Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
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Beta-Lactamase DataBase

Sequence alignment for the BKC-GPC-like beta-lactamase family

BKC-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310...
MTITFSRRQAIAGALLAVPAVSTLAASAGALLAVPAVSTLAASAGAATGGPLEKRLAELEGRHKGRIGVAIHNLATGARIGHRADERFLMCSTFKALLAAHILARVDRKEETLDRRIVVGKSDLVDWSPVVETRVGGEGISIAELCEAAITLSDNAAANLLLSASGGPKAVTQFLRGFGDDVTRLDRTEPTLNYRETPDDERDTTTPAAMAETLRKLIIGDVLARGSKAQLAAWLVMNKTGDTRLRAGFPVDWTTGDKTGTNGDRHGNANDVAIAWSPDRGAVVVTAFCEIPGISGDERNAVIAEIGRIAAEA
BKC-2 .....................F........ATGGLLEKR...........L......................................................................................................................................................................................................................................................................  96.49 %
GPC-1 ....I.....M......I....A----------------.T.GTSR.A.EN.AQ...A..A..G..........S....L..NT...............G...V....G..........KEA..........K.I..DV.........T.............A.........A....L..E.............H...G........S..V....R.LFT...SAR.........I..............A..M..........KA.......V.........I.A..........................V  77.00 %
A-BKC-GPC-like phylogenetic tree

Last updated: November 06, 2021.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database is funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu