 |
|
|
|
Ambler class |
Protein name |
Mutations |
PubMed ID |
DOI |
PDB structures |
Hydrolytic profile |
|---|---|---|---|---|---|---|
| A | SHV-1 | R164H | 21357298 | 10.1128/AAC.01360-10 | view | |
| A | SHV-1 | R164S | 21357298 | 10.1128/AAC.01360-10 | view | |
| A | SHV-1 | D104E | 21294157 | 10.1002/PROT.22961 | view | |
| A | SHV-1 | D104K | 16809340 | 10.1074/JBC.M603878200 | view | |
| A | SHV-1 | E166A | 14744126 | view | ||
| A | SHV-1 | E166A | 16055923 | 10.1074/JBC.M505333200 | view | |
| A | SHV-1 | E166A | 24454944 | 10.1371/JOURNAL.PONE.0085892 | view | |
| A | SHV-1 | E166A M69V | 17002290 | 10.1021/BI060990M | ||
| A | SHV-1 | K234R | 23252553 | 10.1021/JM301490D | view | |
| A | SHV-1 | K234R | 24454944 | 10.1371/JOURNAL.PONE.0085892 | view | |
| A | SHV-1 | M69V | 22438274 | 10.1002/CMDC.201200006 | view | |
| A | SHV-1 | S130G | 15518561 | 10.1021/BI0487903 | view | |
| A | SHV-1 | S130G | 22438274 | 10.1002/CMDC.201200006 | view | |
| A | SHV-1 | S130G | 25691639 | 10.1128/AAC.04405-14 | view | |
| A | SHV-1 | S70C | 22974281 | 10.1021/JA3073676 | view |
Statistics (number of mutants): Overall (167); class A (91); subclass B1 (35); subclass B2 (3); subclass B3 (6); class C (19); class D (13).
Last updated: January 08, 2024.
If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.
The development of the BLDB database is funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).
Contact: contact@bldb.eu