Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
Beta-Lactamase DataBase - Structure and Function Home Enzymes Structures Mutants Kinetics BLAST
Beta-Lactamase DataBase

Sequence alignment for the TEM beta-lactamase family

TEM-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......
-MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW
TEM-2-....................................K......................................................................................................................................................................................................................................................... 99.65 %
TEM-3-....................................K................................................................K.....................................................................................................................................S.................................................. 98.95 %
TEM-4-..................F..................................................................................K.....................................................................................................................................S........................M......................... 98.60 %
TEM-5-.................................................................................................................................................................S........................................................................T.K................................................. 98.95 %
TEM-6-.....................................................................................................K...........................................................H............................................................................................................................ 99.30 %
TEM-7-....................................K............................................................................................................................S............................................................................................................................ 99.30 %
TEM-8-....................................K................................................................K...........................................................S.........................................................................S.................................................. 98.60 %
TEM-9-..................F..................................................................................K...........................................................S..................................................................................................M......................... 98.60 %
TEM-10-.................................................................................................................................................................S..........................................................................K................................................. 99.30 %
TEM-11-....................................K............................................................................................................................H............................................................................................................................ 99.30 %
TEM-12-.................................................................................................................................................................S............................................................................................................................ 99.65 %
TEM-15-.....................................................................................................K.....................................................................................................................................S.................................................. 99.30 %
TEM-16-....................................K................................................................K...........................................................H............................................................................................................................ 98.95 %
TEM-17-.....................................................................................................K........................................................................................................................................................................................ 99.65 %
TEM-19-...........................................................................................................................................................................................................................................S.................................................. 99.65 %
TEM-20-...................................................................................................................................................................................T.......................................................S.................................................. 99.30 %
TEM-21-....................................K................................................................K................................................R....................................................................................S.................................................. 98.60 %
TEM-22-....................................K................................................................K....................................................................................................................................GS.................................................. 98.60 %
TEM-24-....................................K................................................................K...........................................................S........................................................................T.K................................................. 98.25 %
TEM-26-.....................................................................................................K...........................................................S............................................................................................................................ 99.30 %
TEM-28-.................................................................................................................................................................H..........................................................................K................................................. 99.30 %
TEM-29-.................................................................................................................................................................H............................................................................................................................ 99.65 %
TEM-30-................................................................................................................................................................................................................................................S............................................. 99.65 %
TEM-31-................................................................................................................................................................................................................................................C............................................. 99.65 %
TEM-32-..................................................................I................................................................................................................T.......................................................................................................... 99.30 %
TEM-33-..................................................................L........................................................................................................................................................................................................................... 99.65 %
TEM-34-..................................................................V........................................................................................................................................................................................................................... 99.65 %
TEM-35-..................................................................L............................................................................................................................................................................................................D.............. 99.30 %
TEM-36-..................................................................V............................................................................................................................................................................................................D.............. 99.30 %
TEM-37-..................................................................I............................................................................................................................................................................................................D.............. 99.30 %
TEM-39-..................................................................L...............................................................................................R............................................................................................................D.............. 98.95 %
TEM-40-..................................................................I........................................................................................................................................................................................................................... 99.65 %
TEM-43-.....................................................................................................K...........................................................H.................T.......................................................................................................... 98.95 %
TEM-45-..................................................................L...........................................................................................................................................................................................................Q............... 99.30 %
TEM-47-...........................................................................................................................................................................................................................................SK.......................M......................... 98.95 %
TEM-48-..................F........................................................................................................................................................................................................................SK.......................M......................... 98.60 %
TEM-49-..................F........................................................................................................................................................................................................................SK.......................M..G...................... 98.25 %
TEM-52-.....................................................................................................K.............................................................................T.......................................................S.................................................. 98.95 %
TEM-53-..................F..............................................................................................................................................S............................................................................................................................ 99.30 %
TEM-54-................................................................................................................................................................................................................................................L............................................. 99.65 %
TEM-55-.......................................................................................................................................................................................................................E...................................................................... 99.65 %
TEM-57-.........................................................................................D.................................................................................................................................................................................................... 99.65 %
TEM-60-....................................K...........P....................................................K...........................................................S......................R...................................C......L.......................................................... 97.55 %
TEM-61-....................................K............................................................................................................................H..........................................................................K................................................. 98.95 %
TEM-63-..................F..................................................................................K...........................................................S.................T.......................................................................................................... 98.60 %
TEM-67-..................I.................K...........................................................................................................................................................................................................C............................................. 98.95 %
TEM-68-...........................................................................................................................................................................................................................................SK.......................M.........L............... 98.60 %
TEM-70-.........................................................................................................................................................................................................Q.................................................................................... 99.65 %
TEM-71-...........................................................................................................................................................................................................................................SK................................................. 99.30 %
TEM-72-....................................K..............................................................................................................................................T.......................................................SK................................................. 98.60 %
TEM-76-...............................................................................................................................G.............................................................................................................................................................. 99.65 %
TEM-77-..................................................................L.............................................................................................................................................................................S............................................. 99.30 %
TEM-78-..................................................................V...............................................................................................R............................................................................................................D.............. 98.95 %
TEM-79-................................................................................................................................................................................................................................................G............................................. 99.65 %
TEM-80-..................................................................L.........................................................V..................................................................................................................................................D.............. 98.95 %
TEM-81-..................................................................L.........................................................V................................................................................................................................................................. 99.30 %
TEM-82-..................................................................V...........................................................................................................................................................................................................Q............... 99.30 %
TEM-83-..................................................................L...............................................................................................C...........................................................................................................Q............... 98.95 %
TEM-84-...............................................................................................................................................................................................................................................................................D.............. 99.65 %
TEM-85-..................F..............................................................................................................................................S..........................................................................K.......................M......................... 98.60 %
TEM-86-..................F..............................................................................................................................................S........................................................................T.K.......................M......................... 98.25 %
TEM-87-...K.................................................................................................K..........................................................HC.................T.......................................................................................................... 98.25 %
TEM-88-.....................................................................................................K.............................................................................T.............D.........................................S.................................................. 98.60 %
TEM-90-................................................................................................................G............................................................................................................................................................................. 99.65 %
TEM-91-.................................................................................................................................................................C.................T........................................................K................................................. 98.95 %
TEM-92-...K.................................................................................................K.............................................................................T.......................................................S.................................................. 98.60 %
TEM-93-...................................................................................................................................................................................T.......................................................SK................................................. 98.95 %
TEM-94-..................F..................................................................................K.............................................................................T.......................................................S........................M......................... 98.25 %
TEM-95-..............................................................................................................................................A............................................................................................................................................... 99.65 %
TEM-96-................................................................................................................................................................G............................................................................................................................. 99.65 %
TEM-97-.DP...............................................................V.........................................................................................................................................................................................................................L. 98.60 %
TEM-98-.DP.........................................................................................................................................................................................................................................................................................L. 98.95 %
TEM-99-.DP.............................................................................................................................................................................................................................................S...........................................L. 98.60 %
TEM-101-....................................K......................................................................................................................................................................................................SK......................................V.......... 98.60 %
TEM-102-......................VR.............................................................................................................................................................V................................................................V....................................... 98.60 %
TEM-103-..............................................................................................................................................................................................................................................................................L............... 99.65 %
TEM-104-...................................................................................................................................................................................................................................................................................V.......... 99.65 %
TEM-105-.........................................................................................................................N.................................................................................................................................................................... 99.65 %
TEM-106-.....................................................................................................K.............................................................................T.......................................................................................................... 99.30 %
TEM-107-.....................................................................................................K...........................................................H.................T.......................................................S.................................................. 98.60 %
TEM-108-.DP..........................................................................E...................................................................................................................S.............................................................................S.............. 98.25 %
TEM-109-..................................................................L..................................K...........................................................H............................................................................................................................ 98.95 %
TEM-110-..................F.................................................................................................................................................................................................................................................M......................... 99.30 %
TEM-111-.....................................................................................................K.....................................................................................................................................D........................M......................... 98.95 %
TEM-112-......................................................................................................................................................R....................................................................................S.................................................. 99.30 %
TEM-113-....................................K................................................................K.............................................................................T.......................................................S.................................................. 98.60 %
TEM-114-....................................K............................................................................................................................S........................................................................T.K................................................. 98.60 %
TEM-115-..................F..............................................................................................................................................H............................................................................................................................ 99.30 %
TEM-116-.................................................................................I...................................................................................................V........................................................................................................ 99.30 %
TEM-117-..................F........................................................................................................................................................................................................................................................................... 99.65 %
TEM-120-..................F........................................................................................................................................................................................................................S.................................................. 99.30 %
TEM-121-....................................K................................................................K...........................................................S........................................................................T.K...S............................................. 97.90 %
