Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
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Beta-Lactamase DataBase

Sequence alignment for the CTX-M-2-like beta-lactamase family

CTX-M-2
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.
MMTQSIRRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEIKKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDKVTAFARSLGDETFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLKNLTLGKALAETQRAQLVTWLKGNTTGSASIRAGLPKSWVVGDKTGSGDYGTTNDIAVIWPENHAPLVLVTYFTQPEQKAESRRDILAAAAKIVTHGF
CTX-M-4 ...................................................Q...........V....................................RA.........................G.............................................S.....................................................M....G..........................................................  97.25 %
CTX-M-6 ...............................................................L.....................................A.........................G.............................................S........................................................C...............................................V............  97.94 %
CTX-M-7 ...............................................................V....................................RA.....................Q...G.............................................S..........................................................G.............................................V............  97.25 %
CTX-M-20 ......................................................................................................................................................................................................................................................................................F............  99.66 %
CTX-M-31 .................................................................................................................................................................S.................................................................................................................................  99.66 %
CTX-M-35 .........................................................................................................................................................................S.........................................................................................................................  99.66 %
CTX-M-43 .................................................................................................................................................................................................................................................G................................R................  99.31 %
CTX-M-44 ..................................................................................................................................................................................................................................................................................R................  99.66 %
CTX-M-56 ..................................................................................................................................................................................................................................................................................N................  99.66 %
CTX-M-59 ...........................................................................................L.......................................................................................................................................................................................................  99.66 %
CTX-M-74 .........................................................................................................................................................................T.........................................................................................................................  99.66 %
CTX-M-75 .................S.................................................................................................................................................................................................................................................................................  99.66 %
CTX-M-92 ...............................................................................................................................................................................................................T...................................................................................  99.66 %
CTX-M-97 ......G............................................................................................................................................................................................................................................................................................  99.66 %
CTX-M-131 .................................................................................................................................................................................................................................................G.................................................  99.66 %
CTX-M-141 ...............................................................................................................................................................................................................E...................................................................................  99.66 %
CTX-M-165 ..............................S....................................................................................................................................................................................................................................................................  99.66 %
CTX-M-171 ................................................................................................S..................................................................................................................................................................................................  99.66 %
CTX-M-200 ...............................................................................................................................................................................................................................................I...................................................  99.66 %
CTX-M-229 ......................................................................................................................................................................S.......-A...................................................................................................................  98.97 %
CTX-M-253 ...............................................................................V...................................................................................................................................................................................................................  99.66 %
CTX-M-270 .............................T..................................................................................................................................................................................................Q.........................I..........................YV............  98.28 %
KLUA-1 ..........................................................................................................................................................................................................................................................I...........................V............  99.31 %
KLUA-2 .............................T..........................................................................................................................................................................................................G.....................A.......................V............  98.63 %
KLUA-5 .............................T..........................G..H..........K...............................................................................................................................................................................................................V............  98.28 %
KLUA-6 ......................R......T..........................................................................................................................................................................................................G.....................A.......................V............  98.28 %
KLUA-8 ..........................................................................................................................................................................................................................................................I.....QT....................V............  98.63 %
KLUA-9 ................................................................................................................................................................................................................................Q.........................I..................D........V............  98.63 %
KLUA-10 .............................T...........................................................N......................................................................................................................................Q.....................................................V............  98.63 %
KLUA-11 ................................................................................................................................................................................................................................Q...............V...P.TH..I..................D........V............  97.25 %
KLUA-14 ..........................................................................................................................................................................................................................................................I...........................V..........S.  98.97 %
KLUA-15 .............................T..........................................................................................................................................................................................................G.............................................V............  98.97 %
KLUA-16 .............................T.......K..........................................................................................................................................................................................Q.........................I...........................V.........R..  97.94 %
KLUA-17 .............................T....................................................L.............................................................................................................................................Q.....................................................V............  98.63 %
A-CTX-M-2-like phylogenetic tree

Last updated: November 20, 2024.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database was funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

Live statistics (since December 3rd, 2023)