Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
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Beta-Lactamase DataBase

Sequence alignment for the IMI beta-lactamase family

IMI-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290..
MSLNVKPSRIAILFSSCLVSISFFSQANTKGIDEIKDLETDFNGRIGVYALDTGSGKSFSYKANERFPLCSSFKGFLAAAVLKGSQDNQLNLNQIVNYNTRSLEFHSPITTKYKDNGMSLGDMAAAALQYSDNGATNIILERYIGGPEGMTKFMRSIGDKDFRLDRWELDLNTAIPGDERDTSTPAAVAKSLKTLALGNILNEREKETYQTWLKGNTTGAARIRASVPSDWVVGDKTGSCGAYGTANDYAVVWPKNRAPLIISVYTTKNEKEAKHEDKVIAEASRIAIDNLK
IMI-2 ....................................N....................................................................Y..........................................................................................................................................................................................  99.32 %
IMI-3 ......Q.......I...F.................N........V.................................................................................................................E.........................................S..........................................................................................  97.60 %
IMI-4 ............................................................................................................................................................................................................................................................................Y.......................  99.66 %
IMI-5 ..TTLRK.KP.F.LG.F.M...LY.Y..EN......N..KK..................A.R.................S.......K...FSE..........PN....A...EQ..P..E...........A.............V...........EE.....Y..................E..G....N........DS....................S...RE........T...............DD............Y..D....EEF.........KT.N  80.14 %
IMI-6 ..............I...F.................N........V.................................................................................................................E.........................................S..........................................................................................  97.95 %
IMI-7 .......................................K............................................................................................................................................................................................................................................................  99.66 %
IMI-8 ..I.A.K.KA.VFL.YF.IP...Y...D.NAM....K...G.G..V...............R.............................I.E.....K....P.....Q...E....................A...............N.......E............................G....N........DH..................................T.............................S......DE...E.......TH..  85.62 %
IMI-9 ....................................N..........................................................................................................................................................V...................................................................................D................  98.97 %
IMI-12 ....................................N..............................................................................................................................................................................................................................................D................  99.32 %
IMI-13 ....A.....G........L................S........................R....................................S...........................................F................EV..........................IG...EN.......S..................T................................................Q.....D................  94.18 %
IMI-14 .................................................................................................................................................................................................................................................................................M..................  99.66 %
IMI-15 ............................................................................................................................................................................................................................................................................TK......................  99.32 %
IMI-16 .................................D..N..............................................R......S..........T.........................................................E..................................I......S..................................................................Y.......................  96.92 %
IMI-17 ........K.....I...F.................N........V.................................................................................................................E.........................................S..........................................................................................  97.60 %
IMI-18 .................................D..N..............................................R......S....................................................................E..................................I......S..................................................................Y.......................  97.26 %
IMI-19 .................................D..N......................T.......................R......S..........T.........................................................E..................................I......S..................................................................Y.......................  96.58 %
IMI-20 ................F...................N....................................................................Y..........................................................................................................................................................................................  98.97 %
IMI-21 ..........G........L................S........................R....................................S............................................................EV..........................IG...EN.......S..................T................................................Q.....D................  94.86 %
IMI-22 .LF.S.....S..L..F.I....S..V.AS......K......................................................I..V...................E..................A...........................................................N........DH...I....................N..............................................N..L...T.....K...  91.44 %
IMI-23 .L..T...I....L.YF.IP........AS......K..................................A...................I.......A..............E.......................................................................................SH.R.I..........................................................A........N......T.....K...  92.12 %
IMI-24 ..I.E.K.KS.VF..FF.IP...Y...D.NAM....K...G.G..V...............R.............................I.E.....KKN..P.....Q...E....................A...............N.......E.........A..................G....N........DH..................................T.............................S......DE...E.......TH..  84.93 %
A-IMI phylogenetic tree

Last updated: November 16, 2022.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database is funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu