Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
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Beta-Lactamase DataBase

Sequence alignment for the L2-A-like beta-lactamase family

L2-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300...
MLARRRFLQFSGAAVASSLALPLLARAAGKTAASAPTDAALTAATDFAALEKAVRGRFGVTLLDTASGRRIGHRQDERFPMCSTFKSVLAATVLSQAERQPALLDTRVPVRDADLLSHAPVTRRHAGKDMTVRDLCRATIITSDNTAANLLFGVVGGPPAVTAFLRSIGDAVSRTDRLEPELNSFAKGDPRDTTTPAAMAATLQRVVLGEVLQLASRQQLADWLIDNETGDACLRAGLGKLWRVRDKTGSNGEDARNDIAVLWPVAGGAPWVLTAYLQAGAISYEQRATVLAQVGRIADRLIG
L2-2 ..............................AT.N......I...S........CA..L.............................M...........M.....R....GE......................................................AS..T...S......................................P..........................R...G...........................................S..............  93.07 %
L2-3 ......V........................T................T....CA..L.........................................R..................................................................TS......S.....................G................P..........................R...G..........................................................  95.38 %
L2-4 ...........A..................AT.N......I...S........CA..L.............................M...........M.....R....GE......................................................AS..T...S......................................P..........................R...G...........................................S..............  92.74 %
L2-20 ..............................AS.R...E..I.T.N......M.CA..L............L................M...........M.....R..........T.................................................AS......S...........E.............M........D...P......S...................R...G...................LS.................N....G..............  90.10 %
L2-28 ...................V.........APTRA...E..I............CA..L..S.........V................M...........ARP...R............................................................AS..T...S...........E...........I.M...........RP.................E........R...G...........................................M..............  89.77 %
L2-43 ...............................T.N.....T.............CA..L............F................M...........T..................................................................AS......S...........E..........................P..........................R...G...................L...T.................Q.V.............E  93.07 %
L2-47 ..............A...............AS.R...E..I.T.N......M.CA..L............L................M...........A.....R.M...............................V..........................AS..T...S......M....E......................D...P......S...................R...G...................LS.............S...N....G..............  88.78 %
L2-49 ..............................AT.N......I...S........CA..L.............................M...........T.....R....GE......................................................AS..T...S......................................P..........................R...G...........................................S..............  93.07 %
L2-54 ...........A..................AT.N......I...S........CA..L.............S...............M...........M.....R....GE......................................................AS..T...S......................................P..........................R...G...........................................S..............  92.41 %
L2-79 ............................AA.TTAT.A...IS...........CA..L............V................M...........A.....R.....E......................................................AS..T...S......M.R..E.............GS.......Q...P..........................R...G...................R............R..Q.....Q.A..............  88.45 %
A-L2-A-like phylogenetic tree

Last updated: November 06, 2021.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database is funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu