Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
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Beta-Lactamase DataBase

Sequence alignment for the CARB-1-like beta-lactamase family

CARB-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300....
----------------MKFLLAFSLLIPSVVFASSSKFQQVEQDVKAIEVSLSARIGVSVLDTQNGEYWDYNGNQRFPLTSTFKTIACAKLLYDAEQGKVNPNSTVEIKKADLVTYSPVIEKQVGQAITLDDACFATMTTSDNTAANIILSAVGGPKGVTDFLRQIGDKETRLDRIEPDLNEGKLGDLRDTTTPKAIASTLNKFLFGSALSEMNQKKLESWMVNNQVTGNLLRSVLPAGWNIADRSGAGGFGARSITAVVWSEHQAPIIVSIYLAQTQASMEERNDAIVKIGHSIFDVYTSQSR
CARB-2 MLLYKMCDNQNYGVTY.........................................................................................................................................................................................................................................................................A......................  94.41 %
CARB-3 ----------------...........................................................................................................................................................................................L.............................................................................A......................  99.31 %
CARB-4 ----------------..L..V.......M...N..........A.V..A....H..I......T.................................EI..K..I.....................................A......N.L...ES....................E...............N..VN...EL....T..QDG.....Y.................E.........................A.S...........E..IAD.........R...E..S....  86.11 %
CARB-6 ----------------..........................................................................................................................................................................................QL....T...AS.......................VK.S.................I....EKKT..........E...A..........R...E.......  94.10 %
CARB-7 ----------------..S..V.A..M............S...EI.G..S........AI.......S.....D......................H....L.................L.....KP...S...L.............VIN...D..SI................V..E...............N..T....QL....T...AS.......................VK.S.................I....EKK...........E...A..........R...E.......  84.03 %
CARB-9 ----------------..S..V.A..M............S...EI.G..S........AI.......S.....D......................H....L.....V...........L.....KP...S.................VIN...D..SI................V..E...............N..T....QL....T...AS.......................VT.S.................I....EKK...........E...A..........R...E.......  84.03 %
CARB-11 ----------------.....................................................................................S...................................................................................................................................................................................A......................  99.31 %
CARB-12 ----------------.....V................R....................................................................................................................S..........................................................K..................................................................A..........R...........  97.92 %
CARB-52 ----------------..L..V.......M...N..........A.V..A....H..I......T.................................EI..K..I.....................................A......N.L...ES...................SE...............N..VN...EL....T..QDG.....Y.................E.........................A.S...........E..IAD.........R...E..S....  85.76 %
CARB-53 ----------------.........................K...............................................................................................................................................................................................................................................A......................  99.31 %
CARB-55 ----------------....W...H...................................Y............................................................................................................................................................................................................................A......................  98.61 %
CARB-58 ----------------..L......................................................................................................................................................................................................................................................................A......................  99.31 %
A-CARB-1-like phylogenetic tree

Last updated: November 20, 2024.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database was funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

Live statistics (since December 3rd, 2023)