Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
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Beta-Lactamase DataBase

Sequence alignment for the PenA beta-lactamase family

PenA-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300..........
MTHSSQRRILLLAAATAPLALSLGACAARDATVSDAASPVGAAPASFAALERAAGGRLGVCAIDTATGRRALHRADERFPFCSTFKAMLGAAVLAQSVAHPGLLQQRVTYGRSDLVNYSPVTERHVDTGMTVAELCAATIQYSDNTAANELMKRIGGPAAVTAYARSIGDDTFRLDRWETELNTALPGDLRDTTTPAAMAANLRVL--VLGDALPPAQRAQLIEWLRGNKVGDKRIRAGVPTGWRVGDKTGTGDYGTTNDVGVLWPPSRAPIVLAVYYTQTRADAKAKDDVIAAATRIASATLA------
PenA-2 ....P....................................................................................................................................................................................................S....--....................................................A...................A..................I....RAATRE  96.43 %
PenA-3 ...............................A.........................................................................................................................................................................S....--....................................................A...................A..................I....------  98.34 %
PenA-4 ........................................................................Y................................................................................................................................S....--....................................................A...................A..................I...G------  98.01 %
PenA-5 ....P..........................A......................................................................................................................................................K..................S....--....................................................A...................A..................I....------  97.68 %
PenA-6 ....P....................................................................................................................................................................................................S....--...........T......................A.................A...................A..................I....------  97.68 %
PenA-7 ....P....................................................................................................................................................................................................S....--...........T........................................A...................A..................I...G------  97.68 %
PenA-2 ....P..........................A.........................................................A...............................................................................................................S....--....................................................A...................A..................I....------  97.68 %
PenA-9 ...............................A.........................................................A........E......................................................................................................S....--.......A............................................A...................A..................I....------  97.35 %
PenA-10 ..........................................V..............................................................................................................................................................S..M.--....................................................A...................A..................IS..G------  97.35 %
PenA-11 ...............................A..............L..........................................................................................................................................................S....--...........T........................................A...................A..................I...G------  97.35 %
PenA-12 ...............................A.....L..........................A........................................................................................................................................S....--....................................................A...................A..................I...G------  97.35 %
PenA-13 ....P..........................A...............................................R.........A...............................................................................................................S....--....................................................A...................A..................I....------  97.35 %
PenA-15 ....P.................................R..................................................................................................................................................................S....--.............................................A......A...................A..................I...G------  97.35 %
PenA-16 ...............................A........................................Y................A...............................................................................................................S....--.......L............................................A...................A..................I...G------  97.02 %
PenA-17 ....................................P.....S..............................................................................................................................................................S....--.......H..........................A.................A...................A..................I...G------  97.02 %
PenA-18 ....P......................T...A.........................................................................................................................................................................S....--.......L............................................A...................A..................I...G------  97.02 %
PenA-19 ...............................A..........S.............................Y................A...............................................................................................................S....--....................................................A...................A..................I...P------  97.02 %
PenA-20 ...............................A.....L..........................A........................A...............................................................................................................S....--....................................................A...................A..................I...G------  97.02 %
PenA-21 ....P..............................T.....................................................................................................................................................................S....--.......A......S...................A.................A...................A..................I...G------  96.69 %
PenA-22 ....P....................................L-..............................................................................................................................................................S....--.......A..........................A.................A...................A..................I...G------  96.69 %
PenA-23 ...............................A..........S.............................................................R................................................................................................S....--............R.....................A.................A...................A..................I....------  97.02 %
PenA-24 .P..P..........................A..........S.............................Y................A...............................................................................................................S....--....................................................A...................A..................I....------  96.69 %
PenA-25 ...............................A..........S.....................A.......Y...........I....A...............................................................................................................S....--....................................................A...................A........E.........I....------  96.36 %
PenA-26 ....P..........................A...T....................................Y..G.............A...........................................................................................P..............E....S....--....................................................A...................A..................I....------  96.03 %
PenA-27 ....P..........................A...T....................................Y..G.............A......................................................S...................................................E....S....--....................................................A...................A..................I....------  96.03 %
PenA-28 ...............A......V........A......................................T.............................................S....................................L...............................................S....--.......A............................................A................................T.....I...G------  96.03 %
PenA-29 ...............A......V........A...............................................................................Q....S....................................L...............................................S....--.......A.........................A...................................................T.....I...G------  96.03 %
PenA-30 ...............A......V........A......A...............................T.............................................S....................................L...............................................S....--.......A.................R...........................................................T.....I...G------  95.70 %
PenA-31 ...............................A.....L..........................A........................A..................................Y.....A......................................................................S....--....................................................A...................A...............Q..I...G------  96.03 %
PenA-32 ...............A......V........A......................................T.............................................S....................................L...............................................S....--.......A.........................A..................A................................T.....I...G------  95.70 %
PenA-33 ...............A......V........A....................................................................................S....................................L...............................................S....--.......A.........................A..................A..M.............................T.....I...G------  95.70 %
PenA-34 ...............A......V........A....................................................................................S....................................L...............................................S....VL.......A.........................A..................A..M.............................T.....I...G------  95.07 %
PenA-35 ...............A......V........PTDN....G............................................................................S....................................L...............................................S....--.......A.........................A..................A................................T.....I...G------  94.70 %
PenA-37 ...............A......V........PTDN....G..............................T.............................................S....................................L...............................................S....--.......A.........................A.....................M.............................T.....I...G------  94.37 %
PenA-38 ...............A......VC.......STDN....G............................................................................S....................................L...............................................S....--.......A.........................A..................A......................................I...G------  94.70 %
PenA-39 ...............A......V........A......................................T.............................................S....................................L...............................................S....--.......A.........................A.....................M.............................T.....I...G------  95.70 %
A-PenA phylogenetic tree

Last updated: November 20, 2024.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database was funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

Live statistics (since December 3rd, 2023)