..............................................................................----..S..........R...........--  93.94 %
BcII-161 -------.............S....T....M...........QI.........................Y.............--------..............N..................................TA....................S...................T.......................Q..A.......AE..N..................M......----..L......K....R.....W....--  91.83 %
BcII-162 -------.............S.I...................Q..........................Y.............--------..A................K...................................................S...................T.......................Q..A.......AE..........................G.----..S......................--  94.55 %
BcII-163 -------.............S....T........A.......Q..........................Y.............--------..A....................................................................S...................T.......................K..A.......AE..N..................M....G.----..S......................--  93.77 %
BcII-164 -------.............S....T...........L....QI.........................Y.............--------..............N........................................................S...................T.......................K..A.......AE..........................G.----..S......................--  94.16 %
BcII-165 -------............................................................................--------.................................................TA...................NS...........I.S.....T.......................Q..A.......AE..........................G.----..S......................--  94.94 %
BcII-166 -------..............................................................Y.............--------..A...........N.................I.....................................NS...........I.S.....T.......................Q..A.......AE..........................G.----..S......................--  94.16 %
BcII-167 -------.............S....T...........................................Y.............--------..A...........N.................I.....................................NS..........II.S.....T.......................Q..A.......AE........H.................G.----..S......................--  92.61 %
BcII-168 -------........L.V..S...IT.........K.E..L.QI.........................Y.............--------..............N..................................TA...................NS...........I.S.....T.......................Q..A.......AE..........................G.----..S......................--  90.27 %
BcII-169 -------.............S....T................QI.........................Y.............--------..............N..................................TA...................NS...........IMS.....T.......................Q..A.......AE..........................G.----..S......................--  92.22 %
BcII-170 -------.............S....T................QI.........................Y.............--------..............N..................................TA...................NS...........I.S.....T.......................Q..A........E....................D.....G.----..S......................--  92.61 %
BcII-171 -------.............S....T................QK.........................Y.............--------...............................C.................TA....................S...........I.S.....T.......................Q..A.......AE.........S................G.----..S......................--  92.61 %
BcII-172 --------M......L.VY.S...VT.....V...K.E..L.HKA..............N.......................--------...................................F..................................NS..........II.S.....T.......................Q..A.......AE..........................G.----..S......................--  88.72 %
BcII-173 -------.-......L.V..S.I.ITP..........ERT..HK.........................Y...........I.--------........................A....K.S..............................T...................AI.K.............................K..A.......AQ................V.........K.----M.S......D.......V..I....--  87.16 %
BcII-174 -------.-......L.V..S...ITP..........ERT..HK.........................Y......S....I.--------T.........................T..KN...........V...................T...................AI.K..............................M.........A.......IT..................E.----..L.........E............--  87.94 %
BcII-175 -------.-......L.V..S...ITP..........ERTI.HK.........................Y...........I.--------........................A....K.S..........................T...T....................IMK..............................M.........A.T......T..................E.----..L..........R...........--  88.33 %
BcII-176 -------.-......L.V..S...ITP..........ERT..HK.........................Y...........I.--------......................D.A....KN...............................T...................AI.KW.............................M.........A.......IT..................E.----..L......................--  88.72 %
BcII-177 -------.-......L.V..S...ITP..........ERT..HK.........................Y...........I.--------.......................IA....K.S..............................T...................AI.KW.............................M.........A.......IT..................E.----..F......................--  88.72 %
BcII-178 -------.-......L.V..S...ITP..........ERT..HK.........................Y......S....I.--------T.......................A....K.S..............................T...................AI.KW.............................M.........A.......IT..................E.----..L......................--  88.33 %
BcII-179 -------.-......L.V..S...ITP..........ERT..HK.........................Y...........I.--------.........E..............A....K.S..........................T...T...G...............AI.K..............................M.........A.......IT..................E.----..L...............Y......--  87.94 %
BcII-180 -------.-......L.V..S...ITP..........ERT..HK.........................Y...........I.--------........................A....K.S..............................T...................AI.K..............................M.........A.......IT..................E.----..L...............Y......--  89.11 %
BcII-181 -------.-......L.V..S...ITP..........ERT..HK.........................Y...........I.--------........................A....K.S..........................T...T...................AI.K..............................M.........A.......IT..................E.----..L...............Y......--  88.72 %
BcII-182 -------.-......L.V..S...ITP..........ER...HK.........................Y...........I.--------........................A....K.S..............................T...V...............AI.K..............................M.........A.......IT..................E.----..F......................--  89.49 %
BcII-183 -------.-......L.V..S...ITP..........ERT..HK.........................Y...........I.--------........................A....K.S..........................T...T................V..AI.K..............................M.........A.......IT..................E.----..F......................--  88.72 %
BcII-184 -------.-......L.V..S...ITP..........ERT..HK.................I.......Y...........I.--------........................A....K.S..........................T...T................V..AI.K..............................M.........A.......IT..................E.----..F......................--  88.33 %
BcII-185 -------.-......L.V..S...ITP..........ERT..HK.........................Y...........I.--------........................A....K.S.M........................T...T...................AI.K..............................M.........A.......IT..................E.----..F......................--  88.72 %
BcII-186 -------.-......L.V..S...ITP..........ERT..HK.........................Y...........I.--------........................A....K.S..........................T...T...................AI.K..............................M.........A.......IT..................E.----..F......................--  89.11 %
BcII-187 -------.-......L.V..S...ITP..........ERT..HK.........................Y...........I.--------........................A....K.S..........................T...T.......E...........AI.K..............................M.........A........T..................E.----..F......................--  89.11 %
BcII-188 -------.-......L.V..S...ITP..........ERT..HK.........................Y...........I.--------........................A....K.S..............................T.......E...........AI.K..............................M.........A.......IT..................E.----..F......................--  89.11 %
BcII-189 -------.-......L.V..S...ITP..........E.T..HK.........................Y...........I.--------........................A....K.S..............................T...................AI.K..............................M.........A........T..................E.----..F......................--  90.27 %
BcII-190 -------.-......L.V..S...ITP..........ERT..HK.........................Y...........I.--------........................A....K.S..............................T...................AI.K..............................M.........A........T..................E.----..F......................--  89.88 %
BcII-191 -------.-......L.V..S...ITP..........ERT..HK.........................Y...........I.--------T............................K.S..............................T...................AI.K..............................M.........A........T..................E.----..F......................--  89.88 %
BcII-192 -------.-......L.V..S...ITP..........ERT..HK.........................Y...........I.--------T.......................A....K.S..........................T...T...................AI.K..............................M.........A........T..................E.----..F......................--  89.11 %
BcII-193 -------.-......L.V..S...ITP..........ER...HK.........................Y...........I.--------........................A....KNS..........................T...T...................AI.K....Y.........................M.........A........T..................E.----..F......................--  89.11 %
BcII-194 -------.-......L.V..S...ITP..........ERT.AQK.........................Y...........I.--------T............................K.....I..................K...........................AI.K..............................M.........A........T..................E.----..F......................--  89.49 %
BcII-195 -------.-......L.V..S.....P..........ERT..HK.........................Y.S...........--------I............................K..................M...............................I.S................................Q..A.......A.S.........................G.----..L..........R...........--  90.66 %
B1-BcII phylogenetic tree

Last updated: November 20, 2024.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database was funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

Live statistics (since December 3rd, 2023)