Beta-Lactamase DataBase
Beta-Lactamase DataBase - Structure and Function Home Enzymes Structures Mutants Kinetics BLAST
Beta-Lactamase DataBase

Structures

Ambler
class
Protein
name
PDB
code
Resolution
(Å)
Release
date
UniProt
code
PubMed
ID
DOI
PDB
Mutations
Ligands
Space
group
Unit cell parameters
Z
value
DOXA-483HBR1.902009-06-23Q6XEC0 1947741810.1016/J.CHEMBIOL.2009.04.010pdb EDO KCX P 1 21 163.701 107.185 80.787 ♦ 90.00 111.04 90.008
DOXA-484S2J2.542015-02-25Q6XEC0 2762253010.1021/ACSINFECDIS.5B00007pdb *NXL P 21 21 2164.050 108.100 162.810 ♦ 90.00 90.00 90.0016
DOXA-484S2K2.102015-02-25Q6XEC0 2762253010.1021/ACSINFECDIS.5B00007pdb *NXL P 32142.780 142.780 52.420 ♦ 90.00 90.00 120.0012
DOXA-484S2N2.002015-02-25Q6XEC0 2762253010.1021/ACSINFECDIS.5B00007pdb *NXL KCX P 32142.039 142.039 50.401 ♦ 90.00 90.00 120.006
DOXA-484S2P1.702015-02-25Q6XEC0 2762253010.1021/ACSINFECDIS.5B00007pdb KCX P 2 21 2143.410 102.870 124.730 ♦ 90.00 90.00 90.008
DOXA-484WMC2.302014-12-03Q6XEC0 2540683810.1021/CB500703Ppdb *NXL CO2 KCX P 1 21 163.886 165.465 108.524 ♦ 90.00 90.39 90.0012
DOXA-485DTK1.602016-05-25Q6XEC0 2716569210.1021/ACS.JMEDCHEM.6B00660pdb $5F3 CL EDO KCX P 1 21 145.523 124.310 108.742 ♦ 90.00 98.26 90.008
DOXA-485DTS1.942016-05-25Q6XEC0 2716569210.1021/ACS.JMEDCHEM.6B00660pdb $5F8 CL KCX P 21 21 2189.600 109.630 125.010 ♦ 90.00 90.00 90.0016
DOXA-485DTT2.102016-05-25Q6XEC0 2716569210.1021/ACS.JMEDCHEM.6B00660pdb $5F5 CL EDO KCX P 21 21 2188.371 107.622 124.553 ♦ 90.00 90.00 90.0016
DOXA-485DVA2.502016-06-01Q6XEC0 2716569210.1021/ACS.JMEDCHEM.6B00660pdb $5FL CL KCX P 21 21 2191.037 109.660 124.241 ♦ 90.00 90.00 90.0016
DOXA-485FAQ1.962016-01-20Q6XEC0 2673169810.1021/ACSCHEMBIO.5B00944pdb *5VW CD CL CO P 21 21 2172.760 75.470 106.970 ♦ 90.00 90.00 90.008
DOXA-485FAS1.742016-01-20Q6XEC0 2673169810.1021/ACSCHEMBIO.5B00944pdb *5VR CD CL CO P 21 21 2173.080 75.800 106.670 ♦ 90.00 90.00 90.008
DOXA-485FAT2.092016-01-20Q6XEC0 2673169810.1021/ACSCHEMBIO.5B00944pdb *602 CD CL CO P 21 21 2173.110 75.750 106.650 ♦ 90.00 90.00 90.008
DOXA-485HAP1.892016-09-07Q6XEC0 2707300910.1021/ACS.BIOCHEM.6B00056pdbS70A 1PE CL EDO KCX MPD NA PEG PG4 PGE P 65 2 2121.900 121.900 161.451 ♦ 90.00 90.00 120.0024
DOXA-485HAQ2.142016-09-07Q6XEC0 2707300910.1021/ACS.BIOCHEM.6B00056pdbS70G CD FMT KCX P 21 21 2172.660 73.611 106.360 ♦ 90.00 90.00 90.008
DOXA-485OFT3.202018-08-01Q6XEC0 pdbR206A KCX P 65 2 2120.151 120.151 160.107 ♦ 90.00 90.00 120.0024
DOXA-485QA41.952018-01-10Q6XEC0 2934807110.1016/j.ejmech.2017.12.085pdb $TI7 CL EDO KCX P 21 21 2189.099 108.936 124.908 ♦ 90.00 90.00 90.0016
DOXA-485QA51.952018-01-10Q6XEC0 2934807210.1016/j.ejmech.2017.12.085pdb $L5D CL EDO KCX P 21 21 2189.341 109.061 124.906 ♦ 90.00 90.00 90.0016
DOXA-485QA61.952018-01-10Q6XEC0 2934807310.1016/j.ejmech.2017.12.085pdb $AUV CL EDO KCX P 21 21 2189.008 108.992 124.791 ♦ 90.00 90.00 90.0016
DOXA-485QA71.822018-01-10Q6XEC0 2934807410.1016/j.ejmech.2017.12.085pdb $IQQ CL EDO KCX P 21 21 2188.856 108.510 124.852 ♦ 90.00 90.00 90.0016
DOXA-485QA82.502018-01-10Q6XEC0 2934807510.1016/j.ejmech.2017.12.085pdb $JSX CL KCX P 21 21 21125.014 88.339 106.875 ♦ 90.00 90.00 90.0016
DOXA-485QA91.902018-01-10Q6XEC0 2934807610.1016/j.ejmech.2017.12.085pdb $QKU CL EDO KCX P 21 21 2188.981 108.447 124.139 ♦ 90.00 90.00 90.0016
DOXA-485QAA1.952018-01-10Q6XEC0 2934807710.1016/j.ejmech.2017.12.085pdb $EAJ CL EDO KCX P 21 21 2190.280 108.936 124.109 ♦ 90.00 90.00 90.0016
DOXA-485QAB2.152018-01-10Q6XEC0 2934807810.1016/j.ejmech.2017.12.085pdb $XEV CL EDO KCX P 21 21 2188.514 107.483 125.345 ♦ 90.00 90.00 90.0016
DOXA-485QAC2.002018-01-10Q6XEC0 2934807910.1016/j.ejmech.2017.12.085pdb $U4J CL EDO KCX P 21 21 2188.161 106.805 124.907 ♦ 90.00 90.00 90.0016
DOXA-485QAD1.752018-01-10Q6XEC0 2934808010.1016/j.ejmech.2017.12.085pdb $WVV CL EDO KCX P 21 21 2188.919 108.895 124.888 ♦ 90.00 90.00 90.0016
DOXA-485QAE2.102018-01-10Q6XEC0 2934808110.1016/j.ejmech.2017.12.085pdb $Q4G CL EDO KCX P 21 21 2190.302 109.463 125.187 ♦ 90.00 90.00 90.0016
DOXA-485QAF2.152018-01-10Q6XEC0 2934808210.1016/j.ejmech.2017.12.085pdb $S1D CL EDO KCX P 21 21 2188.407 107.087 124.881 ♦ 90.00 90.00 90.0016
DOXA-485QAG2.302018-01-10Q6XEC0 2934808310.1016/j.ejmech.2017.12.085pdb $Q2R CL EDO KCX P 21 21 2190.582 108.927 125.000 ♦ 90.00 90.00 90.0016
DOXA-485QAH1.952018-01-10Q6XEC0 2934808410.1016/j.ejmech.2017.12.085pdb $EFX CL EDO KCX P 21 21 2189.908 108.889 124.809 ♦ 90.00 90.00 90.0016
DOXA-485QAI1.902018-01-10Q6XEC0 2934808510.1016/j.ejmech.2017.12.085pdb $VM7 CL DMS EDO KCX P 21 21 2189.255 108.766 124.263 ♦ 90.00 90.00 90.0016
DOXA-485QAJ2.002018-01-10Q6XEC0 2934808610.1016/j.ejmech.2017.12.085pdb $VBC CL EDO KCX P 21 21 2188.521 107.601 124.439 ♦ 90.00 90.00 90.0016
DOXA-485QAK1.902018-01-10Q6XEC0 2934808710.1016/j.ejmech.2017.12.085pdb $AV4 CL EDO KCX P 21 21 2188.943 107.938 124.947 ♦ 90.00 90.00 90.0016
DOXA-485QAL1.952018-01-10Q6XEC0 2934808810.1016/j.ejmech.2017.12.085pdb $TVZ CL EDO KCX P 21 21 2185.024 104.043 126.849 ♦ 90.00 90.00 90.0016
DOXA-485QAM1.872018-01-10Q6XEC0 2934808910.1016/j.ejmech.2017.12.085pdb $GA6 CL EDO KCX P 21 21 2190.730 109.051 124.085 ♦ 90.00 90.00 90.0016
DOXA-485QAN2.302018-01-10Q6XEC0 2934809010.1016/j.ejmech.2017.12.085pdb $M8Q CL KCX P 1 21 144.935 125.236 107.702 ♦ 90.00 98.42 90.008
DOXA-485QAO2.002018-01-10Q6XEC0 2934809110.1016/j.ejmech.2017.12.085pdb $Z8R CL DMS EDO KCX P 21 21 2188.770 107.275 125.312 ♦ 90.00 90.00 90.0016
DOXA-485QAP1.792018-01-10Q6XEC0 2934809210.1016/j.ejmech.2017.12.085pdb $AV7 CL EDO KCX P 21 21 2188.771 108.629 124.634 ♦ 90.00 90.00 90.0016
DOXA-485QAQ2.402018-01-10Q6XEC0 2934809310.1016/j.ejmech.2017.12.085pdb $S1C CL EDO KCX P 21 21 2189.408 108.440 124.709 ♦ 90.00 90.00 90.0016
DOXA-485QAR2.102018-01-10Q6XEC0 2934809410.1016/j.ejmech.2017.12.085pdb $QIU CL KCX P 21 21 2189.818 108.080 124.060 ♦ 90.00 90.00 90.0016
DOXA-485QAS1.902018-01-10Q6XEC0 2934809510.1016/j.ejmech.2017.12.085pdb $CVF EDO KCX P 21 21 2188.778 108.080 124.379 ♦ 90.00 90.00 90.0016
DOXA-485QAT1.902018-01-10Q6XEC0 2934809610.1016/j.ejmech.2017.12.085pdb $T7O CL EDO KCX P 1 21 145.135 125.260 107.808 ♦ 90.00 98.54 90.008
DOXA-485QAU1.752018-01-10Q6XEC0 2934809710.1016/j.ejmech.2017.12.085pdb $V7V CL EDO KCX P 21 21 2189.695 108.732 124.164 ♦ 90.00 90.00 90.0016
DOXA-485QAV1.722018-01-10Q6XEC0 2934809810.1016/j.ejmech.2017.12.085pdb $L43 CL EDO KCX P 21 21 2190.070 108.424 124.555 ♦ 90.00 90.00 90.0016
DOXA-485QAW2.202018-01-10Q6XEC0 2934809910.1016/j.ejmech.2017.12.085pdb $TVC CL KCX P 21 21 2190.501 109.053 124.636 ♦ 90.00 90.00 90.0016
DOXA-485QAX2.312018-01-10Q6XEC0 2934810010.1016/j.ejmech.2017.12.085pdb $Q92 CL EDO KCX P 1 21 164.196 107.848 85.150 ♦ 90.00 103.82 90.008
DOXA-485QAY1.702018-01-10Q6XEC0 2934810110.1016/j.ejmech.2017.12.085pdb $X6P CL EDO KCX P 21 21 2189.722 108.403 124.870 ♦ 90.00 90.00 90.0016
DOXA-485QAZ2.202018-01-10Q6XEC0 2934810210.1016/j.ejmech.2017.12.085pdb $Q2S CL EDO KCX P 21 21 2188.997 108.495 125.123 ♦ 90.00 90.00 90.0016
DOXA-485QB01.952018-01-10Q6XEC0 2934810310.1016/j.ejmech.2017.12.085pdb $AVA CL EDO KCX P 21 21 2189.211 107.969 124.987 ♦ 90.00 90.00 90.0016
DOXA-485QB11.802018-01-10Q6XEC0 2934810410.1016/j.ejmech.2017.12.085pdb $F1C CL EDO KCX P 1 21 144.962 125.208 107.378 ♦ 90.00 97.82 90.008
DOXA-485QB21.752018-01-10Q6XEC0 2934810510.1016/j.ejmech.2017.12.085pdb $U3M CL EDO KCX P 21 21 2190.035 108.693 124.094 ♦ 90.00 90.00 90.0016
DOXA-485QB32.002018-01-10Q6XEC0 2934810610.1016/j.ejmech.2017.12.085pdb $AVM CL EDO KCX P 21 21 2189.486 108.304 124.569 ♦ 90.00 90.00 90.0016
DOXA-485QB41.952018-01-10Q6XEC0 2934810710.1016/j.ejmech.2017.12.085pdb *IM2 CL EDO KCX P 21 21 2188.790 107.500 124.330 ♦ 90.00 90.00 90.0016
DOXA-486GOA2.552018-07-18Q6XEC0 pdbR189A CL KCX P 1 21 1107.726 85.545 125.805 ♦ 90.00 90.08 90.0016
DOXA-486I5D1.752020-03-04Q6XEC0 pdb CL EDO GOL NO3 PEG PO4 P 21 21 2149.571 92.984 126.391 ♦ 90.00 90.00 90.008
DOXA-486P961.602019-08-07Q6XEC0 3135858410.1128/AAC.01202-19pdb CA CD CL P 21 21 2170.746 76.827 100.044 ♦ 90.00 90.00 90.008
DOXA-486P971.802019-08-07Q6XEC0 3135858410.1128/AAC.01202-19pdb *IM2 CA CD CL P 21 21 2172.131 76.210 101.130 ♦ 90.00 90.00 90.008
DOXA-486P981.752019-08-07Q6XEC0 3135858410.1128/AAC.01202-19pdb *KE1 CA CD CL P 21 21 2173.132 74.563 97.974 ♦ 90.00 90.00 90.008
DOXA-486P992.252019-08-07Q6XEC0 3135858410.1128/AAC.01202-19pdb *1RG CA CD CL P 21 21 2171.883 76.822 101.247 ♦ 90.00 90.00 90.008
DOXA-486P9C1.902019-08-07Q6XEC0 3135858410.1128/AAC.01202-19pdb *4J6 CA CD CL O6P P 21 21 2172.604 76.749 101.188 ♦ 90.00 90.00 90.008
DOXA-486PK01.752020-01-22A0A482LRD5 pdb $HIW CL GOL KCX P 1 21 158.050 105.430 93.570 ♦ 90.00 107.96 90.008
DOXA-486PQI2.052020-01-22A0A482LRD5 pdb *CEF ACT CL P 1 21 159.732 107.005 96.196 ♦ 90.00 104.17 90.008
DOXA-486PSG2.132020-01-22A0A482LRD5 pdb *DGF CL GOL P 1 21 159.555 106.674 96.261 ♦ 90.00 104.19 90.008
DOXA-486PT12.002020-01-22A0A482LRD5 pdb *MER CL GOL P 1 21 159.797 106.512 95.835 ♦ 90.00 104.66 90.008
DOXA-486PT52.302020-01-22A0A482LRD5 pdb *1S7 CL P 1 21 160.246 107.115 96.105 ♦ 90.00 104.06 90.008
DOXA-486PTU2.002020-01-22A0A482LRD5 pdb *ID1 CL P 1 21 158.497 106.656 94.659 ♦ 90.00 107.60 90.008
DOXA-486PXX1.502019-10-09Q6XEC0 3151429110.3390/ANTIBIOTICS8030145pdbK73A *5R7 CL EDO EPE P 21 21 2105.770 125.092 45.120 ♦ 90.00 90.00 90.008
DOXA-486Q5B2.222019-03-20Q6XEC0 3091805510.1128/mSphere.00024-19pdbP68A *NXL CL CO2 KCX SO4 P 21 21 2188.115 105.802 125.268 ♦ 90.00 90.00 90.008
DOXA-486Q5F2.502019-03-20Q6XEC0 3091805510.1128/mSphere.00024-19pdbP68A *CTJ CL KCX PEG PGE SO4 P 21 21 2189.986 105.369 125.281 ♦ 90.00 90.00 90.008
DOXA-486RJ71.732019-07-31Q6XEC0 3131040910.1002/CHEM.201902529pdbT213K5H CA CL K5H KCX P 1 21 164.360 58.030 66.430 ♦ 90.00 91.49 90.004
DOXA-486UVK2.202020-05-06Q6XEC0 3218243210.1021/ACSINFECDIS.0C00015pdb $QHY CL EDO GOL KCX P 65123.054 123.054 161.329 ♦ 90.00 90.00 120.0024
DOXA-486V1O1.802020-03-25A0A482LRD5 3215040710.1021/ACS.JMEDCHEM.9B01976pdb *RM9 CL KCX MG P 1 21 158.440 105.550 94.403 ♦ 90.00 107.92 90.008
DOXA-486XQR2.202021-12-15Q6XEC0 3481716910.1021/ACSINFECDIS.1C00501pdb $VBV CL KCX P 65 2 2122.561 122.561 161.284 ♦ 90.00 90.00 120.0024
DOXA-486ZRJ1.942021-07-21Q6XEC0 pdb *2RG CL EDO KCX PGE P 1 21 163.834 162.839 108.158 ♦ 90.00 90.59 90.0014
DOXA-486ZRP1.742021-07-21Q6XEC0 pdb *DWZ CL EDO KCX P 1 21 146.994 125.286 105.199 ♦ 90.00 77.70 90.004
DOXA-486ZXI1.852021-08-11Q6XEC0 pdb *QS8 CL CO2 EDO P 2 21 2144.798 105.106 125.426 ♦ 90.00 90.00 90.008
DOXA-487ASS1.912020-12-16Q6XEC0 pdbL67F $RYE CL KCX P 21 21 2188.555 108.476 125.423 ♦ 90.00 90.00 90.0016
DOXA-487AUX2.052021-07-21Q6XEC0 3420240210.3390/PH14070612pdb $LKW CL KCX P 21 21 2171.410 72.630 125.660 ♦ 90.00 90.00 90.008
DOXA-487AW51.652021-07-21Q6XEC0 3420240210.3390/PH14070612pdb $LKH CL KCX P 21 21 2172.470 73.680 124.790 ♦ 90.00 90.00 90.008
DOXA-487DML1.942021-12-15Q6XEC0 10.1039/D1CC03026Dpdb *H9O KCX P 1 21 158.455 105.865 94.118 ♦ 90.00 107.81 90.008
DOXA-487JHQ2.002021-12-01Q6XEC0 3481716910.1021/ACSINFECDIS.1C00501pdb $VAJ CL EDO KCX NA PEG P 65120.680 120.680 159.769 ♦ 90.00 90.00 120.0024
DOXA-487K5V2.802021-12-01Q6XEC0 3481716910.1021/ACSINFECDIS.1C00501pdb $BIH CL EDO KCX NA P 65 2 2122.922 122.922 161.143 ♦ 90.00 90.00 120.0024
DOXA-487KH92.292021-02-10Q6XEC0 3349295210.1021/ACSINFECDIS.0C00798pdbK73A *IM2 CL P 2 21 2144.690 104.750 125.070 ♦ 90.00 90.00 90.008
DOXA-487KHQ2.002021-02-10Q6XEC0 3349295210.1021/ACSINFECDIS.0C00798pdbK73A *MER CL ZN P 2 21 2144.285 105.487 125.665 ♦ 90.00 90.00 90.008
DOXA-487L8O2.702021-12-01Q6XEC0 3481716910.1021/ACSINFECDIS.1C00501pdb $XV7 CL EDO KCX NA P 65122.039 122.039 160.787 ♦ 90.00 90.00 120.0024
DOXA-487LXG2.202022-05-25Q6XEC0 pdb CL SO4 YHA P 62143.960 143.960 56.030 ♦ 90.00 90.00 120.0012
DOXA-487R6Z2.102021-12-01Q6XEC0 3481716910.1021/ACSINFECDIS.1C00501pdb $3I0 CL DMS EDO KCX P 65 2 2121.808 121.808 160.462 ♦ 90.00 90.00 120.0024
DOXA-488FAJ1.752023-10-11Q6XEC0 3713008710.1021/ACSINFECDIS.3C00059pdb CA CD CL Y33 P 21 21 2173.564 74.638 97.608 ♦ 90.00 90.00 90.008
DOXA-488SQF2.302024-01-03Q6XEC0 3811768810.1021/ACS.JMEDCHEM.3C01834pdb $WIP BCT KCX P 65 2 2123.083 123.083 161.759 ♦ 90.00 90.00 120.0024
DOXA-488SQG2.032024-01-03Q6XEC0 3811768810.1021/ACS.JMEDCHEM.3C01834pdb $X6Q BCT KCX P 65 2 2121.929 121.929 160.522 ♦ 90.00 90.00 120.0024
Legend for ligands: * Ligand covalently-bound to active site residues; $ Non-covalent ligand (Michaelis complex); # Ligand coordinated to active site metal ions.

Statistics (number of structures): Overall (1663); class A (626); subclass B1 (403); subclass B2 (16); subclass B3 (104); class C (246); class D (268).

Last updated: November 20, 2024.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database was funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

Live statistics (since December 3rd, 2023)