Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
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Beta-Lactamase DataBase

Sequence alignment for the CTX-M-9-like beta-lactamase family

CTX-M-9
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290........
MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQL------TLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTAGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL-
CTX-M-13.....M.................................................K....................................................................................................E.......................................------.....................................V.........................................................- 98.63 %
CTX-M-14....................................................................................................................................................................................................------.....................................V.........................................................- 99.66 %
CTX-M-16....................................................................................................................................................................................................------.............................................G.................................................- 99.66 %
CTX-M-17....................................................................................................................................................................................................------.....................................V......................................................K..- 99.31 %
CTX-M-19.........................................................................................................................................................................S..........................------.....................................V.........................................................- 99.31 %
CTX-M-21............GG.G.........F......G...................................................................................................................................................................------.....................................V.........................................................- 97.94 %
CTX-M-24....................................................................................................................................................................................................------.....................................V........................................R................- 99.31 %
CTX-M-27....................................................................................................................................................................................................------.....................................V.......G.................................................- 99.31 %
CTX-M-38....................................................................................................................................................................................................------..........................R..........V.........................................................- 99.31 %
CTX-M-45..........S............PT................................................................................................................................................................A..G.DVASLRWVMRWAKPSG.V.DV--------AQRQYDR..G..........V.........................................................- 86.20 %
CTX-M-46..............................N...................P.................................................................................................................................................------.....................................V.........................................................- 98.97 %
CTX-M-47.............................................R......................................................................................................................................................------.....................................V.........................................................- 99.31 %
CTX-M-48..............................N.....................................................................................................................................................................------.....................................V.........................................................- 99.31 %
CTX-M-49.............................................R....P.................................................................................................................................................------.....................................V.........................................................- 98.97 %
CTX-M-50..................................................P.................................................................................................................................................------.....................................V.........................................................- 99.31 %
CTX-M-51...............................................................................V....................................................................................................................------...............................................................................................- 99.66 %
CTX-M-65...............................................................................V....................................................................................................................------.....................................V........................................R................- 98.97 %
CTX-M-67............................................................................................................S.......................................................................................------.....................................V.........................................................- 99.31 %
CTX-M-73................................M...................................................................................................................................................................------.....................................V.........................................................- 99.31 %
CTX-M-81....................................................................................E...............Q.................................H.............................................................------.....................................V.........................................................- 98.63 %
CTX-M-83...........................................................H........................................................................................................................................------.....................................V.........................................................- 99.31 %
CTX-M-84....................................................................................................................................................................................................------...............A.....................V.........................................................- 99.31 %
CTX-M-85.........................................................................................................................P..........................................................................------.....................................V.........................................................- 99.31 %
CTX-M-86..............................................................................................................F.....................................................................................------.....................................V.........................................................- 99.31 %
CTX-M-87...............................................................................V.........................................................................................L..........................------.....................................V.........................................................- 98.97 %
CTX-M-90...............................................................................V....................................................................................................................------.....................................V.........................................................- 99.31 %
CTX-M-93...........................................................................................................................................................................Q........................------.....................................V.......G.................................................- 98.97 %
CTX-M-98...............................................................................V....................................................................................................................------.....................................V.......G.................................................- 98.97 %
CTX-M-99.........................................................................................................................................................................S..........................------.....................................V........................................R................- 98.97 %
CTX-M-102....................................................................................................................................................................................................------...........E.........................V.......G.................................................- 98.97 %
CTX-M-104....................................................................................................................................................................................................------.....................................V........................................N................- 99.31 %
CTX-M-105...............................................................................V....................................................................................................................------...........E.........................V.......G.................................................- 98.63 %
CTX-M-110.................................................................................................................E..................................................................................------.....................................V........................................................NL 98.63 %
CTX-M-111...................................................................................................................................................Q................................................------.....................................V.........................................................- 99.31 %
CTX-M-112.............................................................................................................................G......................................................................------.....................................V.........................................................- 99.31 %
CTX-M-113.....................................................................................R..............................................................................................................------.....................................V.........................................................- 99.31 %
CTX-M-121...............................................................................................................T....................................................................................------.....................................V.......G.................................................- 98.97 %
CTX-M-122............................................................................................................................................................S.......................................------.....................................V........................................R................- 98.97 %
CTX-M-125....................................................................................................................................................................................................------.....................................V........................................H................- 99.31 %
CTX-M-126.........................................................................................................................................................................A..........................------.....................................V.........................................................- 99.31 %
CTX-M-129....................................................................................................................................................................................................------..................R..................V.......G.................................................- 98.97 %
CTX-M-130....................................................................................................................................................................................................------.....................................V........................................R.H..............- 98.97 %
CTX-M-134....................................................................................................................................................................................................------.....................................V.......S.................................................- 99.31 %
CTX-M-137..................................................................................................................................................................................................N.------...K...DS........M..........Q....A..VV.......G............KD....I.........PK............K.VTD..- 93.47 %
CTX-M-140...............................................................................................................T....................................................................................------.....................................V.........................................................- 99.31 %
CTX-M-147...............................................................................V.........................................................................................S..........................------.....................................V.........................................................- 98.97 %
CTX-M-148.............................................................................I.V....................................................................................................................------.....................................V........................................R................- 98.63 %
CTX-M-159...........................................................................................................................K........................................................................------.....................................V.......G.................................................- 98.97 %
CTX-M-161....................................................................................................................................................E...............................................------.....................................V.........................................................- 99.31 %
CTX-M-168.........................................................................................................................................................................H..........................------.....................................V.........................................................- 99.31 %
CTX-M-174......L.............................................................................................................................................................................................------.....................................V.......G.................................................- 98.97 %
CTX-M-191......................................................................................................................................D.............................................................------.....................................V.........................................................- 99.31 %
CTX-M-192....................................................................................................................................................................................................------.....................................V..R....G.................................................- 98.97 %
CTX-M-195............................................................................................................S.......................................................................................------.....................................V.......G.................................................- 98.97 %
CTX-M-196....................................................................................................................................................................................................------.....................................V.......G................................R................- 98.97 %
CTX-M-198........................A...........................................................................................................................................................................------.....................................V.........................................................- 99.31 %
CTX-M-201..........................................................................................................Y.........................................................................................------.....................................V.........................................................- 99.31 %
CTX-M-213.....M.................................................E....................................................................................................E.......................................------.....................................V.........................................................- 98.63 %
CTX-M-214...............................................................................................................T....................................................................................------...............................................................................................- 99.66 %
CTX-M-215......................................................................................................................................D.............................................................------.....................................V........................................H................- 98.97 %
CTX-M-219.........................................................................................................................................................................S..........................------.....................................V.............................I...........................- 98.97 %
CTX-M-221.........................................................................................................................................................................S........................N.------...K...DS........M..........Q....A..VV....................KD....I.........PK............K.VTD..- 93.47 %
CTX-M-223............................................................................................................S...................V...................................................................------.....................................V.......G.................................................- 98.63 %
CTX-M-233................................................................................................................................................................K...................................------.....................................V.......G.................................................- 98.97 %
CTX-M-235.........................................................................................................I..........................................................................................------.....................................V.........................................................- 99.31 %
CTX-M-239....................................................................................................................................G...............................................................------.....................................V..R....G.................................................- 98.63 %
CTX-M-240............................................................................................................................................................................S.......................------.....................................V.......G.................................................- 98.97 %
CTX-M-241...............................................................................V..........................................................................................--........................------.....................................V.........................................................- 98.63 %
CTX-M-242....................................................................................................................................................................................................------............K........................V.......G.................................................- 98.97 %
CTX-M-243............................................................................................................S.......................................................................................------.....................................V........................................N................- 98.97 %
CTX-M-247...............................................................................V....................................................G...............................................................------.....................................V........................................R................- 98.63 %
CTX-M-248...............................................................................V.........................................................................................S..........................------.....................................V........................................R................- 98.63 %
CTX-M-249...............................................................................V....................................................G....................................S..........................------.....................................V........................................R................- 98.28 %
CTX-M-252...............................V...............................................V....................................................................................................................------.....................................V........................................R................- 98.63 %
CTX-M-255....................................................................................................................................................................................................------.....................................V....S..G.................................................- 98.97 %
CTX-M-267...............................................................................V....................................................................................................................------.....................................V........................................H................- 98.97 %
CTX-M-269.............V.................................................................V....................................................................................................................------.....................................V.....................................H..R................- 98.28 %
CTX-M-277.................................................................E..................................................................................................................................------.....................................V.......G.................................................- 98.97 %
CTX-M-278..............................................................................................................................V.....................................................................------.....................................V.........................................................- 99.31 %
CTX-M-P45....................................................................................................................................................................................................------.....................................V..R.......................................H.............-- 98.63 %
KLUY-2....................................................................................................................................................................................................------.....................................V..................................R......................- 99.31 %
KLUY-3....K.................................T.............................................................R.T.............................................................................................------.....................................V.........................................................- 98.28 %
KLUY-4....K................S................T.............................................................R.T.............................................................................................------.....................................V.........................................................- 97.94 %
A-CTX-M-9-like phylogenetic tree

Last updated: April 06, 2026.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database was funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

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