Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
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Beta-Lactamase DataBase

Sequence alignment for the CRH beta-lactamase family

CRH-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280..........
MFKHLILFASLAAPLTQAVAADPLAVAADKLAKLERDFGGSIGVYAIDTGSGATVANRPNERFPMCSSFKGFLAAGVLAQSQDKPGLLDKRIRYSKAALPNWSPITTKHQASGMTVAELNAASVQYSDNGAANLLLKEINGPAALTAFMRSIGDASFRLDRREPELNSAIPGDPRDTSTPKAVAESAQKLALGKALPEPQRQQLADWLKGNTTGNARIRAAVPAGWEVGDKTGTCGVYGTANDFAVIWPPKRAPIVLAVYTKHAKKEAKHSDEVIAAAARAALEAFNVKK
CRH-2 ........................S.......................................L.................E.............T................................................................L.......V........................................................................................................................  97.93 %
CRH-3 .......L..IT............S.......................................L...............................T..........................................................R.....L........................................R.......................................................................................  96.90 %
CRH-4 ............T..S..L...............................................................A.............TT......L..Q...N.......S..T...............................TT.....L........................M.........AA................K........D...................Y.........................................L...S  92.41 %
CRH-5 ................................................................L.................QQ............T...........Q..N.................................................L........................M...........A........................................................................N..............K...  96.21 %
CRH-6 .......L...T............S.......................................L.................................................................................T..............L.........R......................................................................................................................  97.59 %
A-CRH phylogenetic tree

Last updated: November 06, 2021.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database is funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu