Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
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Beta-Lactamase DataBase

Sequence alignment for the CTX-M-1-like beta-lactamase family

CTX-M-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290....
---MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAVAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVDGTMSLAELSAAALQYSDNVAMNKLISHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTNGL
CTX-M-3---...............................................................................A....................................N.........................A.................................................................................................................................................D.. 98.63 %
CTX-M-10---..............................V..........Q.....................................A....................................N.........................A.................................................................................................................................................D.. 97.94 %
CTX-M-12---...............A...............................................................A...........S........................N.........................A.......................................................................................................................................I.........D.. 97.59 %
CTX-M-15---...............................................................................A....................................N.........................A..................................................................................................G..............................................D.. 98.28 %
CTX-M-22---...............................................................................A....................................N.........................A.................................................................................................................................................... 98.97 %
CTX-M-23---....................................................................................................................N.........................A..........................T......................................................................................................................... 98.97 %
CTX-M-28---...............................................................................A....................................N.........................A..................................................................................................G................................................. 98.63 %
CTX-M-29---...............A...............................................................A..............................................................A..................................................................................................G................................................. 98.63 %
CTX-M-30---...............A...............................................................A..............................................................A.................................................................................................................................................D.. 98.63 %
CTX-M-32---.................................................................................................................................................................................................................................................G................................................. 99.66 %
CTX-M-33---...............................................................................A............................S.......N.........................A..................................................................................................G..............................................D.. 97.94 %
CTX-M-34---..............................V..........Q.....................................A....................................N.........................A.................................................................................................C...............................................D.. 97.59 %
CTX-M-36---...............................................................................A................................................................................................................................................................................................................... 99.66 %
CTX-M-37---..........................H..............Q.....................................A..............................................................A.................................................................................................................................................D.. 98.28 %
CTX-M-42---...............................................................................A....................................N.........................A..........................T......................................................................................................................D.. 98.28 %
CTX-M-52---....................................................................................................................N.........................A..........................S......................................................................................................................D.. 98.63 %
CTX-M-53---..............................V..........Q..........................................................................N.........................A..................................................................................................G.....................I........................D.. 97.59 %
CTX-M-54---...............................................................................A....................................N.........................A..........................Q......................................................................................................................D.. 98.28 %
CTX-M-55---....................................................................................................................N.........................A..................................................................................................G..............................................D.. 98.63 %
CTX-M-58---.........................................................................................................................................................................T......................................................................................................................... 99.66 %
CTX-M-60---...............A...........................................................................S........................N.........................A.......................................................................................................................................I.........D.. 97.94 %
CTX-M-61---................................................................................................................................................................................................................................................................................................D.. 99.66 %
CTX-M-62---...............................................................................A....................................N.........................A..........................S......................................................................................................................D.. 98.28 %
CTX-M-64---.....................................................................P.........A.....Q..TQKQ....P....PA.............N...T..............T......AQL...GG......AI..........................T.........Q....H...ET........L..........R................G..............................................D.. 90.03 %
CTX-M-66---......................N........................................................A....................................N.........................A.................................................................................................................................................D.. 98.28 %
CTX-M-68---..........................H...V................................................A....................................N.........................A.................D...............................................................................................................................D.. 97.59 %
CTX-M-69---....................................................................................................................N.........................A..................................................................................................G.............................N................... 98.63 %
CTX-M-70---.................................................................................................................................................................................................................................................G..............................................D.. 99.31 %
CTX-M-71---...............................................................................A....................................N.........................A.................................................................................................CG..............................................D.. 97.94 %
CTX-M-72---...............................................................................A....................................N.........................A.......................G.........................................................................................................................D.. 98.28 %
CTX-M-79---....................................................................................................................N.........................A..................................................................................................G................................................. 98.97 %
CTX-M-80---..............................V................................................A....................................N.........................A.................................................................................................................................................D.. 98.28 %
CTX-M-82---.....................................................................P.........A....................................N.........................A..................................................................................................G..............................................D.. 97.94 %
CTX-M-88---...............................................................................A....................................N.........................A..................................................................................................G..................................H...........D.. 97.94 %
CTX-M-96---...............A...............................................................A...........S........................N.........................A..................................................................................................G....................................I.........D.. 97.25 %
CTX-M-101---...............................................................................A....................................N........I................A..................................................................................................G..............................................D.. 97.94 %
CTX-M-103---...............................................................................A....................................N.........................A................................................................................................N.G..............................................D.. 97.94 %
CTX-M-114---............................................................................A.......................................N.........................A..................................................................................................G..............................................D.. 98.28 %
CTX-M-116---....................................................................................................................N.........................A.................................................................................................................................................... 99.31 %
CTX-M-117---...............................................................................A....................................N.........................A.................................Q................................................................G..............................................D.. 97.94 %
CTX-M-123---...............................................................................A....................................N..................T......AQL...GG......AI..........................T.........Q....H...ET........L..........R....T..T........G..............................................D.. 92.78 %
CTX-M-127---...............................................................................A....................................N.................D.......A..................................................................................................G..............................................D.. 97.94 %
CTX-M-132---...............................................................................A....................................N...T..............T......AQL...GG......AI..........................T........................................................G..............................................D.. 95.19 %
CTX-M-136---....................................................................................................................N.........................A.................................................................................................................................................D.. 98.97 %
CTX-M-138---.............................................................................................................................................................................................................................................................................................S..... 99.66 %
CTX-M-139---..........................F....................................................A....................................N.........................A..................................................................................................G..............................................D.. 97.94 %
CTX-M-142---...............................N...............................................A....................................N.........................A..................................................................................................G..............................................D.. 97.94 %
CTX-M-143---...............................................................................A....................................N.........................A.............................S....................................................................G..............................................D.. 97.94 %
CTX-M-144---....................................................................................................................N.........................A....................................L.............................................................G..............................................D.. 98.28 %
CTX-M-150---...............................................................................A....................................N.........................A.........................................................................H.H......................G..............................................D.. 97.59 %
CTX-M-153---.....................................................................P.........A....................................N..................T......AQL...GG......AI..........................T.........Q....H...ET........L..........R....T..T........G..............................................D.. 92.44 %
CTX-M-154---......................................K........................................A....................................N.........................A..................................................................................................G..............................................D.. 97.94 %
CTX-M-155---...............................................................................A....................................N.........................A.........................A........................................................................G........................................G.....D.. 97.59 %
CTX-M-156---...............................................................................A....................................N.........................A..................................................................................................G.............................N................D.. 97.94 %
CTX-M-157---...............................................................................A....................................N.........................A.........................A........................................................................G..............................................D.. 97.94 %
CTX-M-158---..............................................................................................................................V.................................................................................................................................................................... 99.66 %
CTX-M-162---......S........................................................................A....................................N.........................A.................................................................................................................................................D.. 98.28 %
CTX-M-163---......S........................................................................A....................................N.........................A..................................................................................................G..............................................D.. 97.94 %
CTX-M-164---.......K............................................................................................................N.........................A..................................................................................................G..............................................D.. 98.28 %
CTX-M-166---..........................................................................................................................V........................................................................................................................................................................ 99.66 %
CTX-M-167---...............................................................................A....................................N.........................A.................................................................................................C...............................................D.. 98.28 %
CTX-M-169---...............................................................................A...........S........................N.........................A..................................................................................................G..............................................D.. 97.94 %
CTX-M-170---...............................................................................A....................................N.........................A............................................................N.....................................G..............................................D.. 97.94 %
CTX-M-172---...............................................................................A....................................N.......................P.A..................................................................................................G..............................................D.. 97.94 %
CTX-M-173---...............................................................................A....................................N.........................A.........T........................................................................................G..............................................D.. 97.94 %
CTX-M-175---..........................................................................................................................T........................................................................................................................................................................ 99.66 %
CTX-M-176---...............................................................................A....................................N.........................A..................................................................................................G........................A.....................D.. 97.94 %
CTX-M-177---...............................................................................A....................................N.........................A.............L...................................................................................................................................D.. 98.28 %
CTX-M-178---...............................................................................A....................................N.........................A...............................................................................................S..G..............................................D.. 97.94 %
CTX-M-179---....................................................................................................................N.........................A..................................................................................................G..........................T...................D.. 98.28 %
CTX-M-180---...............................................................................A....................................N.........................A............................................................................S.....................G..............................................D.. 97.94 %
CTX-M-181---...............................................................................A....................................N.................H.......A..................................................................................................G..............................................D.. 97.94 %
CTX-M-182---...................................R...........................................A....................................N.........................A..................................................................................................G..............................................D.. 97.94 %
CTX-M-183---.............................K.................................................A....................................N.........................A..................................................................................................G..............................................D.. 97.94 %
CTX-M-184---.........................................................T.....................A....................................N.........................A..................................................................................................G..............................................D.. 97.94 %
CTX-M-186---...................S...........................................................A....................................N.........................A..................................................................................................G..............................................D.. 97.94 %
CTX-M-187---...............................................................................A....................................N.........................A...............................................................................................S.................................................D.S 97.94 %
CTX-M-188---...............................................................................A.T..................................N.........................A..................................................................................................G..............................................D.. 97.94 %
CTX-M-189---...............................................................................A....................................N...............G.........A..................................................................................................G..............................................D.. 97.94 %
CTX-M-190---....................................................................................................................N...............T.........A..................................................................................................G..............................................D.. 98.28 %
CTX-M-193---...............................................................................A...............................T....N.........................A..................................................................................................G..............................................D.. 97.94 %
CTX-M-194---......H........................................................................A....................................N.........................A..................................................................................................G..............................................D.. 97.94 %
CTX-M-197---...............................................................................A....................................N.........................A..............V...................................................................................G..............................................D.. 97.94 %
CTX-M-199---.....................................................................P.........A.....Q..TQKQ....P....PA........T....N...T...........T..T......AQL...GG......AI..........................T.........Q....H...ET........L..........R................G..............................................D.. 89.35 %
CTX-M-202---...............................................................................A....................................N.........................A..................................................................................................G.....................I........................D.. 97.94 %
CTX-M-203---...............................................................................A....................................N.........................A.............................................................................................R...................................................D.. 98.28 %
CTX-M-204---...............................................................................A....................................N.........................A........................I........................................................................................................................D.. 98.28 %
CTX-M-206---...............................................................................A...........S........................N.........................A.................................................................................................................................................D.. 98.28 %
CTX-M-207---....................................................................................................................N.........................A..................................................................................................S..............................................D.. 98.63 %
CTX-M-208---...............................................................................A....................................N.........................A..............................................................................E...................G..............................................D.. 97.94 %
CTX-M-209---...............................................................................A....................................N.........................A....................................................................I.............................G..............................................D.. 97.94 %
CTX-M-210---..............................T................................................A....................................N.........................A..................................................................................................G..............................................D.. 97.94 %
CTX-M-211MVKKS.............................................................................A....................................N.........................A.................................................................................................................................................D.. 96.94 %
CTX-M-212---....................................................................................................................N.........................A..........................T......................................................................................................................D.. 98.63 %
CTX-M-216---...............................................................................A....................................N.........................A..................................................................................................G..............................................DS. 97.94 %
CTX-M-218---...............................................................................A....................................N...............T.........A..................................................................................................G..............................................D.. 97.94 %
CTX-M-220---...............................................................................A............................S.......N.........................A.................................................................................................................................................D.. 98.28 %
CTX-M-222---......................................................................................................................................................I............................................................................................................................................ 99.66 %
CTX-M-224---.......L.......................................................................A....................................N.........................A..................................................................................................G..............................................D.. 97.94 %
CTX-M-225---...............................................................................A....................................N.........................A......................................................................................T...........G..............................................D.. 97.94 %
CTX-M-226---........................T...........................................................................................N.........................A..................................................................................................G..............................................D.. 98.28 %
CTX-M-227---....................................................................................................................N.........................A...............................................................................................S..G..............................................DR. 97.94 %
CTX-M-228---...............................................................................A....................................N.........................A...............................................................................N..................G..............................................D.. 97.94 %
CTX-M-230---....................................................................................................................N.........................A..............................I...................................................................G..............................................D.. 98.28 %
CTX-M-231---..............................E................................................A....................................N.........................A..................................................................................................G..............................................D.. 97.94 %
CTX-M-232---..............T................................................................A....................................N.........................A..................................................................................................G..............................................D.. 97.94 %
CTX-M-234---.....................................................................P..............................................N...T...........T..T......AQL...GG......AI..........................T.........Q....H...ET........L..........R................G..............................................D.. 92.78 %
CTX-M-236---...............................................................................A....................................N.........................A........................................................................................R........................................................D.. 98.28 %
CTX-M-237---...............................................................................A....................................N.........................A...........V......................................................................................G..............................................D.. 97.94 %
CTX-M-238---.........A.....................................................................A....................................N.........................A..................................................................................................G..............................................D.. 97.94 %
CTX-M-244---.........................................................................I.....A....................................N.........................A..................................................................................................G..............................................D.. 97.94 %
CTX-M-245---...............................................................................A....................................N.........................A..................................................................................................G.........................P..................F.D.. 97.59 %
CTX-M-246---..............................V..........Q.....................................A....................................N.....T...................A.................D..................................................A............................................................................D.. 96.91 %
CTX-M-251---...............................................................................A....................................N..................M......A.................................................................................................................................................D.. 98.28 %
CTX-M-254---.......................................................................S.......A....................................N.........................A..................................................................................................G..............................................D.. 97.94 %
CTX-M-256---...............................................................................A....................................N.........................A....Q.............................................................................................G..............................................D.. 97.94 %
CTX-M-257---...............................................................................A....................................N.........................A......................................Y..........................................................................................................D.. 98.28 %
CTX-M-258---..................................................T............................A....................................N.........................A..................................................................................................G..............................................D.. 97.94 %
CTX-M-259---...............................................................................A....................................N.........................A..........................................................................................A.......G..............................................D.. 97.94 %
CTX-M-260---...............................................................................A...........K........................N.........................A......................................Y..........................................................................................................D.. 97.94 %
CTX-M-261---....................................................................................................................N.........................A..................................................................................................G........M.....................................D.. 98.28 %
CTX-M-262---...........K..............................P....................................A....................................N.........................A..................................................................................................G..............................................D.. 97.59 %
CTX-M-263---...........K...P.....RR........................................................A....................................N.........................A..................................................................................................G..............................................D.. 96.91 %
CTX-M-264---...........K...P......C........................................................A........................V...........N.........................A................................V.................................................................G.................................P............D.. 96.22 %
CTX-M-265---...........K...P......C........................................................A....................................N.........................A................................V.................................................................G.................................P............D.. 96.56 %
CTX-M-266---...............................................................................A....................................N.........................A..................................................................................................G...............................D..............D.. 97.94 %
CTX-M-268---...............................................................................A....................................N.........................A..................................................................................................G...............................G..............D.. 97.94 %
CTX-M-271---...............................................................................A....................................N.........................A................................T.................................................................G..............................................D.. 97.94 %
CTX-M-273---...............................................................................A....................................N.........................A..........................S.......................................................................G..............................................D.. 97.94 %
CTX-M-274---...............................................................................A....................................N.........................A.............................................................................................R....G..............................................D.. 97.94 %
CTX-M-275---...............................................................................A....................................N.........................A..................................................................................................G.........................................S....D.. 97.94 %
CTX-M-276---...............................................................................A....................................N.........................A...........................M......................................................................G..............................................D.. 97.94 %
CTX-M-279---...............................................................................A....................................N.........................A..................................................................................................G.............................................ID.. 97.94 %
CTX-M-280---...............................................................................A....................................N.........................A....................................................................A.............................G..............................................D.. 97.94 %
CTX-M-281---....................................................................................................................N...............T.........A.................................................................................................CG..............................................D.. 97.94 %
CTX-M-282---...............................................................................A....................................N.........................A......................................Y...........................................................G..............................................D.. 97.94 %
CTX-M-P5----..............................................................................A.................A..................N.........................A..................................................................................................G..............................................--- 96.91 %
CTX-M-P6----..........................................................R...................A....................................N.........................A..................................................................................................G..............................................K-- 96.91 %
CTX-M-P44---......................................G........................................A....................................N....P....................A......................................................................................................................................H....--------- 94.85 %
FEC-1---................A..S...........................................................A....................................N.........................A.................................................................................................................................................D.. 97.94 %
A-CTX-M-1-like phylogenetic tree

Last updated: April 06, 2026.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database was funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

Live statistics (since March 29th, 2025)