Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
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Beta-Lactamase DataBase

Sequence alignment for the BcI beta-lactamase family

BcI-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.........
---MKNKRMLKIGICVGILGLSITSLEAFTGESLQVEAKEKTGQVKHKNQATHKEFSQLEKKFDARLGVYAIDTGTNQTISYRPNERFAFASTYKALAAGVLLQQNSIDSLNEVITYTKEDLVDYSPVTEKHVDTGMKLGEIAEAAVRSSDNTAGNILFNKIGGPKGYEKALRHMGDRITMSNRFETELNEAIPGDIRDTSTAKAIATNLKAFTVGNALPAEKRKILTEWMKGNATGDKLIRAGIPTDWVVGDKSGAGSYGTRNDIAVVWPPNRAPIIIAILSSKDEKEAIYDNQLIAEATKVIVKALR
BcI-2 MIVL...K.....M............VT...GA...............................................A..........................TKK.D.........................T..........Y..........H.............Q....V...D...............................A.....NH..N...K...............V..N...A...............I....................G.T.........AE...N.F.  88.35 %
BcI-3 ---....K.....M............VT...GA...............................................A..........................TKK.D.........................T..........Y..........H.............K....V...D........................R...D........HQ..N...................V.....DA...............I......S...............T......K..AE.VID.IK  88.24 %
BcI-4 MMIL...........................GA......Q..........................V................S.........................T......F........................................................K....V...D.....................R.......................................V......................I......................S..........E......K  93.53 %
BcI-5 ---..........M........V........GA..................................................H.........................T.....KF..........................................H.............QI...V...D........................S....................................V....I.................I......................T.........PE....S.K  92.81 %
A-BcI phylogenetic tree

Last updated: November 06, 2021.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database is funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu