Beta-Lactamase DataBase
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Beta-Lactamase DataBase

Structures

Ambler
class
Protein
name
PDB
code
Resolution
(Å)
Release
date
UniProt
code
PubMed
ID
DOI
PDB
Mutations
Ligands
Space
group
Unit cell parameters
Z
value
ACTX-M-141YLT1.102005-04-19Q9L5C7 1581137310.1016/J.JMB.2005.02.010pdb SO4 SUC P 21 21 2141.467 62.420 86.742 ♦ 90.00 90.00 90.004
ACTX-M-141YLZ1.352005-04-26Q9L5C7 1582618010.1021/JA042850Apdb *CB4 PO4 P 1 21 145.310 106.892 47.880 ♦ 90.00 101.87 90.004
ACTX-M-144PM51.262014-12-31G8XD06 2548979010.1021/bi501195gpdbS70G $CE3 SO4 P 21 21 2141.550 62.680 86.130 ♦ 90.00 90.00 90.004
ACTX-M-144PM61.562014-12-31G8XD06 2548979010.1021/bi501195gpdbS70G SO4 P 21 21 2141.550 62.280 86.200 ♦ 90.00 90.00 90.004
ACTX-M-144PM71.292014-12-31G8XD06 2548979010.1021/bi501195gpdbS237A S70G $CE3 P 21 21 2141.500 62.630 86.140 ♦ 90.00 90.00 90.004
ACTX-M-144PM81.172014-12-31G8XD06 2548979010.1021/bi501195gpdbS237A S70G SO4 P 21 21 2141.500 62.190 86.080 ♦ 90.00 90.00 90.004
ACTX-M-144PM91.452014-12-31G8XD06 2548979010.1021/bi501195gpdbR276A S237A S70G $CE3 P 21 21 2141.530 61.737 86.675 ♦ 90.00 90.00 90.004
ACTX-M-144PMA1.402014-12-31G8XD06 2548979010.1021/bi501195gpdbR276A S237A S70G SO4 P 21 21 2141.742 62.380 86.701 ♦ 90.00 90.00 90.004
ACTX-M-144UA60.792015-06-24H6UQI0 2605725210.1021/JACS.5B00749pdb K PCA PO4 P 1 21 145.106 106.581 47.716 ♦ 90.00 102.23 90.004
ACTX-M-144UA70.892015-06-24H6UQI0 2605725210.1021/JACS.5B00749pdb $3GK PCA PO4 P 1 21 145.079 106.947 47.761 ♦ 90.00 101.77 90.004
ACTX-M-144UA90.842015-06-24H6UQI0 2605725210.1021/JACS.5B00749pdb *CB4 PCA PO4 P 1 21 145.074 106.632 47.684 ♦ 90.00 102.18 90.004
ACTX-M-144UAA0.862015-06-24H6UQI0 2605725210.1021/JACS.5B00749pdb $3GK PCA PO4 P 1 21 144.968 106.692 47.664 ♦ 90.00 102.08 90.004
ACTX-M-144XXR1.182015-03-18Q9L5C7 2575314910.1039/C5CC00904ApdbE166A $JSC $JSD $JSE K P 1 21 144.899 106.775 47.903 ♦ 90.00 101.87 90.004
ACTX-M-145TOP1.182017-11-08H6UQI0 2909557010.1111/FEBS.14315pdbS45G S70G $7G4 $JSC $JSE K PCA RU P 1 21 145.093 106.821 47.933 ♦ 90.00 101.66 90.004
ACTX-M-145TOY1.302017-11-08H6UQI0 2909557010.1111/FEBS.14315pdbE166A $JSC $JSD K PO4 RU SUC P 1 21 145.012 106.787 47.759 ♦ 90.00 101.76 90.004
ACTX-M-145TW61.702017-06-28Q9L5C7 2861387310.1021/ACS.BIOCHEM.7B00176pdbE166A P167S *CAZ EDO P 32 2 141.540 41.540 231.151 ♦ 90.00 90.00 120.006
ACTX-M-145TWD1.702017-06-28Q9L5C7 2861387310.1021/ACS.BIOCHEM.7B00176pdbP167S P 32 2 141.600 41.600 231.932 ♦ 90.00 90.00 120.006
ACTX-M-145TWE1.502017-06-28Q9L5C7 2861387310.1021/ACS.BIOCHEM.7B00176pdbP167S S70G $CAZ P 32 2 141.610 41.610 232.234 ♦ 90.00 90.00 120.006
ACTX-M-145U531.402017-06-28H6UQI0 2861387310.1021/ACS.BIOCHEM.7B00176pdb *CAZ NO3 P 41 21 242.030 42.030 262.860 ♦ 90.00 90.00 90.008
ACTX-M-145UJO1.352017-02-08A0A1B3B7F6 10.1021/ACS.ORGANOMET.6B00888pdb $LSI *8CY K P 1 21 144.961 107.351 47.956 ♦ 90.00 101.36 90.004
ACTX-M-145VLE0.852017-11-08H6UQI0 2909557010.1111/FEBS.14315pdbE166A $JSC $JSD $JSE K PCA PO4 RU P 1 21 144.745 106.418 47.611 ♦ 90.00 102.38 90.004
ACTX-M-145VTH2.202017-06-28Q9L5C7 2861387310.1021/ACS.BIOCHEM.7B00176pdbE166A P167S P 32 2 141.690 41.690 233.052 ♦ 90.00 90.00 120.006
ACTX-M-146BT61.052018-06-13A0A1B3B7F6 2984403810.1128/AAC.02563-17pdb S237A $3GK PCA P 1 21 145.190 107.130 47.850 ♦ 90.00 101.52 90.004
ACTX-M-146CYK1.702018-10-10Q9L5C7 pdbN106S ACT P 1 21 145.210 107.160 47.800 ♦ 90.00 101.72 90.004
ACTX-M-146CYN1.602018-10-10Q9L5C7 pdbN106S D240G P 3283.238 83.238 231.982 ♦ 90.00 90.00 120.0024
ACTX-M-146CYQ1.702018-10-10Q9L5C7 pdbN106S S70G $CE4 GOL P 3283.375 83.375 232.058 ♦ 90.00 90.00 120.0024
ACTX-M-146CYU1.822018-10-10Q9L5C7 pdbN106S D240G S70G $CE4 P 32 2 141.399 41.399 230.610 ♦ 90.00 90.00 120.006
ACTX-M-146D7H1.802019-07-24H6UQI0 pdb K PO4 P 32 2 141.710 41.710 232.524 ♦ 90.00 90.00 120.006
ACTX-M-146D7I2.002019-07-24H6UQI0 pdbD233N P 32 2 141.809 41.809 231.951 ♦ 90.00 90.00 120.006
ACTX-M-146GTH1.692018-10-10D2D9A0 10.1038/S41467-018-06156-7pdb *NXL P 32 2 141.840 41.840 233.280 ♦ 90.00 90.00 120.006
ACTX-M-146MD81.402019-04-17 3094207810.1021/ACSINFECDIS.9B00052pdb $J84 DMS PCA P 1 21 145.202 106.878 47.781 ♦ 90.00 101.89 90.004
ACTX-M-146MIA1.402019-04-17H6UQI0 3094207810.1021/ACSINFECDIS.9B00052pdb $1CE P 1 21 145.340 107.185 47.881 ♦ 90.00 101.33 90.004
ACTX-M-146MZ11.002019-11-20A0A2S1PK93 3212308410.1073/pnas.1922203117pdb *NXL K NA PCA PO4 P 1 21 145.220 106.720 47.810 ♦ 90.00 101.79 90.004
ACTX-M-146MZ20.832019-11-20A0A2S1PK93 3212308410.1073/pnas.1922203117pdb *NXL K NA PCA PO4 P 1 21 145.161 106.842 47.913 ♦ 90.00 101.82 90.004
ACTX-M-146OOF1.242020-07-01A0A2S1PK93 pdb $R6Z PCA P 1 21 145.161 107.211 47.884 ♦ 90.00 101.66 90.004
ACTX-M-146OOJ1.402020-07-01A0A2S1PK93 pdb $J1X PCA P 1 21 145.096 106.929 47.830 ♦ 90.00 101.61 90.004
ACTX-M-146OOK1.402020-07-01A0A2S1PK93 pdb $MZV PCA PO4 P 1 21 145.003 106.725 47.736 ♦ 90.00 101.73 90.004
ACTX-M-146UNB1.302019-10-30A0A2S1PK93 pdb *TJ7 PCA PO4 P 1 21 145.110 106.460 47.670 ♦ 90.00 101.92 90.004
ACTX-M-146V5E2.302020-04-22Q9L5C7 3229991110.1074/JBC.RA119.012489pdbD240G P167S SEE P 41 21 242.237 42.237 261.638 ♦ 90.00 90.00 90.008
ACTX-M-146V6G1.502020-04-22Q9L5C7 3229991110.1074/JBC.RA119.012489pdbD240G E166A P167S NA PEG P 32 2 141.428 41.428 231.066 ♦ 90.00 90.00 120.006
ACTX-M-146V6P1.552020-04-22Q9L5C7 3229991110.1074/JBC.RA119.012489pdbD240G E166A PEG SO4 P 41 21 241.930 41.930 259.190 ♦ 90.00 90.00 90.008
ACTX-M-146V7H1.002020-08-12A0A2S1PK93 3277854610.1128/AAC.00398-20pdb *4D6 K PCA PO4 WXM P 1 21 145.300 106.695 47.865 ♦ 90.00 101.64 90.004
ACTX-M-146V7T1.342020-04-22Q9L5C7 3229991110.1074/JBC.RA119.012489pdbD240G E166A *CAZ P 1 21 145.110 107.330 47.750 ♦ 90.00 99.86 90.004
ACTX-M-146V831.802020-04-22Q9L5C7 3229991110.1074/JBC.RA119.012489pdbD240G E166A P167S *CAZ P 41 21 242.357 42.357 262.692 ♦ 90.00 90.00 90.008
ACTX-M-146V8V1.802020-04-22Q9L5C7 3229991110.1074/JBC.RA119.012489pdbD240G E166A P167S *CAZ P 32 2 141.273 41.273 231.629 ♦ 90.00 90.00 120.006
ACTX-M-146VHS1.282020-08-26A0A2S1PK93 3265847310.1021/ACS.JMEDCHEM.0C00579pdb *X57 PCA PO4 P 1 21 145.250 106.920 47.870 ♦ 90.00 101.81 90.004
ACTX-M-146VNU1.472020-04-01A0A1B3B7F6 3218239310.1002/CBIC.202000054pdb *TDJ 7G4 K P 1 21 145.152 106.894 47.908 ♦ 90.00 101.68 90.004
ACTX-M-147K2W1.402020-11-04A0A2H4FY00 pdb *CEF P 32 2 141.654 41.654 232.309 ♦ 90.00 90.00 120.006
ACTX-M-147K2X1.802020-11-04A0A2H4FY00 pdb GOL P 3283.373 83.373 232.091 ♦ 90.00 90.00 120.0024
ACTX-M-147K2Y1.622020-11-04A0A2H4FY00 pdb *AIX P 32 2 141.630 41.630 231.473 ♦ 90.00 90.00 120.006
Legend for ligands: * Ligand covalently-bound to active site residues; $ Non-covalent ligand (Michaelis complex); # Ligand coordinated to active site metal ions.

Statistics (number of structures): Overall (1429); class A (543); subclass B1 (348); subclass B2 (15); subclass B3 (82); class C (221); class D (220).

Last updated: November 06, 2021.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database is funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu