Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
Beta-Lactamase DataBase - Structure and Function Home Enzymes Structures Mutants Kinetics BLAST
Beta-Lactamase DataBase

Sequence alignment for the LEN beta-lactamase family

LEN-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280......
MRYVRLCVISLLATLPLVVYAGPQPLEQIKQSESQLSGRVGMVEMDLANGRTLAAWRADERFPMVSTFKVLLCGAVLARVDAGLEQLDRRIHYRQQDLVDYSPVSEKHLVDGMTIGELCAAAITLSDNSAGNLLLATVGGPAGLTAFLRQIGDNVTRLDRWETALNEALPGDARDTTTPASMAATLRKLLTAQHLSARSQQQLLQWMVDDRVAGPLIRAVLPPGWFIADKTGAGERGARGIVALLGPDGKPERIVVIYLRDTPASMAERNQHIAGIGQR-------
LEN-2.................A.D............................S..................................V.................................................................................................................................................................................................AALIEHWQR 95.45 %
LEN-5...I.............A..............................S............................................................T.......................................................................................................................................................................AALIEHWQR 95.45 %
LEN-7.................A.D............................S..................................V.........................T.......................................................................................................................................................................AALIEHWQR 95.10 %
LEN-8....................................P...........S...........................................................................................................H........................................................................................................................AALIEHWQR 95.80 %
LEN-9................................................S....................................................................................................................................................................................................................................AALIEHWQR 96.50 %
LEN-10.................A.D............................S............................................................T..................................................................................................................................................L....................AALIEHWQR 95.10 %
LEN-11.................A.D............................S.............................................................................................................................................................................A......................................................AALIEHWQR 95.45 %
LEN-12.................A..............................S.............................................................................................................................................................................A......................................................AALIEHWQR 95.80 %
LEN-13.................A.D............................S...............................................................................................................................................................................................................L....................AALIEHWQR 95.45 %
LEN-15................................................S...................................................................................................................................................P.........................A........................................................------- 98.92 %
LEN-16.................A..............................S............................................................T.......................................................................................................................................................................AALIEHWQR 95.80 %
LEN-18.................A.D............................S............................................................T....V.............................................................................................................................................L....................AALIEHWQR 94.76 %
LEN-19.................A..............................S............................................................T....V..................................................................................................................................................................AALIEHWQR 95.45 %
LEN-20.................A.D............................S............................................................T....V....................................................................................................................................................V.............AALIEHWQR 94.76 %
LEN-21.................A.D............................S..................................V...V......................................................................................................................................A......................................................AALIEHWQR 94.76 %
LEN-22.................A.D............................S...................................................................................................................................................P.........................A......................................................AALIEHWQR 95.10 %
LEN-23.................A..............................S............................................................T..................................................................................................................................................L....................AALIEHWQR 95.45 %
LEN-24.............N...A.D............................S....................................................................................................................................................................................................................................AALIEHWQR 95.45 %
LEN-25.................A.D............................S................................................................A..............................................................................................................................................L....................AALIEHWQR 95.10 %
LEN-26.............N...A..............................S..................................V.........................T..............M...............................................M.................................................A...........................A.......M.....TI.....Q..A..AALIEHWQR 91.96 %
LEN-27.................A.D............................S............................................................T.......................................................................................................................................................................AALIEHWQR 95.45 %
LEN-28.............N...A.D............................S...................................................................................................................................................P.........................A......................................................AALIEHWQR 94.76 %
LEN-30.............N...A.D............................S............................................................T....V..................................................................................................................................................................AALIEHWQR 94.76 %
LEN-31.................A.D............................S..................................V.........................T....V.........................................H........................................................................................................................AALIEHWQR 94.41 %
LEN-32.................A.D............................S..............V............................................................................................H...................................................................................................L....................AALIEHWQR 94.76 %
LEN-33.................A.D............................S..................................V.........................T....V..................................................................................................................................................................AALIEHWQR 94.76 %
LEN-34.................A..............................S..................................I.........................T.......................................................................................................................................................................AALIEHWQR 95.45 %
LEN-35...I.............A..............................S............................................................T....V..................................................................................................................................................................AALIEHWHD 95.10 %
LEN-36.................A.D............................S.H................................V.........................T....V..................................................................................................................................................................AALIEHWQR 94.41 %
LEN-37.................A.D............................S..................................V..................................................................................................S..............................................................................................AALIEHWQR 95.10 %
LEN-38.............N...A..............................S..................................V........................................M................T..............................M.................................................A...........................A..........................AALIEHWQR 93.71 %
LEN-39.................A..............................S..................................V.........................T....V.........M..........T....................................M.................................................A...........................A..........................AALIEHWQR 93.36 %
LEN-40.............N...A..............................S..................................V........................................M................V................................................................................A..........................NA..........................AALIEHWQR 93.71 %
LEN-41.................A.D............................S..................................V........................................M.................................................................................................A..........................NA..........................AALIEHWQR 94.06 %
LEN-42.................A..............................S..................................V........................................M...............................................M.................................................A...........................A..........................AALIEHWQR 94.41 %
LEN-43.............N...A..............................S..................................V........................................M...............................................M.................................................A...........................A..........................AALIEHWQR 94.06 %
LEN-51................................................S...............................................................................................................................................................................................................L....................AALIEHWQR 96.15 %
LEN-55.................A.D............................S....................................................................................................................................................................................................................................AALIEHWQR 95.80 %
LEN-58.................A.D............................S..................................V.........................F.......................................................................................................................................................................AALIEHWQR 95.10 %
LEN-94.......L...I.A...A.F.S........I.....A....Y......S....................................................................................................................................................................................................................................AALIEHWQR 93.36 %
LEN-95.................A.D............................S..............V............................................................................................H.............S.....................................................................................L....................AALIEHWQR 94.41 %
LEN-96................................................S...............L..................V..............................................................................................................................................................V..................................AALIEHWQR 95.45 %
LEN-97................................................S......................................................................................................................................................................................A..........................P..................AALIEHWQR 95.80 %
LEN-98....................................P...........S..................................................................................................M.................................................................................................................................AALIEHWQR 95.80 %
LEN-99....................................P...........S...P.......................................................................................................H........................................................................................................................AALIEHWQR 95.45 %
LEN-100....................................P...........S..............I............................................................................................H........................................................................................................................AALIEHWQR 95.45 %
LEN-101.................A.D............................S......................................................................................................................................................................................................NN.A....................Q.....AALIEHWQR 94.41 %
LEN-102.................A.D............................S..................................V......................................................................................................................................S...A........................NN.A....................Q.....AALIEHWQR 93.36 %
LEN-103...I...I.........A.H.S........L.................S..................................V.........................T....V..................................................................................................................................................................AALIEHWQR 93.36 %
LEN-104.................A.D............................S......................................................................................KI...........................................................P.........................A......................................................AALIEHWQR 94.41 %
LEN-105.................A.D............................S..................................V.....................D..................M................V................................................................................A..........................NA..........................AALIEHWQR 93.36 %
LEN-106.................A.D............................S..................................V.....................................................I..................................M...........................H.....................A...........................A..........................AALIEHWQR 93.71 %
LEN-107.................A.D............................S..................................V............E...........................................................................M.................................................A.................................L....................AALIEHWQR 94.06 %
LEN-108.H...............A.D............................S..................................V.............................................................................................P............................................A......................................................AALIEHWQR 94.41 %
LEN-109.............N...A.D............................S..........................................P.................T....V..................................................................................................................................................................AALIEHWQR 94.41 %
LEN-110.............N...A.D............................S............................................................T....V..........................T.......................................................................................................................................AALIEHWQR 94.41 %
LEN-111.................A..............................S............................................................T....V..................................................................I..............P.........................A......................................................AALIEHWQR 94.41 %
LEN-112.............N...A..............................S..................................V.........................T..............M.................................................................................................A...........................A..........................AALIEHWQR 94.06 %
LEN-113.................A..............................S..................................V.........................T....V.........M.................................................................................................A......................................................AALIEHWQR 94.41 %
LEN-114.................A.D......................M.....S............................................................T.......................................................................................................................................................................AALIEHWQR 95.10 %
LEN-115.................A.D............................S..................................V.......P.................T....V..................................................................................................................................................................AALIEHWQR 94.41 %
LEN-118.................A.D............................S..................................V.........................T....V..H...............................................................................................................................................................AALIEHWQR 94.41 %
LEN-119.................A.D............................S..................................V.........................T....V...........................................................N......................................................................................................AALIEHWQR 94.41 %
LEN-120.............N...A.D............................S..................................V.........................T....V..................................................................................................................................................................AALIEHWQR 94.41 %
LEN-121.................A.D............................S..................................V.........................T....V................................................................................................................S.................................................AALIEHWQR 94.41 %
LEN-122.................A.D............................S..................................V.........................T...................................................................................................................................I...................................AALIEHWQR 94.76 %
LEN-123....H............A.D............................S..................................V.........................T.......................................................................................................................................................................AALIEHWQR 94.76 %
LEN-124.................A.D............................S..................................V.........................T.........................................................................................................................V.............................................AALIEHWQR 94.76 %
LEN-125.................A.D............................S..................................V.........................T...........................................K................................................................................A..........................................AALIEHWQR 94.41 %
LEN-126.................A.D............................S..................................V.........................T...........................................K...........................................................................................................................AALIEHWQR 94.76 %
LEN-127.................A.D............................S............................................................T............................D........................V.................................................................................................................AALIEHWQR 94.76 %
LEN-128.................A.D............................S............................................................T.........................T.............................................................................................................................................AALIEHWQR 95.10 %
LEN-129.................A.D............................S..................................................G.........T.......................................................................................................................................................................AALIEHWQR 95.10 %
LEN-130.................A.D...................G........S............................................................T.......................................................................................................................................................................AALIEHWQR 95.10 %
LEN-132.................A.D............................S............................................................T.............................................................................................M.........................................................................AALIEHWQR 95.10 %
LEN-133.................A..............................S............................................................T....V.........................................................................................H........................................................................AALIEHWQR 95.10 %
LEN-134.................A..............................S............................................................T....V....................................................................................................................................................V.............AALIEHWQR 95.10 %
LEN-135.................A.D............................S............................................................T....V..................................................................................................................................................................AALIEHWQR 95.10 %
LEN-136.................A.D............................S............................................................T....V..................................................................................S...............................................................................AALIEHWQR 94.76 %
LEN-137....................................P...........S....................................................................................................................................................................................................................................AALIEHWQR 96.15 %
LEN-138....................................P...........S...............................................................................................................................................................................................................L....................AALIEHWQR 95.80 %
LEN-139................................................S............................................................T.......................................................................................................................................................................AALIEHWQH 96.15 %
LEN-140.L..............................................S....................................................................................................................................................................................................................................AALIEHWQR 96.15 %
LEN-141................................................S..................................................................................................M.................................................................................................................................AALIEHWQR 96.15 %
LEN-142................................................S.............................................................................................E......................................................................................................................................AALIEHWQR 96.15 %
LEN-143................................................S...........................................................................................H........................................................................................................................................AALIEHWQR 96.15 %
LEN-144................................................S....................................................................................................................................................C...............................................................................AALIEHWQR 96.15 %
LEN-145................................................S.....................................................................................................................................................................L..............................................................AALIEHWQR 96.15 %
LEN-146................................................S..................................V.........................T.......................................................................................................................................................................AALIEHWQR 95.80 %
LEN-147.................A..............................S............................................................T..................C...............................................................................................................................................L....AALIEHWQR 95.10 %
LEN-148.................A..............................S............................................................T......................................................................................T...........................................................L....................AALIEHWQR 95.10 %
LEN-149.........C.......A..............................S............................................................T............................................F..........................................................................................................................AALIEHWQR 95.10 %
LEN-150.........C.......A..............................S............................................................T.......................................................................................................................................................................AALIEHWQR 95.45 %
LEN-151.................A..............................S............................................................T.............................C.........................................................................................................................................AALIEHWQR 95.45 %
LEN-152.................A..............................S............................................................T.................................................................................................E.....................................................................AALIEHWQR 95.45 %
LEN-153.................A..............................S............................................................T..................................................R....................................................................................................................AALIEHWQR 95.45 %
LEN-154.................A..............................S..........................................P.................T.......................................................................................................................................................................AALIEHWQR 95.45 %
LEN-155.................A..............................S............................................................T...........................G...........................................................................................................................................AALIEHWQR 95.45 %
LEN-156.................A..............................S.................................................G..........T.......................................................................................................................................................................AALIEHWQR 95.45 %
LEN-157.................A..............................S............................................................T.............................................................................................................................P.........................................AALIEHWQR 95.45 %
LEN-159.................A..............................S............................................................T...................................................................S...................................................................................................AALIEHWQR 95.45 %
LEN-160.................A..............................S............................................................T..........................................................R............................................................................................................AALIEHWQR 95.45 %
LEN-161.................A..............................S............................................................T...............................................................S.......................................................................................................AALIEHWQR 95.45 %
LEN-163.................A..............................S............................V...............................T.......................................................................................................................................................................AALIEHWQR 95.45 %
LEN-164.................A..............................S....T.......................................................T.......................................................................................................................................................................AALIEHWQR 95.45 %
LEN-165.................A..............................S............................................................T..........................................................................................................L............................................................AALIEHWQR 95.45 %
LEN-166.................A..............................S......................................................I.....T.......................................................................................................................................................................AALIEHWQR 95.45 %
LEN-167............T....A..............................S............................................................T.......................................................................................................................................................................AALIEHWQR 95.45 %
LEN-168.................A..............................S...........................................................................................................H.................................................................A......................................................AALIEHWQR 95.45 %
LEN-169.................A..............................S..................................V.........................T................................................................................................................A......................................................AALIEHWQR 95.10 %
LEN-170.................A..............................S............................................................T................................................................................................................A......................................................AALIEHWQR 95.45 %
LEN-171.................A.D............................S...........................................................................................................H...................................................................................................L....................AALIEHWPR 95.10 %
LEN-172.................A.D............................S...........................................................................................................H...................................................................................................L.................W..AALIEHWQR 94.76 %
LEN-173.................A.D............................S...........................................................................................................H...................................................................................................L....................AALIEHWQR 95.10 %
LEN-174.................A.D............................S..............V.....................................Y...............................................................................................................................................................................AALIEHWQR 95.10 %
LEN-175.................A.D............................S..............V.....................................................................................................................................................................................................................AALIEHWQR 95.45 %
LEN-176.........Y.......A.D............................S..............V.....................................................................................................................................................................................................................AALIEHWQR 95.10 %
LEN-177.............N...A.D............................S..............................................................................................................................................................................................................................Y.....AALIEHWQR 95.10 %
LEN-178.................A.D............................S.........................................................................V.....................................................................................................................................L....................AALIEHWQR 95.10 %
LEN-179.................A.D......................A.....S...............................................................................................................................................................................................................L....................AALIEHWQR 95.10 %
LEN-180.................A.D............................S...................................................................................................................................................T...........................................................L....................AALIEHWQR 95.10 %
LEN-181.................A.D............................S...................................................................................Q...........................................................................................................................L....................AALIEHWQR 95.10 %
LEN-182.................A.D............................S..................................................G............................................................................................................................................................L....................AALIEHWQR 95.10 %
LEN-183.................A.D............................S..............R................................................................................................................................................................................................L....................AALIEHWQR 95.10 %
LEN-184.................A.D............................S............................................C..................................................................................................................................................................L....................AALIEHWQR 95.10 %
LEN-185.................A.D............................S...................................................................................................................................................................S................................................................AALIEHWQR 95.45 %
LEN-186.................A.D............................S.........................G..........................................................................................................................................................................................................AALIEHWQR 95.45 %
LEN-188.................A.D............................S.......................................................................................................................................R............................................................................................AALIEHWQR 95.45 %
LEN-189.................A.D............................S....................................................................................................................................................................D...............................................................AALIEHWQR 95.45 %
LEN-190.................A.D............................S...............................................................................G.......................................................................................L............................................................AALIEHWQR 95.10 %
LEN-191.................A.D............................S.................................................................................................................K.............................................................................................L....................AALIEHWQR 95.10 %
LEN-192.................A.D............................S..................................V..............................................................................M.............................................................................................L....................AALIEHWQR 94.76 %
LEN-193.................A.D............................S.................................................................................................................M.............................................................................................L....................AALIEHWQR 95.10 %
LEN-194.................A.D............................S..................................V........................................................................................M.................................................A.................................L....................AALIEHWQR 94.41 %
LEN-195.................A.D..........................................................................................................................................................................................................A......................................................AALIEHWQR 95.80 %
LEN-196.................A.D............................S............................V................................................................................................................................................A......................................................AALIEHWQR 95.10 %
LEN-197.................A.D.........................E..S..................................V.................................................................................................................................................................................................AALIEHWQR 95.10 %
LEN-198.................A.D.........................E..S..................................V...........................................................................................................................G.....................................................................AALIEHWQR 94.76 %
LEN-199.......I.........A.D............................S..................................V.................................................................................................................................................................................................AALIEHWQR 95.10 %
LEN-200.................A.D............................S..................................V...................................V.............................................................................................................................................................AALIEHWQR 95.10 %
LEN-201.................A.D............................S..................................V...................................S.............................................................................................................................................................AALIEHWQR 95.10 %
LEN-202.................A.D............................S..................................V.....Q...........................................................................................................................................................................................AALIEHWQR 95.10 %
LEN-203.................A.D............................S..................................V...................................................................................V.............................................................................................................AALIEHWQR 95.10 %
LEN-204.................A.D............................S..................................V...E.............................................................................................................................................................................................AALIEHWQR 95.10 %
LEN-205.................A.D............................S..................................V............................................................................................................................................................................T....................AALIEHWQR 95.10 %
LEN-206.................A.D............................S....T.............................V.................................................................................................................................................................................................AALIEHWQR 95.10 %
LEN-207.................A.D............................S..................................V........................................................................H........................................................................................................................AALIEHWQR 95.10 %
LEN-208.................A.D............................S............................T.....V.................................................................................................................................................................................................AALIEHWQR 95.10 %
LEN-209.................A.D............................S..................................V.............................................................................................................................................................................................S...AALIEHWQR 95.10 %
LEN-210.................A.D....Q.......................S..................................V.................................................................................................................................................................................................AALIEHWQR 95.10 %
LEN-211.H...............A.D............................S..................................V..........................................................................................................................................A......................................................AALIEHWQR 94.76 %
LEN-P5-------..........A.D............................S............................................................T.................................................................................................................................................................Q.....AALI----- 94.31 %
LEN-P6-------.........................................S..............................................................................................................................................................................................................................Q.....AALI----- 95.37 %
A-LEN phylogenetic tree

Last updated: April 06, 2026.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database was funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

Live statistics (since March 29th, 2025)