TEM-122-..............................................................................................................................................................................................................................................................................Q............... 99.65 %
TEM-123-...K.................................................................................................K.....................................................................................................................................S........-.........................A............... 98.25 %
TEM-124-...K.................................................................................................K.............................................................................T................................................................-.........................A............... 98.25 %
TEM-125-.............L....................................................L..............................................................................................SR............................................................................................................D.............. 98.25 %
TEM-126-................................................................................................................................................................................E..T.......................................................................................................... 99.30 %
TEM-127-...........................................................................................................................................................N.................................................................................................................................. 99.65 %
TEM-128-..........................................................................................................................................................E................................................................................................................................... 99.65 %
TEM-129-....................................K................................................................K...........................................................S............................................................................................................................ 98.95 %
TEM-130-................................P...K................................................................K...........................................................S........................................................................T................................................... 98.25 %
TEM-131-..................F..................................................................................K...........................................................S.................T......................................................T................................................... 98.25 %
TEM-132-.................................................................................................................................................................H........V.................................................................K................................................. 98.95 %
TEM-133-..................F..................................................................................K...........................................................S............................................................................................................................ 98.95 %
TEM-134-....................................K................................................................K...........................................................H.........................................................................S.................................................. 98.60 %
TEM-135-...................................................................................................................................................................................T.......................................................................................................... 99.65 %
TEM-136-.................................................................................................................................................................S........................................................................T.K..........................G...................... 98.60 %
TEM-137-.................................................................................................................................................................S..........................................................................R................................................. 99.30 %
TEM-138-.....................................................................................................K......................................................................I..............................................................S.................................................. 98.95 %
TEM-139-....................................K.........M......................................................K.....................................................................................................................................S.................................................. 98.60 %
TEM-141-...............................E.............................................................................................................................................................................................................................................................. 99.65 %
TEM-142-.....................................................................................................K.....................................................................................................................................N........................M......................... 98.95 %
TEM-143-.................................................................................................................................................................C............................................................................................................................ 99.65 %
TEM-144-.................................................................................................................................................................C..........................................................................K................................................. 99.30 %
TEM-145-..........................................................................................................................................................................................................................M.....................H............................................. 99.30 %
TEM-146-...............................................................................................................P................................................................................................................................H............................................. 99.30 %
TEM-147-.................................................................................................................................................................H...........................................................V................................................................ 99.30 %
TEM-148-.........................................................................................................................................................................................K.................................................................................................... 99.65 %
TEM-149-.....................................................................................................K...........................................................S.................T........................................................V................................................. 98.60 %
TEM-150-.........................D.................................................................................................................................................................................................................................................................... 99.65 %
TEM-151-..................................................................V..............................................................................................H.............................................................................................................D.......G...... 98.60 %
TEM-152-..................................................................V..............................................................................................H..........................................................................K..................................D.............. 98.60 %
TEM-153-.....................................................................................................K.............................................................................T..................................................................................V....................... 98.95 %
TEM-154-..................................................................L..............................................................................................S............................................................................................................................ 99.30 %
TEM-155-....................................K............................................................................................................................S..........................................................................K................................................. 98.95 %
TEM-156-........................................................................................................................................................I..................................................................................................................................... 99.65 %
TEM-157-.................................................................................I...............S...................................................................................V........................................................................................................ 98.95 %
TEM-158-..................................................................L..............................................................................................S.............................................................................................................D.............. 98.95 %
TEM-159-..................F...............................................I................................................................................................................T.......................................................................................................... 98.95 %
TEM-160-....................................K.............................V........................................................................................................................................................................................................................... 99.30 %
TEM-162-.........................K.........N.........................K...................I...............S.V.................................................................................V........................................................................................................ 97.55 %
TEM-163-..............................................................................................................................................................................................................................................................................Q.............L. 99.30 %
TEM-164-.....................................V............................................................................................................................................................................................................................................T........... 99.30 %
TEM-166-.....................................................................................................................G........................................................................................................................................................................ 99.65 %
TEM-167-..................F..................................................................................K.......................................................................................................................V.............S........................M......................... 98.25 %
TEM-168-....................................................................................................................................................................................................................................................................M......................... 99.65 %
TEM-169-..................................................................L...............................................................................................G........................................................................................................................... 99.30 %
TEM-171-.................................................................................I............................................................................................................................................................................................................ 99.65 %
TEM-176-.............................................................................................................................................................................................................................V................................................................ 99.65 %
TEM-177-...K................................K................................................................K...........................................................S.................T......................................................T.K................................................. 97.55 %
TEM-178-.......................................STS....................................................................................................SQ...............................A.................................A-........................R.................................................. 96.85 %
TEM-181-.....................................................................................................................................................................................V........................................................................................................ 99.65 %
TEM-182-..................................................................I...............................................................................................L...........................................................................................................L............... 98.95 %
TEM-183-...................................................................................................................................................................................................................................L.......................................................... 99.65 %
TEM-184-...K.................................................................................................K......................V....................................S.................T.......................................................................................................... 98.25 %
TEM-185-..................................................................L...............................................................................................R........................................................................................................................... 99.30 %
TEM-186-.............................................................................................................................................................................N................................................................................................................ 99.65 %
TEM-187-..................F..............................................................................................................................................H...................V..............................................................................M........................- 98.25 %
TEM-188-..................F........................................................................................................................................................................................................................SK................................................. 98.95 %
TEM-189-..................................................................L.........................................................................................................................................................................K................................................. 99.30 %
TEM-190-..................................................................L...............................................................................................G............................................................................................................D.............. 98.95 %
TEM-191-............................................................................................................................................................................................................................................K................................................. 99.65 %
TEM-193-.....................................................................................................................................H.F.........................C.G.K.T....H..........V.N...............................I.................................................................... 96.50 %
TEM-194-................................................................................................R.....................................I..................R..................H.........PV.....T...V........PR.............I.................................................................... 96.15 %
TEM-195-................................................................................................R................................................................C..........H..........V...................................................................................................... 98.60 %
TEM-196-......................................................F....................................................................................................................................................................................................................................... 99.65 %
TEM-197-.....................................................................................................K...............................................................................V.....................................................S.................................................. 98.95 %
TEM-198-..........................................................................................................................................................................................................................................................................I................... 99.65 %
TEM-201-...........................V...........................................................................................................................................................................................................................................G...................... 99.30 %
TEM-204-...K.................................................................................................K...........................................................H.................T.......................................................S.................................................. 98.25 %
TEM-205-.................................................................................I...................K...........................................................S.................T.V........................................................................................................ 98.25 %
TEM-206-........T..................................................................................................................................................................................................................................................................................... 99.65 %
TEM-207-............................................................................................................................................................................................................................................G................................................. 99.65 %
TEM-208-...................................................................................................F.......................................................................................................................................................................................... 99.65 %
TEM-209-......................................D....................................................................................................................................................................................................................................................... 99.65 %
TEM-210-..............................................M...................L........................................................................................................................................................................................................................... 99.30 %
TEM-211-...K.................................................................................................K.........................T...................................................T.......................................................S..................................L............... 97.90 %
TEM-212-......................................................................................................N....................................................................................................................................................................................... 99.65 %
TEM-213-......................................................................................................F....................................................................................................................................................................................... 99.65 %
TEM-214-..........F................................................................................................................................................................................................................................................................................... 99.65 %
TEM-215-......................................................................................................................................................R....................................................................................................................................... 99.65 %
TEM-216-........S...............................P..................................................................................................................................................................................................................................................... 99.30 %
TEM-217-..................................................................................................................................................................................................................................................................M........................... 99.65 %
TEM-219-.................................................................................................................................................................................................................................................................F............................ 99.65 %
TEM-220-...................................................................................................................................................................................T..T....................................................................................................... 99.30 %
TEM-224-...K.................................................................................................K.........................T.................................S.................T.......................................................................................................... 98.25 %
TEM-225-.....................................................................................................K.............................................................................T.......................................................S.............................V.................... 98.60 %
TEM-226-.....................................................................................................K.......................................................................................................................V.............S.................................................. 98.95 %
TEM-227-....................................K................................................................K..........N..........................................................................................................................S...........................................T...... 98.25 %
TEM-228-......................................................................................................................................................................................T....................................................................................................... 99.65 %
TEM-229-.................................................................................I...................................................................................................V.........................................................................V.............................. 98.95 %
TEM-230-........................................................................................................................................................................................................................................T...........................M......................... 99.30 %
TEM-231-...................................................................................................................................................................................I.......................................................................................................... 99.65 %
TEM-232-..............................................................S..................................................................................................S............................................................................................................................ 99.30 %
TEM-233-.......................................................................................H..............SP......................................................................................................................................................................A............... 98.60 %
TEM-234-.........................................................................................................................................................................................................................................................................S.................... 99.65 %
TEM-235-.....................................................................................................................................................................................................................................D........................................................ 99.65 %
TEM-236-.................................................................................................................................................................C.................T.......................................................................................................... 99.30 %
TEM-237-.......................................................................................................................................................................................................................................................................G...................... 99.65 %
TEM-238-..................................................................I...............................................................................................R................T.......................................................................................................... 98.95 %
TEM-239MSIQ.Y......................................................................................................................................................................................................................................................................................... 98.26 %
TEM-240-...................................................................................................................................................................................T.........................................................H................................................ 99.30 %
TEM-241-....................................K.................................................................................................................R..........H............................................................................................................................ 98.95 %
TEM-242-.....................................................................................................K...........................................................S.................T.......................................................................................................... 98.95 %
TEM-243-.........RR................................................................................................................................................................................................................................................................................... 99.30 %
TEM-244-.........................A.................................................................................................................................................................................................................................................................... 99.65 %
TEM-245-....................................................................................................................................................................S......................................................................................................................... 99.65 %
TEM-246-...................H................................................................W......................................................................................................................................................................................................... 99.30 %
TEM-247-.......................................................................................................................................F...................................................................................................................................................... 99.65 %
TEM-248-...........................V.................................................................................................................................................................................................................................................................. 99.65 %
TEM-249-............................................................................................................................................................................................................................................................................................D. 99.65 %
TEM-250-..................F..............................................................................................................................................H..........................................................................K.......................M......................... 98.60 %
TEM-251-..................................................................I...............................................................................................L................T.......................................................................................................... 98.95 %
TEM-252-.................................................................................................................................................................S..........................................................................K..........................G...................... 98.95 %
TEM-253-.............S....................................................................................................................................................................................................................................................................T........... 99.30 %
TEM-254-.............S....................................................L...............................................................................................G........................................................................................................................... 98.95 %
TEM-255-......................................................................................................................................................................................................I....................................................................................... 99.65 %
TEM-256-......................................................................................................................................................................................................................T....................................................................... 99.65 %
TEM-257-...................................................................................................................................................................................V.......................................................................................................... 99.65 %
TEM-258-....................................K.............................L........................................................................................................................................................................................................................... 99.30 %
TEM-259-...................................................................................T.......................................................................................................................................................................................................... 99.65 %
TEM-260-..............................................M............................................................................................................................................................................................................................................... 99.65 %
TEM-261-..................................................................V..................................K.............................................................................T.......................................................................................................... 98.95 %
TEM-262-...K.................................................................................................K...........................................................S.................T......................................................T.K................................................. 97.90 %
TEM-263-..................................................................................................................................................................L........................................................................................................................... 99.65 %
TEM-264-........................................................................................................................................................................................................................................................L..................................... 99.65 %
TEM-265-.......................................................................................................................................................................................................................................................................................S.P.... 99.30 %
TEM-266-.......................................................................................................................................................................................................................................................................................S.PN... 98.95 %
TEM-267-...................................................................................................................................................................................................................................C.......................................................... 99.65 %
TEM-268-.......................................................................................................................................................................................................................................................R..............A....................... 99.30 %
TEM-269-...................................................................................................................................................................................................................................V...............................................G.......... 99.30 %
TEM-270-......................................................................................................................................................................................................................................................................A....................... 99.65 %
TEM-271-........................................................................................................................................................................................................................T..G.......V.......................................................... 98.95 %
TEM-272-...................................................................................................................................................................................................................................V.......................................................... 99.65 %
TEM-P14-----------.......................................................I...................................................................................................................................................................................................------------------------- 87.41 %
TEM-P114-....................................K..........................................................................................G.....................................................................................................................................................--------- 96.15 %
TEM-P116----.................................K..V...................................................................................................................................................................................................SK.......................M.......................-- 96.50 %
TEM-P117-------------......F..............................................................................................................................................H..................................................................................................M............------------- 90.21 %
TEM-P118-------------.....................................................................................................................................................H..................................................................................................M............------------- 90.56 %
TEM-P120-....................................K................................................................K.........................G...........................................................................................................S..........................................-------- 95.80 %
TEM-P121----.................................K................................................................K..................................................I..................................................................................S.................................................. 97.55 %
A-TEM phylogenetic tree

Last updated: April 06, 2026.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database was funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

Live statistics (since March 29th, 2025)