Beta-Lactamase DataBase (BLDB): Structure and Function

Ambler class	Protein name	PDB code	Resolution (Å)	Release date	UniProt code	PubMed ID	DOI	PDB	Mutations	Ligands	Space group	Unit cell parameters	Z value
▲ ▼	▲ ▼	▲ ▼	▲ ▼	▲ ▼							▲ ▼
A	CTX-M-44	1BZA	1.80	1999-04-27	Q47066	9925786	10.1006/JMBI.1998.2432	pdb	E166A	SO4	P 32 2 1	73.309 73.309 99.374 ♦ 90.00 90.00 120.00	6
A	CTX-M-44	1IYO	1.80	2002-12-11	Q47066	12221102	10.1074/JBC.M207884200	pdb	E166A	*CEF SO4	P 32 2 1	72.581 72.581 98.179 ♦ 90.00 90.00 120.00	6
A	CTX-M-44	1IYP	2.00	2002-12-11	Q47066	12221102	10.1074/JBC.M207884200	pdb	E166A	*CEP SO4	P 32 2 1	73.229 73.229 100.229 ♦ 90.00 90.00 120.00	6
A	CTX-M-44	1IYQ	2.10	2002-12-11	Q47066	12221102	10.1074/JBC.M207884200	pdb	E166A	*PNM SO4	P 32 2 1	72.799 72.799 99.467 ♦ 90.00 90.00 120.00	6
A	CTX-M-44	1IYS	1.65	2003-10-14	Q47066	12962487	10.1021/BI0342822	pdb		SO4	P 32 2 1	72.592 72.592 97.891 ♦ 90.00 90.00 120.00	6
A	CTX-M-44	1WE4	1.70	2005-03-15	Q47066	15595829	10.1021/BI048488U	pdb	G238C A26M	SO4	P 32 2 1	72.705 72.705 98.268 ♦ 90.00 90.00 120.00	6
A	CTX-M-44	2WYX	2.10	2010-01-12	Q47066	20036259	10.1016/J.JMB.2009.12.036	pdb	E166A R274N R276N		P 32 2 1	72.993 72.993 98.365 ♦ 90.00 90.00 120.00	6
A	CTX-M-44	2XQZ	2.10	2010-12-22	Q47066	21168411	10.1016/J.FEBSLET.2010.12.017	pdb	R274N R276N		P 32 2 1	72.956 72.956 98.526 ♦ 90.00 90.00 120.00	6
A	CTX-M-44	2XR0	2.20	2010-12-22	Q47066	21168411	10.1016/J.FEBSLET.2010.12.017	pdb	R274N R276N	SO4	P 32 2 1	73.500 73.500 99.330 ♦ 90.00 90.00 120.00	6
A	CTX-M-44	2ZQ7	0.94	2009-07-28	Q47066			pdb	E166A R274N R276N	SO4	P 32 2 1	72.545 72.545 97.656 ♦ 90.00 90.00 120.00	6
A	CTX-M-44	2ZQ8	1.03	2009-07-28	Q47066	19342785	10.1107/S1744309109008240	pdb	R274N R276N	SO4	P 32 2 1	72.511 72.511 97.477 ♦ 90.00 90.00 120.00	6
A	CTX-M-44	2ZQ9	1.07	2009-07-28	Q47066			pdb	E166A R274N R276N	^$CLS *CEO SO4 SPA	P 32 2 1	72.421 72.421 97.518 ♦ 90.00 90.00 120.00	6
A	CTX-M-44	2ZQA	0.95	2009-07-28	Q47066			pdb	E166A R274N R276N	*PCZ SO4	P 32 2 1	72.522 72.522 97.960 ♦ 90.00 90.00 120.00	6
A	CTX-M-44	2ZQC	1.07	2009-07-28	Q47066			pdb	E166A R274N R276N	*AZR SO4	P 32 2 1	72.293 72.293 97.578 ♦ 90.00 90.00 120.00	6
A	CTX-M-44	2ZQD	1.19	2009-07-28	Q47066			pdb	E166A R274N R276N	*CAZ SO4	P 32 2 1	72.413 72.413 97.665 ♦ 90.00 90.00 120.00	6
A	CTX-M-44	4BD0	1.21	2013-01-09	Q47066	23255594	10.1074/JBC.M112.436238	pdb	R274N R276N	*BZB SO4	P 32 2 1	72.500 72.500 97.670 ♦ 90.00 90.00 120.00	6
A	CTX-M-44	4BD1	2.00	2013-01-16	Q47066	23255594	10.1074/JBC.M112.436238	pdb	R274N R276N	*BZB	P 32 2 1	73.429 73.429 99.112 ♦ 90.00 90.00 120.00	6
A	CTX-M-44	4C3Q	2.20	2014-07-09	Q47066		10.1107/S1600576714010772	pdb	R274N R276N	*BZB	P 32 2 1	72.889 72.889 98.189 ♦ 90.00 90.00 120.00	6
A	CTX-M-44	4X69	1.42	2015-07-01	Q47066	26089439	10.1093/JAC/DKV166	pdb	A26G	*OP0 EDO	P 1 21 1	51.533 72.982 63.052 ♦ 90.00 109.29 90.00	4
A	CTX-M-44	5KSC	2.10	2016-11-09	Q47066	27795378	10.1128/AAC.01636-16	pdb	R271N R273N E165A	*AZR	P 32 2 1	73.296 73.296 99.093 ♦ 90.00 90.00 120.00	6
A	CTX-M-44	5KMW	1.10	2017-03-01	Q47066			pdb	R271N R273N E165A	^$PNN *PNM SO4	P 32 2 1	72.262 72.262 98.193 ♦ 90.00 90.00 120.00	6
A	CTX-M-44	6C78	1.75	2018-03-21	Q47066		10.1021/ACSCATAL.7B04114	pdb	S70A R274N R276N		P 32 2 1	73.400 73.400 99.390 ♦ 90.00 90.00 120.00	6
A	CTX-M-44	6C79	1.10	2018-03-21	Q47066		10.1021/ACSCATAL.7B04114	pdb	S70A R274N R276N	^$CE3 SO4	P 32 2 1	72.720 72.720 98.944 ♦ 90.00 90.00 120.00	6
A	CTX-M-44	6C7A	1.05	2018-03-21	Q47066		10.1021/ACSCATAL.7B04114	pdb	S70A R274N R276N	SO4	P 32 2 1	71.825 71.825 96.534 ♦ 90.00 90.00 120.00	6
A	CTX-M-44	6U58	1.90	2020-02-19	A3FFV8	32038042	10.1107/S2059798319016334	pdb	R276N E166Q	SO4	P 32 2 1	73.543 73.543 99.721 ♦ 90.00 90.00 120.00	6

Legend for ligands: * Ligand covalently-bound to active site residues; ^$ Non-covalent ligand (Michaelis complex); ^# Ligand coordinated to active site metal ions.

Statistics (number of structures): Overall (1663); class A (626); subclass B1 (403); subclass B2 (16); subclass B3 (104); class C (246); class D (268).

Last updated: January 08, 2024.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database is funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

Live statistics (since December 3rd, 2023)

Structures