Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
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Beta-Lactamase DataBase

Sequence alignment for the CTX-M-1-like beta-lactamase family

CTX-M-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290....
---MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAVAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVDGTMSLAELSAAALQYSDNVAMNKLISHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTNGL
CTX-M-10 ---..............................V..........Q.....................................A....................................N.........................A.................................................................................................................................................D..  97.94 %
CTX-M-12 ---...............A...............................................................A...........S........................N.........................A.......................................................................................................................................I.........D..  97.59 %
CTX-M-15 ---...............................................................................A....................................N.........................A..................................................................................................G..............................................D..  98.28 %
CTX-M-22 ---...............................................................................A....................................N.........................A....................................................................................................................................................  98.97 %
CTX-M-23 ---....................................................................................................................N.........................A..........................T.........................................................................................................................  98.97 %
CTX-M-28 ---...............................................................................A....................................N.........................A..................................................................................................G.................................................  98.63 %
CTX-M-29 ---...............A...............................................................A..............................................................A..................................................................................................G.................................................  98.63 %
CTX-M-30 ---...............A...............................................................A..............................................................A.................................................................................................................................................D..  98.63 %
CTX-M-32 ---.................................................................................................................................................................................................................................................G.................................................  99.66 %
CTX-M-33 ---...............................................................................A............................S.......N.........................A..................................................................................................G..............................................D..  97.94 %
CTX-M-34 ---..............................V..........Q.....................................A....................................N.........................A.................................................................................................C...............................................D..  97.59 %
CTX-M-36 ---...............................................................................A...................................................................................................................................................................................................................  99.66 %
CTX-M-42 ---...............................................................................A....................................N.........................A..........................T......................................................................................................................D..  98.28 %
CTX-M-52 ---....................................................................................................................N.........................A..........................S......................................................................................................................D..  98.63 %
CTX-M-53 ---..............................V..........Q..........................................................................N.........................A..................................................................................................G.....................I........................D..  97.59 %
CTX-M-54 ---...............................................................................A....................................N.........................A..........................Q......................................................................................................................D..  98.28 %
CTX-M-55 ---....................................................................................................................N.........................A..................................................................................................G..............................................D..  98.63 %
CTX-M-58 ---.........................................................................................................................................................................T.........................................................................................................................  99.66 %
CTX-M-60 ---...............A...........................................................................S........................N.........................A.......................................................................................................................................I.........D..  97.94 %
CTX-M-61 ---................................................................................................................................................................................................................................................................................................D..  99.66 %
CTX-M-62 ---...............................................................................A....................................N.........................A..........................S......................................................................................................................D..  98.28 %
CTX-M-64 ---.....................................................................P.........A.....Q..TQKQ....P....PA.............N...T..............T......AQL...GG......AI..........................T.........Q....H...ET........L..........R................G..............................................D..  90.03 %
CTX-M-66 ---......................N........................................................A....................................N.........................A.................................................................................................................................................D..  98.28 %
CTX-M-68 ---..........................H...V................................................A....................................N.........................A.................D...............................................................................................................................D..  97.59 %
CTX-M-69 ---....................................................................................................................N.........................A..................................................................................................G.............................N...................  98.63 %
CTX-M-70 ---.................................................................................................................................................................................................................................................G..............................................D..  99.31 %
CTX-M-71 ---...............................................................................A....................................N.........................A.................................................................................................CG..............................................D..  97.94 %
CTX-M-72 ---...............................................................................A....................................N.........................A.......................G.........................................................................................................................D..  98.28 %
CTX-M-79 ---....................................................................................................................N.........................A..................................................................................................G.................................................  98.97 %
CTX-M-80 ---..............................V................................................A....................................N.........................A.................................................................................................................................................D..  98.28 %
CTX-M-82 ---.....................................................................P.........A....................................N.........................A..................................................................................................G..............................................D..  97.94 %
CTX-M-88 ---...............................................................................A....................................N.........................A..................................................................................................G..................................H...........D..  97.94 %
CTX-M-96 ---...............A...............................................................A...........S........................N.........................A..................................................................................................G....................................I.........D..  97.25 %
CTX-M-101 ---...............................................................................A....................................N........I................A..................................................................................................G..............................................D..  97.94 %
CTX-M-103 ---...............................................................................A....................................N.........................A................................................................................................N.G..............................................D..  97.94 %
CTX-M-114 ---............................................................................A.......................................N.........................A..................................................................................................G..............................................D..  98.28 %
CTX-M-116 ---....................................................................................................................N.........................A....................................................................................................................................................  99.31 %
CTX-M-117 ---...............................................................................A....................................N.........................A.................................Q................................................................G..............................................D..  97.94 %
CTX-M-123 ---...............................................................................A....................................N..................T......AQL...GG......AI..........................T.........Q....H...ET........L..........R....T..T........G..............................................D..  92.78 %
CTX-M-127 ---...............................................................................A....................................N.................D.......A..................................................................................................G..............................................D..  97.94 %
CTX-M-132 ---...............................................................................A....................................N...T..............T......AQL...GG......AI..........................T........................................................G..............................................D..  95.19 %
CTX-M-136 ---....................................................................................................................N.........................A.................................................................................................................................................D..  98.97 %
CTX-M-138 ---.............................................................................................................................................................................................................................................................................................S.....  99.66 %
CTX-M-139 ---..........................F....................................................A....................................N.........................A..................................................................................................G..............................................D..  97.94 %
CTX-M-142 ---...............................N...............................................A....................................N.........................A..................................................................................................G..............................................D..  97.94 %
CTX-M-143 ---...............................................................................A....................................N.........................A.............................S....................................................................G..............................................D..  97.94 %
CTX-M-144 ---....................................................................................................................N.........................A....................................L.............................................................G..............................................D..  98.28 %
CTX-M-150 ---...............................................................................A....................................N.........................A.........................................................................H.H......................G..............................................D..  97.59 %
CTX-M-153 ---.....................................................................P.........A....................................N..................T......AQL...GG......AI..........................T.........Q....H...ET........L..........R....T..T........G..............................................D..  92.44 %
CTX-M-154 ---......................................K........................................A....................................N.........................A..................................................................................................G..............................................D..  97.94 %
CTX-M-155 ---...............................................................................A....................................N.........................A.........................A........................................................................G........................................G.....D..  97.59 %
CTX-M-156 ---...............................................................................A....................................N.........................A..................................................................................................G.............................N................D..  97.94 %
CTX-M-157 ---...............................................................................A....................................N.........................A.........................A........................................................................G..............................................D..  97.94 %
CTX-M-158 ---..............................................................................................................................V....................................................................................................................................................................  99.66 %
CTX-M-162 ---......S........................................................................A....................................N.........................A.................................................................................................................................................D..  98.28 %
CTX-M-163 ---......S........................................................................A....................................N.........................A..................................................................................................G..............................................D..  97.94 %
CTX-M-164 ---.......K............................................................................................................N.........................A..................................................................................................G..............................................D..  98.28 %
CTX-M-166 ---..........................................................................................................................V........................................................................................................................................................................  99.66 %
CTX-M-167 ---...............................................................................A....................................N.........................A.................................................................................................C...............................................D..  98.28 %
CTX-M-169 ---...............................................................................A...........S........................N.........................A..................................................................................................G..............................................D..  97.94 %
CTX-M-170 ---...............................................................................A....................................N.........................A............................................................N.....................................G..............................................D..  97.94 %
CTX-M-172 ---...............................................................................A....................................N.......................P.A..................................................................................................G..............................................D..  97.94 %
CTX-M-173 ---...............................................................................A....................................N.........................A.........T........................................................................................G..............................................D..  97.94 %
CTX-M-175 ---..........................................................................................................................T........................................................................................................................................................................  99.66 %
CTX-M-176 ---...............................................................................A....................................N.........................A..................................................................................................G........................A.....................D..  97.94 %
CTX-M-177 ---...............................................................................A....................................N.........................A.............L...................................................................................................................................D..  98.28 %
CTX-M-178 ---...............................................................................A....................................N.........................A...............................................................................................S..G..............................................D..  97.94 %
CTX-M-179 ---....................................................................................................................N.........................A..................................................................................................G..........................T...................D..  98.28 %
CTX-M-180 ---...............................................................................A....................................N.........................A............................................................................S.....................G..............................................D..  97.94 %
CTX-M-181 ---...............................................................................A....................................N.................H.......A..................................................................................................G..............................................D..  97.94 %
CTX-M-182 ---...................................R...........................................A....................................N.........................A..................................................................................................G..............................................D..  97.94 %
CTX-M-183 ---.............................K.................................................A....................................N.........................A..................................................................................................G..............................................D..  97.94 %
CTX-M-184 ---.........................................................T.....................A....................................N.........................A..................................................................................................G..............................................D..  97.94 %
CTX-M-186 ---...................S...........................................................A....................................N.........................A..................................................................................................G..............................................D..  97.94 %
CTX-M-187 ---...............................................................................A....................................N.........................A...............................................................................................S.................................................D.S  97.94 %
CTX-M-188 ---...............................................................................A.T..................................N.........................A..................................................................................................G..............................................D..  97.94 %
CTX-M-189 ---...............................................................................A....................................N...............G.........A..................................................................................................G..............................................D..  97.94 %
CTX-M-190 ---....................................................................................................................N...............T.........A..................................................................................................G..............................................D..  98.28 %
CTX-M-193 ---...............................................................................A...............................T....N.........................A..................................................................................................G..............................................D..  97.94 %
CTX-M-194 ---......H........................................................................A....................................N.........................A..................................................................................................G..............................................D..  97.94 %
CTX-M-197 ---...............................................................................A....................................N.........................A..............V...................................................................................G..............................................D..  97.94 %
CTX-M-199 ---.....................................................................P.........A.....Q..TQKQ....P....PA........T....N...T...........T..T......AQL...GG......AI..........................T.........Q....H...ET........L..........R................G..............................................D..  89.35 %
CTX-M-202 ---...............................................................................A....................................N.........................A..................................................................................................G.....................I........................D..  97.94 %
CTX-M-203 ---...............................................................................A....................................N.........................A.............................................................................................R...................................................D..  98.28 %
CTX-M-204 ---...............................................................................A....................................N.........................A........................I........................................................................................................................D..  98.28 %
CTX-M-206 ---...............................................................................A...........S........................N.........................A.................................................................................................................................................D..  98.28 %
CTX-M-207 ---....................................................................................................................N.........................A..................................................................................................S..............................................D..  98.63 %
CTX-M-208 ---...............................................................................A....................................N.........................A..............................................................................E...................G..............................................D..  97.94 %
CTX-M-209 ---...............................................................................A....................................N.........................A....................................................................I.............................G..............................................D..  97.94 %
CTX-M-210 ---..............................T................................................A....................................N.........................A..................................................................................................G..............................................D..  97.94 %
CTX-M-211 MVKKS.............................................................................A....................................N.........................A.................................................................................................................................................D..  96.94 %
CTX-M-212 ---....................................................................................................................N.........................A..........................T......................................................................................................................D..  98.63 %
CTX-M-216 ---...............................................................................A....................................N.........................A..................................................................................................G..............................................DS.  97.94 %
CTX-M-218 ---...............................................................................A....................................N...............T.........A..................................................................................................G..............................................D..  97.94 %
CTX-M-220 ---...............................................................................A............................S.......N.........................A.................................................................................................................................................D..  98.28 %
CTX-M-222 ---......................................................................................................................................................I............................................................................................................................................  99.66 %
CTX-M-224 ---.......L.......................................................................A....................................N.........................A..................................................................................................G..............................................D..  97.94 %
CTX-M-225 ---...............................................................................A....................................N.........................A......................................................................................T...........G..............................................D..  97.94 %
CTX-M-226 ---........................T...........................................................................................N.........................A..................................................................................................G..............................................D..  98.28 %
CTX-M-227 ---....................................................................................................................N.........................A...............................................................................................S..G..............................................DR.  97.94 %
CTX-M-228 ---...............................................................................A....................................N.........................A...............................................................................N..................G..............................................D..  97.94 %
CTX-M-230 ---....................................................................................................................N.........................A..............................I...................................................................G..............................................D..  98.28 %
CTX-M-231 ---..............................E................................................A....................................N.........................A..................................................................................................G..............................................D..  97.94 %
CTX-M-232 ---..............T................................................................A....................................N.........................A..................................................................................................G..............................................D..  97.94 %
CTX-M-234 ---.....................................................................P..............................................N...T...........T..T......AQL...GG......AI..........................T.........Q....H...ET........L..........R................G..............................................D..  92.78 %
CTX-M-236 ---...............................................................................A....................................N.........................A........................................................................................R........................................................D..  98.28 %
CTX-M-237 ---...............................................................................A....................................N.........................A...........V......................................................................................G..............................................D..  97.94 %
CTX-M-238 ---.........A.....................................................................A....................................N.........................A..................................................................................................G..............................................D..  97.94 %
CTX-M-244 ---.........................................................................I.....A....................................N.........................A..................................................................................................G..............................................D..  97.94 %
CTX-M-245 ---...............................................................................A....................................N.........................A..................................................................................................G.........................P..................F.D..  97.59 %
CTX-M-246 ---..............................V..........Q.....................................A....................................N.....T...................A.................D..................................................A............................................................................D..  96.91 %
CTX-M-251 ---...............................................................................A....................................N..................M......A.................................................................................................................................................D..  98.28 %
CTX-M-254 ---.......................................................................S.......A....................................N.........................A..................................................................................................G..............................................D..  97.94 %
CTX-M-256 ---...............................................................................A....................................N.........................A....Q.............................................................................................G..............................................D..  97.94 %
CTX-M-257 ---...............................................................................A....................................N.........................A......................................Y..........................................................................................................D..  98.28 %
CTX-M-258 ---..................................................T............................A....................................N.........................A..................................................................................................G..............................................D..  97.94 %
CTX-M-259 ---...............................................................................A....................................N.........................A..........................................................................................A.......G..............................................D..  97.94 %
CTX-M-260 ---...............................................................................A...........K........................N.........................A......................................Y..........................................................................................................D..  97.94 %
CTX-M-261 ---....................................................................................................................N.........................A..................................................................................................G........M.....................................D..  98.28 %
CTX-M-262 ---...........K..............................P....................................A....................................N.........................A..................................................................................................G..............................................D..  97.59 %
CTX-M-263 ---...........K...P.....RR........................................................A....................................N.........................A..................................................................................................G..............................................D..  96.91 %
CTX-M-264 ---...........K...P......C........................................................A........................V...........N.........................A................................V.................................................................G.................................P............D..  96.22 %
CTX-M-265 ---...........K...P......C........................................................A....................................N.........................A................................V.................................................................G.................................P............D..  96.56 %
CTX-M-266 ---...............................................................................A....................................N.........................A..................................................................................................G...............................D..............D..  97.94 %
CTX-M-268 ---...............................................................................A....................................N.........................A..................................................................................................G...............................G..............D..  97.94 %
CTX-M-P4 ----..............................................................................A....................................N.........................A.............................................................................................R....G..............................................---  96.91 %
CTX-M-P5 ----..............................................................................A.................A..................N.........................A..................................................................................................G..............................................---  96.91 %
CTX-M-P6 ----..........................................................R...................A....................................N.........................A..................................................................................................G..............................................K--  96.91 %
CTX-M-P44 ---......................................G........................................A....................................N....P....................A......................................................................................................................................H....---------  94.85 %
FEC-1 ---................A..S...........................................................A....................................N.........................A.................................................................................................................................................D..  97.94 %
KLUB-1 ---...............................................................................A....................................N.........................A.................................................................................................................................................D..  98.63 %
KLUB-2 ---..........................H..............Q.....................................A..............................................................A.................................................................................................................................................D..  98.28 %
A-CTX-M-1-like phylogenetic tree

Last updated: November 20, 2024.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database was funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

Live statistics (since December 3rd, 2023)