Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
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Beta-Lactamase DataBase

Sequence alignment for the PAL beta-lactamase family

PAL-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.........
MTLRFKTFAAFILSMPLVSSAFALTLQDQV-KQYEKEGWKVGLSIIFPDDKTISINGNQRFPLDSTVKSIACANVLAKVDAKKLSLNHSMIVTEKNIVTYSPVAKDYMNKPFTLEQACKAANEYSDNTAANFAIFSGGGPEALTAFMRAIGDTVTRSDRYEPELTVNPEGDLRDTTTPDAMSKSIKKILTGEVLSHSSKEQLKEWMVNNKVADNMLRASLPKGWKIADRSGASDYGVRGITSMVWSNNHDPVFISIYVRKADTSLDERSEVIRILGSHIFDEYLSH---
PAL-2.K..LTI..TLV....MAP........E..-..............LSS..........................................V.....................................................E...S...................VD.........................DA..A.....................................................................A...T............--- 91.58 %
PAL-3.K..LTI..TLV....MAP...........-..............LSS..........................................V.....................................................E...S...................VD.........................DA..A........................E..........................I.................A...T............--- 91.23 %
PAL-4.K..LTI..TLV....MAP...........-..............LSS..........................................V.....................................................E...S...................VD.........................DA..A.....................................................................A...T............--- 91.93 %
PAL-5.N....A..TLV....I......S......-..............LSS.G....................................................................................S.................................VN.........................D...A.........................................................................T............--- 94.04 %
PAL-6..........L...................-.......................................................S..........................................................................................................................................................................................V............--- 98.95 %
PAL-7.K..LTI..TLV....MAP...........-...........V..LSS..........................I...............V.....................................................E...S...................VD.........................DA..A.....................................................................A...T............--- 91.23 %
PAL-8..........L......GILCICFDFTGSRLSNTK.RVGRLVCP.K........................................S..........................................................................................................................................................................................V.....L......LKK 88.24 %
A-PAL phylogenetic tree

Last updated: April 06, 2026.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database was funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

Live statistics (since March 29th, 2025)